A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment

Balestrini et al. show the identification of a TRPA1 inhibitor that suppresses airway smooth muscle contraction, inflammation, edema, and cough in preclinical models and show target engagement in humans, demonstrating that pharmacologic inhibition of TRPA1 is a promising therapy for asthma.

• Publication year

  2021

• Venue

  Journal of Experimental Medicine

• Publication date

  2021-02-23

• Fields of study

  Medicine

• Identifiers
  DOI 10.1084/jem.20201637PMID 33620419PMCID 7918756
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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