Insulin Treatment Improves Hepatic Morphology and Function Through Modulation of Hepatic Signals After Severe Trauma

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Annals of Surgery

• Publication date

  2004-08-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1097/01.sla.0000133353.57674.cdPMID 15273560PMCID PMC1356412
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Serum albumin

  2005cited by this paper
• Insulin: a wonder drug in the critically ill?

  2002cited by this paper
• Intensive insulin therapy in critically ill patients.

  2002cited by this paper
• Insulin Attenuates the Systemic Inflammatory Response to Thermal Trauma

  2002cited by this paper
• IGF-I/IGFBP-3 Equilibrates Ratios of Pro- to Anti-inflammatory Cytokines, Which Are Predictors for Organ Function in Severely Burned Pediatric Patients

  2002cited by this paper
• Interleukin-6-induced Tethering of STAT3 to the LAP/C/EBPβ Promoter Suggests a New Mechanism of Transcriptional Regulation by STAT3*

  2001cited by this paper
• Intensive insulin therapy in critically ill patients.

  2001cited by this paper
• Fatty infiltration of the liver in severely burned pediatric patients: autopsy findings and clinical implications.

  2001cited by this paper
• The effect of burn injury on suppressors of cytokine signalling.

  2000cited by this paper
• SOCS-3 Is an Insulin-induced Negative Regulator of Insulin Signaling*

  2000cited by this paper
• Increased mortality associated with growth hormone treatment in critically ill adults.

  1999cited by this paper
• Major burn trauma in rats promotes cardiac and gastrointestinal apoptosis.

  1999cited by this paper
• Apoptosis: cell death by proteolytic scalpel.

  1999cited by this paper
• Cutaneous burn increases apoptosis in the gut epithelium of mice.

  1999cited by this paper
• Change in the ratio of interleukin-6 to interleukin-10 predicts a poor outcome in patients with systemic inflammatory response syndrome.

  1999cited by this paper
• Caspases

  1999cited by this paper
• GENETIC COMPONENT IN THE INFLAMMATORY RESPONSE INDUCED BY BACTERIAL LIPOPOLYSACCHARIDE

  1998cited by this paper
• Apoptosis: programmed cell death.

  1998cited by this paper
• The influence of apoptosis on intestinal barrier integrity in rats.

  1998cited by this paper
• THERAPEUTIC IMPLICATIONS OF INTERLEUKIN‐10 IN SURGICAL DISEASE

  1998cited by this paper
• Insulin stimulates pyruvate dehydrogenase and protects human ventricular cardiomyocytes from simulated ischemia.

  1998cited by this paper
• Caspases: Intracellular Minireview Signaling by Proteolysis

  1997cited by this paper
• Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

  1997cited by this paper
• Transient Exposure of Human Myoblasts to Tumor Necrosis Factor-α Inhibits Serum and Insulin-Like Growth Factor-I Stimulated Protein Synthesis.

  1997cited by this paper
• Cytokines and the hepatic acute phase response

  1997influential reference
• Transient exposure of human myoblasts to tumor necrosis factor-alpha inhibits serum and insulin-like growth factor-I stimulated protein synthesis.

  1997cited by this paper
• A comparison of the suppression of human transferrin synthesis by lead and lipopolysaccharide.

  1997cited by this paper
• Apoptosis or programmed cell death.

  1997cited by this paper
• Regulation of the acute phase response genes alpha 1-acid glycoprotein and alpha 1-antitrypsin correlates with sensitivity to thermal injury.

  1996cited by this paper
• C/EBP-β/LAP Controls Down-regulation of Albumin Gene Transcription during Liver Regeneration*

  1996cited by this paper
• Contributions of de novo synthesis of fatty acids to total VLDL-triglyceride secretion during prolonged hyperglycemia/hyperinsulinemia in normal man.

  1996cited by this paper
• Sepsis and multiple organ dysfunction syndrome: a clinical-mechanistic overview.

  1995cited by this paper
• Mechanisms and genes of cellular suicide

  1995cited by this paper
• Regulation of cytokine gene expression: tumor necrosis factor, interleukin-1, and the emerging biology of cytokine receptors.

  1995cited by this paper
• INTERLEUKIN‐1 AND INTERLEUKIN‐1 ANTAGONISM IN SEPSIS, SYSTEMIC INFLAMMATORY RESPONSE SYNDROME, AND SEPTIC SHOCK

  1995cited by this paper
• Increased whole body protein breakdown predominates over increased whole body protein synthesis in multiple organ failure.

  1993cited by this paper
• Genomic organization and transcriptional regulation of the RANTES chemokine gene.

  1993cited by this paper
• Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes

  1991cited by this paper
• Serum albumin

  1988cited by this paper
• Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia

  1987cited by this paper
• Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.

  1987cited by this paper
• Muscle protein turnover and the wasting due to injury and disease.

