Mutations in the gene encoding the transcription factor CCAAT/enhancer binding protein alpha in myelodysplastic syndromes and acute myeloid leukemias.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Blood

• Publication date

  2002-02-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1182/BLOOD.V99.4.1332PMID 11830484
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia.

  2001cited by this paper
• c-Myc Is a Critical Target for C/EBPα in Granulopoiesis

  2001cited by this paper
• Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-α (C/EBPα), in acute myeloid leukemia

  2001cited by this paper
• CCAAT/Enhancer-binding Protein-α Cooperates with p21 to Inhibit Cyclin-dependent Kinase-2 Activity and Induces Growth Arrest Independent of DNA Binding*

  2001cited by this paper
• C/EBPα Inhibits Cell Growth via Direct Repression of E2F-DP-Mediated Transcription

  2000cited by this paper
• Separation of C/EBPalpha-mediated proliferation arrest and differentiation pathways.

  1999cited by this paper
• C/EBPα Regulates Formation of S-Phase-Specific E2F-p107 Complexes in Livers of Newborn Mice

  1999cited by this paper
• Identification of Transcriptional Activation and Repression Domains in Human CCAAT/Enhancer-binding Protein ε*

  1998cited by this paper
• Upregulation of interleukin 6 and granulocyte colony-stimulating factor receptors by transcription factor CCAAT enhancer binding protein alpha (C/EBP alpha) is critical for granulopoiesis.

  1998cited by this paper
• Expression of CCAAT/enhancer binding proteins (C/EBP) is associated with squamous differentiation in epidermis and isolated primary keratinocytes and is altered in skin neoplasms.

  1998cited by this paper
• Lack of C/EBPα gene expression results in increased DNA synthesis and an increased frequency of immortalization of freshly isolated mice hepatocytes

  1998cited by this paper
• Hepatocytes Deficient in CCAAT/Enhancer Binding Protein α (C/EBPα) Exhibit both Hepatocyte and Biliary Epithelial Cell Character

  1998cited by this paper
• Human Translocation Liposarcoma-CCAAT/Enhancer Binding Protein (C/EBP) Homologous Protein (TLS-CHOP) Oncoprotein Prevents Adipocyte Differentiation by Directly Interfering with C/EBPβ Function*

  1998cited by this paper
• Identification of transcriptional activation and repression domains in human CCAAT/enhancer-binding protein epsilon.

  1998cited by this paper
• CCAAT/enhancer binding protein alpha is a regulatory switch sufficient for induction of granulocytic development from bipotential myeloid progenitors.

  1998cited by this paper
• Upregulation of Interleukin 6 and Granulocyte Colony-Stimulating Factor Receptors by Transcription Factor CCAAT Enhancer Binding Protein α (C/EBPα) Is Critical for Granulopoiesis

  1998cited by this paper
• Hepatocytes deficient in CCAAT/enhancer binding protein alpha (C/EBP alpha) exhibit both hepatocyte and biliary epithelial cell character.

  1998cited by this paper
• Lack of C/EBP alpha gene expression results in increased DNA synthesis and an increased frequency of immortalization of freshly isolated mice [correction of rat] hepatocytes.

  1998cited by this paper
• CCAAT/enhancer binding protein alpha regulates p21 protein and hepatocyte proliferation in newborn mice

  1997cited by this paper
• Cloning of the novel human myeloid-cell-specific C/EBP-epsilon transcription factor

  1997cited by this paper
• Inhibition of growth of human leukemia cell lines by retrovirally expressed wild-type p16INK4A

  1997cited by this paper
• C/EBP proteins contain nuclear localization signals imbedded in their basic regions.

  1997cited by this paper
• Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice.

  1997influential reference
• Characteristic sequence motifs at the breakpoints of the hybrid genes FUS/CHOP, EWS/CHOP and FUS/ERG in myxoid liposarcoma and acute myeloid leukemia

  1997cited by this paper
• CCAAT/enhancer-binding protein alpha (C/EBP alpha) inhibits cell proliferation through the p21 (WAF-1/CIP-1/SDI-1) protein.

