Degranulation plays an essential part in regulating cell surface expression of Fas ligand in T cells and natural killer cells

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Nature Medicine

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/4779PMID 9883845
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells

  1998cited by this paper
• Constitutive Expression of FasL in Thyrocytes

  1998cited by this paper
• Protein sorting and secretion during CTL killing.

  1997cited by this paper
• Perforin is activated by a proteolytic cleavage during biosynthesis which reveals a phospholipid‐binding C2 domain

  1997cited by this paper
• Protein sorting by tyrosine-based signals: adapting to the Ys and wherefores.

  1997cited by this paper
• Human monocytic cells contain high levels of intracellular Fas ligand: rapid release following cellular activation.

  1997cited by this paper
• Secretory lysosomes - a special mechanism of regulated secretion in haemopoietic cells.

  1996cited by this paper
• Different responses are elicited in cytotoxic T lymphocytes by different levels of T cell receptor occupancy

  1996cited by this paper
• Fas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege

  1995cited by this paper
• TCR/CD3 coupling to Fas-based cytotoxicity

  1995cited by this paper
• Serial killing by cytotoxic T lymphocytes: T cell receptor triggers degranulation, re‐filling of the lytic granules and secretion of lytic proteins via a non‐granule pathway

  1995cited by this paper
• The Fas death factor

  1995cited by this paper
• Metalloproteinase-mediated release of human Fas ligand

  1995cited by this paper
• Regulation of cell surface APO‐1/Fas (CD95) ligand expression by metalloproteases

  1995cited by this paper
• Expression of the Fas ligand in cells of T cell lineage.

  1995cited by this paper
• Fas involvement in cytotoxicity mediated by human NK cells.

  1995cited by this paper
• Molecular characterization of the early activation antigen CD69: A type II membrane glycoprotein related to a family of natural killer cell activation antigens

  1993cited by this paper
• Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family.

  1993cited by this paper
• The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen.

  1992cited by this paper
• A noncytotoxic mast cell tumor line exhibits potent IgE-dependent cytotoxicity after transfection with the cytolysin/perforin gene.

  1991cited by this paper
• Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes

  1991cited by this paper
• Molecules relevant for T cell‐target cell interaction are present in cytolytic granules of human T lymphocytes

  1989cited by this paper
• Antigen receptor-regulated exocytosis in cytotoxic T lymphocytes

  1987cited by this paper
• Human T cell activation. III. Rapid induction of a phosphorylated 28 kD/32 kD disulfide-linked early activation antigen (EA 1) by 12-o- tetradecanoyl phorbol-13-acetate, mitogens, and antigens

  1986cited by this paper
• TCGF (IL 2)-receptor inducing factor(s). I. Regulation of IL 2 receptor on a natural killer-like cell line (YT cells).

  1985cited by this paper
• Cytolytic activity of purified cytoplasmic granules from cytotoxic rat large granular lymphocyte tumors

  1984cited by this paper

• T-Cell-Derived Exosomes From Multi Core Granules Exhibit Superior Caspase-3-Mediated Tumor-Suppressive Activity Compared to Those From Multivesicular Bodies.

  2026cites this paper
• V-ATPase a3 Directs Secretory Lysosome Transport in Enamel Formation.

  2026cites this paper
• Unraveling Lysosomal Exocytosis: From Molecular Mechanisms to Physiological Functions

  2025cites this paper
• IFT20 regulates TFEB-dependent lytic granule biogenesis in cytotoxic T lymphocytes by orchestrating the MPR-dependent transport of granzyme B

  2025cites this paper
• Arsenic trioxide-induced pyroptosis promotes the release of HMGB1 to activate natural killer cells related immunogenic cell death in leukemia

  2025cites this paper
• IFNγ Expression Correlates with Enhanced Cytotoxicity in CD8+ T Cells

  2025cites this paper
• Cancer stem cell markers: Symphonic masters of chemoresistance and immune evasion.

