Transcription factors NF-IL6 and CREB recognize a common essential site in the human prointerleukin 1 beta gene

No abstract is available for this paper.

• Publication year

  1994

• Venue

  Molecular and Cellular Biology

• Publication date

  1994-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/mcb.14.11.7285-7297.1994PMID 7935442PMCID PMC359263
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Genomlc Footprinting Reveals Cell Type-Specific DNA Binding of Ubiquitous Factors

  2008cited by this paper
• Cytokine signal transduction.

  1995cited by this paper
• Fos and Jun repress transcription activation by NF-IL6 through association at the basic zipper region

  1994cited by this paper
• Cytokine signal transduction.

  1994cited by this paper
• A CRE/ATF-like site in the upstream regulatory sequence of the human interleukin 1 beta gene is necessary for induction in U937 and THP-1 monocytic cell lines

  1993cited by this paper
• The functional versatility of CREM is determined by its modular structure.

  1993cited by this paper
• Relative roles of CCAAT/enhancer-binding protein beta and cAMP regulatory element-binding protein in controlling transcription of the gene for phosphoenolpyruvate carboxykinase (GTP).

  1993influential reference
• Lipopolysaccharide induces phosphorylation of MAD3 and activation of c-Rel and related NF-kappa B proteins in human monocytic THP-1 cells.

  1993cited by this paper
• Distinct mechanisms for regulation of the interleukin-8 gene involve synergism and cooperativity between C/EBP and NF-kappa B

  1993cited by this paper
• Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6.

  1993cited by this paper
• Functional and physical associations between NF-kappa B and C/EBP family members: a Rel domain-bZIP interaction.

  1993cited by this paper
• Synergism between protein-kinase C and cAMP-dependent pathways in the expression of the interleukin-1 beta gene is mediated via the activator-protein-1 (AP-1) enhancer activity.

  1993cited by this paper
• C/ATF, a member of the activating transcription factor family of DNA-binding proteins, dimerizes with CAAT/enhancer-binding proteins and directs their binding to cAMP response elements.

  1993cited by this paper
• A member of the C/EBP family, NF-IL6β, forms a heterodimer and transcriptionally synergizes with NF-IL6

  1993cited by this paper
• The human prointerleukin 1 beta gene requires DNA sequences both proximal and distal to the transcription start site for tissue-specific induction

  1993cited by this paper
• Regulation of CREB phosphorylation in the suprachiasmatic nucleus by light and a circadian clock.

  1993influential reference
• Bacterial lipopolysaccharide induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in macrophages.

  1992cited by this paper
• Opposing actions of Fos and Jun on transcription of the phosphoenolpyruvate carboxykinase (GTP) gene. Dominant negative regulation by Fos.

  1992cited by this paper
• Signal transduction and gene control: the cAMP pathway.

  1992cited by this paper
• Selection of optimal kappa B/Rel DNA-binding motifs: interaction of both subunits of NF-kappa B with DNA is required for transcriptional activation

  1992cited by this paper
• Calcium-Regulated Phosphorylation Within the Leucine Zipper of C/EBPβ

  1992cited by this paper
• A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6.

  1992cited by this paper
• Phosphorylation of CREB affects its binding to high and low affinity sites: implications for cAMP induced gene transcription.

  1992cited by this paper
• The p50 subunit of NF-kappa B associates with the NF-IL6 transcription factor.

  1992cited by this paper
• Prolonged Elevation of Intracellular Cyclic AMP Activates Interleukin‐1 Production in Human Peripheral Blood Monocytes

  1992cited by this paper
• cAMP stimulates the C/EBP-related transcription factor rNFIL-6 to trans-locate to the nucleus and induce c-fos transcription.

  1991cited by this paper
• Identification and functional characterisation of the cellular activating transcription factor 43 (ATF-43) protein.

  1991cited by this paper
• c-JUN, JUN B, and JUN D differ in their binding affinities to AP-1 and CRE consensus sequences: effect of FOS proteins.

  1991cited by this paper
• Modulation of interleukin-1 beta production by cyclic AMP in human monocytes.

  1990cited by this paper
• Negative and positive regulation by transcription factor cAMP response element-binding protein is modulated by phosphorylation.

