CELLULAR MEDIATORS OF ANTI-LISTERIA IMMUNITY AS AN ENLARGED POPULATION OF SHORT-LIVED, REPLICATING T CELLS

An intravenous immunizing infection with the facultative, intracellular parasite, Listeria monocytogenes results in the production in the spleen of a population of immunologically-committed lymphocytes which can adoptively immunize normal recipients against a lethal challenge infection. These cellular mediators of immunity are first produced in the spleen between days 2 and 4 of infection and reach peak production on day 6. Their production then progressively decreases until about day 20 when their presence can no longer be detected. Increased production of cellular mediators is coincident with major increases in cell division, cellularity, and spleen weight. Decreased production of cellular mediators, on the other hand, is associated with decreases in cell division, cellularity, and spleen weight. Again, the level of delayed sensitivity to Listeria antigens expressed by the host at any one time is proportional to the number of cellular mediators in the spleen. Increased production of cellular mediators is also associated with major increases in the total numbers of replicating T cells and B cells in the spleen. That the cellular mediators of immunity are part of the replicating T cell population, rather than the B cell population, is evidenced by their susceptibility to anti-θ serum and by their resistance to anti-Ig serum. Furthermore, they can be completely eliminated from the spleen by a brief pulse of the antimitotic drug, vinblastine. This study allows the conclusion that the cellular mediators of anti-Listeria immunity belong to an expanded population of rapidly dividing, short-lived T cells. It is suggested that they have the same properties as the T cell effectors of allograft immunity.

• Publication year

  1973

• Venue

  Journal of Experimental Medicine

• Publication date

  1973-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1084/JEM.138.2.342PMID 4198199PMCID 2139407
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• THE MEDIATOR OF CELLULAR IMMUNITY

  1973cited by this paper
• Importance of thymus-derived lymphocytes in cell-mediated immunity to infection.

  1973cited by this paper
• Cellular and humoral immunity after allogeneic transplantation in the rat. I. Cellular and humoral immunity of measured by a 51 Cr cytotoxicity assay after allogeneic tumor and renal transplantation.

  1973cited by this paper
• Greater sensitivity to inhibition by anti-immunoglobulin of splenic than of bone marrow B-lymphocytes.

  1973cited by this paper
• The action of cortisone acetate on cell-mediated immunity to infection: histogenesis of the lymphoid cell response and selective elimination of committed lymphocytes.

  1972influential reference
• B lymphocytes can be stimulated by concanavalin A in the presence of humoral factors released by T cells

  1972cited by this paper
• The histogenesis of immunologically committed lymphocytes.

  1972influential reference
• REQUIREMENT OF THYMUS (T) LYMPHOCYTES FOR RESISTANCE TO LISTERIOSIS

  1972cited by this paper
• Cell‐Mediated Immunity to Bacterial Infection in the Mouse. Thymus‐Derived Cells as Effectors of Acquired Resistance to Listeria monocytogenes

  1972cited by this paper
• THE MEDIATOR OF CELLULAR IMMUNITY

  1971cited by this paper
• THE PERITONEAL EXUDATE LYMPHOCYTE

  1971cited by this paper
• THE MEDIATOR OF CELLULAR IMMUNITY

  1971cited by this paper
• QUANTITATIVE ASSESSMENT OF CELLULAR AND HUMORAL RESPONSES TO SKIN AND TUMOR ALLOGRAFTS

  1971cited by this paper
• Absorption of guinea pig serum with agar. A method for elimination of itscytotoxicity for murine thymus cells.

  1970cited by this paper
• Hydrocortisne resistance of graft vs host activity in mouse thymus, spleen and bone marrow.

  1970cited by this paper
• Two distinct populations of peripheral lymphocytes in mice distinguishable by immunofluorescence.

  1970influential reference
• Hydrocortisone Resistance of Graft vs Host Activity in Mouse Thymus, Spleen and Bone Marrow

  1970cited by this paper
• THE INFLUENCE OF IMMUNOLOGICALLY COMMITTED LYMPHOID CELLS ON MACROPHAGE ACTIVITY IN VIVO

  1969cited by this paper
• An in vitro assay for growth-inhibiting activity of vinblastine.

