FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Cell

• Publication date

  2015-07-16

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.cell.2015.06.034PMID 26186191PMCID PMC4519016
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Loss of mTOR-dependent macroautophagy causes autistic-like synaptic pruning deficits.

  2014influential reference
• Developmental regulation of GABAergic signalling in the hippocampus of neuroligin 3 R451C knock-in mice: an animal model of Autism

  2013cited by this paper
• Adjusting head circumference for covariates in autism: clinical correlates of a highly heritable continuous trait.

  2013influential reference
• Integrative functional genomic analyses implicate specific molecular pathways and circuits in autism.

  2013cited by this paper
• Cerebral organoids model human brain development and microcephaly

  2013cited by this paper
• Coexpression networks implicate human midfetal deep cortical projection neurons in the pathogenesis of autism.

  2013cited by this paper
• SFARI Gene 2.0: a community-driven knowledgebase for the autism spectrum disorders (ASDs)

  2013cited by this paper
• Autistic behavior in Scn1a+/− mice and rescue by enhanced GABAergic transmission

  2012cited by this paper
• Specific deletion of NaV1.1 sodium channels in inhibitory interneurons causes seizures and premature death in a mouse model of Dravet syndrome

  2012cited by this paper
• Modeling human cortical development in vitro using induced pluripotent stem cells

  2012influential reference
• Synaptic dysfunction in neurodevelopmental disorders associated with autism and intellectual disabilities.

  2012cited by this paper
• Somatic copy-number mosaicism in human skin revealed by induced pluripotent stem cells

  2012cited by this paper
• Spatiotemporal transcriptome of the human brain

  2011cited by this paper
• A more efficient method to generate integration-free human iPS cells

  2011cited by this paper
• Autism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical synaptic function

  2011cited by this paper
• Early generalized overgrowth in boys with autism.

  2011cited by this paper
• CNVnator: an approach to discover, genotype, and characterize typical and atypical CNVs from family and population genome sequencing.

  2011cited by this paper
• The core FOXG1 syndrome phenotype consists of postnatal microcephaly, severe mental retardation, absent language, dyskinesia, and corpus callosum hypogenesis

  2011cited by this paper
• Neuron number and size in prefrontal cortex of children with autism.

  2011cited by this paper
• Revisiting the phenotype associated with FOXG1 mutations: two novel cases of congenital Rett variant

  2010cited by this paper
• Parvalbumin‐, calbindin‐, and calretinin‐immunoreactive hippocampal interneuron density in autism

  2010cited by this paper
• Three hypotheses for developmental defects that may underlie some forms of autism spectrum disorder

  2010cited by this paper
• Increased dendritic spine densities on cortical projection neurons in autism spectrum disorders.

  2010influential reference
• Autism and autism spectrum disorders: diagnostic issues for the coming decade.

  2009cited by this paper
• edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

  2009cited by this paper
• Novel FOXG1 mutations associated with the congenital variant of Rett syndrome

  2009cited by this paper
• Regulation of Cerebral Cortical Size and Neuron Number by Fibroblast Growth Factors: Implications for Autism

  2009cited by this paper
• Bmi-1 cooperates with Foxg1 to maintain neural stem cell self-renewal in the forebrain.

  2009cited by this paper
• FOXG1 is responsible for the congenital variant of Rett syndrome.

  2008cited by this paper
• WGCNA: an R package for weighted correlation network analysis

  2008cited by this paper
• Neuroligins and neurexins link synaptic function to cognitive disease

  2008cited by this paper
• Self-organized formation of polarized cortical tissues from ESCs and its active manipulation by extrinsic signals.

  2008cited by this paper
• Correction of fragile X syndrome in mice.

  2007cited by this paper
• A Neuroligin-3 Mutation Implicated in Autism Increases Inhibitory Synaptic Transmission in Mice

  2007cited by this paper
• Mapping early brain development in autism.

  2007cited by this paper
• Nav1.1 Localizes to Axons of Parvalbumin-Positive Inhibitory Interneurons: A Circuit Basis for Epileptic Seizures in Mice Carrying an Scn1a Gene Mutation

  2007cited by this paper
• Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy

  2006cited by this paper
• Head circumference and height in autism: A study by the collaborative program of excellence in autism

  2006influential reference
• International Union of Pharmacology. XLVIII. Nomenclature and Structure-Function Relationships of Voltage-Gated Calcium Channels

  2005cited by this paper
• From the Cover: Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

  2005cited by this paper
• Foxg1 is required for specification of ventral telencephalon and region-specific regulation of dorsal telencephalic precursor proliferation and apoptosis.

