Mitochondrial glutathione peroxidase 4 disruption causes male infertility

No abstract is available for this paper.

• Publication year

  2009

• Venue

  The FASEB Journal

• Publication date

  2009-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1096/fj.09-132795PMID 19417079
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death.

  2008cited by this paper
• Translational regulation of glutathione peroxidase 4 expression through guanine-rich sequence-binding factor 1 is essential for embryonic brain development.

  2008cited by this paper
• Physiological role of phospholipid hydroperoxide glutathione peroxidase in mammals

  2007cited by this paper
• The Role of Phospholipid Hydroperoxide Glutathione Peroxidase Isoforms in Murine Embryogenesis*

  2006cited by this paper
• Functional Interaction of Phospholipid Hydroperoxide Glutathione Peroxidase with Sperm Mitochondrion-associated Cysteine-rich Protein Discloses the Adjacent Cysteine Motif as a New Substrate of the Selenoperoxidase*

  2005cited by this paper
• The Nuclear Form of Phospholipid Hydroperoxide Glutathione Peroxidase Is a Protein Thiol Peroxidase Contributing to Sperm Chromatin Stability

  2005cited by this paper
• Selenoprotein P Is Required for Mouse Sperm Development1

  2005cited by this paper
• Intracytoplasmic injection of spermatozoa and spermatogenic cells: its biology and applications in humans and animals.

  2005cited by this paper
• Essential Role for Mitochondrial Thioredoxin Reductase in Hematopoiesis, Heart Development, and Heart Function

  2004cited by this paper
• Testis-Specific Expression of the Nuclear Form of Phospholipid Hydroperoxide Glutathione Peroxidase (PHGPx)

  2003cited by this paper
• Characterization of Mammalian Selenoproteomes

  2003cited by this paper
• Optimized vector for conditional gene targeting in mouse embryonic stem cells.

  2003cited by this paper
• Distinct Promoters Determine Alternative Transcription of gpx-4 into Phospholipid-Hydroperoxide Glutathione Peroxidase Variants*

  2003cited by this paper
• The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults.

  2003cited by this paper
• Deletion of Selenoprotein P Alters Distribution of Selenium in the Mouse*

  2003cited by this paper
• Identification of a specific sperm nuclei selenoenzyme necessary for protamine thiol cross‐linking during sperm maturation

  2001cited by this paper
• Phospholipid hydroperoxide glutathione peroxidase protects against singlet oxygen-induced cell damage of photodynamic therapy.

  2001cited by this paper
• Hyperresistance to cholesterol hydroperoxide-induced peroxidative injury and apoptotic death in a tumor cell line that overexpresses glutathione peroxidase isotype-4.

  2001cited by this paper
• Protein tyrosine nitration in mouse peritoneal macrophages activated in vitro and in vivo: evidence against an essential role of peroxynitrite

  2001cited by this paper
• Mitochondrial Phospholipid Hydroperoxide Glutathione Peroxidase Suppresses Apoptosis Mediated by a Mitochondrial Death Pathway*

  1999cited by this paper
• Dual function of the selenoprotein PHGPx during sperm maturation.

  1999cited by this paper
• Mitochondrial Phospholipid Hydroperoxide Glutathione Peroxidase Plays a Major Role in Preventing Oxidative Injury to Cells*

  1999cited by this paper
• Dissipation of mitochondrial membrane potential by exogenous phospholipid monohydroperoxide and protection against this effect by transfection of cells with phospholipid hydroperoxide glutathione peroxidase gene.

  1998cited by this paper
• Testosterone mediates expression of the selenoprotein PHGPx by induction of spermatogenesis and not by direct transcriptional gene activation

  1998cited by this paper
• Import into mitochondria of phospholipid hydroperoxide glutathione peroxidase requires a leader sequence.

  1996cited by this paper
• Intracytoplasmic sperm injection in the mouse.

  1995cited by this paper
• Rat Phospholipid-hydroperoxide Glutathione Peroxidase

  1995cited by this paper
• Phospholipid hydroperoxide glutathione peroxidase.

  1990cited by this paper
• Dynamics of the thiol status of rat spermatozoa during maturation: analysis with the fluorescent labeling agent monobromobimane.

