STUDIES ON INFLAMMATION

Trypan blue injected into the circulating blood stream of frogs accumulates rapidly in an inflamed area. When trypan blue is injected directly into the area of inflammation it is fixed in situ and fails to diffuse outward. If the dye is injected at the periphery of an inflamed area it fails to enter the site of inflammation. This failure of penetration is caused by the occlusion of lymphatic vessels and the presence of a network of fibrin in the inflamed area. These experiments furnish additional evidence that fixation of foreign substances by the inflammatory reaction is due to mechanical obstruction caused by a network of fibrin and by thrombosed lymphatics at the site of inflammation.

• Publication year

  1931

• Venue

  Journal of Experimental Medicine

• Publication date

  1931-01-31

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1084/JEM.53.2.179PMID 19869834PMCID 2131926
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• STUDIES ON INFLAMMATION

  1931cited by this paper
• STUDIES ON INFLAMMATION

  1930cited by this paper
• STUDIES ON INFLAMMATION

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