Ama1p-activated anaphase-promoting complex regulates the destruction of Cdc20p during meiosis II

During meiosis, the APC/C is activated by either Cdc20 or the meiosis-specific activator Ama1. Upon exit from meiosis II, APC/CAma1 mediates Cdc20 destruction using Db1 and GxEN degrons. The amino terminus of Ama1, which contains the Cdc20-binding domain, is sufficient for Cdc20 degradation but not spore formation.

• Publication year

  2011

• Venue

  Molecular Biology of the Cell

• Publication date

  2011-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1091/mbc.E10-04-0360PMID 21118994PMCID 3031463
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Stress and developmental regulation of the yeast

  2013cited by this paper
• Regulated degradation of the APC coactivator Cdc20

  2010cited by this paper
• The anaphase promoting complex targeting subunit Ama1 links meiotic exit to cytokinesis during sporulation in Saccharomyces cerevisiae.

  2009cited by this paper
• Analysis of activator-binding sites on the APC/C supports a cooperative substrate-binding mechanism.

  2009cited by this paper
• Pds1p Is Required for Meiotic Recombination and Prophase I Progression in Saccharomyces cerevisiae

  2009cited by this paper
• A role for the Fizzy/Cdc20 family of proteins in activation of the APC/C distinct from substrate recruitment.

  2008cited by this paper
• Pseudosubstrate Inhibition of the Anaphase-Promoting Complex by Acm1: Regulation by Proteolysis and Cdc28 Phosphorylation

  2008cited by this paper
• Inactivation of Cdh1 by synergistic action of Cdk1 and polo kinase is necessary for proper assembly of the mitotic spindle

  2008cited by this paper
• Cdc20, an activator at last.

  2008cited by this paper
• Meiosis I is established through division-specific translational control of a cyclin.

  2008cited by this paper
• Modulation of the mitotic regulatory network by APC-dependent destruction of the Cdh1 inhibitor Acm1.

  2008cited by this paper
• Cdc28 and Cdc14 Control Stability of the Anaphase-promoting Complex Inhibitor Acm1*

  2008cited by this paper
• Unique D Box and KEN Box Sequences Limit Ubiquitination of Acm1 and Promote Pseudosubstrate Inhibition of the Anaphase-promoting Complex*

  2008cited by this paper
• Cdc20: a WD40 activator for a cell cycle degradation machine.

  2007cited by this paper
• Inhibition of APCCdh1 Activity by Cdh1/Acm1/Bmh1 Ternary Complex Formation*

  2007cited by this paper
• Developmental Role and Regulation of cortex, a Meiosis-Specific Anaphase-Promoting Complex/Cyclosome Activator

  2007cited by this paper
• Meiosis-specific destruction of the Ume6p repressor by the Cdc20-directed APC/C.

  2007cited by this paper
• Roles of the anaphase-promoting complex/cyclosome and of its activator Cdc20 in functional substrate binding

  2006cited by this paper
• An architectural map of the anaphase-promoting complex.

  2006cited by this paper
• Acm1 Is a Negative Regulator of the Cdh1-Dependent Anaphase-Promoting Complex/Cyclosome in Budding Yeast

  2006cited by this paper
• The yeast APC/C subunit Mnd2 prevents premature sister chromatid separation triggered by the meiosis-specific APC/C-Ama1.

  2005influential reference
• Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C.

  2005cited by this paper
• The Ama1-Directed Anaphase-Promoting Complex Regulates the Smk1 Mitogen-Activated Protein Kinase During Meiosis in Yeast

  2005influential reference
• Coactivator functions in a stoichiometric complex with anaphase‐promoting complex/cyclosome to mediate substrate recognition

  2005cited by this paper
• The APC subunit Doc1 promotes recognition of the substrate destruction box.

  2005cited by this paper
• Mnd2, an essential antagonist of the anaphase-promoting complex during meiotic prophase.

  2005cited by this paper
• The WD40 propeller domain of Cdh1 functions as a destruction box receptor for APC/C substrates.

  2005cited by this paper
• Assembly of an APC-Cdh1-substrate complex is stimulated by engagement of a destruction box.

  2005cited by this paper
• Morphogenetic Pathway of Spore Wall Assembly in Saccharomyces cerevisiae

  2004cited by this paper
• The DNA damage checkpoint and PKA pathways converge on APC substrates and Cdc20 to regulate mitotic progression

  2004cited by this paper
• Cell cycle-regulated recognition of the destruction box of cyclin B by the APC/C in Xenopus egg extracts.