  1989cited by this paper
• Microsomal lipid peroxidation: Effect of vitamin E and its functional interaction with phospholipid hydroperoxide glutathione peroxidase

  1989cited by this paper
• Improved pregnancy rate in human in vitro fertilization with the use of a medium based on the composition of human tubal fluid.

  1985cited by this paper
• Effects of selenium deficiency on the shape and arrangement of rodent sperm mitochondria

  1983cited by this paper
• Purification from pig liver of a protein which protects liposomes and biomembranes from peroxidative degradation and exhibits glutathione peroxidase activity on phosphatidylcholine hydroperoxides.

  1982cited by this paper
• Activation of mammalian oocytes by intracellular injection of calcium

  1978cited by this paper
• Effect of selenium, vitamin E, and antioxidants on testicular function in rats.

  1973cited by this paper
• Incorporation of Selenium into Spermatogenic Pathway in Mice.∗

  1967cited by this paper
• Distribution of Selenium in Mice Studied by Whole-Body Autoradiography After Injection of Se75-Sodium Selenite

  1965cited by this paper

• Integrated brain and testis transcriptomic analyses reveal the benefits of sandy environmental enrichment in Senegalese sole male (Solea senegalensis) reproduction

  2026cites this paper
• Ferroptosis and metastasis: molecular checkpoints, microenvironmental dynamics, and therapeutic opportunities

  2026cites this paper
• Genetics of selenoproteins and selenoprotein metabolism - An overview of current concepts and emerging aspects.

  2026cites this paper
• Impact of selenium and selenoproteins on idiopathic male infertility: a comprehensive review

  2026influential citation
• Redundant or resilient? A systems view of ferroptosis surveillance mechanisms.

  2026cites this paper
• Spatiotemporal dynamics of reactive oxygen species: implications for cellular homeostasis and redox therapies.

  2026cites this paper
• Ferroptotic vulnerability of post-meiotic germ cells skews sex chromosome ratios in aged testis

  2026cites this paper
• Selenium supplementation and male fertility: Mechanistic insights and therapeutic potential.

  2026cites this paper
• Mechanisms of Development of Sperm Defects.

  2025cites this paper
• Ferroptosis as an Emerging Target in Diabetic Osteoporosis

  2025cites this paper
• Recommendations for robust and reproducible research on ferroptosis

  2025cites this paper
• Redox signaling regulation in human spermatozoa: a primary role of peroxiredoxins

  2025cites this paper
• Bovine viral diarrhea virus E2 targets SLC3A2 to modulate lipid peroxidation for replication advantage.

  2025cites this paper
• Targeting Cellular Energetics via Ferroptosis Mediated Cell Death in Resistant Colorectal Cancer Stem Cells

  2025cites this paper
• Sequestration of the polyunsaturated fatty acids protects the cells with oxidative phosphorylation deficiency from ferroptosis

  2025cites this paper
• Bovine Spermatogenesis.

  2025cites this paper
• The Ultrastructure and Composition of Bovine Spermatozoa.

  2025cites this paper
• The role of iron in normal and impaired testicular function.

  2025cites this paper
• Assessment of Electroacupuncture Therapy with Distant-Approximal Acupoints Based on the HPT Axis in Rats with Oligoasthenospermia Through Transcriptomic Analysis

  2025cites this paper
• Central SELENOT deficiency impairs gonadotrope axis function, sexual behavior, and fertility in male and female mice

  2025cites this paper
• Burkitt's Lymphoma and Early B Cell Transformation as Paradigms of How Epstein-Barr Virus Overcomes Apoptosis and Ferroptosis.

  2025cites this paper
• Role of Redox-Induced Protein Modifications in Spermatozoa in Health and Disease

  2025cites this paper
• Iron and ferroptosis in kidney disease: molecular and metabolic mechanisms

  2025cites this paper
• A novel mechanism of sperm midpiece epididymal maturation and the role of CCDC112 in sperm midpiece formation and establishing an optimal flagella waveform

  2025cites this paper
• Sperm mitochondrial sheath formation - how and why?

  2025cites this paper
• Selenoproteins: Minute yet vital players governing cellular fate

  2025cites this paper
• Molecular Alterations in Semen of Per-And Polyfluoroalkyl Substance Exposed Subjects: Association Between DNA Integrity, Antioxidant Capacity and Lipoperoxides

  2025cites this paper
• Targeting ferroptosis in cancer stem cells: A novel strategy to improve cancer treatment

  2025cites this paper
• Inhibition of mitochondrial complex I induces mitochondrial ferroptosis by regulating CoQH2 levels in cancer

  2025cites this paper
• Targeting ferroptosis in cancer therapy: Mechanisms, strategies, and clinical applications

  2025cites this paper
• Is Ferroptosis a cause for concern in Male Infertility.

