Transgenerational impairment of hippocampal Akt‐mTOR signaling and behavioral deficits in the offspring of mice that experience postpartum depression‐like illness

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Progress in Neuro-psychopharmacology and Biological Psychiatry

• Publication date

  2017-02-06

• Fields of study

  Biology, Medicine, Psychology

• Identifiers
  DOI 10.1016/j.pnpbp.2016.09.008PMID 27693392
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Topiramate increases the rewarding properties of cocaine in young-adult mice limiting its clinical usefulness

  2016cited by this paper
• Chronic stress prior to pregnancy potentiated long-lasting postpartum depressive-like behavior, regulated by Akt-mTOR signaling in the hippocampus

  2016cited by this paper
• Activation of basolateral amygdala in juvenile C57BL/6J mice during social approach behavior.

  2016cited by this paper
• The effects of early life stress on neurobehavioral development in children and adolescents: Mediation by the HPA axis.

  2015cited by this paper
• Effects of stress early in gestation on hippocampal neurogenesis and glucocorticoid receptor density in pregnant rats.

  2015cited by this paper
• Fluoxetine regulates mTOR signalling in a region-dependent manner in depression-like mice

  2015cited by this paper
• The role of glucocorticoid receptor-dependent activity in the amygdala central nucleus and reversibility of early-life stress programmed behavior

  2015cited by this paper
• Involvement of normalized NMDA receptor and mTOR-related signaling in rapid antidepressant effects of Yueju and ketamine on chronically stressed mice

  2015cited by this paper
• Adversity in childhood and depression: linked through SIRT1

  2015cited by this paper
• REDD1 is essential for stress-induced synaptic loss and depressive behavior

  2014cited by this paper
• Variation in the oxytocin receptor gene is associated with increased risk for anxiety, stress and depression in individuals with a history of exposure to early life stress.

  2014influential reference
• Serotonin 2C receptor antagonists induce fast-onset antidepressant effects

  2014cited by this paper
• Serotonin 2C receptor antagonists induce fast-onset antidepressant effects

  2014cited by this paper
• Pathological brain plasticity and cognition in the offspring of males subjected to postnatal traumatic stress

  2014cited by this paper
• Early-life stress and HPA axis trigger recurrent adulthood depression.

  2014cited by this paper
• Differential gene body methylation and reduced expression of cell adhesion and neurotransmitter receptor genes in adverse maternal environment

  2013cited by this paper
• The mTOR signaling pathway in the prefrontal cortex is compromised in major depressive disorder.

  2011cited by this paper
• CD-1 and Balb/cJ mice do not show enduring antidepressant-like effects of ketamine in tests of acute antidepressant efficacy

  2011cited by this paper
• Using Animal Models to Disentangle the Role of Genetic, Epigenetic, and Environmental Influences on Behavioral Outcomes Associated with Maternal Anxiety and Depression

  2011cited by this paper
• Involvement of AMPA receptor in both the rapid and sustained antidepressant-like effects of ketamine in animal models of depression.

  2011cited by this paper
• A randomized add-on trial of an N-methyl-D-aspartate antagonist in treatment-resistant bipolar depression.

  2010cited by this paper
• mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

  2010cited by this paper
• Postpartum depression effects on early interactions, parenting, and safety practices: a review.

  2010cited by this paper
• The Prevalence of Postpartum Depression among Women with Substance Use, an Abuse History, or Chronic Illness: A Systematic Review

  2009cited by this paper
• DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212.

  2009cited by this paper
• Effect of in utero and early-life conditions on adult health and disease.

  2008cited by this paper
• Depression in mothers.

  2007cited by this paper
• A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression.

  2006cited by this paper
• Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood.

  2006cited by this paper
• Hippocampal neuroplasticity induced by early-life stress: functional and molecular aspects.

  2006cited by this paper
• High post-partum levels of corticosterone given to dams influence postnatal hippocampal cell proliferation and behavior of offspring: A model of post-partum stress and possible depression.

  2006cited by this paper
• History of Child Abuse and Severity of Adult Depression: The Mediating Role of Cognitive Schema

  2006cited by this paper
• Perinatal depression: prevalence, screening accuracy, and screening outcomes.

  2005cited by this paper
• Perinatal Depression: A Systematic Review of Prevalence and Incidence

  2005cited by this paper
• Upstream and downstream of mTOR.

  2004cited by this paper
• Emotional reactivity in mice may not be inherited but influenced by parents.

  2004cited by this paper
• Early life influences on life-long patterns of behavior and health.

  2003cited by this paper
• Validation of a simple, ethologically relevant paradigm for assessing anxiety in mice.

  2003cited by this paper
• Severity, chronicity, and timing of maternal depression and risk for adolescent offspring diagnoses in a community sample.

  2003cited by this paper
• Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations.

  2001cited by this paper
• Variations in maternal care in infancy regulate the development of stress reactivity.