  2004cited by this paper
• The spindle checkpoint, aneuploidy, and cancer

  2004cited by this paper
• Xkid Is Degraded in a D-Box, KEN-Box, and A-Box-Independent Pathway

  2003cited by this paper
• Doc1 mediates the activity of the anaphase‐promoting complex by contributing to substrate recognition

  2003cited by this paper
• The CCT chaperonin promotes activation of the anaphase-promoting complex through the generation of functional Cdc20.

  2003cited by this paper
• Cks1-dependent proteasome recruitment and activation of CDC20 transcription in budding yeast

  2003cited by this paper
• Mitotic regulation of the human anaphase‐promoting complex by phosphorylation

  2003cited by this paper
• TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1.

  2003cited by this paper
• The Doc1 subunit is a processivity factor for the anaphase-promoting complex

  2002cited by this paper
• Cell cycle-dependent nuclear export of Cdh1p may contribute to the inactivation of APC/C(Cdh1).

  2002cited by this paper
• The anaphase-promoting complex: it's not just for mitosis any more.

  2002cited by this paper
• Saccharomyces cerevisiae C-Type Cyclin Ume3p/Srb11p Is Required for Efficient Induction and Execution of Meiotic Development

  2002cited by this paper
• The destruction box of the cyclin Clb2 binds the anaphase-promoting complex/cyclosome subunit Cdc23.

  2002cited by this paper
• Structure and function of a protein folding machine: the eukaryotic cytosolic chaperonin CCT

  2002cited by this paper
• Identification of a new APC/C recognition domain, the A box, which is required for the Cdh1-dependent destruction of the kinase Aurora-A during mitotic exit.

  2002influential reference
• Cell cycle‐dependent nuclear export of Cdh1p may contribute to the inactivation of APC/CCdh1

  2002cited by this paper
• Activity of the APCCdh1 form of the anaphase-promoting complex persists until S phase and prevents the premature expression of Cdc20p

  2001cited by this paper
• Yeast Hct1 recognizes the mitotic cyclin Clb2 and other substrates of the ubiquitin ligase APC

  2001cited by this paper
• The KEN box regulates Clb2 proteolysis in G1 and at the metaphase-to-anaphase transition.

  2001cited by this paper
• The anaphase inhibitor Pds1 binds to the APC/C-associated protein Cdc20 in a destruction box-dependent manner.

  2001cited by this paper
• Identification of an Overlapping Binding Domain on Cdc20 for Mad2 and Anaphase-Promoting Complex: Model for Spindle Checkpoint Regulation

  2001cited by this paper
• D box and KEN box motifs in budding yeast Hsl1p are required for APC-mediated degradation and direct binding to Cdc20p and Cdh1p.

  2001cited by this paper
• A Conserved Cyclin-Binding Domain Determines Functional Interplay between Anaphase-Promoting Complex–Cdh1 and Cyclin A-Cdk2 during Cell Cycle Progression

  2001cited by this paper
• Substrate recognition by the Cdc20 and Cdh1 components of the anaphase-promoting complex.

  2001influential reference
• A screen for genes required for meiosis and spore formation based on whole-genome expression.

  2001cited by this paper
• Cortex, a Drosophila gene required to complete oocyte meiosis, is a member of the Cdc20/fizzy protein family

  2001cited by this paper
• The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1.

  2000cited by this paper
• Cdc20 protein contains a destruction-box but, unlike Clb2, its proteolysisis not acutely dependent on the activity of anaphase-promoting complex.

  2000influential reference
• Ama1p is a meiosis-specific regulator of the anaphase promoting complex/cyclosome in yeast.

  2000cited by this paper
• A yeast intronic splicing enhancer and Nam8p are required for Mer1p-activated splicing.

  2000cited by this paper
• Destruction of the securin Pds1p occurs at the onset of anaphase during both meiotic divisions in yeast

  2000cited by this paper
• Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14.

  1999cited by this paper
• APCCdc20 promotes exit from mitosis by destroying the anaphase inhibitor Pds1 and cyclin Clb5

  1999influential reference
• Functional analysis of the Ume3p/ Srb11p-RNA polymerase II holoenzyme interaction.

  1999cited by this paper
• Oxidative Stress-Induced Destruction of the Yeast C-Type Cyclin Ume3p Requires Phosphatidylinositol-Specific Phospholipase C and the 26S Proteasome

  1999cited by this paper
• Chromosome separation and exit from mitosis in budding yeast: dependence on growth revealed by cAMP-mediated inhibition.

