Intensive insulin therapy in severely burned pediatric patients: a prospective randomized trial.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  American Journal of Respiratory and Critical Care Medicine

• Publication date

  2010-08-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1164/rccm.201002-0190OCPMID 20395554PMCID PMC2921599
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• POST-BURN HEPATIC INSULIN RESISTANCE IS ASSOCIATED WITH ENDOPLASMIC RETICULUM (ER) STRESS

  2010cited by this paper
• Insulin increases resistance to burn wound infection-associated sepsis

  2010cited by this paper
• Calcium and ER stress mediate hepatic apoptosis after burn injury

  2009cited by this paper
• Severe Burn-Induced Endoplasmic Reticulum Stress and Hepatic Damage in Mice

  2009cited by this paper
• Pathophysiologic Response to Severe Burn Injury

  2009influential reference
• Intensive versus conventional glucose control in critically ill patients.

  2009cited by this paper
• Intensive insulin therapy for patients in paediatric intensive care: a prospective, randomised controlled study.

  2009influential reference
• Pediatric critical illness hyperglycemia: risk factors associated with development and severity of hyperglycemia in critically ill children.

  2009cited by this paper
• Abnormal insulin sensitivity persists up to three years in pediatric patients post-burn.

  2009cited by this paper
• Intensive Insulin Therapy and Pentastarch Resuscitation in Severe Sepsis

  2008cited by this paper
• Gender Differences in Pediatric Burn Patients: Does It Make a Difference?

  2008cited by this paper
• Pathophysiologic Response to Severe Burn Injury

  2008cited by this paper
• CHARACTERIZATION OF THE INFLAMMATORY RESPONSE DURING ACUTE AND POST-ACUTE PHASES AFTER SEVERE BURN

  2008cited by this paper
• The Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008.

  2008cited by this paper
• Intensive insulin therapy and pentastarch resuscitation in severe sepsis.

  2008influential reference
• Hyperglycemia in the pediatric intensive care unit: a few steps closer to sweetening the pot.

  2008cited by this paper
• Insulin Resistance Postburn: Underlying Mechanisms and Current Therapeutic Strategies

  2008cited by this paper
• Intensive insulin therapy is associated with reduced infectious complications in burn patients.

  2008cited by this paper
• Blood transfusions are associated with increased risk for development of sepsis in severely burned pediatric patients*

  2007cited by this paper
• The Effect of Oxandrolone on the Endocrinologic, Inflammatory, and Hypermetabolic Responses During the Acute Phase Postburn

  2007cited by this paper
• CHANGES IN LIVER FUNCTION AND SIZE AFTER A SEVERE THERMAL INJURY

  2007cited by this paper
• Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008

  2007cited by this paper
• American Burn Association Consensus Conference to Define Sepsis and Infection in Burns

  2007cited by this paper
• Clinical experience with tight glucose control by intensive insulin therapy

  2007cited by this paper
• Signal integration in the endoplasmic reticulum unfolded protein response

  2007influential reference
• CYTOKINE EXPRESSION PROFILE OVER TIME IN SEVERELY BURNED PEDIATRIC PATIENTS

  2006cited by this paper
• The Influence of Age and Gender on Resting Energy Expenditure in Severely Burned Children

  2006influential reference
• Body composition changes with time in pediatric burn patients.

  2006cited by this paper
• Strict blood glucose control with insulin during intensive care after cardiac surgery: impact on 4-years survival, dependency on medical care, and quality-of-life.

  2006cited by this paper
• Burn size determines the inflammatory and hypermetabolic response

  2006cited by this paper
• Survival benefits of intensive insulin therapy in critical illness: impact of maintaining normoglycemia versus glycemia-independent actions of insulin.

  2006cited by this paper
• Intensive insulin therapy in the medical ICU.

  2006cited by this paper
• Metabolic and Hormonal Changes of Severely Burned Children Receiving Long-Term Oxandrolone Treatment

  2005cited by this paper
• Persistent hyperglycemia in critically ill children.

  2005cited by this paper
• Impact of tight glycemic control in severely burned children.

  2005cited by this paper
• Insulin prevents liver damage and preserves liver function in lipopolysaccharide-induced endotoxemic rats.

  2005cited by this paper
• Inflammation, stress, and diabetes.

  2005cited by this paper
• Insulin attenuates the systemic inflammatory response in endotoxemic rats.

  2004cited by this paper
• Glucose control and mortality in critically ill patients.

