Transcriptional silencing at Saccharomyces telomeres: implications for other organisms

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Oncogene

• Publication date

  2002-01-21

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/sj.onc.1205078PMID 11850776
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Repair of chromosome ends after telomere loss in Saccharomyces.

  2001cited by this paper
• Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

  2001cited by this paper
• Telomere looping permits gene activation by a downstream UAS in yeast

  2001cited by this paper
• Localization of yeast telomeres to the nuclear periphery is separable from transcriptional repression and telomere stability functions.

  2001cited by this paper
• Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells.

  2001cited by this paper
• Malaria: Cooperative silencing elements in var genes

  2001cited by this paper
• The role of the Mre11-Rad50-Xrs2 complex in telomerase- mediated lengthening of Saccharomyces cerevisiae telomeres.

  2001cited by this paper
• Telomere Position Effect in Human Cells

  2001cited by this paper
• t‐loops at trypanosome telomeres

  2001cited by this paper
• Involvement of the Checkpoint Protein Mec1p in Silencing of Gene Expression at Telomeres in Saccharomyces cerevisiae

  2000cited by this paper
• Frequent ectopic recombination of virulence factor genes in telomeric chromosome clusters of P. falciparum

  2000cited by this paper
• The Mre11p/Rad50p/Xrs2p complex and the Tel1p function in a single pathway for telomere maintenance in yeast.

  2000cited by this paper
• Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

  2000cited by this paper
• Identification of human Rap1: implications for telomere evolution.

  2000cited by this paper
• Ku acts in a unique way at the mammalian telomere to prevent end joining.

  2000cited by this paper
• Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres

  2000cited by this paper
• Telomeric silencing of a natural subtelomeric gene

  2000cited by this paper
• Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G‐strand overhang

  2000cited by this paper
• Role of NAD(+) in the deacetylase activity of the SIR2-like proteins.

  2000cited by this paper
• The dynamics of yeast telomeres and silencing proteins through the cell cycle.

  2000cited by this paper
• Telomere Folding Is Required for the Stable Maintenance of Telomere Position Effects in Yeast

  2000cited by this paper
• MEC1-dependent redistribution of the Sir3 silencing protein from telomeres to DNA double-strand breaks.

  1999cited by this paper
• Mammalian telomeres end in a large duplex loop.

  1999cited by this paper
• Sir-Ku-itous routes to make ends meet.

  1999cited by this paper
• Yeast Ku protein plays a direct role in telomeric silencing and counteracts inhibition by rif proteins.

  1999influential reference
• Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast.

  1999influential reference
• The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms.

  1999cited by this paper
• Cohabitation of insulators and silencing elements in yeast subtelomeric regions

  1999influential reference
• Limitations of silencing at native yeast telomeres

  1999influential reference
• DNA damage triggers disruption of telomeric silencing and Mec1p-dependent relocation of Sir3p.

  1999cited by this paper
• An enzymatic activity in the yeast Sir2 protein that is essential for gene silencing.

  1999cited by this paper
• Ku is associated with the telomere in mammals.

  1999cited by this paper
• Silencing at Drosophila telomeres: nuclear organization and chromatin structure play critical roles

  1999cited by this paper
• Telomeres of polytene chromosomes in a ciliated protozoan terminate in duplex DNA loops.

  1999cited by this paper
• Chromosomal landscape of nucleosome-dependent gene expression and silencing in yeast

  1999cited by this paper
• Yeast Ku as a regulator of chromosomal DNA end structure.

  1998cited by this paper
• Changing the end: antigenic variation orchestrated at the telomeres of African trypanosomes.

  1998cited by this paper
• beta-D-glucosyl-hydroxymethyluracil is a conserved DNA modification in kinetoplastid protozoans and is abundant in their telomeres.

  1998cited by this paper
• Fission yeast Taz1 protein is required for meiotic telomere clustering and recombination

  1998cited by this paper
• Antigenic variation in malaria: in situ switching, relaxed and mutually exclusive transcription of var genes during intra‐erythrocytic development in Plasmodium falciparum

  1998cited by this paper
• Mutation of yeast Ku genes disrupts the subnuclear organization of telomeres.

  1998cited by this paper
• Sir Proteins, Rif Proteins, and Cdc13p BindSaccharomyces Telomeres In Vivo

  1998cited by this paper
• Components of the Ku‐dependent non‐homologous end‐joining pathway are involved in telomeric length maintenance and telomeric silencing

  1998cited by this paper
• Defective meiosis in telomere-silencing mutants of Schizosaccharomyces pombe

  1998cited by this paper
• Perinuclear localization of chromatin facilitates transcriptional silencing

  1998cited by this paper
• The yeast Cac1 protein is required for the stable inheritance of transcriptionally repressed chromatin at telomeres.