  2024cites this paper
• CD8+ T Cell Biology in Cytokine Storm Syndromes.

  2024cites this paper
• Natural Killer cells at the frontline in the fight against cancer

  2024cites this paper
• Endolysosomal transient receptor potential mucolipins and two-pore channels: implications for cancer immunity

  2024cites this paper
• HDAC Inhibition Increases CXCL12 Secretion to Recruit Natural Killer Cells in Peripheral T Cell Lymphoma.

  2024cites this paper
• Early innate cell interactions with Mycobacterium tuberculosis in protection and pathology of tuberculosis

  2023cites this paper
• Non-coding RNAs: emerging roles in the characterization of immune microenvironment and immunotherapy of prostate cancer.

  2023cites this paper
• Exploiting the RUSH System to Study Lytic Granule Biogenesis in Cytotoxic T Lymphocytes

  2023cites this paper
• Role of ferroptosis in esophageal cancer and corresponding immunotherapy

  2023cites this paper
• CAR-T-Derived Extracellular Vesicles: A Promising Development of CAR-T Anti-Tumor Therapy

  2023cites this paper
• Natural killer cell-based strategies for immunotherapy of cancer.

  2022cites this paper
• Identification of distinct cytotoxic granules as the origin of supramolecular attack particles in T lymphocytes

  2022cites this paper
• T Lymphocyte and CAR-T Cell-Derived Extracellular Vesicles and Their Applications in Cancer Therapy

  2022cites this paper
• Recent Development in NKT-Based Immunotherapy of Glioblastoma: From Bench to Bedside

  2022cites this paper
• TroTNFSF6, a tumor necrosis factor ligand superfamily member, promotes antibacterial immune response of golden pompano, Trachinotus ovatus.

  2022cites this paper
• Locked and Loaded: Mechanisms Regulating Natural Killer Cell Lytic Granule Biogenesis and Release

  2022cites this paper
• The Expanding Arsenal of Cytotoxic T Cells

  2022influential citation
• T Lymphocyte-Derived Exosomes and Their Applications in Cancer Therapy

  2022cites this paper
• The War Is on: The Immune System against Glioblastoma—How Can NK Cells Drive This Battle?

  2022cites this paper
• Preventive Cancer Vaccination by P5 HER-2/neo Derived Peptide-pulsed Peripheral Blood Mononuclear Cells in Mouse Model of Breast Cancer.

  2021cites this paper
• Natural Killer Cell Group 7 Sequence in Cytotoxic Cells Optimizes Exocytosis of Lytic Granules Essential for the Perforin-Dependent, but Not Fas Ligand–Dependent, Cytolytic Pathway

  2021cites this paper
• Natural Kills Cells: Cellular Biology and Role in Infections and Human Disease

  2021cites this paper
• MSH2, MSH6, MLH1 & PMS2 CORRELATION WITH CLINICOPATHOLOGICAL FEATURES IN COLORECTAL CARCINOMA : AN EXPERIENCE FROM A TERTIARY CARE ONCOLOGY CENTER

  2021cites this paper
• Intra- and Extracellular Effector Vesicles From Human T And NK Cells: Same-Same, but Different?

  2021cites this paper
• “Built‐in” PD‐1 blocker to rescue NK‐92 activity from PD‐L1–mediated tumor escape mechanisms

  2021cites this paper
• Cytotoxic CD4+ T cells driven by T-cell intrinsic IL-18R/MyD88 signaling predominantly infiltrate Trypanosoma cruzi-infected hearts

  2021cites this paper
• Dark-Side of Exosomes.

  2021cites this paper
• Responsiveness to i.v. immunoglobulin therapy in patients with toxic epidermal necrolysis: A novel pharmaco‐immunogenetic concept

  2020cites this paper
• Actin remodeling and vesicular trafficking at the tumor cell side of the immunological synapse direct evasion from cytotoxic lymphocytes.