  2004cited by this paper
• Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes

  2004cited by this paper
• Validation of insulin sensitivity indices from oral glucose tolerance test parameters in obese children and adolescents.

  2004cited by this paper
• Insulin Treatment Improves the Systemic Inflammatory Reaction to Severe Trauma

  2004cited by this paper
• Increased liver weights in severely burned children: comparison of ultrasound and autopsy measurements.

  2004cited by this paper
• Insulin Treatment Improves Hepatic Morphology and Function Through Modulation of Hepatic Signals After Severe Trauma

  2004cited by this paper
• Indices of insulin action, disposal, and secretion derived from fasting samples and clamps in normal glucose-tolerant black and white children.

  2002cited by this paper
• Hyperglycemia exacerbates muscle protein catabolism in burn-injured patients

  2002cited by this paper
• Intensive insulin therapy in critically ill patients.

  2002influential reference
• Insulin Attenuates the Systemic Inflammatory Response to Thermal Trauma

  2002cited by this paper
• The effect of prolonged euglycemic hyperinsulinemia on lean body mass after severe burn.

  2002cited by this paper
• Association of hyperglycemia with increased mortality after severe burn injury.

  2001cited by this paper
• Recent advances in our understanding of insulin action and insulin resistance.

  2001cited by this paper
• Intensive insulin therapy in critically ill patients.

  2001cited by this paper
• Determinants of Skeletal Muscle Catabolism After Severe Burn

  2000cited by this paper
• Influence of glucose kinetics on plasma lactate concentration and energy expenditure in severely burned patients.

  2000cited by this paper
• Persistence of muscle catabolism after severe burn.

  2000cited by this paper
• ER stress response: getting the UPR hand on misfolded proteins.

  2000influential reference
• The c-Jun NH2-terminal Kinase Promotes Insulin Resistance during Association with Insulin Receptor Substrate-1 and Phosphorylation of Ser307 *

  2000cited by this paper
• Recent advances in the study of the biosynthesis and functions of sulfated glycosaminoglycans.

  2000cited by this paper
• A submaximal dose of insulin promotes net skeletal muscle protein synthesis in patients with severe burns.

  1999cited by this paper
• Insulin but not growth hormone stimulates protein anabolism in skin wound and muscle.

  1999cited by this paper
• Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp.

  1999cited by this paper
• Insulin but not growth hormone stimulates protein anabolism in skin wound and muscle.

  1999cited by this paper
• Effects of insulin on wound healing.

  1998cited by this paper
• The insulin signalling system and the IRS proteins

  1997cited by this paper
• The insulin receptor and its substrate: molecular determinants of early events in insulin action.

  1993cited by this paper
• Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man

  1985cited by this paper
• Glucose and lactate kinetics in burn shock.

  1977cited by this paper

• Complement response to burn injury: systematic review and meta-analysis of patient and animal studies

  2026cites this paper
• Obesity's Impact on Pediatric Scald Burns: How Much Weight Does It Carry?

  2025cites this paper
• Metabolic and Hormonal Changes in Pediatric Burn Patients: Mechanisms, Evidence, and Care Strategies

  2025cites this paper
• Biologic Mechanisms Underlying the Heterogeneous Response to Tight Glycemic Control among Differentially Inflamed Patients in the HALF-PINT Trial.

  2025cites this paper
• Metabolic response to burn injury: a comprehensive bibliometric study

  2025cites this paper
• On how to feed critically ill children in intensive care: A slowly shifting paradigm

  2025cites this paper
• The flux of energy in critical illness and the obesity paradox.

  2025cites this paper
• The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2024

  2025cites this paper
• The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2024

  2025cites this paper
• The impact of peripheral burn insult on the central nervous system.

  2025cites this paper
• Metformin administration improves adverse outcomes in older adult burn patients: a single-centre cohort study

  2025cites this paper
• Beyond diabetes: harnessing the power of metformin in burn care

  2025cites this paper
• Metformin is associated with reduced risk of mortality and morbidity in burn patients compared to insulin.

  2024cites this paper
• Society of Critical Care Medicine Guidelines on Glycemic Control for Critically Ill Children and Adults 2024: Executive Summary

  2024cites this paper
• Society of Critical Care Medicine Guidelines on Glycemic Control for Critically Ill Children and Adults 2024

  2024influential citation
• Decoding burn trauma: biomarkers for early diagnosis of burn-induced pathologies

  2024cites this paper
• Update in the Management of Burns in Children 2024

  2024cites this paper
• Update on Hypermetabolism in Pediatric Burn Patients

  2024cites this paper
• Glucose Metabolism and Stress Hyperglycemia in Critically Ill Children

  2023cites this paper
• Surviving Sepsis After Burn Campaig.

