The RhoGAP activity of the Yersinia pseudotuberculosis cytotoxin YopE is required for antiphagocytic function and virulence

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Molecular Microbiology

• Publication date

  2000-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1046/j.1365-2958.2000.02021.xPMID 10931345
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• YopH dephosphorylates Cas and Fyn-binding protein in macrophages.

  1999influential reference
• The Tranquilizing Injection of Yersinia Proteins: A Pathogens Strategy to Resist Host Defense

  1999cited by this paper
• Bidirectional signaling between the cytoskeleton and integrins.

  1999influential reference
• YopJ of Yersinia spp. Is Sufficient To Cause Downregulation of Multiple Mitogen-Activated Protein Kinases in Eukaryotic Cells

  1999influential reference
• The amino‐terminal domain of Pseudomonas aeruginosa ExoS disrupts actin filaments via small‐molecular‐weight GTP‐binding proteins

  1999cited by this paper
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  1999influential reference
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  1999influential reference
• Localization of the Yersinia PTPase to focal complexes is an important virulence mechanism

  1999cited by this paper
• Bacterial Toxins Inhibiting or Activating Small GTP‐Binding Proteins

  1999cited by this paper
• The Cytotoxin YopT of Yersinia enterocoliticaInduces Modification and Cellular Redistribution of the Small GTP-binding Protein RhoA*

  1999cited by this paper
• Type III Protein Secretion Systems in Bacterial Pathogens of Animals and Plants

  1998influential reference
• The Virulence Plasmid of Yersinia, an Antihost Genome

  1998influential reference
• Identification of an amino‐terminal substrate‐binding domain in the Yersinia tyrosine phosphatase that is required for efficient recognition of focal adhesion targets

  1998cited by this paper
• Identification of two distinct mechanisms of phagocytosis controlled by different Rho GTPases.

  1998influential reference
• The Salmonella typhimurium tyrosine phosphatase SptP is translocated into host cells and disrupts the actin cytoskeleton

  1998cited by this paper
• YopT, a new Yersinia Yop effector protein, affects the cytoskeleton of host cells

  1998cited by this paper
• Rho GTPases and the actin cytoskeleton.

  1998influential reference
• The Yersinia Yops inhibit invasion of Listeria, Shigella and Edwardsiella but not Salmonella into epithelial cells

  1998influential reference
• GTPase-activating proteins: helping hands to complement an active site.

  1998influential reference
• Fc receptor‐mediated phagocytosis requires CDC42 and Rac1

  1998cited by this paper
• Rho GTPases and signaling networks.

  1997cited by this paper
• Identification of p130Cas as a substrate of Yersinia YopH (Yop51), a bacterial protein tyrosine phosphatase that translocates into mammalian cells and targets focal adhesions

  1997influential reference
• The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants.

  1997cited by this paper
• Rho proteins: targets for bacterial toxins.

  1997cited by this paper
• Structure at 1.65 Å of RhoA and its GTPase-activating protein in complex with a transition-state analogue

  1997cited by this paper
• Yersinia enterocolitica: the charisma continues

  1997cited by this paper
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  1997influential reference
• The Yersinia Yop virulon: a bacterial system for subverting eukaryotic cells

  1997cited by this paper
• The YopB protein of Yersinia pseudotuberculosis is essential for the translocation of Yop effector proteins across the target cell plasma membrane and displays a contact‐dependent membrane disrupting activity.

  1996cited by this paper
• A secreted protein tyrosine phosphatase with modular effector domains in the bacterial pathogen Salmonella typhimurlum

  1996cited by this paper
• Status of YopM and YopN in the Yersinia Yop virulon: YopM of Y.enterocolitica is internalized inside the cytosol of PU5–1.8 macrophages by the YopB, D, N delivery apparatus.

  1996influential reference
• Cross-talk between bacterial pathogens and their host cells.

  1996cited by this paper
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  1995cited by this paper
• Inhibition of the Fc receptor-mediated oxidative burst in macrophages by the Yersinia pseudotuberculosis tyrosine phosphatase

  1995influential reference
• Measurement of intrinsic nucleotide exchange and GTP hydrolysis rates.

  1995cited by this paper
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  1995cited by this paper
• Cloning the structural gene for the 49-kDa form of exoenzyme S (exoS) from Pseudomonas aeruginosa strain 388.

  1994cited by this paper
• Binding and internalization of microorganisms by integrin receptors.

  1994cited by this paper
• Regulation and polarized transfer of the Yersinia outer proteins (Yops) involved in antiphagocytosis.

  1994cited by this paper
• Target cell contact triggers expression and polarized transfer of Yersinia YopE cytotoxin into mammalian cells.

  1994cited by this paper
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  1993cited by this paper
• Yops of Yersinia spp. pathogenic for humans

  1993cited by this paper
• Factors promoting acute and chronic diseases caused by yersiniae

  1991cited by this paper
• Intracellular targeting of the Yersinia YopE cytotoxin in mammalian cells induces actin microfilament disruption

  1991cited by this paper
• Tyrosine phosphate hydrolysis of host proteins by an essential Yersinia virulence determinant.

  1991cited by this paper
• Multiple β1 chain integrins are receptors for invasin, a protein that promotes bacterial penetration into mammalian cells

  1990cited by this paper
• Multiple beta 1 chain integrins are receptors for invasin, a protein that promotes bacterial penetration into mammalian cells.

  1990cited by this paper
• The cytotoxic protein YopE of Yersinia obstructs the primary host defence

  1990cited by this paper
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  1989influential reference
• The virulence protein Yop5 of Yersinia pseudotuberculosis is regulated at transcriptional level by plasmid-plB1-encoded trans-acting elements controlled by temperature and calcium.

  1988cited by this paper
• The virulence protein Yop5 of Yersinia pseudotuberculosis is regulated at transcriptional level by plasmid‐plB1 ‐encoded trans‐acting elements controlled by temperature and calcium

  1988cited by this paper
• Inhibition of phagocytosis in Yersinia pseudotuberculosis: a virulence plasmid-encoded ability involving the Yop2b protein

  1988cited by this paper
• Double immunofluorescence microscopic technique for accurate differentiation of extracellularly and intracellularly located bacteria in cell culture

  1985cited by this paper

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