  1990cited by this paper
• LAP, a novel member of the C/EBP gene family, encodes a liver-enriched transcriptional activator protein.

  1990cited by this paper
• A nuclear factor for IL‐6 expression (NF‐IL6) is a member of a C/EBP family.

  1990influential reference
• Cyclic AMP response element binding proteins: a cornucopia of transcription factors.

  1990cited by this paper
• The role of the CCAAT/enhancer-binding protein in the transcriptional regulation of the gene for phosphoenolpyruvate carboxykinase (GTP)

  1990cited by this paper
• Modulation ofinterleukin‐1β production by cyclic AMP in human monocytes

  1990cited by this paper
• Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133.

  1989cited by this paper
• Suppression of MHC class I gene expression by N‐myc through enhancer inactivation.

  1989cited by this paper
• Asymmetrical recognition of the palindromic AP1 binding site (TRE) by Fos protein complexes.

  1989cited by this paper
• The human haptoglobin gene promoter: interleukin-6-responsive elements interact with a DNA-binding protein induced by interleukin-6.

  1989cited by this paper
• Identification of basal and cyclic AMP regulatory elements in the promoter of the phosphoenolpyruvate carboxykinase gene

  1988cited by this paper
• Structural determinants for transcriptional activation by cAMP-responsive DNA elements.

  1988cited by this paper
• Human pro-IL-1 beta gene expression in monocytic cells is regulated by two distinct pathways.

  1988cited by this paper
• Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB

  1988cited by this paper
• Transcriptional regulation of the human prointerleukin 1 beta gene.

  1987cited by this paper
• Cyclic AMP regulation of the human glycoprotein hormone alpha-subunit gene is mediated by an 18-base-pair element.

  1987cited by this paper
• A nonchromatographic assay for expression of the chloramphenicol acetyltransferase gene in eucaryotic cells.

  1986cited by this paper
• Genomic sequence for human prointerleukin 1 beta: possible evolution from a reverse transcribed prointerleukin 1 alpha gene.

  1986cited by this paper
• Identification of a cyclic-AMP-responsive element within the rat somatostatin gene.

  1986cited by this paper
• Characterization of the phosphoenolpyruvate carboxykinase (GTP) promoter-regulatory region. II. Identification of cAMP and glucocorticoid regulatory domains.

  1986cited by this paper
• A cyclic AMP- and phorbol ester-inducible DNA element

  1986cited by this paper

• ATF1 Restricts Human Herpesvirus 6A Replication via Beta Interferon Induction

  2022cites this paper
• Placentas associated with female neonates from pregnancies complicated by urinary tract infections have higher cAMP content and cytokines expression than males

  2021cites this paper
• C/EBPβ is a key transcription factor of ox-LDL inducing THP-1 cells to release multiple pro-inflammatory cytokines

  2021cites this paper
• Functional Characteristics of the Mouse Il1b Promoter in Various Tissues Before and After Irradiation

  2020cites this paper
• C/EBPß Isoform Specific Gene Regulation: It’s a Lot more Complicated than you Think!

  2020influential citation
• Toward targeting inflammasomes: insights into their regulation and activation

  2020cites this paper
• Transcriptional Regulation of Inflammasomes

  2020cites this paper
• A combined computational and experimental approach reveals the structure of a C/EBPβ–Spi1 interaction required for IL1B gene transcription

  2018cites this paper
• CCAAT/Enhancer binding protein β silencing mitigates glial activation and neurodegeneration in a rat model of Parkinson’s disease

  2017cites this paper
• TREATING HIV INFECTION

  2017cites this paper
• Epigenetic Alterations Induced by Bacterial Lipopolysaccharides.

  2016cites this paper
• Complement component 3 (C3) expression in the hippocampus after excitotoxic injury: role of C/EBPβ

  2016cites this paper
• C/EBPβ and C/EBPδ transcription factors: Basic biology and roles in the CNS.

  2015cites this paper
• C/EBPβ is a transcriptional key regulator of IL-36α in murine macrophages.

  2015cites this paper
• A comprehensive C/EBPβ interactome

  2015influential citation
• Melatonin or ramelteon therapy differentially affects hepatic gene expression profiles after haemorrhagic shock in rat--A microarray analysis.

