Asymmetric activation of Dll4-Notch signaling by Foxn4 and proneural factors activates BMP/TGFβ signaling to specify V2b interneurons in the spinal cord

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Development

• Publication date

  2014-01-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/dev.092536PMID 24257627PMCID PMC3865758
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Specification

  2020cited by this paper
• BMP receptor-activated Smads confer diverse functions during the development of the dorsal spinal cord.

  2012cited by this paper
• Forkhead box N4 (Foxn4) activates Dll4-Notch signaling to suppress photoreceptor cell fates of early retinal progenitors

  2012cited by this paper
• Sonic hedgehog signaling in the developing CNS where it has been and where it is going.

  2011cited by this paper
• Phylotypic expression of the bHLH genes Neurogenin2, Neurod, and Mash1 in the mouse embryonic forebrain

  2010cited by this paper
• Sox1 Is Required for the Specification of a Novel p2-Derived Interneuron Subtype in the Mouse Ventral Spinal Cord

  2010influential reference
• A Cre transgenic line for studying V2 neuronal lineages and functions in the spinal cord

  2010cited by this paper
• Neurogenin 1 (Neurog1) expression in the ventral neural tube is mediated by a distinct enhancer and preferentially marks ventral interneuron lineages.

  2010cited by this paper
• Dynamic regulation of Notch signaling in neural progenitor cells.

  2009cited by this paper
• Ascl1 and Neurog2 form novel complexes and regulate Delta-like3 (Dll3) expression in the neural tube.

  2009cited by this paper
• Context dependence of proneural bHLH proteins.

  2008cited by this paper
• Dynamic Notch signaling in neural progenitor cells and a revised view of lateral inhibition

  2008cited by this paper
• [P2.15]: Oscillations in notch signaling regulate maintenance of neural progenitors

  2008cited by this paper
• Prox1 regulates a transitory state for interneuron neurogenesis in the spinal cord

  2008cited by this paper
• A regulatory network involving Foxn4, Mash1 and delta-like 4/Notch1 generates V2a and V2b spinal interneurons from a common progenitor pool

  2007influential reference
• Notch and MAML signaling drives Scl-dependent interneuron diversity in the spinal cord.

  2007cited by this paper
• The TGFβ intracellular effector Smad3 regulates neuronal differentiation and cell fate specification in the developing spinal cord

  2007influential reference
• Ascl1 defines sequentially generated lineage-restricted neuronal and oligodendrocyte precursor cells in the spinal cord

  2007cited by this paper
• Combinatorial actions of patterning and HLH transcription factors in the spatiotemporal control of neurogenesis and gliogenesis in the developing spinal cord

  2007cited by this paper
• dILA neurons in the dorsal spinal cord are the product of terminal and non-terminal asymmetric progenitor cell divisions, and require Mash1 for their development

  2006cited by this paper
• Neurogenin 2 is required for the development of ventral midbrain dopaminergic neurons

  2006cited by this paper
• Coupling of cell migration with neurogenesis by proneural bHLH factors

  2006influential reference
• Proneural bHLH and Brn proteins coregulate a neurogenic program through cooperative binding to a conserved DNA motif.

  2006cited by this paper
• Ascl1 and Gsh1/2 control inhibitory and excitatory cell fate in spinal sensory interneurons

  2006cited by this paper
• Foxn4 acts synergistically with Mash1 to specify subtype identity of V2 interneurons in the spinal cord.

  2005influential reference
• Sequential roles for Mash1 and Ngn2 in the generation of dorsal spinal cord interneurons

  2005influential reference
• Single small-interfering RNA expression vector for silencing multiple transforming growth factor-β pathway components

  2005cited by this paper
• Coordinate regulation of neural tube patterning and proliferation by TGFbeta and WNT activity.

  2004cited by this paper
• Foxn4 controls the genesis of amacrine and horizontal cells by retinal progenitors.

  2004influential reference
• Distinct domains within Mash1 and Math1 are required for function in neuronal differentiation versus neuronal cell-type specification

  2004influential reference
• Differential requirements for Smad4 in TGFβ-dependent patterning of the early mouse embryo

  2004cited by this paper
• Role of the Barhl2 homeobox gene in the specification of glycinergic amacrine cells

  2004cited by this paper
• Distinct activities of Msx1 and Msx3 in dorsal neural tube development

  2004cited by this paper
• Secreted antagonists of the Wnt signalling pathway

  2003cited by this paper
• A requirement for retinoic acid-mediated transcriptional activation in ventral neural patterning and motor neuron specification.