  1985cited by this paper
• Journal of Clinical Endocrinology and Metabolism Printed in U.S.A. Copyright © 1997 by The Endocrine Society The Somatotropic Axis in Critical Illness: Effect of Continuous Growth Hormone (GH)-Releasing Hormone and GH-Releasing Peptide-2 Infusion*

  year unknowncited by this paper

• Insulin-activated β-cell-liver axis protects against acetaminophen-induced acute liver injury by suppressing oxidative stress and purine catabolism.

  2025cites this paper
• Metabolic response to burn injury: a comprehensive bibliometric study

  2025cites this paper
• Metformin administration improves adverse outcomes in older adult burn patients: a single-centre cohort study

  2025cites this paper
• Protective effects of insulin treatment in the morphological alterations and oxidative damage to DNA in the liver of young rats subjected to skin scald burn injury.

  2025cites this paper
• Update in the Management of Burns in Children 2024

  2024cites this paper
• The Role of the Insulin/Glucose Ratio in the Regulation of Pathogen Biofilm Formation

  2023cites this paper
• Metabolic and Nutritional Support.

  2023cites this paper
• Modulation of Burn Hypermetabolism in Preclinical Models

  2023cites this paper
• Hyperglycaemia in the Newborn Infant. Physiology Verses Pathology

  2021cites this paper
• Agonist antibody discovery: experimental, computational, and rational engineering approaches.

  2021cites this paper
• Hepatic functional pathophysiology and morphological damage following severe burns: a systematic review and meta-analysis.

  2021cites this paper
• Challenges of the intensive insulin therapy in experimental models of extensive burn injury

  2020cites this paper
• Nutrition of the Burned Patient and Treatment of the Hypermetabolic Response

  2020cites this paper
• Pathophysiology and Management of Disorders of Carbohydrate Metabolism and Neonatal Diabetes

  2020cites this paper
• Insulin Modulates Myogenesis and Muscle Atrophy Resulting From Skin Scald Burn in Young Male Rats.

  2020cites this paper
• Evaluation of neuroprotective effects of insulin on immuno-inflammatory and systemic disorders induced by kaliotoxin, a Kv1.3 channel blocker

  2018cites this paper
• CONTROVERSIES IN TREATING DIABETES

  2018cites this paper
• Short time insulin treatment post burn improves elastic-collagen rearrangement and reepithelization

  2018cites this paper
• Diabetes Mellitus and Sepsis: A Challenging Association.

  2017cites this paper
• Postburn Hypermetabolism: Past, Present, and Future

  2016cites this paper
• Melatonin protects against burn-induced hepatic oxidative injury by inducing HO-1 via the Nrf2 pathway

  2016cites this paper
• Glucose Control in Severely Burned Patients Using Metformin: An Interim Safety and Efficacy Analysis of a Phase II Randomized Controlled Trial

  2016cites this paper
• Cell Security and Efficacy of Intra-Portal Infusion of Autologous Stem Cells for Liver Regeneration a Randomized Pilot Study

  2015cites this paper
• Melatonin protects against burn-induced hepatic oxidative injury by inducing HO-1 via the Nrf 2 pathway

  2015cites this paper
• Burns in children: standard and new treatments.

  2014cites this paper
• Integrative and Translational Physiology : Integrative Aspects of Energy Homeostasis and Metabolic Diseases Insulin effects on glucose tolerance , hypermetabolic response , and circadian-metabolic protein expression in a rat burn and disuse model

  2014cites this paper
• Hypoglycemia Is Associated With Increased Postburn Morbidity and Mortality in Pediatric Patients*

  2014cites this paper
• Insulin Treatment Modulates the Host Immune System To Enhance Pseudomonas aeruginosa Wound Biofilms

  2013cites this paper
• Glucose control in severely burned patients-current best practice

  2013cites this paper
• Burn Care and Treatment: A Practical Guide

  2013cites this paper
• Melatonin modulates the expression of Bcl-2 family proteins in liver after thermal injury in rats

  2013cites this paper
• WHAT, HOW, AND HOW MUCH SHOULD BURN PATIENTS BE FED?

  2012cites this paper
• Endoplasmic reticulum stress and insulin resistance post-trauma: similarities to type 2 diabetes

  2012cites this paper
• Acute treatment of severely burned pediatric patients

  2012cites this paper
• Insulin therapy improves protein metabolism in the critically ill

  2012cites this paper
• Modulation of the Hypermetabolic Response after Burn Injury

  2012cites this paper
• The hepatic response to thermal injury

  2012cites this paper
• Metabolic Syndrome as a Disorder of the Brain with Its Origins in the Perinatal Period

  2011cites this paper
• What, how, and how much should patients with burns be fed?