  2000influential reference
• The effects of early postnatal stimulation on Morris water-maze acquisition in adult mice: genetic and maternal factors

  1996cited by this paper
• Link between emotional memory and anxiety states: a study by principal component analysis.

  1995cited by this paper
• The course of major depression in the offspring of depressed parents. Incidence, recurrence, and recovery.

  1992cited by this paper
• Longitudinal study of diagnoses in children of women with unipolar and bipolar affective disorder.

  1990cited by this paper
• Behavioral despair in mice: a primary screening test for antidepressants.

  1977cited by this paper
• Effect of in Utero and Early-life Conditions on Adult Health and Disease Epidemiol Ogic a Nd Clinic a L Observations

  year unknowncited by this paper

• Effect of low-dose esketamine combined with labor analgesia on postpartum depressive symptoms following spontaneous labor: a randomized controlled trial.

  2026cites this paper
• Corticosterone-induced postpartum depression induces depression-like behavior and impairs hippocampal neurogenesis in adolescent offspring via HPA axis and BDNF-mTOR pathway

  2025cites this paper
• Investigation of depression-like phenotypes and their behavioral correlates in cynomolgus monkeys (Macaca fascicularis)

  2025cites this paper
• The impact of maternal premating stress on the postnatal outcomes of offspring in rodent studies: A systematic review.

  2025influential citation
• Deciphering the Role of siRNA in Anxiety and Depression.

  2024cites this paper
• S-ketamine alleviates depression-like behavior and hippocampal neuroplasticity in the offspring of mice that experience prenatal stress

  2024cites this paper
• Intergenerational transfer of binge eating-like behavior: the additive impact of juvenile stress.

  2024cites this paper
• Antidepressant effects of esketamine via the BDNF/AKT/mTOR pathway in mice with postpartum depression and their offspring.

  2024cites this paper
• Differential susceptibility of male and female germ cells to glucocorticoid-mediated signaling

  2024cites this paper
• The Relationship between Maternal Perinatal Depression and Offspring Depression: A Meta-Analysis

  2024cites this paper
• Ketamine causes poor maternal care in rats with postpartum depression and leads to few behavioral and neurochemical alterations on male offspring.

  2023cites this paper
• Differential susceptibility of male and female germ cells to glucocorticoid-mediated signaling

  2023cites this paper
• Ketamine as Potential Treatment for Postpartum Depression: A Narrative Review

  2022cites this paper
• Dysregulation of AMPK-mTOR signaling leads to comorbid anxiety in Dip2a KO mice.

  2022cites this paper
• mTOR Knockdown in the Infralimbic Cortex Evokes A Depressive-like State in Mouse

  2021cites this paper
• Epigenetics and the Impact of Early-Life Stress Across Generations

  2021cites this paper
• Interleukin-1 receptor-associated kinase 4 (IRAK4) in the nucleus accumbens regulates opioid-seeking behavior in male rats.

  2021cites this paper
• Rapid and prolonged antidepressant-like effect of crocin is associated with GHSR mediated hippocampal plasticity-related proteins in mice exposed to prenatal stress.

  2020cites this paper
• The involvement of PI3K/Akt/mTOR/GSK3β signaling pathways in the antidepressant-like effect of AZD6765.

  2020cites this paper
• Augmentation effect of ketamine by guanosine in the novelty-suppressed feeding test is dependent on mTOR signaling pathway.

  2019cites this paper
• Rodent ketamine depression-related research: finding patterns in a literature of variability.

  2019cites this paper
• Loss of Glutamate Decarboxylase 67 in Somatostatin-Expressing Neurons Leads to Anxiety-Like Behavior and Alteration in the Akt/GSK3β Signaling Pathway

  2019cites this paper
• Transgenerational deep sequencing revealed hypermethylation of hippocampal mGluR1 gene with altered mRNA expression of mGluR5 and mGluR3 associated with behavioral changes in Sprague Dawley rats with history of prolonged febrile seizure

  2019cites this paper
• Intracellular Signaling Pathways Implicated in the Pathophysiology of Depression

  2019cites this paper
• Human and animal evidence of potential transgenerational inheritance of health effects: An evidence map and state-of-the-science evaluation.

  2018cites this paper
• Transcriptomic analysis reveals transgenerational effect of hypoxia on the neural control of testicular functions.

  2018cites this paper
• Transgenerational Epigenetics of Traumatic Stress.

  2018cites this paper
• LITERATURE SEARCH RESULTS FOR THE SYSTEMATIC REVIEW OF TRANSGENERATIONAL INHERITANCE OF HEALTH EFFECTS

  2017cites this paper
• Serotonin transporter immunoreactivity is modulated during development and after fluoxetine treatment in the rodent visual system.

  2017cites this paper
• Single dose ketamine injection affects activation of cells in the nucleus accumbens of prenatally stressed rats

  2017cites this paper
• Chronic stress prior to pregnancy potentiated long-lasting postpartum depressive-like behavior, regulated by Akt-mTOR signaling in the hippocampus

  2016influential citation