Multidonor analysis reveals structural elements, genetic determinants, and maturation pathway for HIV-1 neutralization by VRC01-class antibodies.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Immunity

• Publication date

  2013-08-22

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.immuni.2013.04.012PMID 23911655PMCID PMC3985390
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Engineering HIV envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodies

  2013cited by this paper
• Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus

  2013cited by this paper
• Structural basis for germline gene usage of a potent class of antibodies targeting the CD4 binding site of HIV-1 gp120

  2012cited by this paper
• Increased HIV-1 vaccine efficacy against viruses with genetic signatures in Env-V2

  2012cited by this paper
• Structural and genetic basis for development of broadly neutralizing influenza antibodies

  2012cited by this paper
• Rational immunogen design to target specific germline B cell receptors

  2012cited by this paper
• Selection Pressure on HIV-1 Envelope by Broadly Neutralizing Antibodies to the Conserved CD4-Binding Site

  2012cited by this paper
• Human antibodies that neutralize HIV-1: identification, structures, and B cell ontogenies.

  2012cited by this paper
• Statistical interpretation of the RV144 HIV vaccine efficacy trial in Thailand: a case study for statistical issues in efficacy trials.

  2011cited by this paper
• Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding

  2011cited by this paper
• Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing

  2011cited by this paper
• Antibody-based Protection Against HIV Infection by Vectored ImmunoProphylaxis

  2011cited by this paper
• A Limited Number of Antibody Specificities Mediate Broad and Potent Serum Neutralization in Selected HIV-1 Infected Individuals

  2010cited by this paper
• Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01

  2010cited by this paper
• Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1

  2010cited by this paper
• Human Immunodeficiency Virus Type 1 Elite Neutralizers: Individuals with Broad and Potent Neutralizing Activity Identified by Using a High-Throughput Neutralization Assay together with an Analytical Selection Algorithm

  2009cited by this paper
• Effective, low-titer antibody protection against low-dose repeated mucosal SHIV challenge in macaques

  2009cited by this paper
• Precise determination of the diversity of a combinatorial antibody library gives insight into the human immunoglobulin repertoire

  2009cited by this paper
• Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection

  2008cited by this paper
• Profiling the Specificity of Neutralizing Antibodies in a Large Panel of Plasmas from Patients Chronically Infected with Human Immunodeficiency Virus Type 1 Subtypes B and C

  2008cited by this paper
• Efficient protein boosting after plasmid DNA or recombinant adenovirus immunization with HIV-1 vaccine constructs.

  2007cited by this paper
• Phaser crystallographic software

  2007cited by this paper
• Dissecting the Neutralizing Antibody Specificities of Broadly Neutralizing Sera from Human Immunodeficiency Virus Type 1-Infected Donors

  2007cited by this paper
• Broad HIV-1 neutralization mediated by CD4-binding site antibodies

  2007cited by this paper
• Coot: model-building tools for molecular graphics.

  2004cited by this paper
• Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120.

  2004cited by this paper
• Rapid evolution of the neutralizing antibody response to HIV type 1 infection

  2003cited by this paper
• Antibody neutralization and escape by HIV-1

  2003cited by this paper
• X-ray snapshots of the maturation of an antibody response to a protein antigen

  2003cited by this paper
• B‐cell repertoire formation: role of the recombination signal sequence in non‐random V segment utilization

  2000cited by this paper
• Protection of macaques against vaginal transmission of a pathogenic HIV-1/SIV chimeric virus by passive infusion of neutralizing antibodies

  2000cited by this paper
• [20] Processing of X-ray diffraction data collected in oscillation mode.

  1997cited by this paper
• Processing of X-ray diffraction data collected in oscillation mode.

  1997cited by this paper
• The CCP4 suite: programs for protein crystallography.