  2015cites this paper
• Cyclin D 1 and C / EBP LAP 1 Operate in a Common Pathway To Promote Mammary Epithelial Cell Differentiation

  2014influential citation
• Cyclin D1 and C/EBPβ LAP1 Operate in a Common Pathway To Promote Mammary Epithelial Cell Differentiation

  2014influential citation
• CCAAT-Enhancer Binding Protein-β Expression and Elevation in Alzheimer’s Disease and Microglial Cell Cultures

  2014cites this paper
• Curcumin attenuates carcinogenesis by down regulating proinflammatory cytokine interleukin-1 (IL-1α and IL-1β) via modulation of AP-1 and NF-IL6 in lymphoma bearing mice.

  2014cites this paper
• Spatial training in the Morris water maze induces differential changes in interleukin-1 beta(IL-1β) expression in hippocampal and extra-hippocampal tissue

  2014cites this paper
• Combinatorial Recruitment of CREB, C/EBPβ and c-Jun Determines Activation of Promoters upon Keratinocyte Differentiation

  2013cites this paper
• IL-20 receptor signaling inhibits cutaneous IL-1β and IL-17A production to promote methicillin-resistant Staphylococcus aureus infection

  2013cites this paper
• Localization, and Activity in Macrophages Expression, β Autocrine Signals Control CCAAT/Enhancer Binding Protein

  2013cites this paper
• Molecular Insights into the Distinct Mechanisms Regulating the TLR4 Mediated Activation, Shut Down, and Endotoxin Tolerance of the IL1B and TNF Genes

  2013influential citation
• Myelin Basic Protein-primed T Helper 2 Cells Suppress Microglial Activation via AlphaVBeta3 Integrin: Implications for Multiple Sclerosis

  2013cites this paper
• Distinct Mechanisms for Induction and Tolerance Regulate the Immediate Early Genes Encoding Interleukin 1β and Tumor Necrosis Factor α

  2013influential citation
• with the Binding of TATA-Binding Protein Region Activity in HeLa Cells by Interfering Papillomavirus Type 18 Upstream Regulatory Represses Human β Overexpression of C/EBP

  2013cites this paper
• Investigation of IL-1-beta response and caspase-1 activity in preterm neonates

  2012cites this paper
• Reduced Infiltration and Increased Apoptosis of Leukocytes at Sites of Inflammation by Systemic Administration of a Membrane-Permeable I κ B α Repressor

  2012cites this paper
• Interleukin-1β in Central Nervous System Injury and Repair.

  2012cites this paper
• CCAAT/enhancer binding protein delta (CEBPD) elevating PTX3 expression inhibits macrophage-mediated phagocytosis of dying neuron cells.

  2012cites this paper
• New Targets in Inflammation

  2012cites this paper
• IMiD immunomodulatory compounds block C/EBP{beta} translation through eIF4E down-regulation resulting in inhibition of MM.

  2011cites this paper
• The CCAAT/enhancer (C/EBP) family of basic-leucine zipper (bZIP) transcription factors is a multifaceted highly-regulated system for gene regulation.

  2011influential citation
• The chemical and computational biology of inflammation

  2011cites this paper
• Mechanism of HIV‐1‐TAT induction of interleukin‐1β from human monocytes: Involvement of the phospholipase C/protein kinase C signaling cascade

  2010cites this paper
• Changes in chromatin structure and methylation of the human interleukin‐1β gene during monopoiesis

  2010cites this paper
• A specific interleukin-1B haplotype correlates with high levels of IL1B mRNA in the lung and increased risk of non-small cell lung cancer.

  2009cites this paper
• Type 2 diabetes in Sri Lanka : Genetic epidemiology and periodontal association.

  2009cites this paper
• mRNA in the lung and increased risk of non-small cell lung cancer

  2009cites this paper
• Inhibition of inducible NO synthase, cyclooxygenase‐2 and interleukin‐1β by torilin is mediated by mitogen‐activated protein kinases in microglial BV2 cells

  2009cites this paper
• C/EBPbeta regulates transcription factors critical for proliferation and survival of multiple myeloma cells.

