Aquaporin 1, a potential therapeutic target for migraine with aura

The pathophysiology of migraine remains largely unknown. However, evidence regarding the molecules participating in the pathophysiology of migraine has been accumulating. Water channel proteins, known as aquaporins (AQPs), notably AQP-1 and AQP-4, appears to be involved in the pathophysiology of several neurological diseases. This review outlines newly emerging evidence indicating that AQP-1 plays an important role in pain signal transduction and migraine and could therefore serve as a potential therapeutic target for these diseases.

• Publication year

  2010

• Venue

  Molecular Pain

• Publication date

  2010-01-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1186/1744-8069-6-68PMID 20969805PMCID 2974658
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Role of AQP1 in the Ameliorating Effect of Electroacupuncture in a Rodent Model of Visceral Hypersensitivity

  2025cites this paper
• Use of Aquaporins as Biomarkers in Drowning Cases: Review Paper

  2025cites this paper
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• Structure and Function of Aquaporins: the Membrane Water Channel Proteins

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• Effect of Dexmedetomidine on Postoperative Lung Injury during One-Lung Ventilation in Thoracoscopic Surgery

  2020cites this paper
• Advances on distribution and function of aquaporin 1 in the peripheral nervous system

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• Nodal Global Efficiency in Front-Parietal Lobe Mediated Periventricular White Matter Hyperintensity (PWMH)-Related Cognitive Impairment

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• Migraine Aura: Pathophysiology, Mimics, and Treatment Options

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