  1994cited by this paper
• Sequences of proteins of immunological interest

  1991cited by this paper
• Electronic Reprint Biological Crystallography Phenix: Building New Software for Automated Crystallographic Structure Determination Biological Crystallography Phenix: Building New Software for Automated Crystallographic Structure Determination

  year unknowncited by this paper

• A SARS-CoV-2 variant-induced NTD-targeting antibody enhances viral infection via a distinctive binding mode

  2026cites this paper
• Heterologous immunization modulates B-cell epitope competition between helper peptides and the MPER segment in MPER/liposome vaccines

  2026cites this paper
• Divalent HIV-1 gp120 Immunogen Exhibits Selective Avidity for Broadly Neutralizing Antibody VRC01 Precursors

  2026cites this paper
• Increased immunogen valency improves the maturation of vaccine-elicited HIV-1 VRC01-class antibodies

  2025cites this paper
• Profiling of HIV-1 elite neutralizer cohort reveals a CD4bs bnAb for HIV-1 prevention and therapy

  2025influential citation
• Engineering HIV antibodies with enhanced breadth and potency of neutralization through multistate affinity maturation

  2025cites this paper
• Precise targeting of human HIV broadly neutralizing antibody precursors

  2025cites this paper
• Function and structure of broadly neutralizing antibodies against SARS-CoV-2 Omicron variants isolated from prototype strain infected convalescents

  2025cites this paper
• Conformational Variability of HIV-1 Env Trimer and Viral Vulnerability

  2025cites this paper
• Unveiling Interaction Signatures Across Viral Pathogens through VASCO: Viral Antigen-Antibody Structural COmplex dataset

  2025cites this paper
• Mapping essential somatic hypermutations in a CD4-binding site bNAb informs HIV-1 vaccine design

  2025cites this paper
• Structure and function of a pair of non-competing monoclonal antibodies against Langya henipavirus attachment glycoprotein.

  2025cites this paper
• Structural and genetic basis of HIV-1 envelope V2 apex recognition by rhesus broadly neutralizing antibodies

  2025cites this paper
• Rapid acquisition of HIV-1 neutralization breadth in a rhesus V2 apex germline antibody mouse model after a single bolus immunization

  2025cites this paper
• Structural convergence and water-mediated substrate mimicry enable broad neuraminidase inhibition by human antibodies

  2025cites this paper
• Accelerating antibody discovery and optimization with high-throughput experimentation and machine learning

  2025cites this paper
• Distinct modes of evolution drive HIV escape from two broadly neutralizing antibodies

  2025cites this paper
• Profiling a large HIV-1 elite neutralizer cohort reveals remarkable CD4bs bNAb for HIV-1 prevention and therapy

  2025cites this paper
• Structurally conserved human anti-A35 antibodies protect mice and macaques from mpox virus infection.

  2025cites this paper
• Yeast Display Reveals Plentiful Mutations That Improve Fusion Peptide Vaccine-Elicited Antibodies Beyond 59% HIV-1 Neutralization Breadth

  2025cites this paper
• Vaccination with mRNA-encoded nanoparticles drives early maturation of HIV bnAb precursors in humans.

  2025cites this paper
• Resistance mutations that distinguish HIV-1 envelopes with discordant VRC01 phenotypes from multi-lineage infections in the HVTN703/HPTN081 trial: implications for cross-resistance

  2025cites this paper
• Structural insights into VRC01-class bnAb precursors with diverse light chains elicited in the IAVI G001 human vaccine trial

  2025influential citation
• Heterologous immunization modulates B-cell epitope competition between helper peptides and the MPER segment in MPER/liposome vaccines

  2025cites this paper
• Divalent HIV-1 gp120 Immunogen Exhibits Selective Avidity for Broadly Neutralizing Antibody VRC01 Precursors

  2025cites this paper
• NIEAs elicited by wild-type SARS-CoV-2 primary infection fail to enhance the infectivity of Omicron variants

  2025cites this paper
• Structural development of the HIV-1 apex-directed PGT145-PGDM1400 antibody lineage

  2025cites this paper
• A comprehensive engineering strategy improves potency and manufacturability of a near pan-neutralizing antibody against HIV

  2025cites this paper
• Low nanomolar affinity to major grass pollen allergen Phl p 5 as achieved in an unmutated human antibody-lineage ancestor

  2025cites this paper
• Structural insights into VRC01-class bnAb precursors with diverse light chains elicited in the IAVI G001 human vaccine trial

  2025influential citation
• Increased immunogen valency improves the maturation of vaccine-elicited HIV-1 VRC01-like antibodies

  2025cites this paper
• Priming VRC01-precursor B cells with non-envelope immunogens disfavors boosting with HIV-1 envelope

  2025cites this paper
• mRNA-LNP prime–boost evolves precursors toward VRC01-like broadly neutralizing antibodies in preclinical humanized mouse models

  2024cites this paper
• High affinity mAb infusion can enhance maximum affinity maturation during HIV Env immunization

  2024cites this paper
• A SARS-CoV-2 Interaction Dataset and VHH Sequence Corpus for Antibody Language Models

  2024cites this paper
• Human immunoglobulin gene allelic variation impacts germline-targeting vaccine priming

  2024cites this paper
• B cell somatic hypermutation following COVID-19 vaccination with Ad26.COV2.S

  2024cites this paper
• RAIN: machine learning-based identification for HIV-1 bNAbs

  2024cites this paper
• Vaccine induction of CD4-mimicking HIV-1 broadly neutralizing antibody precursors in macaques.

