Hippocampal neuroplasticity induced by early-life stress: functional and molecular aspects.

Whereas genetic factors contribute crucially to brain function, early-life events, including stress, exert long-lasting influence on neuronal function. Here, we focus on the hippocampus as the target of these early-life events because of its crucial role in learning and memory. Using a novel immature-rodent model, we describe the deleterious consequences of chronic early-life 'psychological' stress on hippocampus-dependent cognitive tasks. We review the cellular mechanisms involved and discuss the roles of stress-mediating molecules, including corticotropin releasing hormone, in the process by which stress impacts the structure and function of hippocampal neurons.

• Publication year

  2006

• Venue

  Frontiers in neuroendocrinology (Print)

• Publication date

  2006-07-01

• Fields of study

  Biology, Medicine, Psychology

• Identifiers
  DOI 10.1016/J.YFRNE.2006.02.001PMID 16603235PMCID PMC2937188
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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