  1965cited by this paper
• CELLULAR RESISTANCE TO INFECTION

  1962cited by this paper

• Potential Utility of Induced Translocation of Engineered Bacteria as a Therapeutic Agent for Mounting a Personalized Neoantigen‐Based Tumor Immune Response

  2021cites this paper
• Defining the Kinetics, Phenotype, and Function of T Cells Induced by Mycobacterium tuberculosis: Pillar of Immunity to Tuberculosis

  2017cites this paper
• A ROLE OF MACROPHAGES: AN OVERVIEW

  2017cites this paper
• Innate and adaptive immunologic functions of complement in the host response to Listeria monocytogenes infection.

  2016cites this paper
• Relative immunogenicity of streptomycin-susceptible and -resistant strains of BCG. II. Effect of the route of inoculation on growth and immunogenicity.

  2015cites this paper
• Biological Effects of Listeriolysin O: Implications for Vaccination

  2015cites this paper
• Macrophage Polarization in Inflammatory Diseases

  2014cites this paper
• Attenuated Listeria monocytogenes: a powerful and versatile vector for the future of tumor immunotherapy

  2014cites this paper
• THE ROLE OF THE C5A RECEPTOR IN HOST DEFENSE AGAINST LISTERIA MONOCYTOGENES

  2014cites this paper
• Innate immune pathways triggered by Listeria monocytogenes and their role in the induction of cell-mediated immunity.

  2012cites this paper
• Studies with Listeria monocytogenes lead the way.

  2012cites this paper
• Characterization of Listeria monocytogenes Peptidoglycan N-Deacetylase and O-Acetylase Mutations and the Role of Lysozyme Resistance During Infection

  2011influential citation
• Forward genetics to identify Listeria monocytogenes components that activate mammalian cytosolic surveillance pathways

  2011cites this paper
• Particle Size Determines Activation of the Innate Immune System in the Lung

  2009cites this paper
• Alternative activation of macrophages: an immunologic functional perspective.

  2009cites this paper
• Particles from wood smoke and road traffic differently affect the innate immune system of the lung

  2009cites this paper
• The alternatively activated human--redux.

  2009cites this paper
• Survival and Death of Leishmania in Macrophages

  2008cites this paper
• Particle size and source; effects on allergy adjuvant activity and innate immunity

  2008cites this paper
• PrimaryListeria monocytogenes infection in gestating mice

  2008cites this paper
• Interactions in vitro Between Toxoplasma gondii and Mouse Cells

  2008cites this paper
• Anti-Infective Vaccine Strategies

  2008cites this paper
• Fungistatic and fungicidal activities of murine polymorphonuclear leucocytes against yeast cells of Paracoccidioides brasiliensis: Antifungal activity of PMN for P. brasiliensis

  2008cites this paper
• The Onset of CD8 (cid:1) -T-Cell Contraction Is Influenced by the Peak of Listeria monocytogenes Infection and Antigen Display

  2006cites this paper
• The Onset of CD8+-T-Cell Contraction Is Influenced by the Peak of Listeria monocytogenes Infection and Antigen Display

  2006cites this paper
• Effects of continous administration of low-dose of Escherichia coli lipopolysaccharide in chicks and poults fed non toxic doses of aflatoxin B1 and T-2 toxin

  2005cites this paper
• Virulence of different strains ofListeria monocytogenes serovar 1/2a

  2005cites this paper
• Comparison of responsiveness to the monocytosis-producing activity of listeria monocytogenes in mice genetically susceptible or resistant to listeriosis

  2005cites this paper
• Protection from Bacterial Infection by a Single Vaccination with Replication-Deficient Mutant Herpes Simplex Virus Type 1

  2004cites this paper
• A Specific Role for B Cells in the Generation of CD8 T Cell Memory by Recombinant Listeria monocytogenes 1

  2003cites this paper
• SEA STAR COELOMOCYTE EXTRACT AND CELLULAR IMMUNITY

  2003cites this paper
• Detection of C 3 and C 5 on Monoeytes by the Direct Immunofluorescent Antibody Technique

  2003cites this paper
• Adjuvanticity of an IL-12 fusion protein expressed by recombinant deltaG-vesicular stomatitis virus.