  2024cites this paper
• The Question of HIV Vaccine: Why Is a Solution Not Yet Available?

  2024cites this paper
• A multidonor class of highly glycan-dependent HIV-1 gp120-gp41 interface-targeting broadly neutralizing antibodies.

  2024cites this paper
• Rapid affinity optimization of an anti-TREM2 clinical lead antibody by cross-lineage immune repertoire mining

  2024cites this paper
• Short CDRL1 in intermediate VRC01-like mAbs is not sufficient to overcome key glycan barriers on HIV-1 Env

  2024influential citation
• Parallel HIV-1 fitness landscapes shape viral dynamics in humans and macaques that develop broadly neutralizing antibodies

  2024cites this paper
• Identification of a mimotope of a complex gp41 human immunodeficiency virus epitope related to a non-structural protein of Hepacivirus previously implicated in Kawasaki disease

  2024cites this paper
• Immunization with germ line–targeting SOSIP trimers elicits broadly neutralizing antibody precursors in infant macaques

  2024cites this paper
• Ultrapotent Broadly Neutralizing Human‐llama Bispecific Antibodies against HIV‐1

  2024cites this paper
• RAIN: a Machine Learning-based identification for HIV-1 bNAbs

  2024cites this paper
• Single-component multilayered self-assembling protein nanoparticles presenting glycan-trimmed uncleaved prefusion optimized envelope trimers as HIV-1 vaccine candidates

  2023cites this paper
• ‘Immunization during ART and ATI for HIV-1 vaccine discovery/development’

  2023cites this paper
• Discovery medicine – the HVTN's iterative approach to developing an HIV-1 broadly neutralizing vaccine

  2023cites this paper
• Engaging an HIV vaccine target through the acquisition of low B cell affinity

  2023cites this paper
• Engineering immunogens that select for specific mutations in HIV broadly neutralizing antibodies

  2023cites this paper
• Germline-targeting SOSIP trimer immunization elicits precursor CD4 binding-site targeting broadly neutralizing antibodies in infant macaques

  2023cites this paper
• HIV-1 neutralizing antibodies elicited in humans by a prefusion-stabilized envelope trimer form a reproducible class targeting fusion peptide

  2023cites this paper
• Zika-specific neutralizing antibodies targeting inter-dimer envelope epitopes

  2023cites this paper
• Omicron BQ.1.1 and XBB.1 unprecedentedly escape broadly neutralizing antibodies elicited by prototype vaccination

  2023cites this paper
• Microsecond dynamics control the HIV-1 envelope conformation

  2023cites this paper
• Multi-Task Learning with Loop Specific Attention for CDR Structure Prediction

  2023cites this paper
• Signatures of VH1-69-derived hepatitis C virus neutralizing antibody precursors defined by binding to envelope glycoproteins

  2023cites this paper
• Characterization of RBD-specific cross-neutralizing antibodies responses against SARS-CoV-2 variants from COVID-19 convalescents

  2023cites this paper
• Vaccine induction of CD4-mimicking broadly neutralizing antibody precursors in macaques

  2023cites this paper
• Application of germline antibody features to vaccine development, antibody discovery, antibody optimization and disease diagnosis.