  2020cites this paper
• SAM50, a side door to the mitochondria: The case of cytotoxic proteases.

  2020cites this paper
• The role of lysosomes in cancer development and progression

  2020cites this paper
• Lysosomes and Peroxisomes

  2020cites this paper
• Lysosome as the Black Hole for Checkpoint Molecules.

  2020cites this paper
• T Lymphocyte–Antigen Presenting Cell Immune Synapse and exosome secretion

  2020cites this paper
• Inducible Polarized Secretion of Exosomes in T and B Lymphocytes

  2020cites this paper
• Supramolecular attack particles are autonomous killing entities released from cytotoxic T cells

  2020cites this paper
• ImmunoPhysics and ImmunoEngineering

  2020cites this paper
• Characterization of the anti-tumor activity of plants extracts from North Africa: Morocco

  2019cites this paper
• CD8+ T Cell Biology in Cytokine Storm Syndromes

  2019cites this paper
• Mechanisms of natural killer cell‐mediated cellular cytotoxicity

  2019cites this paper
• Mitochondrial Entry of Cytotoxic Proteases: A New Insight into the Granzyme B Cell Death Pathway

  2019cites this paper
• CD8+ T-Cell Response to HIV Infection in the Era of Antiretroviral Therapy

  2019cites this paper
• Protein Kinase C δ Regulates the Depletion of Actin at the Immunological Synapse Required for Polarized Exosome Secretion by T Cells

  2019cites this paper
• Pancreatic islets engineered with a FasL protein induce systemic tolerance at the induction phase that evolves into long‐term graft‐localized immune privilege

  2019cites this paper
• Imaging Polarized Secretory Traffic at the Immune Synapse in Living T Lymphocytes

  2018cites this paper
• Human CD8 T‐cell activation in acute and chronic chikungunya infection

  2018cites this paper
• Granule-Dependent NK Cell Killing of Cryptococcus Requires Kinesin to Reposition the Cytolytic Machinery for Directed Cytotoxicity.

  2018cites this paper
• Tumor Necrosis Factor Receptor Superfamily in T Cell Priming and Effector Function.

  2018cites this paper
• The Tumor Necrosis Factor Family: Family Conventions and Private Idiosyncrasies.

  2018cites this paper
• Mechanistic peculiarities of activation-induced mobilization of cytotoxic effector proteins in human T cells

  2018cites this paper
• Loss of Fas Expression and Function Is Coupled with Colon Cancer Resistance to Immune Checkpoint Inhibitor Immunotherapy

  2018cites this paper
• Recent trends in mucopolysaccharidosis research

  2018cites this paper
• Role of acid sphingomyelinase in T lymphocyte activation

  2018cites this paper
• An early history of T cell-mediated cytotoxicity

  2018cites this paper
• Significance of Serum Soluble Fas (sFas/CD95) and Tumor Necrosis Factor- Alpha (TNF-α) in Radiologically Diagnosed Patients with Uterine Leiomyoma

  2018cites this paper
• Fas Ligand localizes to intraluminal vesicles within NK cell cytolytic granules and is enriched at the immune synapse

  2018cites this paper
• The cytotoxic action of the CD56+ fraction of cytokine-induced killer cells against a K562 cell line is mainly restricted to the natural killer cell subset.

  2017cites this paper
• T cell development in the human thymus

  2017cites this paper
• Licensed to Kill: Towards Natural Killer Cell Immunotherapy

  2017cites this paper
• Proteomic and functional analysis identifies galectin-1 as a novel regulatory component of the cytotoxic granule machinery

  2017cites this paper
• IMPROVING NK CELL THERAPY FOR OSTEOSARCOMA

  2017cites this paper
• Oncolytic measles virus enhances antitumour responses of adoptive CD8+NKG2D+ cells in hepatocellular carcinoma treatment

  2017cites this paper
• CD40L is transferred to antigen‐presenting B cells during delivery of T‐cell help

  2017cites this paper
• Targeting Fas pathway as an effective means of inducing tolerance to pancreatic islets.