  2011cites this paper
• The Hepatic Acute Phase Response to Thermal Injury

  2011cites this paper
• Effect of Perioperative Intensive Insulin Therapy for Liver Dysfunction After Hepatic Resection

  2011cites this paper
• Insulin Protects against Hepatic Damage Postburn

  2011cites this paper
• Intensive insulin therapy in severely burned pediatric patients: a prospective randomized trial.

  2010cites this paper
• Glucose metabolism in burn patients: the role of insulin and other endocrine hormones.

  2010cites this paper
• Inhibitory Effect of Pioglitazone on Type-2 Diabetes Induced Nuclear Damages in Wistar Rats

  2010cites this paper
• Relationship of serum C-reactive protein and blood glucose levels with injury severity and patient morbidity in a pediatric trauma population.

  2009cites this paper
• The effects and mechanisms of insulin on systemic inflammatory response and immune cells in severe trauma, burn injury, and sepsis.

  2009cites this paper
• Advances in the care of children with burns.

  2009cites this paper
• Relationship between perioperative glycemic control and postoperative infections.

  2009cites this paper
• Tight perioperative glycemic control using an artificial endocrine pancreas

  2009cites this paper
• Calcium and ER stress mediate hepatic apoptosis after burn injury

  2009cites this paper
• Severe Burn-Induced Endoplasmic Reticulum Stress and Hepatic Damage in Mice

  2009cites this paper
• Gene expression profiling of long-term changes in rat liver following burn injury.

  2009cites this paper
• The Hepatic Response to Thermal Injury: Is the Liver Important for Postburn Outcomes?

  2009cites this paper
• [Hepatotoxicity in the critically ill patient. The liver under an acute severe insult].

  2008cites this paper
• Hepatotoxicidad en el paciente crítico: El hígado bajo agresión aguda grave

  2008cites this paper
• Glycaemic control and perioperative organ protection.

  2008cites this paper
• Intensive insulin therapy for the critically ill patient

  2008cites this paper
• The Diabetes of Injury: Novel Insights and Clinical Implications

  2008cites this paper
• Glucose metabolism and insulin resistance in sepsis.

  2008cites this paper
• Experimental Therapeutic Strategies for Severe Sepsis

  2008cites this paper
• Insulin Resistance Postburn: Underlying Mechanisms and Current Therapeutic Strategies

  2008cites this paper
• The Hepatic Response to Severe Injury

  2007influential citation
• The Role of Insulin and Blood Glucose Control

  2007cites this paper
• Chapter 26 – The hepatic response to a thermal injury

  2007cites this paper
• Effect of insulin on the inflammatory and acute phase response after burn injury.

  2007cites this paper
• Early Glucose Normalization Does Not Improve Outcome in the Critically Ill Trauma Population

  2007cites this paper
• GLYCOGEN SYNTHASE KINASE 3&bgr; AS A TARGET FOR THE THERAPY OF SHOCK AND INFLAMMATION

  2007cites this paper
• INSULIN ATTENUATES THE CYTOKINE RESPONSE IN A BURN WOUND INFECTION MODEL

  2007cites this paper
• ALR and Liver Regeneration

  2006cites this paper
• Glucose metabolism and insulin therapy.

  2006cites this paper
• Intensive insulin therapy in high-risk cardiac surgery patients: evidence from the Leuven randomized study.

  2006cites this paper
• Diabetes of injury: novel insights.

  2006cites this paper
• Insulin reduces the multiple organ injury and dysfunction caused by coadministration of lipopolysaccharide and peptidoglycan independently of blood glucose: Role of glycogen synthase kinase-3&bgr; inhibition*

  2006cites this paper
• Hyperglycemia has a stronger relation with outcome in trauma patients than in other critically ill patients.

  2006cites this paper
• Rôle de l’insuline et du contrôle de la glycémie en réanimation Role of insulin and blood glucose control to improve outcome of critical illness

  2006cites this paper
• Rôle de l'insuline et du contrôle de la glycémie en réanimation

  2006cites this paper
• Intensive insulin therapy in the intensive care unit: update on clinical impact and mechanisms of action.

  2006cites this paper
• Glycaemic control in trauma patients, is there a role?

  2006cites this paper
• Glycemic and nonglycemic effects of insulin: how do they contribute to a better outcome of critical illness?

  2005cites this paper
• Interaction of exogenous liposomal insulin‐like growth factor‐I cDNA gene transfer with growth factors on collagen expression in acute wounds

  2005cites this paper
• The Role of Insulin Therapy in Critically I11 Patients

  2005cites this paper
• Insulin prevents liver damage and preserves liver function in lipopolysaccharide-induced endotoxemic rats.

  2005cites this paper
• Insulin promotes sinusoidal endothelial cell proliferation mediated by upregulation of vascular endothelial growth factor in regenerating rat liver after partial hepatectomy.

  2005cites this paper
• Expression of Nrf2 in Macrophage (RAW264.7) Induced by Serum of Burn Septic Rat

  year unknowncites this paper