  1996cited by this paper
• Impaired proliferation and tumorigenicity induced by CCAAT/enhancer-binding protein.

  1996cited by this paper
• CCAAT enhancer-binding protein (C/EBP) and AML1 (CBF alpha2) synergistically activate the macrophage colony-stimulating factor receptor promoter

  1996cited by this paper
• Glucocorticoid-stimulated CCAAT/enhancer-binding protein alpha expression is required for steroid-induced G1 cell cycle arrest of minimal-deviation rat hepatoma cells

  1996cited by this paper
• Increased Hepatic Cell Proliferation and Lung Abnormalities in Mice Deficient in CCAAT/Enhancer Binding Protein α*

  1996cited by this paper
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  1996cited by this paper
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  1995cited by this paper
• Inhibition of cell proliferation by C/EBPα occurs in many cell types, does not require the presence of p53 or Rb, and is not affected by large T-antigen

  1995cited by this paper
• PU.1 (Spi-1) and C/EBP alpha regulate expression of the granulocyte-macrophage colony-stimulating factor receptor alpha gene

  1995cited by this paper
• Inhibition of cell proliferation by C/EBP alpha occurs in many cell types, does not require the presence of p53 or Rb, and is not affected by large T-antigen.

  1995cited by this paper
• Expression of the liver-enriched transcription factors C/EBP alpha, C/EBP beta, HNF-1, and HNF-4 in preneoplastic nodules and hepatocellular carcinoma in rat liver.

  1995cited by this paper
• CRP2 (C/EBP beta) contains a bipartite regulatory domain that controls transcriptional activation, DNA binding and cell specificity.

  1995cited by this paper
• Molecular cloning, sequence, and expression patterns of the human gene encoding CCAAT/enhancer binding protein alpha (C/EBP alpha).

  1995cited by this paper
• Three levels of functional interaction determine the activity of CCAAT/enhancer binding protein-alpha on the serum albumin promoter.

  1994cited by this paper
• Ectopic expression of the CCAAT/enhancer-binding protein alpha promotes the adipogenic program in a variety of mouse fibroblastic cells.

  1994cited by this paper
• CCAAT/enhancer binding protein alpha is sufficient to initiate the 3T3-L1 adipocyte differentiation program.

  1994influential reference
• Expression and hormonal regulation of the CCAAT enhancer binding protein-alpha during differentiation of rat ovarian follicles.

  1993cited by this paper
• Cell lineage-specific and differentiation-dependent patterns of CCAAT/enhancer binding protein alpha expression in the gut epithelium of normal and transgenic mice.

  1993cited by this paper
• Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma

  1993cited by this paper
• Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma

  1993cited by this paper
• CCAAT/enhancer-binding protein mRNA is translated into multiple proteins with different transcription activation potentials.

  1993cited by this paper
• Antisense CCAAT/enhancer-binding protein RNA suppresses coordinate gene expression and triglyceride accumulation during differentiation of 3T3-L1 preadipocytes.

  1992cited by this paper
• Transplantable myeloproliferative disease induced in mice by an interleukin 6 retrovirus

  1992cited by this paper
• A novel temporal expression pattern of three C/EBP family members in differentiating myelomonocytic cells.

  1992cited by this paper
• The leucine zipper symmetrically positions the adjacent basic regions for specific DNA binding.

  1991cited by this paper
• Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells.

  1991cited by this paper
• The CCAAT/enhancer binding protein and its role in adipocyte differentiation: evidence for direct involvement in terminal adipocyte development.

  1991cited by this paper
• A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro.

  1991cited by this paper
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  1990influential reference
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  1990cited by this paper
• The role of the CCAAT/enhancer-binding protein in the transcriptional regulation of the gene for phosphoenolpyruvate carboxykinase (GTP)

  1990cited by this paper
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  1989cited by this paper
• Is CCAAT/enhancer-binding protein a central regulator of energy metabolism?

  1989cited by this paper
• Cognate DNA binding specificity retained after leucine zipper exchange between GCN4 and C/EBP.

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