TRPA1 gene polymorphisms and childhood asthma

V. Gallo,F. N. Dijk,J. Holloway,S. Ring,G. Koppelman,D. Postma,D. Strachan,R. Granell,J. C. Jongste,V. Jaddoe,H. Dekker,L. Duijts,A. J. Henderson,S. Shaheen

Published 2016 in Pediatric Allergy and Immunology

ABSTRACT

Animal data have suggested that the transient receptor potential ankyrin‐1 (TRPA1) ion channel plays a key role in promoting airway inflammation in asthma and may mediate effects of paracetamol on asthma, yet confirmatory human data are lacking. To study associations of TRPA1 gene variants with childhood asthma and total IgE concentration, and interactions between TRPA1 and prenatal paracetamol exposure on these outcomes.

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