  2009cites this paper
• Immunomics: At the Forefront of Innate Immunity Research

  2009cites this paper
• Acute Lung Injury:Apoptosis and Signaling Mechanisms

  2009cites this paper
• Combinatorial Transcription Factor Regulation of the Cyclic AMP-response Element on the Pgc-1α Promoter in White 3T3-L1 and Brown HIB-1B Preadipocytes*

  2009cites this paper
• EBP regulates transcription factors critical for proliferation and survival of multiple myeloma cells

  2009cites this paper
• A specific interleukin-1 B haplotype correlates with high levels of IL 1 B mRNA in the lung and increased risk of non-small cell lung cancer

  2009cites this paper
• Dynamic Protein Associations Define Two Phases of IL-1β Transcriptional Activation1

  2008cites this paper
• Inhibition of IL-1beta transcription by peptides derived from the hCMV IE2 transactivator.

  2008cites this paper
• Up-regulation of activating transcription factor-5 suppresses SAP expression to activate T cells in hemophagocytic syndrome associated with Epstein-Barr virus infection and immune disorders.

  2008cites this paper
• Transcriptional Regulation by C/EBPa and -/S in the Expression of the Gene for the MRP14Myeloid Calcium Binding Protein

  2007cites this paper
• Corticosteroids and β2 Agonists Differentially Regulate Rhinovirus-induced Interleukin-6 via Distinct Cis-acting Elements*

  2007cites this paper
• ATF4 differentially regulates transcriptional activation of myeloid‐specific genes by C/EBPε and C/EBPα

  2007cites this paper
• C/EBPβ Reprograms White 3T3-L1 Preadipocytes to a Brown Adipocyte Pattern of Gene Expression*

  2007cites this paper
• IL-1 family members as candidate genes modulating scrapie susceptibility in sheep: localization, partial characterization, and expression

  2007cites this paper
• ATF4 differentially regulates transcriptional activation of myeloid-specific genes by C/EBPepsilon and C/EBPalpha.

  2007cites this paper
• Phosphorylation of IRF8 in a pre-associated complex with Spi-1/PU.1 and non-phosphorylated Stat1 is critical for LPS induction of the IL1B gene.

  2007cites this paper
• Cyclic AMP response element-binding protein (CREB) and CAAT/enhancer-binding protein beta (C/EBPbeta) bind chimeric DNA sites with high affinity.

  2006cites this paper
• Glucocorticoid inhibits the human pro-interleukin lbeta gene (ILIB) by decreasing DNA binding of transactivators to the signal-responsive enhancer.

  2006cites this paper
• CCAAT/enhancer-binding proteins (C/EBPs) regulate the basal and cAMP-induced transcription of the human 11beta-hydroxysteroid dehydrogenase encoding gene in adipose cells.

  2006cites this paper
• Direct interaction of C/EBPdelta and Sp1 at the GC-enriched promoter region synergizes the IL-10 gene transcription in mouse macrophage.

  2006cites this paper
• Regulation of the potential tumorsuppressor gene mad1 by G-CSF

  2006cites this paper
• The role of titanium surface topography on J774A.1 macrophage inflammatory cytokines and nitric oxide production.

  2006cites this paper
• Human neutrophil gene expression profiling following xenogeneic encounter with porcine aortic endothelial cells: the occult role of neutrophils in xenograft rejection revealed

  2005cites this paper
• Human interleukin-1 alpha gene expression is regulated by Sp1 and a transcriptional repressor.

  2005cites this paper
• The Neuropeptide VIP and the IL-6 Family of Cytokines in Bone - Effects on Bone Resorption, Cytokine Expression and Receptor Signalling in Osteoblasts and Bone Marrow Stromal Cells

  2005cites this paper
• Human interleukin-1α gene expression is regulated by Sp1 and a transcriptional repressor

  2005cites this paper
• Conserved ETS Domain Arginines Mediate DNA Binding, Nuclear Localization, and a Novel Mode of bZIP Interaction*♦

  2005cites this paper
• Inhibition of NF-IL6 activity by manassantin B, a dilignan isolated from Saururus chinensis, in phorbol myristate acetate-stimulated U937 promonocytic cells.