  1997cited by this paper
• SIR2 and SIR4 interactions differ in core and extended telomeric heterochromatin in yeast.

  1997influential reference
• Regulation of telomere length and function by a Myb-domain protein in fission yeast

  1997cited by this paper
• The ubiquitin-conjugating enzyme Rad6 (Ubc2) is required for silencing in Saccharomyces cerevisiae

  1997cited by this paper
• Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae.

  1997cited by this paper
• Telomeric transcriptional silencing in a natural context

  1997influential reference
• A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae.

  1997cited by this paper
• Localization of Sir2p: the nucleolus as a compartment for silent information regulators

  1997cited by this paper
• The clustering of telomeres and colocalization with Rap1, Sir3, and Sir4 proteins in wild-type Saccharomyces cerevisiae

  1996influential reference
• GFP tagging of budding yeast chromosomes reveals that protein-protein interactions can mediate sister chromatid cohesion.

  1996cited by this paper
• The Saccharomyces retrotransposon Ty5 integrates preferentially into regions of silent chromatin at the telomeres and mating loci.

  1996cited by this paper
• Structure, function, and replication of Saccharomyces cerevisiae telomeres.

  1996cited by this paper
• The Saccharomyces CDC13 protein is a single-strand TG1-3 telomeric DNA-binding protein in vitro that affects telomere behavior in vivo.

  1996cited by this paper
• Spreading of transcriptional represser SIR3 from telomeric heterochromatin

  1996cited by this paper
• Evidence for silencing compartments within the yeast nucleus: a role for telomere proximity and Sir protein concentration in silencer-mediated repression.

  1996cited by this paper
• TEL2, an essential gene required for telomere length regulation and telomere position effect in Saccharomyces cerevisiae

  1996cited by this paper
• Silencing of genes at nontelomeric sites in yeast is controlled by sequestration of silencing factors at telomeres by Rap 1 protein.

  1996cited by this paper
• Cdc13p: A Single-Strand Telomeric DNA-Binding Protein with a Dual Role in Yeast Telomere Maintenance

  1996cited by this paper
• The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability.

  1995cited by this paper
• Histone H3 and H4 N-termini interact with SIR3 and SIR4 proteins: a molecular model for the formation of heterochromatin in yeast.

  1995cited by this paper
• The chromosome ends of Saccharomyces cerevisiae

  1995cited by this paper
• Disturbance of normal cell cycle progression enhances the establishment of transcriptional silencing in Saccharomyces cerevisiae

  1995cited by this paper
• A developmentally regulated position effect at a telomeric locus in Trypanosoma brucei.

  1995cited by this paper
• Action of a RAP1 carboxy-terminal silencing domain reveals an underlying competition between HMR and telomeres in yeast.

  1995cited by this paper
• Protein-DNA interactions in soluble telosomes from Saccharomyces cerevisiae.

  1995cited by this paper
• The carboxy termini of Sir4 and Rap1 affect Sir3 localization: evidence for a multicomponent complex required for yeast telomeric silencing

  1995cited by this paper
• The unusual telomeres of Drosophila.

  1995cited by this paper
• Extra telomeres, but not internal tracts of telomeric DNA, reduce transcriptional repression at Saccharomyces telomeres.

  1995cited by this paper
• Chromosome aberrations in desmoid tumors. Trisomy 8 may be a predictor of recurrence.

  1995cited by this paper
• Overcoming telomeric silencing: a trans-activator competes to establish gene expression in a cell cycle-dependent way.

  1994cited by this paper
• The chromosome end in yeast: its mosaic nature and influence on recombinational dynamics.

  1994cited by this paper
• Transcription of a yeast telomere alleviates telomere position effect without affecting chromosome stability.

  1994cited by this paper
• Internal tracts of telomeric DNA act as silencers in Saccharomyces cerevisiae.

  1994cited by this paper
• Telomere‐associated chromosome breakage in fission yeast results in variegated expression of adjacent genes.

  1994cited by this paper
• Evidence that a complex of SIR proteins interacts with the silencer and telomere-binding protein RAP1.

  1994cited by this paper
• RAP1 and telomere structure regulate telomere position effects in Saccharomyces cerevisiae.

  1993influential reference
• β-d-glucosyl-hydroxymethyluracil: A novel modified base present in the DNA of the parasitic protozoan T. brucei

  1993cited by this paper
• Loss of a yeast telomere: arrest, recovery, and chromosome loss.

  1993cited by this paper
• Transcriptional silencing in yeast is associated with reduced nucleosome acetylation.