  2023cites this paper
• Diverse Murine Vaccinations Reveal Distinct Antibody Classes to Target Fusion Peptide and Variation in Peptide Length to Improve HIV Neutralization

  2023cites this paper
• TitrationAnalysis: a tool for high throughput binding kinetics data analysis for multiple label-free platforms

  2023cites this paper
• High frequency of HIV precursor-target-specific B cells in sub-Saharan populations

  2023cites this paper
• Accurate prediction of antibody function and structure using bio-inspired antibody language model

  2023cites this paper
• Adjuvants influence the maturation of VRC01-like antibodies during immunization

  2022cites this paper
• Humanized V(D)J-rearranging and TdT-expressing mouse vaccine models with physiological HIV-1 broadly neutralizing antibody precursors

  2022cites this paper
• Design of human immunodeficiency virus-1 neutralizing peptides targeting CD4-binding site: An integrative computational biologics approach

  2022cites this paper
• Journal Pre-proof A key F27I substitution within HCDR1 facilitates the rapid maturation of P2C-1F11-like neutralizing antibodies in a SARS-CoV-2-infected donor

  2022cites this paper
• Broad coverage of neutralization-resistant SIV strains by second-generation SIV-specific antibodies targeting the region involved in binding CD4

  2022cites this paper
• Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies

  2022cites this paper
• A key F27I substitution within HCDR1 facilitates the rapid maturation of P2C-1F11-like neutralizing antibodies in a SARS-CoV-2-infected donor

  2022influential citation
• Triggering rare HIV antibodies by vaccination

  2022cites this paper
• CD4-binding site immunogens elicit heterologous anti-HIV-1 neutralizing antibodies in transgenic and wildtype animals

  2022cites this paper
• Journal Pre-proof A key F27I substitution within HCDR1 facilitates the rapid maturation of P2C-1F11-like neutralizing antibodies in a SARS-CoV-2-infected donor

  2022cites this paper
• Efficient isolation of rare B cells using next-generation antigen barcoding

  2022cites this paper
• Probabilities of HIV-1 bNAb development in healthy and chronically infected individuals

  2022cites this paper
• Antibody dependent cell cytotoxicity is maintained by the unmutated common ancestor of 6F5, a Gp41 conformational epitope targeting antibody that utilizes heavy chain VH1-2.

  2022cites this paper
• Adjuvants influence the maturation of VRC01-like antibodies during immunization

  2022cites this paper
• Identification of IOMA-class neutralizing antibodies targeting the CD4-binding site on the HIV-1 envelope glycoprotein

  2022cites this paper
• Vaccination induces HIV broadly neutralizing antibody precursors in humans

  2022cites this paper
• AIRRscape: An interactive tool for exploring B-cell receptor repertoires and antibody responses

  2022cites this paper
• Safety and tolerability of AAV8 delivery of a broadly neutralizing antibody in adults living with HIV: a phase 1, dose-escalation trial

  2022cites this paper
• Title: A naturally arising broad and potent CD4-binding site antibody with low somatic mutation 1 Short Title: An HIV-1 bNAb with low somatic mutation

  2022cites this paper
• Structure of an influenza group 2-neutralizing antibody targeting the hemagglutinin stem supersite.

  2022cites this paper
• Viral resistance to VRC01-like antibodies with mutations in loop D and V5 from an HIV-1 B' subtype infected individual with broadly neutralization activity.

  2022cites this paper
• A naturally arising broad and potent CD4-binding site antibody with low somatic mutation

  2022cites this paper
• Single-component multilayered self-assembling protein nanoparticles 1 presenting glycan-trimmed uncleaved prefusion optimized envelope trimers 2 as HIV-1 vaccine candidates 3 4

  2022cites this paper
• Highly mutated antibodies capable of neutralizing N276 glycan-deficient HIV after a single immunization with an Env trimer

  2022cites this paper
• Complementary Roles of Antibody Heavy and Light Chain Somatic Hypermutation in Conferring Breadth and Potency to the HIV-1-Specific CAP256-VRC26 bNAb Lineage

  2022cites this paper
• The evolutionary and functional significance of germline immunoglobulin gene variation.

  2022cites this paper
• HIV-1 CD4-binding site germline antibody–Env structures inform vaccine design

  2022cites this paper
• Characterization of a VRC01-like antibody lineage with immature VL from an HIV-1 infected Chinese donor.

  2022cites this paper
• Vaccination with prefusion-stabilized respiratory syncytial virus fusion protein induces genetically and antigenically diverse antibody responses.

  2021cites this paper
• Development of a VRC01-class germline targeting immunogen derived from anti-idiotypic antibodies

  2021cites this paper
• Vaccine genetics of IGHV1-2 VRC01-class broadly neutralizing antibody precursor naïve human B cells

  2021cites this paper
• Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies

  2021cites this paper
• Design of immunogens to elicit broadly neutralizing antibodies against HIV targeting the CD4 binding site

  2021influential citation