  2017cites this paper
• Belongs to the TNF Family A New Class of Reverse Signaling Costimulators

  2017cites this paper
• CTL Via Fas Ligand and Cannot Be Endothelial Cells, Can Be Killed by Human Porcine Endothelial Cells, Unlike Human

  2017cites this paper
• The cytotoxic T lymphocyte immune synapse at a glance

  2016cites this paper
• Diversification and Functional Specialization of Human NK Cell Subsets.

  2016cites this paper
• Uptake of poly-dispersed single-walled carbon nanotubes and decline of functions in mouse NK cells undergoing activation

  2016cites this paper
• Preparing the lethal hit: interplay between exo- and endocytic pathways in cytotoxic T lymphocytes

  2016cites this paper
• New development of the yolk sac theory in diabetic embryopathy: molecular mechanism and link to structural birth defects.

  2016cites this paper
• Exosomes: emerging roles in communication between blood cells and vascular tissues during atherosclerosis

  2015cites this paper
• Lysosome‐Related Effector Vesicles in T Lymphocytes and NK Cells

  2015cites this paper
• Subcellular localization and activation of ADAM proteases in the context of FasL shedding in T lymphocytes.

  2015cites this paper
• Regulation of FasL expression, and delineation of differentiation states of cytotoxic lymphocytes

  2015cites this paper
• Phenotypic and functional analyses of NK and NKT-like populations during the early stages of chikungunya infection

  2015cites this paper
• Diacylglycerol kinases in membrane trafficking

  2015cites this paper
• Directed delivery of CD40 ligand from helper T cells to antigen-presenting B cells

  2015cites this paper
• Protein kinase D1/2 is involved in the maturation of multivesicular bodies and secretion of exosomes in T and B lymphocytes

  2015cites this paper
• Lipopolysaccharide‐induced expression of FAS ligand in cultured immature boar sertoli cells through the regulation of pro‐inflammatory cytokines and miR‐187

  2015cites this paper
• Lokalisation und Aktivierung von ADAM-Proteasen im Kontext der Fas-Ligand-Proteolyse in T-Zellen

  2014cites this paper
• The Combination of Type I IFN, TNF-α, and Cell Surface Receptor Engagement with Dendritic Cells Enables NK Cells To Overcome Immune Evasion by Dengue Virus

  2014cites this paper
• The biogenesis of lysosomes and lysosome-related organelles.

  2014cites this paper
• Differential protein-protein interactions of full length human FasL and FasL fragments generated by proteolysis.

  2014cites this paper
• Regulation of TRAIL-Receptor Expression by the Ubiquitin-Proteasome System

  2014cites this paper
• Methods of purification of CTL-derived exosomes.

  2014cites this paper
• Novo papel da galectina-1 como molécula efetora de células citotóxicas.

  2014cites this paper
• Mucopolysaccharide diseases: A complex interplay between neuroinflammation, microglial activation and adaptive immunity

  2014cites this paper
• Overcome Immune Evasion by Dengue Virus Dendritic Cells Enables NK Cells To Cell Surface Receptor Engagement with , and a The Combination of Type I IFN, TNF-Makoto

  2014cites this paper
• Killer B Cells: Regulation of the Growth and Function of Fas Ligand-Expressing B Lymphocytes.

  2013cites this paper
• Modulation of Tumor Immunity by Soluble and Membrane-Bound Molecules at the Immunological Synapse

  2013cites this paper
• Immune Cells, Suggesting Molecules and Convey Apoptosis in Activated Carry Functional Fas Ligand and TRAIL Exosomes Secreted by Human Placenta

  2013cites this paper
• Selective depletion of FOXP3(high) cells by Fas-Fas-L-induced apoptosis occurs in CD4(+)CD25(+)-enriched populations during repeated expansion.

  2013cites this paper
• Mechanisms underlying innate immunesenescence

  2013cites this paper