  1993cited by this paper
• Silent domains are assembled continuously from the telomere and are defined by promoter distance and strength, and by SIR3 dosage.

  1993cited by this paper
• Distortion of the DNA double helix by RAP1 at silencers and multiple telomeric binding sites.

  1993cited by this paper
• SIR3 and SIR4 proteins are required for the positioning and integrity of yeast telomeres.

  1993cited by this paper
• Cell cycle-dependent specific positioning and clustering of centromeres and telomeres in fission yeast

  1993cited by this paper
• ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex

  1992cited by this paper
• Telomere positional effects and the regulation of cellular senescence.

  1992cited by this paper
• A RAP1-interacting protein involved in transcriptional silencing and telomere length regulation.

  1992influential reference
• Telomere-proximal DNA in Saccharomyces cerevisiae is refractory to methyltransferase activity in vivo.

  1992cited by this paper
• Saccharomyces telomeres assume a non-nucleosomal chromatin structure.

  1992cited by this paper
• C-terminal truncation of RAP1 results in the deregulation of telomere size, stability, and function in Saccharomyces cerevisiae

  1992cited by this paper
• Modifiers of position effect are shared between telomeric and silent mating-type loci in S. cerevisiae.

  1991cited by this paper
• Position effect at S. cerevisiae telomeres: reversible repression of Pol II transcription.

  1990cited by this paper
• RAP1 protein interacts with yeast telomeres in vivo: overproduction alters telomere structure and decreases chromosome stability.

  1990cited by this paper
• A new role for a yeast transcriptional silencer gene, SIR2, in regulation of recombination in ribosomal DNA.

  1989cited by this paper
• Transcription interferes with elements important for chromosome maintenance in Saccharomyces cerevisiae

  1988cited by this paper
• Genetic manipulation of centromere function

  1987cited by this paper

• Mapping the Telomeric 3D Interactome with Telomere-C Reveals Repetitive Element Hubs Associated with Telomere Maintenance

  2025cites this paper
• Transcription termination complex, Rtt103-Rai1-Rat1, regulates sub-telomeric transcripts in Saccharomyces cerevisiae

  2023cites this paper
• Systematic profiling of subtelomeric silencing factors in budding yeast

  2023cites this paper
• Telomere and subtelomere high polymorphism might contribute to the specificity of homologous recognition and pairing during meiosis in barley in the context of breeding

  2023cites this paper
• A high-resolution map of small-scale inversions in the gibbon genome

  2022cites this paper
• Genomewide identification of subtelomeric silencing factors in budding yeast

  2022cites this paper
• Genetic and Epigenetic Inheritance at Telomeres

  2022cites this paper
• Regulation of Gene Expression by Telomere Position Effect

  2021cites this paper
• Exercise, epigenetics, and aging

  2021cites this paper
• Gametes deficient for Pot1 telomere binding proteins alter levels of telomeric foci for multiple generations

  2021cites this paper
• RNAi and Ino80 complex control rate limiting translocation step that moves rDNA to eroding telomeres

  2021influential citation
• Global histone protein surface accessibility in yeast indicates a uniformly loosely packed genome with canonical nucleosomes

  2021cites this paper
• Improving Healthspan through Patient-Derived Artificial Organs from Induced Pluripotent Stem Cells and Two-Photon Polymerization

  2021cites this paper
• Genomic Instability and Cellular Senescence: Lessons From the Budding Yeast

  2021cites this paper
• Gametes deficient for Pot1 telomere binding proteins alter levels of telomeric foci for multiple generations

  2021cites this paper
• Unraveling the regulation of sophorolipid biosynthesis in Starmerella bombicola.

  2020cites this paper
• Yeast mismatch repair components are required for stable inheritance of gene silencing

  2020cites this paper
• Telomere attrition: metabolic regulation and signalling function?

  2019cites this paper
• Esc2 promotes telomere stability in response to DNA replication stress

  2019cites this paper
• F8 Inversions at Xq28 Causing Hemophilia A Are Associated With Specific Methylation Changes: Implication for Molecular Epigenetic Diagnosis

  2019cites this paper
• POT-1 telomere binding protein promotes a novel form of Transgenerational Epigenetic Inheritance

  2019cites this paper
• Epigenetic Mechanisms Impacting Aging: A Focus on Histone Levels and Telomeres

  2018cites this paper
• Comparative structural genomics and phylogenomics of African Trypanosomes

  2018cites this paper
• Chromatin architecture and virulence-related gene expression in eukaryotic microbial pathogens

  2018cites this paper
• TelAP1 links telomere complexes with developmental expression site silencing in African trypanosomes

