The cytotoxic T lymphocyte immune synapse at a glance

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Journal of Cell Science

• Publication date

  2016-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/jcs.186205PMID 27505426
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Signaling

  2018cited by this paper
• Comparative Anatomy of Phagocytic and Immunological Synapses

  2016cited by this paper
• Hermansky F, Pudlak P. Albinism associated with hemorrhagic diathesis and unusual pigmented reticular cells in the bone marrow: report of two cases with histochemical studies. Blood. 1959;14(2):162-169.

  2016cited by this paper
• Integrins Form an Expanding Diffusional Barrier that Coordinates Phagocytosis.

  2016cited by this paper
• Centrin2 regulates CP110 removal in primary cilium formation

  2015cited by this paper
• Cytotoxic granule secretion by lymphocytes and its link to immune homeostasis

  2015influential reference
• Munc18‐2 is required for Syntaxin 11 Localization on the Plasma Membrane in Cytotoxic T‐Lymphocytes

  2015influential reference
• Actin Depletion Initiates Events Leading to Granule Secretion at the Immunological Synapse

  2015influential reference
• Mother Centriole Distal Appendages Mediate Centrosome Docking at the Immunological Synapse and Reveal Mechanistic Parallels with Ciliogenesis

  2015influential reference
• The dendritic cell cytoskeleton promotes T cell adhesion and activation by constraining ICAM-1 mobility

  2015cited by this paper
• Hemophagocytic lymphohistiocytosis (HLH): A heterogeneous spectrum of cytokine-driven immune disorders.

  2015cited by this paper
• LYST Controls the Biogenesis of the Endosomal Compartment Required for Secretory Lysosome Function

  2015cited by this paper
• F-actin flow drives affinity maturation and spatial organization of LFA-1 at the immunological synapse

  2015cited by this paper
• Failed CTL/NK cell killing and cytokine hypersecretion are directly linked through prolonged synapse time

  2015influential reference
• IFT20 controls LAT recruitment to the immune synapse and T-cell activation in vivo

  2015cited by this paper
• XLP: Clinical Features and Molecular Etiology due to Mutations in SH2D1A Encoding SAP

  2014cited by this paper
• Accumulation of dynamic catch bonds between TCR and agonist peptide-MHC triggers T cell signaling.

  2014cited by this paper
• Serine-threonine kinases in TCR signaling

  2014cited by this paper
• Insights into the initiation of TCR signaling

  2014cited by this paper
• Familial Hemophagocytic Lymphohistiocytosis: When Rare Diseases Shed Light on Immune System Functioning

  2014cited by this paper
• Syntaxin11 serves as a t‐SNARE for the fusion of lytic granules in human cytotoxic T lymphocytes

  2014cited by this paper
• Analysis of Familial Hemophagocytic Lymphohistiocytosis Type 4 (FHL-4) Mutant Proteins Reveals that S-Acylation Is Required for the Function of Syntaxin 11 in Natural Killer Cells

  2014cited by this paper
• Munc18-2 and Syntaxin 3 Control Distinct Essential Steps in Mast Cell Degranulation

  2014cited by this paper
• Quantitative Phosphoproteomics of Cytotoxic T Cells to Reveal Protein Kinase D 2 Regulated Networks*

  2014cited by this paper
• Protein kinase D2 is a digital amplifier of T cell receptor–stimulated diacylglycerol signaling in naïve CD8+ T cells

  2014cited by this paper
• Specific recycling receptors are targeted to the immune synapse by the intraflagellar transport system

  2014cited by this paper
• Syntaxin binding mechanism and disease-causing mutations in Munc18-2

  2013cited by this paper
• Orchestrating cytoskeleton and intracellular vesicle traffic to build functional immunological synapses

  2013cited by this paper
• Centriole distal appendages promote membrane docking, leading to cilia initiation.

  2013cited by this paper
• The function of sub‐synaptic vesicles during T‐cell activation

  2013cited by this paper
• Hedgehog Signaling Controls T Cell Killing at the Immunological Synapse

  2013cited by this paper
• Centrosome repositioning in T cells is biphasic and driven by microtubule end-on capture-shrinkage

  2013cited by this paper
• The Enlarged Lysosomes in beigej Cells Result From Decreased Lysosome Fission and Not Increased Lysosome Fusion

  2012cited by this paper
• CD4+ T-cell synapses involve multiple distinct stages

  2011cited by this paper
• A Cascade of Protein Kinase C Isozymes Promotes Cytoskeletal Polarization in T Cells

  2011cited by this paper
• The munc13-4-rab27 complex is specifically required for tethering secretory lysosomes at the plasma membrane.

