Role of recombination activating genes in the generation of antigen receptor diversity and beyond

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Immunology

• Publication date

  2012-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/imm.12009PMID 23039142PMCID PMC3530083
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Differential reaction kinetics, cleavage complex formation, and nonamer binding domain dependence dictate the structure-specific and sequence-specific nuclease activity of RAGs.

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• Functional Characterization of an Active Rag-like Transposase

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• Mechanism of Fragility at BCL2 Gene Minor Breakpoint Cluster Region during t(14;18) Chromosomal Translocation*

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• Recombination centres and the orchestration of V(D)J recombination

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• How does DNA break during chromosomal translocations?

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• The RAG2 C-terminus suppresses genomic instability and lymphomagenesis

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• Nonhomologous DNA End Joining in Cell-Free Extracts

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• The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway.

  2010cited by this paper
• The in vivo pattern of binding of RAG1 and RAG2 to antigen receptor loci.

  2010cited by this paper
• Cytosines, but Not Purines, Determine Recombination Activating Gene (RAG)-induced Breaks on Heteroduplex DNA Structures

  2010cited by this paper
• Formation of a G-quadruplex at the BCL2 major breakpoint region of the t(14;18) translocation in follicular lymphoma

  2010cited by this paper
• A non-sequence-specific DNA binding mode of RAG1 is inhibited by RAG2.

  2009cited by this paper
• Regulation of RAG transposition.

  2009cited by this paper
• H3K4me3 stimulates the V(D)J RAG complex for both nicking and hairpinning in trans in addition to tethering in cis: implications for translocations.

  2009cited by this paper
• Mechanism and regulation of class switch recombination.

  2008cited by this paper
• V(D)J Recombinase Binding and Cleavage of Cryptic Recombination Signal Sequences Identified from Lymphoid Malignancies*

  2008cited by this paper
• RAG 2 PHD finger couples histone H 3 lysine 4 trimethylation with V ( D ) J recombination

  2007cited by this paper
• A plant homeodomain in RAG-2 that binds Hypermethylated lysine 4 of histone H3 is necessary for efficient antigen-receptor-gene rearrangement.

  2007cited by this paper
• The structure-specific nicking of small heteroduplexes by the RAG complex: implications for lymphoid chromosomal translocations.

  2007cited by this paper
• RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination

  2007cited by this paper
• The Beyond 12/23 Restriction Is Imposed at the Nicking and Pairing Steps of DNA Cleavage during V(D)J Recombination

  2007cited by this paper
• XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining.

  2006cited by this paper
• Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly.

  2006cited by this paper
• Nonoverlapping functions of DNA polymerases mu, lambda, and terminal deoxynucleotidyltransferase during immunoglobulin V(D)J recombination in vivo.

  2006cited by this paper
• Beyond the 12/23 Rule of VDJ Recombination Independent of the Rag Proteins 1

  2005cited by this paper
• Double-Strand Break Formation by the RAG Complex at the Bcl-2 Major Breakpoint Region and at Other Non-B DNA Structures In Vitro

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• From the authors

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• A gradient of template dependence defines distinct biological roles for family X polymerases in nonhomologous end joining.

  2005cited by this paper
• A PHD Finger Motif in the C Terminus of RAG2 Modulates Recombination Activity*[boxs]

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• Immunoglobulin locus silencing and allelic exclusion.

  2005cited by this paper
• The recombination activating genes, RAG 1 and RAG 2, are on chromosome 11p in humans and chromosome 2p in mice

  2004cited by this paper
• A non-B-DNA structure at the Bcl-2 major breakpoint region is cleaved by the RAG complex

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• Extrachromosomal recombination substrates recapitulate beyond 12/23 restricted VDJ recombination in nonlymphoid cells.

  2003cited by this paper
• Antigen receptor selection by editing or downregulation of V(D)J recombination.

  2003cited by this paper
• The RAG 1 N-terminal domain is an E 3 ubiquitin ligase

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• In vivo transposition mediated by V(D)J recombinase in human T lymphocytes

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  2002cited by this paper
• Leaky Scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice.

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• The mechanism and regulation of chromosomal V(D)J recombination.

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• Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination.

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• Somatic hypermutation

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• Targeted Transposition by the V(D)J Recombinase

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• V(D)J recombination

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• V(D)J-mediated Translocations in Lymphoid Neoplasms

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• J-mediated Translocations in Lymphoid Neoplasms : A Functional Assessment of Genomic Instability by Cryptic Sites

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• Analysis of the V(D)J Recombination Efficiency at Lymphoid Chromosomal Translocation Breakpoints*

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• RAG1 and RAG2 in V(D)J recombination and transposition

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• Identification of basic residues in RAG2 critical for DNA binding by the RAG1-RAG2 complex.

  2001cited by this paper
• Identification of Two Topologically Independent Domains in RAG1 and Their Role in Macromolecular Interactions Relevant to V(D)J Recombination*

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• Three-dimensional Clustering of Human RAG2 Gene Mutations in Severe Combined Immune Deficiency*

  2000cited by this paper
• Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2).

  2000cited by this paper
• Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme.

  2000cited by this paper
• Recombination signal sequences restrict chromosomal V(D)J recombination beyond the 12/23 rule

  2000cited by this paper
• The RAG proteins and V(D)J recombination: complexes, ends, and transposition.

  2000cited by this paper
• Identification of two catalytic residues in RAG1 that define a single active site within the RAG1/RAG2 protein complex.

  2000cited by this paper
• Follicular lymphomas' BCL-2/IgH junctions contain templated nucleotide insertions: novel insights into the mechanism of t(14;18) translocation.

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• Mutations in Conserved Regions of the Predicted RAG2 Kelch Repeats Block Initiation of V(D)J Recombination and Result in Primary Immunodeficiencies

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• Detection of RAG Protein-V(D)J Recombination Signal Interactions Near the Site of DNA Cleavage by UV Cross-Linking

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• DNA Hairpin Opening Mediated by the RAG1 and RAG2 Proteins

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• The RAG1/RAG2 complex constitutes a 3' flap endonuclease: implications for junctional diversity in V(D)J and transpositional recombination.

  1999cited by this paper
• Mutational analysis of RAG 1 and RAG 2 identifies three catalytic amino acids in RAG 1 critical for both cleavage steps of V ( D ) J recombination

  1999cited by this paper
• in vivo.

  1999cited by this paper
• Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination.

  1999cited by this paper
• Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase.

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• The Effect of Me2+ Cofactors at the Initial Stages of V(D)J Recombination*

  1998cited by this paper
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  1998cited by this paper
• The V(D)J recombination activating protein RAG2 consists of a six-bladed propeller and a PHD fingerlike domain, as revealed by sequence analysis

  1998cited by this paper
• Assembly of a 12/23 paired signal complex: a critical control point in V(D)J recombination.

  1998cited by this paper
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  1998cited by this paper
• DNA transposition by the RAG1 and RAG2 proteins: a possible source of oncogenic translocations.

  1998cited by this paper
• A stable RAG1-RAG2-DNA complex that is active in V(D)J cleavage.

  1997cited by this paper
• Self-antigen does not accelerate immature B cell apoptosis, but stimulates receptor editing as a consequence of developmental arrest.

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  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1996cited by this paper
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• A DNA end-binding factor involved in double-strand break repair and V(D)J recombination

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• Receptor editing in self-reactive bone marrow B cells

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• Receptor editing: an approach by autoreactive B cells to escape tolerance

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