  2018cites this paper
• Malaria parasites possess a telomere repeat-binding protein that shares ancestry with transcription factor IIIA

  2017cites this paper
• Sirtuins in the phylum Basidiomycota: A role in virulence in Cryptococcus neoformans

  2017cites this paper
• Telomeres and Telomerase in Neuroblastoma Telomeres and Telomerase in Neuroblastoma

  2017cites this paper
• Yeast genome-wide telomere screens and insights into cancer

  2017cites this paper
• Telomeres and Telomerase in Neuroblastoma

  2017cites this paper
• Heterochromatin assembly by interrupted Sir3 bridges across neighboring nucleosomes

  2016cites this paper
• Epigenetics and genome stability in the human fungal pathogen Candida albicans

  2016cites this paper
• Impacts on Sirtuin Function and Bioavailability of the Dietary Bioactive Compound Dihydrocoumarin

  2016cites this paper
• Heterogeneous Spatial Distribution of Transcriptional Activity in Budding Yeast Nuclei

  2016cites this paper
• General Introduction: Fungal Secondary Metabolites Gene Clusters: Strategies to Activate the Biosynthesis of Non-expressed and Novel Compounds

  2015cites this paper
• The effects of telomere shortening on cancer cells: a network model of proteomic and microRNA analysis.

  2015cites this paper
• A beginning of the end: new insights into the functional organization of telomeres

  2015cites this paper
• Genomic integrity and the ageing brain

  2015cites this paper
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• Is programmed aging a cause for optimism?

  2015cites this paper
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  2015cites this paper
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  2014cites this paper
• Study of DNA G-quadruplex structures by Nuclear Magnetic Resonance (NMR)

  2014cites this paper
• The long reach of telomeres

  2014cites this paper
• Analysis of silencing in Saccharomyces cerevisiae.

  2014cites this paper
• Loss of the Set2 histone methyltransferase increases cellular lifespan in yeast cells.

  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2013cites this paper
• Mapping the telomere integrated genome of human herpesvirus 6A and 6B.

  2013cites this paper
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  2013cites this paper
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  2012cites this paper
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  2012cites this paper
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  2012cites this paper
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  2012cites this paper
• Epigenetic mechanisms, nuclear architecture and the control of gene expression in trypanosomes

  2012cites this paper
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  2012cites this paper
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  2012cites this paper
• A Novel Downstream Regulatory Element Cooperates with the Silencing Machinery to Repress EPA1 Expression in Candida glabrata

  2012cites this paper
• Analysis of subtelomeric silencing in Candida glabrata.

  2011cites this paper
• A common telomeric gene silencing assay is affected by nucleotide metabolism.

  2011cites this paper
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  2011cites this paper
• Identification and Characterization of the Human Herpesviruses 6A and 6B Genome Integration into Telomeres of Human Chromosomes during Latency

  2011cites this paper
• HSP90 Controls SIR2 Mediated Gene Silencing

  2011influential citation
• Telomere length in cardiovascular disease and type 2 diabetes

  2011cites this paper
• Epigenetic Control of Aging

  2011cites this paper
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  2010cites this paper
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  2010cites this paper
• Epigenetic regulation of PGU1 transcription in Saccharomyces cerevisiae.

  2010cites this paper
• Differential participation of homologous recombination and nucleotide excision repair in yeast survival to ultraviolet light radiation.

  2010cites this paper
• Secondary metabolism in fungi: does chromosomal location matter?

  2010cites this paper
• Subtelomeric Silencing of the MTL3 Locus of Candida glabrata Requires yKu70, yKu80, and Rif1 Proteins

  2010cites this paper
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  2010cites this paper
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  2010cites this paper
• Chromatin regulation and non-coding RNAs at mammalian telomeres.

  2010cites this paper
• Telomeric Heterochromatin in Plasmodium falciparum

  2010influential citation
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  2010cites this paper
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  2010cites this paper
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  2009cites this paper
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  2009cites this paper
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  2009influential citation
• Telomeres do the (un)twist: helicase actions at chromosome termini.

  2009cites this paper
• Telomere length regulates ISG15 expression in human cells

  2009cites this paper
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  2009cites this paper
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  2009cites this paper
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  2009cites this paper
• A ‘higher order' of telomere regulation: telomere heterochromatin and telomeric RNAs

  2009influential citation
• Subtelomeric ACS-containing proto-silencers act as antisilencers in replication factors mutants in Saccharomyces cerevisiae.

  2008cites this paper
• The DNA End-Binding Protein Ku Regulates Silencing at the Internal HML and HMR Loci in Saccharomyces cerevisiae

  2008cites this paper
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  2008cites this paper