  2003cited by this paper
• Specification of dorsal spinal cord interneurons.

  2003cited by this paper
• Gli proteins and the control of spinal‐cord patterning

  2003cited by this paper
• The amino-terminal region of Gli3 antagonizes the Shh response and acts in dorsoventral fate specification in the developing spinal cord.

  2003cited by this paper
• A DNA vector-based RNAi technology to suppress gene expression in mammalian cells

  2002cited by this paper
• Proneural genes and the specification of neural cell types

  2002influential reference
• Opponent activities of Shh and BMP signaling during floor plate induction in vivo.

  2002cited by this paper
• The homeodomain factor lbx1 distinguishes two major programs of neuronal differentiation in the dorsal spinal cord.

  2002cited by this paper
• BMP signaling patterns the dorsal and intermediate neural tube via regulation of homeobox and helix-loop-helix transcription factors.

  2002cited by this paper
• Comparison of the generic neuronal differentiation and neuron subtype specification functions of mammalian achaete-scute and atonal homologs in cultured neural progenitor cells.

  2002influential reference
• A mitogen gradient of dorsal midline Wnts organizes growth in the CNS.

  2002cited by this paper
• Localized BMP4-noggin interactions generate the dynamic patterning of noggin expression in somites.

  2002cited by this paper
• Divergent functions of the proneural genes Mash1 and Ngn2 in the specification of neuronal subtype identity.

  2002cited by this paper
• Wnt signaling plays an essential role in neuronal specification of the dorsal spinal cord.

  2002cited by this paper
• Crossinhibitory activities of Ngn1 and Math1 allow specification of distinct dorsal interneurons.

  2001influential reference
• Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus

  2001cited by this paper
• Pax-6 Regulates Expression ofSFRP-2 and Wnt-7b in the Developing CNS

  2001cited by this paper
• All Brn3 genes can promote retinal ganglion cell differentiation in the chick.

  2000cited by this paper
• Radial glial identity is promoted by Notch1 signaling in the murine forebrain.

  2000influential reference
• GATA2 is required for the generation of V2 interneurons.

  2000influential reference
• Regulation of the neural patterning activity of sonic hedgehog by secreted BMP inhibitors expressed by notochord and somites.

  2000cited by this paper
• Neuronal specification in the spinal cord: inductive signals and transcriptional codes

  2000cited by this paper
• Neurogenin1 and neurogenin2 control two distinct waves of neurogenesis in developing dorsal root ganglia.

  1999cited by this paper
• Progression from extrinsic to intrinsic signaling in cell fate specification: a view from the nervous system.

  1999influential reference
• Targeted Disruption of Smad3 Reveals an Essential Role in Transforming Growth Factor β-Mediated Signal Transduction

  1999influential reference
• NEUROGENIN 1 and NEUROGENIN 2 control two distinct waves of neurogenesis in developing dorsal root ganglia

  1999cited by this paper
• Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite.

  1998cited by this paper
• Mechanisms of Wnt signaling in development.

  1998cited by this paper
• Motor neuron-derived retinoid signaling specifies the subtype identity of spinal motor neurons.

  1998influential reference
• Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling.

  1997cited by this paper
• A role for the roof plate and its resident TGFbeta-related proteins in neuronal patterning in the dorsal spinal cord.

  1997cited by this paper
• Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling.

  1997cited by this paper
• Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling

  1997cited by this paper
• Development

  1996cited by this paper
• Msx3: a novel murine homologue of the Drosophila msh homeobox gene restricted to the dorsal embryonic central nervous system.

  1996influential reference
• Msx3: a novel murine homologue of the Drosophila msh homeoɡ gene restricted to the dorsal embryonic central nervous system

  1996cited by this paper
• Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus

  1995cited by this paper
• Protein molecules as computational elements in living cells

  1995cited by this paper
• Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus.

  1995cited by this paper
• Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus

  1995cited by this paper
• Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants

  1995cited by this paper
• Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos.