  2025cites this paper
• Iron and selenium: At the crossroads of development and death in oligodendrocytes.

  2025cites this paper
• Polystyrene microplastics induced spermatogenesis disorder via disrupting mitochondrial function through the regulation of the Sirt1-Pgc1α signaling pathway in male mice.

  2024cites this paper
• Spatial Organization of the Sperm Cell Glycoproteome

  2024cites this paper
• Emerging mechanisms of lipid peroxidation in regulated cell death and its physiological implications

  2024cites this paper
• Ferroptosis: when metabolism meets cell death.

  2024cites this paper
• Potential role and therapeutic implications of glutathione peroxidase 4 in the treatment of Alzheimer’s disease

  2024cites this paper
• Ferroptosis in health and disease

  2024cites this paper
• Unresolved questions regarding cellular cysteine sources and their possible relationships to ferroptosis.

  2024cites this paper
• Non-coding RNA: A key regulator in the Glutathione-GPX4 pathway of ferroptosis

  2024cites this paper
• A comprehensive review of peroxiredoxin 4, a redox protein evolved in oxidative protein folding coupled with hydrogen peroxide detoxification.

  2024cites this paper
• Recent Advances in the Inhibition of Membrane Lipid Peroxidation by Food-Borne Plant Polyphenols via the Nrf2/GPx4 Pathway.

  2024cites this paper
• The role of ferroptosis in central nervous system damage diseases

  2024cites this paper
• Pharmacological approaches for targeting lysosomes to induce ferroptotic cell death in cancer.

  2024cites this paper
• Ferroptosis in cancer: from molecular mechanisms to therapeutic strategies

  2024cites this paper
• The Understanding and Treatment of Male Infertility Caused by Varicocele Due to Oxidative Stress

  2024cites this paper
• A comprehensive review on potential role of selenium, selenoproteins and selenium nanoparticles in male fertility

  2024cites this paper
• Ferroptosis in head and neck squamous cell carcinoma: from pathogenesis to treatment

  2024cites this paper
• A guide to ferroptosis in cancer

  2024cites this paper
• Mechanism of ferroptosis regulating ischemic stroke and pharmacologically inhibiting ferroptosis in treatment of ischemic stroke

  2024cites this paper
• GPX4 in cell death, autophagy, and disease

  2023influential citation
• Effects of Reactive Oxygen and Nitrogen Species on Male Fertility

  2023cites this paper
• Mitochondrial Peroxiredoxin 3 Is Rapidly Oxidized and Hyperoxidized by Fatty Acid Hydroperoxides

  2023cites this paper
• Mechanisms That Protect Mammalian Sperm from the Spontaneous Acrosome Reaction

  2023cites this paper
• The concentration of glucose in the media influences the susceptibility of stallion spermatozoa to ferroptosis.

  2023cites this paper
• Renal Epithelial Mitochondria: Implications for Hypertensive Kidney Disease.

  2023cites this paper
• AOP Report: Glutathione Conjugation Leading to Reproductive Dysfunction via Oxidative Stress

  2023cites this paper
• Cholesterol Hydroperoxide Co-trafficking in Testosterone-generating Leydig Cells: GPx4 Inhibition of Cytotoxic and Anti-steroidogenic Effects

  2023cites this paper
• Molecular Mechanisms of Ferroptosis and Updates of Ferroptosis Studies in Cancers and Leukemia

  2023cites this paper
• “Alphabet” Selenoproteins: Implications in Pathology

  2023cites this paper
• Mitochondria-mediated Ferroptosis in Diseases Therapy: From Molecular Mechanisms to Implications

  2023cites this paper
• Repression of ferroptotic cell death by mitochondrial calcium signaling

  2023cites this paper
• Reply to: DHODH inhibitors sensitize to ferroptosis by FSP1 inhibition

  2023cites this paper
• Disruption of testis-enriched cytochrome c oxidase subunit COX6B2 but not COX8C leads to subfertility

  2023cites this paper
• Reactivity of mitochondrial peroxiredoxins with biological hydroperoxides