  2005influential reference
• International Union of Pharmacology. XLVII. Nomenclature and Structure-Function Relationships of Voltage-Gated Sodium Channels

  2005influential reference
• Haploinsufficiency of novel FOXG1B variants in a patient with severe mental retardation, brain malformations and microcephaly

  2005cited by this paper
• Foxg1 Suppresses Early Cortical Cell Fate

  2004influential reference
• DAVID: Database for Annotation, Visualization, and Integrated Discovery

  2003cited by this paper
• DAVID: Database for Annotation, Visualization, and Integrated Discovery

  2003cited by this paper
• Disruption in the Inhibitory Architecture of the Cell Minicolumn: Implications for Autisim

  2003cited by this paper
• Minicolumnar pathology in autism

  2002cited by this paper
• Unusual brain growth patterns in early life in patients with autistic disorder

  2001cited by this paper
• Unusual brain growth patterns in early life in patients with autistic disorder: An MRI study

  2001cited by this paper
• Regional brain enlargement in autism: a magnetic resonance imaging study.

  1996cited by this paper
• Winged helix transcription factor BF-1 is essential for the development of the cerebral hemispheres.

  1995influential reference
• Bioinformatics Applications Note Genome Analysis Bedtools: a Flexible Suite of Utilities for Comparing Genomic Features

  year unknowncited by this paper
• Bioinformatics Applications Note Gene Expression Rseqtools: a Modular Framework to Analyze Rna-seq Data Using Compact, Anonymized Data Summaries

  year unknowncited by this paper

• Multi-omic analysis of guided and unguided forebrain organoids reveals differences in cellular composition and metabolic profiles.

  2026cites this paper
• Mapping the Evolution of Brain Organoid Research: A Decade of Progress and Future Perspectives (2015–2025)

  2026cites this paper
• "SHANK3 deficiency alters early progenitor dynamics and reveals shared pathways with neurodegeneration".

  2026cites this paper
• Lateral shearing optical diffraction tomography of brain organoid with reduced spatial coherence

  2026cites this paper
• Induced pluripotent stem cells in autism research: a review of current advances and future directions

  2026cites this paper
• Organoids for disease modeling and treatment: state-of-the-art

  2026cites this paper
• Engineered Microfluidic Organoid Systems: New Paradigms for Menopause Mechanism Research and Personalized Medicine

  2026cites this paper
• Organoids in Genetic Disorders: from Disease Modeling to Translational Applications

  2025cites this paper
• Brain assembloids decode human cortical networks in Rett syndrome.

  2025cites this paper
• What makes the human brain special - from cellular function to clinical translation.

  2025cites this paper
• Mapping human neurodevelopment-Brain organoids meet lineage tracing.

  2025cites this paper
• MeCP2 regulates telencephalic development in human cerebral organoids

  2025cites this paper
• Two- and Three-Dimensional In Vitro Models of Parkinson’s and Alzheimer’s Diseases: State-of-the-Art and Applications

  2025cites this paper
• Exploring preservation of autism spectrum disorder dysregulated co-expression modules in accessible cell models

  2025cites this paper
• Brain Organoids in Neurodegenerative Disease Modeling: Advances, Applications and Future Perspectives

  2025cites this paper
• Glioblastoma-midbrain assembloid-based Electrophysiological sensor composed of dual-channel flexible Au nanodot patterned electrodes to evaluate cancer drug.

  2025cites this paper
• Sensory abnormalities in autism spectrum disorder and their in vitro modeling

  2025cites this paper
• Human cerebral organoids maintain integrity and viability after transport through mail

  2025cites this paper
• Analysis of neuronal activity impairment in iPSC-derived neurons from idiopathic autism patients

  2025cites this paper
• Mapping the Trajectory of Organoid Research: Insights into Complex Models and Advanced Technologies- bibliometric driven review

  2025cites this paper
• Gut Microbiotas, Plasma Metabolites, and Autism Spectrum Disorder: A Bidirectional Mendelian Randomization Analysis

  2025cites this paper
• A new protocol for the development of organoids based on molecular mechanisms in the developing newborn rat brain: Prospective applications in the study of Alzheimer's disease.

  2025cites this paper
• Metformin Restores Mitochondrial Function and Neurogenesis in POLG Patient‐Derived Brain Organoids

  2025cites this paper
• Human cortical organoids recapitulate inter-individual variability in infant brain-growth trajectories.

  2025cites this paper
• Single-cell analysis of dup15q syndrome reveals developmental and postnatal molecular changes in autism

  2025cites this paper
• Genetic Heterogeneity of Autism Spectrum Disorder: Identification of Five Novel Mutations (RIMS2, FOXG1, AUTS2, ZCCHC17, and SPTBN5) in Iranian Families via Whole-Exome and Whole-Genome Sequencing.