  2011cited by this paper
• Munc18-1 domain-1 controls vesicle docking and secretion by interacting with syntaxin-1 and chaperoning it to the plasma membrane

  2011cited by this paper
• The insider's guide to leukocyte integrin signalling and function

  2011influential reference
• Activation of the innate immune receptor Dectin-1 upon formation of a “phagocytic synapse”

  2011cited by this paper
• Cytokine Secretion Is Distinct from Secretion of Cytotoxic Granules in NK Cells

  2010cited by this paper
• Familial hemophagocytic lymphohistiocytosis type 5 (FHL-5) is caused by mutations in Munc18-2 and impaired binding to syntaxin 11.

  2009cited by this paper
• Munc18-2 deficiency causes familial hemophagocytic lymphohistiocytosis type 5 and impairs cytotoxic granule exocytosis in patient NK cells.

  2009influential reference
• Intraflagellar transport is required for polarized recycling of the TCR/CD3 complex to the immune synapse

  2009cited by this paper
• Involvement of Munc18 isoforms in the regulation of granule exocytosis in neutrophils.

  2008influential reference
• Binding of the Munc13-1 MUN domain to membrane-anchored SNARE complexes.

  2008cited by this paper
• Structure and duplication of the centrosome

  2007cited by this paper
• Recruitment of dynein to the Jurkat immunological synapse

  2006cited by this paper
• Centrosome polarization delivers secretory granules to the immunological synapse

  2006cited by this paper
• Reply to Re-examination of P-PTEN staining patterns in the intestinal crypt

  2005cited by this paper
• A minimal domain responsible for Munc13 activity

  2005cited by this paper
• SAP controls the cytolytic activity of CD8+ T cells against EBV-infected cells.

  2005cited by this paper
• Linkage of familial hemophagocytic lymphohistiocytosis (FHL) type-4 to chromosome 6q24 and identification of mutations in syntaxin 11.

  2005cited by this paper
• Munc13-4 Is a GTP-Rab27-binding Protein Regulating Dense Core Granule Secretion in Platelets*

  2004cited by this paper
• Munc13-4 is an effector of rab27a and controls secretion of lysosomes in hematopoietic cells.

  2004cited by this paper
• Adaptor protein 3–dependent microtubule-mediated movement of lytic granules to the immunological synapse

  2003cited by this paper
• Direct observation of catch bonds involving cell-adhesion molecules

  2003cited by this paper
• Munc13-4 is essential for cytolytic granules fusion and is mutated in a form of familial hemophagocytic lymphohistiocytosis (FHL3).

  2003influential reference
• Evidence of a role for Munc18-2 and microtubules in mast cell granule exocytosis

  2003cited by this paper
• Dynamic polarization of the microtubule cytoskeleton during CTL-mediated killing.

  2002cited by this paper
• P-, E-, and L-Selectin Mediate Migration of Activated CD8+ T Lymphocytes into Inflamed Skin1

  2002cited by this paper
• Syntaxin 1A is delivered to the apical and basolateral domains of epithelial cells: the role of munc-18 proteins.

  2001cited by this paper
• Formation of supramolecular activation clusters on fresh ex vivo CD8+ T cells after engagement of the T cell antigen receptor and CD8 by antigen-presenting cells

  2001cited by this paper
• Mapping the Zap-70 phosphorylation sites on LAT (linker for activation of T cells) required for recruitment and activation of signalling proteins in T cells.

  2001cited by this paper
• Rab27a Regulates the Peripheral Distribution of Melanosomes in Melanocytes

  2001cited by this paper
• Rab27a Is Required for Regulated Secretion in Cytotoxic T Lymphocytes

  2001cited by this paper
• The immunological synapse of CTL contains a secretory domain and membrane bridges.

  2001influential reference
• Rab27a enables myosin Va-dependent melanosome capture by recruiting the myosin to the organelle.

  2001cited by this paper
• Defective Granule Exocytosis in Rab27a-Deficient Lymphocytes from Ashen Mice

  2001cited by this paper
• Mutations in RAB27A cause Griscelli syndrome associated with haemophagocytic syndrome

  2000cited by this paper
• Perforin gene defects in familial hemophagocytic lymphohistiocytosis.

  1999cited by this paper
• Degranulation plays an essential part in regulating cell surface expression of Fas ligand in T cells and natural killer cells

  1999cited by this paper
• Localization of a gene for familial hemophagocytic lymphohistiocytosis at chromosome 9q21.3-22 by homozygosity mapping.

  1999cited by this paper
• The immunological synapse: a molecular machine controlling T cell activation.

  1999cited by this paper
• Altered trafficking of lysosomal proteins in Hermansky-Pudlak syndrome due to mutations in the beta 3A subunit of the AP-3 adaptor.

  1999cited by this paper
• Uncoupling of nonreceptor tyrosine kinases from PLC-gamma1 in an SLP-76-deficient T cell.

