Neurogenin 2 is required for the development of ventral midbrain dopaminergic neurons

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Development

• Publication date

  2006-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/dev.02223PMID 16410412
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2003influential reference
• Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a

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  2003influential reference
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• A role for neural determination genes in specifying the dorsoventral identity of telencephalic neurons.

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• Generation of neurons by transient expression of neural bHLH proteins in mammalian cells.

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  1997influential reference
• Cooperation of Pax2 and Pax5 in midbrain and cerebellum development

  1997cited by this paper
• Identification of neurogenin, a vertebrate neuronal determination gene.

  1996cited by this paper
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  1996cited by this paper
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  1995cited by this paper
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• Rescue of the En-1 mutant phenotype by replacement of En-1 with En-2.

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• Transient and restricted expression during mouse embryogenesis of Dll1, a murine gene closely related to Drosophila Delta.

  1995influential reference
• Multiple developmental defects in Engrailed-1 mutant mice: an early mid-hindbrain deletion and patterning defects in forelimbs and sternum.

  1994cited by this paper
• Dynamic expression of the murine Achaete-Scute homologue Mash-1 in the developing nervous system.

  1993cited by this paper
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• Detection of messenger RNA by in situ hybridization to postimplantation embryo whole mounts.

  1993cited by this paper
• Molecular characterization of a rat negative regulator with a basic helix-loop-helix structure predominantly expressed in the developing nervous system.

  1992influential reference
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  1990cited by this paper
• Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development

  1990cited by this paper
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  year unknowncited by this paper

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