  2023cites this paper
• Identification and Functional Assignment of Genes Implicated in Sperm Maturation of Tibetan Sheep

  2023cites this paper
• Nonmetabolic role for CKB in ferroptosis

  2023cites this paper
• Emerging roles of ferroptosis in male reproductive diseases

  2023cites this paper
• Biological and Catalytic Properties of Selenoproteins

  2023cites this paper
• Bisphenol S induces oxidative stress‐mediated impairment of testosterone synthesis by inhibiting the Nrf2/HO‐1 signaling pathway

  2022cites this paper
• Gpx4, Selenov, and Txnrd3 Are Three Most Testis-Abundant Selenogenes Resistant to Dietary Selenium Concentrations and Actively Expressed During Reproductive Ages in Rats

  2022cites this paper
• Ferroptosis-related genes involved in animal reproduction: An Overview.

  2022cites this paper
• The Role of Selenium in Pathologies: An Updated Review

  2022cites this paper
• The multifaceted role of ferroptosis in liver disease

  2022cites this paper
• Effects of BPA, BPS, and BPF on Oxidative Stress and Antioxidant Enzyme Expression in Bovine Oocytes and Spermatozoa

  2022cites this paper
• GPX4: old lessons, new features.

  2022cites this paper
• The molecular and metabolic landscape of iron and ferroptosis in cardiovascular disease

  2022cites this paper
• A white paper on Phospholipid Hydroperoxide Glutathione Peroxidase (GPx4) forty years later.

  2022cites this paper
• An Overview of Essential Microelements and Common Metallic Nanoparticles and Their Effects on Male Fertility

  2022cites this paper
• The Impact of Lifestyle on Sperm Function, Telomere Length, and IVF Outcomes

  2022cites this paper
• Biallelic mutations in ARMC12 cause asthenozoospermia and multiple midpiece defects in humans and mice

  2022cites this paper
• Function and regulation of GPX4 in the development and progression of fibrotic disease

  2022cites this paper
• Mitochondrial glutathione peroxidase 4 is indispensable for photoreceptor development and survival in mice

  2022cites this paper
• Sperm Redox System Equilibrium: Implications for Fertilization and Male Fertility.

  2022cites this paper
• Targeting ferroptosis as a vulnerability in cancer

  2022cites this paper
• Immunohistochemical Expression of Ki-67, cytokeratin-18 and BCL-2 in Wistar rats testes treated with Rauwolfia vomitoria, Chlorpromazine and Co-administration of Reserpine, Ascorbate and Zinc

  2022cites this paper
• Mitochondrial regulation of ferroptosis

  2021cites this paper
• Production and purification of homogenous recombinant human selenoproteins reveals a unique codon skipping event in E. coli and GPX4-specific affinity to bromosulfophthalein

  2021cites this paper
• Glutathione Content and Glutathione Peroxidase Activity of Sperm in Males with Unexplained Infertility

  2021cites this paper
• Chapter 6: Selenium in boar nutrition

  2021cites this paper
• The Possible Mechanism of Physiological Adaptation to the Low-Se Diet and Its Health Risk in the Traditional Endemic Areas of Keshan Diseases

  2021cites this paper
• Na,K-ATPase Atp1a4 isoform is important for maintaining sperm flagellar shape

  2021cites this paper
• Predicting the Outcome of Arsenic Toxicity on Exposed Juvenile Male-Humans: A Shift to Infertility

  2021cites this paper
• A mitochondrial gatekeeper that helps cells escape death by ferroptosis

  2021cites this paper
• Characterization of Glutathione Peroxidase 4 in Rat Oocytes, Preimplantation Embryos, and Selected Maternal Tissues during Early Development and Implantation

  2021cites this paper
• The effect of Phoenix dactylifera pollen on the expression of NRF2, SOD2, CAT, and GPX4 genes, and sperm parameters of fertile and infertile men: A controlled clinical trial

  2021cites this paper
• Ferroptosis: mechanisms, biology and role in disease

  2021cites this paper
• Ferroptosis: mechanisms and links with diseases

  2021cites this paper
• In-cell structures of a conserved supramolecular array at the mitochondria-cytoskeleton interface in mammalian sperm

  2021cites this paper
• Suppression of uterine and placental ferroptosis by N-acetylcysteine in a rat model of polycystic ovary syndrome.

  2021cites this paper