Adult Ciliary Epithelial Cells, Previously Identified as Retinal Stem Cells with Potential for Retinal Repair, Fail to Differentiate into New Rod Photoreceptors

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Stem Cells

• Publication date

  2010-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/stem.423PMID 20506130
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cell fate determination in the vertebrate retina.

  2012cited by this paper
• Generation of light-sensitive photoreceptor phenotypes by genetic modification of human adult ocular stem cells with Crx.

  2010cited by this paper
• Modeling early retinal development with human embryonic and induced pluripotent stem cells

  2009cited by this paper
• In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule induction

  2009cited by this paper
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• Chromosomal number aberrations and transformation in adult mouse retinal stem cells in vitro.

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• Cells previously identified as retinal stem cells are pigmented ciliary epithelial cells

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• Transplantation of human embryonic stem cell-derived photoreceptors restores some visual function in Crx-deficient mice.

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• Reprogramming progeny cells of embryonic RPE to produce photoreceptors: development of advanced photoreceptor traits under the induction of neuroD.

  2008cited by this paper
• Induction of functional photoreceptor phenotype by exogenous Crx expression in mouse retinal stem cells.

  2008cited by this paper
• Retinal cells integrate into the outer nuclear layer and differentiate into mature photoreceptors after subretinal transplantation into adult mice.

  2008cited by this paper
• Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming.

  2008cited by this paper
• Toward the generation of rod and cone photoreceptors from mouse, monkey and human embryonic stem cells

  2008cited by this paper
• Isolation and characterisation of neural progenitor cells from the adult Chx10(orJ/orJ) central neural retina.

  2008cited by this paper
• Reprogramming of human somatic cells to pluripotency with defined factors

  2008cited by this paper
• Generation of human induced pluripotent stem cells from dermal fibroblasts

  2008cited by this paper
• Why myc? An unexpected ingredient in the stem cell cocktail.

  2008cited by this paper
• Comparative Analysis of Progenitor Cells Isolated from the Iris, Pars Plana, and Ciliary Body of the Adult Porcine Eye

  2007cited by this paper
• Fibroblast growth factor and epidermal growth factor differently affect differentiation of murine retinal stem cells in vitro.

  2007cited by this paper
• Induction of pluripotent stem cells from adult human fibroblasts by defined factors.

  2007cited by this paper
• Notch 1 inhibits photoreceptor production in the developing mammalian retina

  2006cited by this paper
• Notch1 functions to suppress cone-photoreceptor fate specification in the developing mouse retina

  2006cited by this paper
• Retinal repair by transplantation of photoreceptor precursors

  2006cited by this paper
• Efficient generation of retinal progenitor cells from human embryonic stem cells

  2006cited by this paper
• Targeting of GFP to newborn rods by Nrl promoter and temporal expression profiling of flow-sorted photoreceptors.

  2006cited by this paper
• Retinal properties and potential of the adult mammalian ciliary epithelium stem cells.

  2005cited by this paper
• Iris-derived cells from adult rodents and primates adopt photoreceptor-specific phenotypes.

  2005cited by this paper
• Generation of Rx+/Pax6+ neural retinal precursors from embryonic stem cells.

  2005cited by this paper
• Long-term expansion of human neural progenitor cells by epigenetic stimulation in vitro.

  2005cited by this paper
• Otx2 homeobox gene induces photoreceptor-specific phenotypes in cells derived from adult iris and ciliary tissue.

  2004cited by this paper
• Retinal stem cells and regeneration.

  2004cited by this paper
• Facile isolation and the characterization of human retinal stem cells.

  2004cited by this paper
• Specification of the vertebrate eye by a network of eye field transcription factors

  2003cited by this paper
• Transdifferentiation of Pigmented Epithelial Cells: A Source of Retinal Stem Cells?

  2001cited by this paper
• Roles of homeobox and bHLH genes in specification of a retinal cell type.

  2001cited by this paper
• Nrl is required for rod photoreceptor development

  2001cited by this paper
• Identification of neural progenitors in the adult mammalian eye.

  2000cited by this paper
• Cellular senescence: mitotic clock or culture shock?

  2000cited by this paper
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  2000cited by this paper
• Identification of a proliferating marginal zone of retinal progenitors in postnatal chickens.

  2000cited by this paper
• Retinal stem cells in the adult mammalian eye.

  2000cited by this paper
• A Defined Window for Efficient Gene Marking of Severe Combined Immunodeficient-Repopulating Cells Using a Gibbon Ape Leukemia Virus-Pseudotyped Retroviral Vector

  2000cited by this paper
• Current understanding on the role of retinal pigment epithelium and its pigmentation.

  1999cited by this paper
• Differentiation and transdifferentiation of the retinal pigment epithelium.

  1997cited by this paper
• Crx, a novel otx-like homeobox gene, shows photoreceptor-specific expression and regulates photoreceptor differentiation.

  1997cited by this paper
• Crx, a novel Otx-like paired-homeodomain protein, binds to and transactivates photoreceptor cell-specific genes.

  1997cited by this paper
• Cell fate determination in the vertebrate retina.

  1996cited by this paper
• Expression of the bZIP transcription factor gene Nrl in the developing nervous system.

  1996cited by this paper
• Cell differentiation in the retina of the mouse

  1985cited by this paper
• The growth of the retina in Xenopus laevis: an autoradiographic study.

  1971cited by this paper
• Differential addition of cells to the retina in Rana pipiens tadpoles.

  1968cited by this paper
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  year unknowncited by this paper

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  2019cites this paper
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  2017cites this paper
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  2016cites this paper
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• Cellular strategies for retinal repair by photoreceptor replacement.

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  2013cites this paper
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  2012cites this paper
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  2012cites this paper
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  2011cites this paper
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  2011cites this paper
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  2011cites this paper
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  2011cites this paper
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  2011cites this paper