  2025cites this paper
• Emerging brain organoids: 3D models to decipher, identify and revolutionize brain

  2025cites this paper
• Developmental deficits, synapse and dendritic abnormalities in a Clcn4 KO autism mice model: endophenotypic target for ASD

  2025cites this paper
• Advancing Brain Organoid Electrophysiology: Minimally Invasive Technologies for Comprehensive Characterization

  2025cites this paper
• Individuals with intellectual disability have an increased burden of de novo variants in cis-regulatory elements of glutamatergic neurons

  2025cites this paper
• Transcriptional analysis of human cell organoids for the identification of gene signatures associated with Autism Spectrum Disorder

  2025cites this paper
• Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine

  2025cites this paper
• Differentiation Defect Into GABAergic Neurons in Cerebral Organoids From Autism Patients

  2025cites this paper
• Specification of human brain regions with orthogonal gradients of WNT and SHH in organoids reveals patterning variations across cell lines.

  2025cites this paper
• The use of single-cell and spatial omics to study copy number variants.

  2025cites this paper
• Advances, challenges, and opportunities of human midbrain organoids for modelling of the dopaminergic system

  2025cites this paper
• An integrated framework for functional dissection of variable expressivity in genetic disorders

  2025cites this paper
• Microglial involvement in autism spectrum disorder: insights from human data and iPSC models.

  2025cites this paper
• Advanced neural activity mapping in brain organoids via field potential imaging with ultra-high-density CMOS microelectrode arrays

  2025cites this paper
• Selective chr21 homolog silencing reveals polymorphisms influence the epigenetic silencing and functional dosage of RWDD2B

  2025cites this paper
• Prenatal Acetaminophen Exposure Does Not Disrupt Human Fetal Brain Development in Cortical Organoid Models

  2025cites this paper
• Preclinical models for autism spectrum disorder: past, present, and future.

  2025cites this paper
• Developmental regression of novel space preference in an autism spectrum disorder model is unlinked to GABAergic and social circuitry

  2025cites this paper
• Advances in Human Brain Organoids: Methodological Innovations and Future Directions for Drug Discovery.

  2025cites this paper
• Organotypic models of the mammalian brain for molecular psychiatry and neurology

  2025cites this paper
• Toxicity assessment using neural organoids: innovative approaches and challenges

  2025cites this paper
• Approaches in vivo and in vitro for solving the vascularization issue of brain organoids

  2025cites this paper
• Gain and loss of function changes in CACNA1C affect neuronal networks through divergent pathways

  2025cites this paper
• Neurosteroid withdrawal disrupts GABAergic system development in human cortical organoids: implications for preterm birth

  2025cites this paper
• Pluripotent stem cells-based neural organoids for modelling human brain development and diseases

  2025cites this paper
• From Organoids to Assembloids: Experimental Approaches to Study Human Neuropsychiatric Disorders.

  2025cites this paper
• Functional Neurogenomics to Dissect Disease Mechanisms Across Models.

  2025cites this paper
• The ADCY1-mediated cAMP signaling pathway mediates functional effects of montelukast treatment in brain organoids

  2025cites this paper
• Brain Organoids: Tools for Understanding the Uniqueness and Individual Variability of the Human Brain.

  2025cites this paper
• Sulforaphane protects developing neural networks from VPA-induced synaptic alterations

  2025influential citation
• Advancements in the in vitro culture of human pluripotent stem cells: progress, challenges, and future directions: comprehensive review

  2025cites this paper
• Early cell cycle genes in cortical organoid progenitors predict interindividual variability in infant brain growth trajectories

  2025cites this paper
• Variability vs. phenotype: Multimodal analysis of Dravet syndrome brain organoids powered by deep learning

  2025cites this paper
• Three-Dimensional Morphological Characterisation of Human Cortical Organoids Using a Customised Image Analysis Workflow

  2025cites this paper
• Prenatal stress alters mouse offspring dorsal striatal development and placental function in sex-specific ways.

  2025cites this paper
• Functional development of midbrain and pons during human gestation and electrophysiological markers for DS intervention.

  2025cites this paper
• Investigating the Effects of Long-Term Fine Particulate Matter Exposure on Autism Spectrum Disorder Severity: Evidence from Multiple Analytical Approaches

  2025cites this paper
• Direct pathway bias and altered striatal neurogenesis in human iPSC models of 16p11.2 CNVs: Evidence from single-cell and functional analyses

  2025cites this paper
• Model systems for emulating human tissue and physiology in psychiatric research

  2025cites this paper
• Advancing autism research: Insights from brain organoid modeling.