  1992cited by this paper
• The ski oncogene induces muscle differentiation in quail embryo cells.

  1989cited by this paper

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  2024cites this paper
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  2024cites this paper
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  2024cites this paper
• Delta like 4 regulates cerebrovascular development and endothelial integrity via DLL4‐NOTCH‐CLDN5 pathway and is vulnerable to neonatal hyperoxia

  2024cites this paper
• Insights into the mechanisms of neuron generation and specification in the zebrafish ventral spinal cord

  2023cites this paper
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  2023cites this paper
• Single-cell chromatin accessibility profiling of cell-state-specific gene regulatory programs during mouse organogenesis

  2023cites this paper
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  2022cites this paper
• Neurons gating behavior—developmental, molecular and functional features of neurons in the Substantia Nigra pars reticulata

  2022cites this paper
• Pten associates with important gene regulatory network to fine‐tune Müller glia‐mediated zebrafish retina regeneration

  2022cites this paper
• The mitochondrial micropeptide Stmp1 promotes retinal cell differentiation.

  2022cites this paper
• Direct neuronal reprogramming: Fast forward from new concepts toward therapeutic approaches.

  2021cites this paper
• Heterogeneity of neurons reprogrammed from spinal cord astrocytes by the proneural factors Ascl1 and Neurogenin2

  2021influential citation
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  2021cites this paper
• Heterogeneity of neurons reprogrammed from spinal cord astrocytes by the proneural factors Ascl1 and Neurogenin2

  2021influential citation
• Spatiotemporal mapping of gene expression landscapes and developmental trajectories during zebrafish embryogenesis

  2021cites this paper
• Notch signaling determines cell-fate specification of the two main types of vomeronasal neurons of rodents

  2021cites this paper
• Multi-omic analysis of lung tumors defines pathways activated in neuroendocrine transformation

  2020cites this paper
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  2020cites this paper
• Regional gene expression patterns are associated with task‐specific brain activation during reward and emotion processing measured with functional MRI

  2020cites this paper
• A Notch-mediated, temporal asymmetry in BMP pathway activation promotes photoreceptor subtype diversification

  2019cites this paper
• Vsx1 and Chx10 paralogs sequentially secure V2 interneuron identity during spinal cord development

  2019cites this paper
• Onecut Factors and Pou2f2 Regulate the Distribution of V2 Interneurons in the Mouse Developing Spinal Cord

  2018cites this paper
• Requirement of the Mowat-Wilson Syndrome Gene Zeb2 in the Differentiation and Maintenance of Non-photoreceptor Cell Types During Retinal Development

  2018cites this paper
• E proteins sharpen neurogenesis by modulating proneural bHLH transcription factors’ activity in an E-box-dependent manner

  2018cites this paper
• E proteins differentially co-operate with proneural bHLH transcription factors to sharpen neurogenesis

  2018influential citation
• Defined Culture Conditions Accelerate Small-molecule-assisted Neural Induction for the Production of Neural Progenitors from Human-induced Pluripotent Stem Cells

  2017cites this paper
• Lunatic Fringe is a potent tumor suppressor in Kras-initiated pancreatic cancer

  2016cites this paper
• The Journal of Clinical Investigation

  2016cites this paper
• Vsx1 Transiently Defines an Early Intermediate V2 Interneuron Precursor Compartment in the Mouse Developing Spinal Cord

  2016influential citation
• Transcriptional Regulation of Notch1 Expression by Nkx6.1 in Neural Stem/Progenitor Cells during Ventral Spinal Cord Development

  2016cites this paper
• Tfap2a and 2b act downstream of Ptf1a to promote amacrine cell differentiation during retinogenesis

  2015cites this paper
• Second-generation Notch1 activity-trap mouse line (N1IP::CreHI) provides a more comprehensive map of cells experiencing Notch1 activity

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• Genetic dissection of Gata2 selective functions during specification of V2 interneurons in the developing spinal cord

  2015cites this paper
• Minimally manipulated autologous adherent bone marrow cells (ABMCs): a promising cell therapy of spinal cord injury

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  2015cites this paper
• A multi-resource data integration approach: identification of candidate genes regulating cell proliferation during neocortical development

  2014cites this paper
• RBP-J imposes a requirement for ITAM-mediated costimulation of osteoclastogenesis.

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