Hippocampal dysfunction and disruption of dopamine system regulation in an animal model of schizophrenia

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Neurotoxicity research

• Publication date

  2008-06-01

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1007/BF03033801PMID 19073417PMCID PMC2879641
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Neuroplasticity of Neocortical Circuits in Schizophrenia

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• Aberrant Hippocampal Activity Underlies the Dopamine Dysregulation in an Animal Model of Schizophrenia

  2007influential reference
• Regulation of firing of dopaminergic neurons and control of goal-directed behaviors.

  2007cited by this paper
• Decrease in parvalbumin‐expressing neurons in the hippocampus and increased phencyclidine‐induced locomotor activity in the rat methylazoxymethanol (MAM) model of schizophrenia

  2006cited by this paper
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  2006cited by this paper
• Fronto-hippocampal function during temporal context monitoring in schizophrenia.

  2006cited by this paper
• Intermediate phenotypes and genetic mechanisms of psychiatric disorders

  2006cited by this paper
• A neurobehavioral systems analysis of adult rats exposed to methylazoxymethanol acetate on E17: implications for the neuropathology of schizophrenia.

  2006influential reference
• Correlations Between rCBF and Symptoms in Two Independent Cohorts of Drug-Free Patients with Schizophrenia

  2006cited by this paper
• Alterations in medial prefrontal cortical activity and plasticity in rats with disruption of cortical development.

  2006influential reference
• The Hippocampus Modulates Dopamine Neuron Responsivity by Regulating the Intensity of Phasic Neuron Activation

  2006cited by this paper
• Treatments for schizophrenia: a critical review of pharmacology and mechanisms of action of antipsychotic drugs

  2005cited by this paper
• Cortical inhibitory neurons and schizophrenia

  2005cited by this paper
• Do we still believe in the dopamine hypothesis? New data bring new evidence.

  2004cited by this paper
• The hippocampus in schizophrenia: a review of the neuropathological evidence and its pathophysiological implications

  2004cited by this paper
• The hippocampus in schizophrenia.

  2004cited by this paper
• The medial temporal lobe.

  2004cited by this paper
• Working memory deficits in adult rats after prenatal disruption of neurogenesis

  2004cited by this paper
• Disruption of Neurogenesis on Gestational Day 17 in the Rat Causes Behavioral Changes Relevant to Positive and Negative Schizophrenia Symptoms and Alters Amphetamine-Induced Dopamine Release in Nucleus Accumbens

  2004cited by this paper
• Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia.

  2003cited by this paper
• Afferent modulation of dopamine neuron firing differentially regulates tonic and phasic dopamine transmission

  2003influential reference
• Gene Expression Deficits in a Subclass of GABA Neurons in the Prefrontal Cortex of Subjects with Schizophrenia

  2003cited by this paper
• Differential hippocampal expression of glutamic acid decarboxylase 65 and 67 messenger RNA in bipolar disorder and schizophrenia.

  2002cited by this paper
• Hippocampal neurons in schizophrenia

  2002cited by this paper
• Schizophrenia as a disorder of neurodevelopment.

  2002cited by this paper
• Differential involvement of amygdala and hippocampus in responding to novel objects and contexts.

  2002cited by this paper
• Understanding the neurotransmitter pathology of schizophrenia: selective deficits of subtypes of cortical GABAergic neurons

  2002cited by this paper
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• Evidence for abnormal cortical functional connectivity during working memory in schizophrenia.

  2001cited by this paper
• Infectious and immune factors in the pathogenesis of neurodevelopmental disorders: epidemiology, hypotheses, and animal models.

  2001cited by this paper
• A review of MRI findings in schizophrenia.

  2001cited by this paper
• GABAergic Interneurons: Implications for Understanding Schizophrenia and Bipolar Disorder

  2001cited by this paper
• Probing the human hippocampus using rCBF: Contrasts in schizophrenia

  2001cited by this paper
• The tonic/phasic model of dopamine system regulation and its implications for understanding alcohol and psychostimulant craving.

  2000cited by this paper
• Impaired Sensory Gating and Attention in Rats with Developmental Abnormalities of the Mesocortex: Implications for Schizophrenia

  2000cited by this paper
• The neurodevelopmental hypothesis of schizophrenia: Following a trail of evidence from cradle to grave

  2000cited by this paper
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  2000cited by this paper
• Obstetric complications and congenital malformation in schizophrenia.

  2000cited by this paper
• Network interactions in schizophrenia - therapeutic implications.

  2000cited by this paper
• The neuropathology of schizophrenia. A critical review of the data and their interpretation.

  1999cited by this paper
• The neurodevelopmental basis of schizophrenia: clinical clues from cerebro-craniofacial dysmorphogenesis, and the roots of a lifetime trajectory of disease.

  1999cited by this paper
• Dopamine as the wind of the psychotic fire: new evidence from brain imaging studies

  1999cited by this paper
• Injections of N‐methyl‐D‐aspartate into the ventral hippocampus increase extracellular dopamine in the ventral tegmental area and nucleus accumbens

  1999cited by this paper
• Methylazoxymethanol acetate-induced abnormalities in the entorhinal cortex of the rat; parallels with morphological findings in schizophrenia.

  1998cited by this paper
• Regulation of information flow in the nucleus accumbens: A model for the pathophysiology of schizophrenia.

  1998cited by this paper
• Predictive reward signal of dopamine neurons.

  1998cited by this paper
• Hippocampal volume reduction in schizophrenia as assessed by magnetic resonance imaging: a meta-analytic study.

  1998cited by this paper
• Impaired recruitment of the hippocampus during conscious recollection in schizophrenia

  1998cited by this paper
• Temporal Lobe Metabolic Differences in Medication-Free Outpatients with Schizophrenia via the PET-600

  1996cited by this paper
• Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics.

  1995cited by this paper
• Symptoms, signs, and diagnosis of schizophrenia.

  1995cited by this paper
• Perinatal risk factors and schizophrenia: selective review and methodological concerns.

  1995cited by this paper
• Subthalamic nucleus modulates burst firing of nigral dopamine neurones via NMDA receptors.

  1994cited by this paper
• Genes, viruses and neurodevelopmental schizophrenia.

  1992cited by this paper
• Paranoid schizophrenia may be caused by dopamine hyperactivity of CA1 hippocampus.

  1992cited by this paper
• Hippocampal Function and Schizophrenia. Experimental Psychological Evidence a

  1992cited by this paper
• Neuropsychological function in schizophrenia. Selective impairment in memory and learning.

  1991cited by this paper
• Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia.

  1991cited by this paper
• Epilepsy and Psychiatry

  1983cited by this paper

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• THPP-1 PDE10A inhibitor reverses the cognitive deficits and hyperdopaminergic state in a neurodevelopment model of schizophrenia.

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• The excitatory-inhibitory balance as a target for the development of novel drugs to treat schizophrenia.

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  2020cites this paper
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