  2025cites this paper
• Patient-derived Brain Organoids Reveal Divergent Neuronal Activity Across Subpopulations of Autism Spectrum Disorder

  2025cites this paper
• Protein Arginine Methyltransferases from Regulatory Function to Clinical Implication in Central Nervous System

  2025cites this paper
• Alcohol Use Disorder Associated Gene FNDC4 Alters Glutamatergic and GABAergic Neurogenesis

  2025cites this paper
• SLC35A2 loss-of-function variants affect glycomic signatures, neuronal fate and network dynamics.

  2025cites this paper
• Advanced neural activity mapping in brain organoids via field potential imaging with ultra-high-density CMOS microelectrodes

  2025cites this paper
• Mechanisms of brain overgrowth in autism spectrum disorder with macrocephaly

  2025cites this paper
• Brain Organoids and Assembloids—From Disease Modeling to Drug Discovery

  2025cites this paper
• Foxg1 gene mutation impairs auditory cortex response and reduces sound tolerance

  2025cites this paper
• Patient‐Derived Cortical Organoids Reveal Senescence of Neural Progenitor Cells in Hutchinson‐Gilford Progeria Syndrome

  2025cites this paper
• A Concise Review of Organoid Tissue Engineering: Regenerative Applications and Precision Medicine

  2025cites this paper
• Micropatterned neural induction with heat-inactivated extracellular matrix protein by on-demand high-speed laser

  2025cites this paper
• Development of Human Brain Organoids, The Formation of Neural Circuits and Relationship with Neurodevelopmental Diseases

  2025cites this paper
• Navigating Brain Organoid Maturation: From Benchmarking Frameworks to Multimodal Bioengineering Strategies

  2025cites this paper
• Untangling the Molecular Mechanisms Contributing to Autism Spectrum Disorder Using Stem Cells

  2025cites this paper
• Human brain organoids: an innovative model for neurological disorder research and therapy

  2025cites this paper
• Giftedness and atypical sexual differentiation: enhanced perceptual functioning through estrogen deficiency instead of androgen excess

  2024cites this paper
• Induced Pluripotent Stem Cells and Organoids in Advancing Neuropathology Research and Therapies

  2024cites this paper
• Emerging neurodevelopmental mechanisms in patient induced pluripotent stem cells-derived spheroids modelling SCN1A Dravet Syndrome

  2024cites this paper
• GABA/Glutamate Neuron Differentiation Imbalance and Increased AKT/mTOR Signaling in CNTNAP2−/− Cerebral Organoids

  2024cites this paper
• Simple modeling of familial Alzheimer’s disease using human pluripotent stem cell-derived cerebral organoid technology

  2024cites this paper
• Induced pluripotent stem cells (iPSCs): molecular mechanisms of induction and applications

  2024cites this paper
• Guidelines for Manufacturing and Application of Organoids: Brain

  2024cites this paper
• Menin Deficiency Induces Autism‐Like Behaviors by Regulating Foxg1 Transcription and Participates in Foxg1‐Related Encephalopathy

  2024cites this paper
• Chronic hypoxia remodels the tumor microenvironment to support glioma stem cell growth

  2024cites this paper
• Deciphering the Enigma of Neuron-Glial Interactions in Neurological Disorders.

  2024cites this paper
• Organoids as preclinical models of human disease: progress and applications

  2024cites this paper
• Dynamic culture of cerebral organoids using a pillar/perfusion plate for the assessment of developmental neurotoxicity

  2024cites this paper
• Brain organoid protocols and limitations

  2024cites this paper
• Non-Invasive Label-free Analysis Pipeline for In Situ Characterization of Differentiation in 3D Brain Organoid Models

  2024cites this paper
• A microglia-containing cerebral organoid model to study early life immune challenges

  2024cites this paper
• Cortical brain organoid slices (cBOS) for the study of human neural cells in minimal networks

  2024cites this paper
• Neuropathogenesis-on-chips for neurodegenerative diseases

  2024cites this paper
• Impaired oxysterol-liver X receptor signaling underlies aberrant cortical neurogenesis in a stem cell model of neurodevelopmental disorder.

  2024cites this paper
• Efficient generation of human cerebral organoids directly from adherent cultures of pluripotent stem cells

  2024cites this paper
• NMDA glutamate receptor antagonist MK‐801 induces proteome changes in adult human brain slices which are partially counteracted by haloperidol and clozapine

  2024cites this paper