  2002cites this paper
• Nitric Oxide in Listeriosis

  2002influential citation
• A Critical Role for Interleukin 18 in Primary and Memory Effector Responses to Listeria monocytogenes That Extends Beyond Its Effects on Interferon γ Production

  2001cites this paper
• Serum Antibody Response Against Listeria ivanovii in Experimentally Infected Rabbits

  2001cites this paper
• PDFlib PLOP: PDF Linearization, Optimization, Protection Page inserted by evaluation version

  2001cites this paper
• Immunity to Listeria infection.

  2000cites this paper
• Listeria monocytogenes Protection Against Primary and Secondary MHC Class Ib-Restricted CTL Provide

  2000cites this paper
• Depletion of a gd T Cell Subset Can Increase Host Resistance to a Bacterial Infection

  2000cites this paper
• Depletion of a γδ T Cell Subset Can Increase Host Resistance to a Bacterial Infection1

  2000cites this paper
• ClpC ATPase Is Required for Cell Adhesion and Invasion of Listeria monocytogenes

  2000cites this paper
• MHC Class Ib-Restricted CTL Provide Protection Against Primary and Secondary Listeria monocytogenes Infection1

  2000cites this paper
• Depletion of a gamma delta T cell subset can increase host resistance to a bacterial infection.

  2000cites this paper
• Th 1 T Cell Responses to HIV-1 Gag Protein Delivered by a Listeria monocytogenes Vaccine Are Similar to Those Induced by Endogenous Listerial Antigens 1

  1999cites this paper
• A comparison of T cell memory against the same antigen induced by virus versus intracellular bacteria.

  1999cites this paper
• Fungistatic and fungicidal activities of murine polymorphonuclear leucocytes against yeast cells of Paracoccidioides brasiliensis.

  1999cites this paper
• Antiorthostatic Suspension Stimulates Profiles of Macrophage Activation in Mice

  1999cites this paper
• Endogenous Listerial Antigens Vaccine Are Similar to Those Induced by Listeria monocytogenes Delivered by a Th1 T Cell Responses to HIV-1 Gag Protein

  1999cites this paper
• Thymic Independence of Adaptive Immunity to the Intracellular Pathogen Shigella flexneri Serotype 2a

  1999cites this paper
• CD8+ T Cells Are a Biologically Relevant Source of Macrophage Inflammatory Protein-1α In Vivo

  1999cites this paper
• CD8+ T cells are a biologically relevant source of macrophage inflammatory protein-1 alpha in vivo.

  1999cites this paper
• Th1 T cell responses to HIV-1 Gag protein delivered by a Listeria monocytogenes vaccine are similar to those induced by endogenous listerial antigens.

  1999cites this paper
• Polyclonal antibody responses against Listeria monocytogenes 4b surface proteins in asymptomatic human carriers

  1998cites this paper
• 2-deoxy-D-glucose-induced metabolic stress enhances resistance to Listeria monocytogenes infection in mice.

  1998cites this paper
• Suppression of major histocompatibility complex class I and class II gene expression in Listeria monocytogenes-infected murine macrophages.

  1998cites this paper
• Induction of cytokine messenger RNA transcripts in mouse macrophages by Listeria monocytogenes isolated from channel catfish.

  1998cites this paper
• Central Nervous System Infection with Listeria monocytogenes : 33 Years' Experience at a General Hospital and Review of 776 Episodes from the Literature

  1998cites this paper
• Host resistance against Listeria monocytogenes is reciprocal during the course of infection in alymphoplastic aly mutant mice.

  1998cites this paper
• Long-lived protective immunity to Listeria is conferred by immunization with particulate or soluble listerial antigen preparations coadministered with IL-12.

  1998cites this paper
• Immunity to Listeria monocytogenes.

  1998cites this paper
• Acquired immunity to an intracellular pathogen:immunologic recognition of L. monocytogenes‐infected cells

  1997cites this paper
• Effective adjuvants for the induction of antigen-specific delayed-type hypersensitivity.

  1997cites this paper
• Studies in listeriosis show the strong symbiosis between the innate cellular system and the T‐cell response

  1997cites this paper
• Murine listeriosis as a model of antimicrobial defense

  1997cites this paper
• Locomotion and chemotaxis of lymphocytes.