  2023cites this paper
• The association of hypoglycemia with outcome of critically ill children in relation to nutritional and blood glucose control strategies

  2023cites this paper
• Insulin resistance in critical illness: consequences for nutrition therapy and glucose management

  2023cites this paper
• Tight Glycemic Control, Inflammation, and the ICU: Evidence for Heterogeneous Treatment Effects in Two Randomized Controlled Trials.

  2023cites this paper
• Our Scientific Journey through the Ups and Downs of Blood Glucose Control in the ICU.

  2023cites this paper
• High-Throughput Profiling of Serological Immunoglobulin G N-Glycome as a Noninvasive Biomarker of Gastrointestinal Cancers

  2023cites this paper
• Adipose Tissue Remodeling in Pathophysiology.

  2022cites this paper
• Is the Urokinase Plasminogen Activator/Plasminogen Activator Inhibitor-1 Ratio a Marker of Sonographic Septations in Pleural Infection?

  2022cites this paper
• The Japanese Society for Burn Injuries (JSBI) Clinical Practice Guidelines for Management of Burn Care (3rd Edition)

  2022cites this paper
• ISPAD clinical practice consensus guidelines 2022: Management of children and adolescents with diabetes requiring surgery

  2022cites this paper
• The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 (J‐SSCG 2020)

  2021cites this paper
• Nanocarrier-Mediated Topical Insulin Delivery for Wound Healing

  2021cites this paper
• The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 (J-SSCG 2020)

  2021cites this paper
• Chronic Critical Illness and PICS Nutritional Strategies

  2021cites this paper
• Extracorporeal Membrane Oxygenation for Pediatric Burn Patients: Is Management Improving Over Time?

  2021cites this paper
• Burn-induced hypermetabolism and skeletal muscle dysfunction.

  2021cites this paper
• Contemporary Aspects of Burn Care

  2021cites this paper
• Feeding May Modulate the Relationship Between Systemic Inflammation, Insulin Resistance, and Poor Outcome Following Cardiopulmonary Bypass for Pediatric Cardiac Surgery.

  2020cites this paper
• Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children

  2020cites this paper
• A systematic review of intervention studies demonstrates the need to develop a minimum set of indicators to report the presence of burn wound infection.

  2020cites this paper
• Shedding of proangiogenic microvesicles from hypertrophic scar myofibroblasts

  2020cites this paper
• Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children

  2020cites this paper
• Nutrition of the Burned Patient and Treatment of the Hypermetabolic Response

  2020cites this paper
• A Flowable Placental Formulation Prevents Bleomycin-Induced Dermal Fibrosis in Aged Mice

  2020cites this paper
• Specialized nutrition support in burns, wasting, deconditioning, and hypermetabolic conditions

  2020cites this paper
• intervention studies demonstrates the

  2020influential citation
• Critical care management in burns: a review of current evidence and guidelines - Part 2

  2020cites this paper
• Adipose Tissue Metabolic Function and Dysfunction: Impact of Burn Injury

  2020cites this paper
• Glucose Control in the Intensive Care Unit

  2020cites this paper
• Challenges of the intensive insulin therapy in experimental models of extensive burn injury

  2020influential citation
• Results of a Multi-Center Feasibility Study of an Automated Bedside Glucose Monitoring System in the Burn Intensive Care Setting.

  2020cites this paper
• Anabolic and Anticatabolic Agents in Burns

  2019cites this paper
• Admission of Burn Patients to the Burn Center Including Burn Wound Evaluation

  2019cites this paper
• Anabolic and anticatabolic agents used in burn care: What is known and what is yet to be learned.

  2019cites this paper
• Short-Term Adverse Outcomes Associated With Hypoglycemia in Critically Ill Children

  2019cites this paper
• Inducible nitric oxide synthase contributes to insulin resistance and cardiac dysfunction after burn injury in mice.

  2019cites this paper
• The effect of diabetes on burn patients: a retrospective cohort study

  2019cites this paper
• Glucose control in the ICU.

  2019cites this paper
• Energy Expenditure and Protein Requirements Following Burn Injury.