  2005cites this paper
• Chapter 7 – DNA Sequence-Specific Transcription Factors

  2005cites this paper
• Transcription Factors in Sertoli Cells

  2005cites this paper
• CCAAT/enhancer binding protein delta (C/EBPdelta) expression and elevation in Alzheimer's disease.

  2004cites this paper
• What turns CREB on?

  2004cites this paper
• CCAAT/enhancer binding protein δ (C/EBPδ) expression and elevation in Alzheimer’s disease

  2004cites this paper
• cAMP increases the expression of human angiotensinogen gene through a combination of cyclic AMP responsive element binding protein and a liver specific transcription factor

  2004cites this paper
• Amplification of the synovial inflammatory response through activation of mitogen-activated protein kinases and nuclear factor kappaB using ligation of CD40 on CD14+ synovial cells from patients with rheumatoid arthritis.

  2004cites this paper
• Excretory/secretory products from plerocercoids of Spirometra erinaceieuropaei suppress interleukin-1beta gene expression in murine macrophages.

  2004cites this paper
• Cytokine gene polymorphism and immunoregulation in periodontal disease.

  2004cites this paper
• Reduced infiltration and increased apoptosis of leukocytes at sites of inflammation by systemic administration of a membrane-permeable IkappaBalpha repressor.

  2004cites this paper
• Hypothermia and stroke: the pathophysiological background.

  2003cites this paper
• A mechanism of cyclin D1 action encoded in the patterns of gene expression in human cancer.

  2003cites this paper
• Heat Shock Factor 1 Contains Two Functional Domains That Mediate Transcriptional Repression of the c-fos and c-fms Genes*

  2003cites this paper
• The granulocytic inducer C / EBP a inactivates the myeloid master regulator PU . 1 : possible role in lineage commitment decisions

  2003cites this paper
• The interplay between the glucocorticoid receptor and nuclear factor-kappaB or activator protein-1: molecular mechanisms for gene repression.

  2003cites this paper
• Cyclic AMP increases endogenous granulocyte colony‐stimulating factor formation in monocytes and THP‐1 macrophages despite attenuated TNF‐α formation

  2003cites this paper
• Synergism between Calcium and Cyclic GMP in Cyclic AMP Response Element-Dependent Transcriptional Regulation Requires Cooperation between CREB and C/EBP-β

  2003cites this paper
• cAMP-induced Interleukin-10 Promoter Activation Depends on CCAAT/Enhancer-binding Protein Expression and Monocytic Differentiation*

  2003cites this paper
• Effects of wogonin, a plant flavone from Scutellaria radix, on skin inflammation: in vivo regulation of inflammation-associated gene expression.

  2003cites this paper
• Direct Influence of Mild Hypothermia on Cytokine Expression and Release in Cultures of Human Peripheral Blood Mononuclear Cells

  2002cites this paper
• Induction and Regulation of Endogenous Granulocyte Colony-Stimulating Factor Formation

  2002cites this paper
• Autocrine Induction of the Human Pro-IL-1β Gene Promoter by IL-1β in Monocytes

  2002influential citation
• Identification of a novel regulatory element in the human interleukin 1 alpha (IL-1alpha) gene promoter.

  2002cites this paper
• NF-IL6 and HSF1 have mutually antagonistic effects on transcription in monocytic cells.

  2002cites this paper
• Heat Shock Factor 1 Represses Transcription of theIL-1β Gene through Physical Interaction with the Nuclear Factor of Interleukin 6*

  2002cites this paper
• PU.l (Spi-l) and C/EBPa Regulate the Granulocyte Colony-Stimulating Factor Receptor Promoter in Myeloid Cells

  2002cites this paper
• Classification of Human B-ZIP Proteins Based on Dimerization Properties

  2002cites this paper
• Autocrine induction of the human pro-IL-1beta gene promoter by IL-1beta in monocytes.

  2002cites this paper
• Granulocyte inducer C/EBPalpha inactivates the myeloid master regulator PU.1: possible role in lineage commitment decisions.

  2002cites this paper
• Regulation of CCAAT/Enhancer-binding Protein (C/EBP) Activator Proteins by Heterodimerization with C/EBPγ (Ig/EBP)*

  2002cites this paper