Listeria monocytogenes infection in beta 2 microglobulin-deficient mice

beta 2 microglobulin-deficient mice, in which the beta 2m gene has been disrupted by homologous recombination, lack functional CD8 T cells and are able to contain but not resolve an intravenous immunizing inoculum of Listeria monocytogenes. We present evidence that compensatory immunity in such immunodeficient mice was mediated by a population of gamma delta T-cell receptor-positive cells; in contrast, neither CD4 cells nor natural killer cells appeared to play any part in this process. These data further support the emerging hypothesis that immune cells other than those bearing the alpha beta T-cell receptor type can also play an important role in acquired resistance to listeriosis.

• Publication year

  1993

• Venue

  Infection and Immunity

• Publication date

  1993-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/iai.61.3.1113-1116.1993PMID 8432593PMCID PMC302846
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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