  1997cites this paper
• Innate resistance to Listeria monocytogenes in tumor‐bearing mice

  1997cites this paper
• Why Listeriosis? A perspective on cellular immunity to infection

  1997cites this paper
• Antigen‐specific chemotaxis of B cells

  1997cites this paper
• Enhanced in vitro engulfment of Listeria monocytogenes by rabbit polymorphonuclear leukocytes in the presence of sera from immune rabbits.

  1996cites this paper
• Molecular and genetic determinants involved in invasion of mammalian cells by Listeria monocytogenes.

  1996cites this paper
• Bacterial Invasiveness

  1996influential citation
• Protective Immunity to Listeria monocytogenes Elicited by Immunization with Heat‐Killed Listeria and IL‐12

  1996cites this paper
• Early pathogenesis of Listeria monocytogenes infection in the mouse spleen.

  1996cites this paper
• Role of Th1 and Th2 cells in bacterial infections.

  1996cites this paper
• The inlAB locus mediates the entry of Listeria monocytogenes into hepatocytes in vivo

  1996cites this paper
• A monoclonal antibody against T-cell receptor αβ induces endogenous cytokines and prevents mice from a lethal infection with Listeria monocytogenes

  1995cites this paper
• Human T-cell recognition of Listeria monocytogenes: recognition of listeriolysin O by TcR alpha beta + and TcR gamma delta + T cells

  1995cites this paper
• Nonviable bacterial antigens administered with IL-12 generate antigen-specific T cell responses and protective immunity against Listeria monocytogenes.

  1995cites this paper
• A monoclonal antibody against T-cell receptor alpha beta induces endogenous cytokines and prevents mice from a lethal infection with Listeria monocytogenes.

  1995cites this paper
• Evidence that gamma delta T cells play a limited role in resistance to murine listeriosis.

  1994cites this paper
• Role of IL-6 in activation of T cells for acquired cellular resistance to Listeria monocytogenes.

  1994cites this paper
• Influence of antiorthostatic suspension on resistance to murine Listeria monocytogenes infection

  1994cites this paper
• Cellular Biology of Listeria monocytogenes Infection

  1994cites this paper
• An anti-CD3 monoclonal antibody protects mice against a lethal infection with Listeria monocytogenes through induction of endogenous cytokines

  1993cites this paper
• Comparison of gamma interferon, tumor necrosis factor, and direct cell contact in activation of antimycobacterial defense in murine macrophages

  1993cites this paper
• Influence of suspension on the expression of protective immunological memory to murine Listeria monocytogenes infection

  1993cites this paper
• Listeria monocytogenes infection in beta 2 microglobulin-deficient mice

  1993cites this paper
• Diagnostic ultrastructure of Listeria monocytogenes in human central nervous tissue.

  1993cites this paper
• Pathogenesis of Listeria monocytogenes

  1992cites this paper
• Endogenous tumor necrosis factor, interleukin-6, and gamma interferon levels during Listeria monocytogenes infection in mice

  1992cites this paper
• Immunostimulatory human urinary protein.

  1992cites this paper
• Introduction of Francisella tularensis at skin sites induces resistance to infection and generation of protective immunity.

  1992cites this paper
• Pathogenicity and immunogenicity of Listeria monocytogenes small-plaque mutants defective for intracellular growth and cell-to-cell spread

  1992cites this paper
• Activation of Kupffer cell tumoricidal activity by immunomodulators encapsulated in liposomes.

  1992cites this paper
• Limitations of the adoptive immunity assay for analyzing anti-Listeria immunity.

  1991cites this paper
• Analysis of the time course of IFN-gamma mRNA and protein production during primary murine listeriosis. The immune phase of bacterial elimination is not temporally linked to IFN production in vivo.

  1991cites this paper
• Reproducibility of seasonal effects in antibody formation and host resistance in the outbred mouse.

  1991cites this paper
• Purification and characterization of an extracellular 29-kilodalton phospholipase C from Listeria monocytogenes

  1991cites this paper
• Identification of cytokines which enhance (CSF-1, IL-3) or restrict (IFN-gamma) growth of intramacrophage Listeria monocytogenes.

  1991cites this paper