  1999cited by this paper
• SCF and Cullin/Ring H2-based ubiquitin ligases.

  1999influential reference
• Transcription Factor E2F and Cyclin E-Cdk2 Complex Cooperate to Induce Chromosomal DNA Replication in Xenopus Oocytes*

  1998cited by this paper
• The transcriptional program of sporulation in budding yeast.

  1998influential reference
• Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1.

  1998cited by this paper
• The regulation of Cdc20 proteolysis reveals a role for APC components Cdc23 and Cdc27 during S phase and early mitosis.

  1998influential reference
• The Polo‐like kinase Cdc5p and the WD‐repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae

  1998cited by this paper
• Additional modules for versatile and economical PCR‐based gene deletion and modification in Saccharomyces cerevisiae

  1998cited by this paper
• Control of cyclin ubiquitination by CDK-regulated binding of Hct1 to the anaphase promoting complex.

  1998cited by this paper
• Yeast Hct1 is a regulator of Clb2 cyclin proteolysis.

  1997cited by this paper
• Drosophila fizzy-related down-regulates mitotic cyclins and is required for cell proliferation arrest and entry into endocycles.

  1997cited by this paper
• Stress and developmental regulation of the yeast C‐type cyclin Ume3p (Srb11p/Ssn8p)

  1997cited by this paper
• CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis.

  1997cited by this paper
• The Drosophila cell cycle gene fizzy is required for normal degradation of cyclins A and B during mitosis and has homology to the CDC20 gene of Saccharomyces cerevisiae

  1995cited by this paper
• Multifunctional yeast high-copy-number shuttle vectors.

  1992cited by this paper
• Cyclin is degraded by the ubiquitin pathway

  1991cited by this paper
• Identification of negative regulatory genes that govern the expression of early meiotic genes in yeast.

  1989cited by this paper

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  2024cites this paper
• The middle domain of Hsp104 can ensure substrates are functional after processing

  2024cites this paper
• MIT Open Access

  2022cites this paper
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  2021cites this paper
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  2021cites this paper
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  2020cites this paper
• The meiosis‐specific APC activator FgAMA1 is dispensable for meiosis but important for ascosporogenesis in Fusarium graminearum

  2019influential citation
• for Most Protein Complex during Meiosis.

  2019cites this paper
• An E2-ubiquitin thioester-driven approach to identify substrates modified with ubiquitin and ubiquitin-like molecules

  2018cites this paper
• Precise Post-translational Tuning Occurs for Most Protein Complex Components during Meiosis

  2018cites this paper
• APC/C Cdh1-mediated degradation of Cdh1 during meiosis in S. cerevisiae

  2018cites this paper
• The meiosis-specific Cdc20 family-member Ama1 promotes binding of the Ssp2 activator to the Smk1 MAP kinase

  2018cites this paper
• A complex molecular switch directs stress-induced cyclin C nuclear release through SCFGrr1-mediated degradation of Med13

  2017cites this paper
• Long non-coding RNA-based mechanisms for the inhibition of cell growth and development by 5 - Fluorouracil

  2016cites this paper
• Timely Closure of the Prospore Membrane Requires SPS1 and SPO77 in Saccharomyces cerevisiae

  2016cites this paper
• Arabidopsis Cell Division Cycle 20.1 Is Required for Normal Meiotic Spindle Assembly and Chromosome Segregation[OPEN]

  2015cites this paper
• Role of oxidative stress in the pathogenesis of triple A syndrome and familial glucocorticoid deficiency

  2014cites this paper
• Slt2p phosphorylation induces cyclin C nuclear-to-cytoplasmic translocation in response to oxidative stress

  2014cites this paper
• Etude de deux régulateurs de l’APC/C et de leurs rôles dans le contrôle du cycle cellulaire et de la cohésion lors de la méiose chez Arabidopsis thaliana

  2013cites this paper
• A Meiosis-Specific Form of the APC/C Promotes the Oocyte-to-Embryo Transition by Decreasing Levels of the Polo Kinase Inhibitor Matrimony

  2013cites this paper
• Mutually dependent degradation of Ama1p and Cdc20p terminates APC/C ubiquitin ligase activity at the completion of meiotic development in yeast

  2013influential citation
• Meiotic control of the APC/C: similarities & differences from mitosis

  2011cites this paper
• Sporulation in the Budding Yeast Saccharomyces cerevisiae

  2011cites this paper
• e-Publications@Marquette e-Publications@Marquette

  year unknowncites this paper