  2019cites this paper
• Nutrition for Chronic Critical Illness and Persistent Inflammatory, Immunosuppressed, Catabolic Syndrome

  2019cites this paper
• Pediatric Diabetes: Review Article

  2019cites this paper
• The relationship between enteral nutrition, energy metabolism and gut homeostasis during the course of critical illness

  2019cites this paper
• Acute pancreatic beta cell apoptosis by IL-1β is responsible for postburn hyperglycemia: Evidence from humans and mice.

  2019cites this paper
• A Critical Update of the Assessment and Acute Management of Patients with Severe Burns

  2019cites this paper
• Burn-Induced Muscle Wasting: Changes in Muscle Progenitor Cells

  2018cites this paper
• Effects of a restrictive blood transfusion protocol on acute pediatric burn care: Transfusion threshold in pediatric burns

  2018cites this paper
• Chronic Critical Illness: Application of What We Know

  2018cites this paper
• ESPGHAN / ESPEN / ESPR guidelines on pediatric parenteral nutrition : Carbohydrates

  2018cites this paper
• Nutritional Support for Abdominal Sepsis

  2018cites this paper
• Beyond Survival: Pediatric Critical Care Interventional Trial Outcome Measure Preferences of Families and Healthcare Professionals*

  2018cites this paper
• ISPAD Clinical Practice Consensus Guidelines 2018: Management of children and adolescents with diabetes requiring surgery

  2018cites this paper
• Nutrition Support and Tight Glucose Control in Critically Ill Children: Food for Thought!

  2018cites this paper
• Reduced Postburn Hypertrophic Scarring and Improved Physical Recovery With Yearlong Administration of Oxandrolone and Propranolol

  2018cites this paper
• ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: Carbohydrates.

  2018cites this paper
• The Long-Term Impact of Severe Burn Trauma on Musculoskeletal Health.

  2018cites this paper
• Safe and effective glycaemic control in premature infants: observational clinical results from the computerised STAR-GRYPHON protocol

  2018cites this paper
• Short time insulin treatment post burn improves elastic-collagen rearrangement and reepithelization

  2018cites this paper
• The Effect of Burn Trauma on Lipid and Glucose Metabolism: Implications for Insulin Sensitivity.

  2018cites this paper
• The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016)

  2018cites this paper
• Tight glycemic control in critically ill pediatric patients: a meta-analysis and systematic review of randomized controlled trials

  2018cites this paper
• Endocrine and Metabolic Alterations in Sepsis and Implications for Treatment.

  2018cites this paper
• The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J‐SSCG 2016)

  2018cites this paper
• Short-term metformin and exercise training effects on strength, aerobic capacity, glycemic control, and mitochondrial function in children with burn injury.

  2018cites this paper
• Tight glycemic control in critically ill pediatric patients: a meta-analysis and systematic review of randomized controlled trials

  2018influential citation
• Nutrition: reducing the hypermetabolic response to thermal injury.

  2018cites this paper
• Autophagy: should it play a role in ICU management?

  2018cites this paper
• Tight glycemic control in critically ill pediatric patients: a systematic review and meta-analysis

  2018cites this paper
• The P50 Research Center in Perioperative Sciences: How the investment by the National Institute of General Medical Sciences in team science has reduced postburn mortality

  2017cites this paper
• Metabolic and Endocrine Considerations After Burn Injury.

  2017cites this paper
• Tight Glycemic Control in Critically Ill Children.

  2017cites this paper
• Pediatric Multiple Organ Dysfunction Syndrome: Promising Therapies

  2017cites this paper
• Tight Glycemic Control in Critically Ill Children

  2017cites this paper
• The Metabolic Response to Stress and Infection in Critically Ill Children: The Opportunity of an Individualized Approach

  2017cites this paper
• Intensive insulin therapy, insulin sensitisers and insulin secretagogues for burns: A systematic review of effectiveness and safety.

  2017cites this paper
• Avaluació dels factors pronòstics de la sèpsia en l'edat pediàtrica

  2017influential citation
• Hypermetabolic Response to Burn Injury

  2016cites this paper
• Moderate glycemic control safe in critically ill adult burn patients: A 15 year cohort study.

  2016cites this paper
• Thermische Verletzungen im Kindesalter

  2016cites this paper
• Alteration of Homeostasis: Prevalence, Effect of Therapy and Outcome in Pediatric Intensive Care Unit at a Tertiary Care Centre

  2016cites this paper
• Tight Glycemic Control in the Pediatric Intensive Care Unit

  2016cites this paper
• Postburn Hypermetabolism: Past, Present, and Future

  2016cites this paper