  1998influential reference
• Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene

  1998cited by this paper
• Three-dimensional segregation of supramolecular activation clusters in T cells

  1998cited by this paper
• Identification of the homologous beige and Chediak–Higashi syndrome genes

  1997cited by this paper
• Phosphorylation of SLP-76 by the ZAP-70 Protein-tyrosine Kinase Is Required for T-cell Receptor Function*

  1996cited by this paper
• Identification of the murine beige gene by YAC complementation and positional cloning

  1996influential reference
• Homozygosity mapping of the gene for Chediak-Higashi syndrome to chromosome 1q42-q44 in a segment of conserved synteny that includes the mouse beige locus (bg).

  1996influential reference
• Genetic and physical mapping of the Chediak-Higashi syndrome on chromosome 1q42-43.

  1996influential reference
• Identification and mutation analysis of the complete gene for Chediak–Higashi syndrome

  1996influential reference
• Identification of the homologous beige and Chediak–Higashi syndrome genes

  1996influential reference
• Loss of cytotoxic T lymphocyte function in Chediak-Higashi syndrome arises from a secretory defect that prevents lytic granule exocytosis.

  1995cited by this paper
• Primary cilia in normal and pathological tissues.

  1995cited by this paper
• Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

  1994cited by this paper
• Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases.

  1994cited by this paper
• ZAP-70: A 70 kd protein-tyrosine kinase that associates with the TCR ζ chain

  1992influential reference
• ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain.

  1992influential reference
• Perforin-mediated target cell lysis by cytolytic T lymphocytes.

  1990cited by this paper
• The reorientation of the Golgi apparatus and the microtubule-organizing center in the cytotoxic effector cell is a prerequisite in the lysis of bound target cells.

  1985cited by this paper
• Reorientation of the microtubule-organizing center and the Golgi apparatus in cloned cytotoxic lymphocytes triggered by binding to lysable target cells.

  1984cited by this paper
• Polarization of the Golgi apparatus and the microtubule-organizing center within cloned natural killer cells bound to their targets.

  1983cited by this paper
• Spatial relationships of microtubule-organizing centers and the contact area of cytotoxic T lymphocytes and target cells

  1982cited by this paper
• A syndrome associating partial albinism and immunodeficiency.

  1978influential reference
• Albinism associated with hemorrhagic diathesis and unusual pigmented reticular cells in the bone marrow: report of two cases with histochemical studies.

  1959influential reference
• Congenital gigantism of peroxidase granules; the first case ever reported of qualitative abnormity of peroxidase.

  1954influential reference
• [New leukocyte anomaly of constitutional and familial character].

  1952influential reference
• Familial Haemophagocytic Reticulosis

  1952influential reference

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  2025cites this paper
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  2025cites this paper
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  2025cites this paper
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  2025cites this paper
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  2024cites this paper
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  2024cites this paper
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  2024cites this paper
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  2024cites this paper
• Mechanoimmunology in the solid tumor microenvironment.

  2024cites this paper
• NFIL3 contributes to cytotoxic T lymphocyte-mediated killing

  2024cites this paper
• Harnessing the cytotoxic granule exocytosis to augment the efficacy of T-cell-engaging bispecific antibody therapy

  2024cites this paper
• Immunoinformatics design of a multi-epitope vaccine for Chlamydia trachomatis major outer membrane proteins

  2024cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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• Cytotoxic T lymphocytes require transcription for infiltration but not target cell lysis

  2023cites this paper
• Engineering of regulatory T cells by means of mRNA electroporation in a GMP-compliant manner.

  2022cites this paper
• Unspecific CTL Killing Is Enhanced by High Glucose via TNF-Related Apoptosis-Inducing Ligand

  2022cites this paper
• The complex web of canonical and non‐canonical Hedgehog signaling

  2022cites this paper
• Hot and cold tumor: Recent developments and perspectives on oral cancer.

  2022cites this paper
• Systemic Delivery of mPEG‐Masked Trispecific T‐Cell Nanoengagers in Synergy with STING Agonists Overcomes Immunotherapy Resistance in TNBC and Generates a Vaccination Effect

  2022cites this paper
• Hemophagocytic Lymphohistiocytosis

  2022cites this paper
• Computational image features of immune architecture is associated with clinical benefit and survival in gynecological cancers across treatment modalities

  2022cites this paper
• ESCRTed resistance to T cell attack.

  2022cites this paper
• Current methods to analyze lysosome morphology, positioning, motility and function

  2022cites this paper
• Lysosomes and lysosome‐related organelles in immune responses

  2022cites this paper
• Targeting the Microtubule-Network Rescues CTL Killing Efficiency in Dense 3D Matrices

  2021cites this paper
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  2021cites this paper
• Cytoskeletal control of the secretory immune synapse.

  2021cites this paper
• Turning cold tumors into hot tumors by improving T-cell infiltration

  2021cites this paper
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  2021cites this paper
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  2019influential citation
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  2019cites this paper
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  2019cites this paper
• Regulation of global CD8+ T‐cell positioning by the actomyosin cytoskeleton

  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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