Phosphatases and kinases as regulators of the endothelial barrier function

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Cell and Tissue Research

• Publication date

  2014-02-25

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s00441-014-1812-1PMID 24566520
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The role of VE-cadherin in vascular morphogenesis and permeability control.

  2013cited by this paper
• Cutting Edge: Endothelial-Specific Gene Ablation of CD99L2 Impairs Leukocyte Extravasation In Vivo

  2013cited by this paper
• How T cells trigger the dissociation of the endothelial receptor phosphatase VE-PTP from VE-cadherin.

  2013cited by this paper
• VE‐PTP and VE‐cadherin ectodomains interact to facilitate regulation of phosphorylation and cell contacts

  2013cited by this paper
• VE-PTP regulates VEGFR2 activity in stalk cells to establish endothelial cell polarity and lumen formation

  2013cited by this paper
• Locking endothelial junctions blocks leukocyte extravasation, but not in all tissues

  2013cited by this paper
• Effects of vascular-endothelial protein tyrosine phosphatase inhibition on breast cancer vasculature and metastatic progression.

  2013cited by this paper
• Tyrosine phosphorylation of DEP-1/CD148 as a mechanism controlling Src kinase activation, endothelial cell permeability, invasion, and capillary formation.

  2012cited by this paper
• Phosphorylation of VE-cadherin is modulated by haemodynamic forces and contributes to the regulation of vascular permeability in vivo

  2012cited by this paper
• Ve-ptp Modulates Vascular Integrity by Promoting Adherens Junction Maturation

  2012cited by this paper
• Intracellular mediators of JAM‐A–dependent epithelial barrier function

  2012cited by this paper
• UvA-DARE ( Digital Academic Repository ) Dynamic control of VE-cadherin-based junctions

  2012cited by this paper
• VEGF-induced vascular permeability is mediated by FAK.

  2012cited by this paper
• Role of FAK in S1P-regulated endothelial permeability.

  2012cited by this paper
• Acute administration of recombinant Angiopoietin-1 ameliorates multiple-organ dysfunction syndrome and improves survival in murine sepsis.

  2011cited by this paper
• The synthetic Tie2 agonist peptide vasculotide protects against vascular leakage and reduces mortality in murine abdominal sepsis

  2011cited by this paper
• Junctional adhesion molecule-C (JAM-C) regulates polarized neutrophil transendothelial cell migration in vivo

  2011cited by this paper
• Dissociation of VE-PTP from VE-cadherin is required for leukocyte extravasation and for VEGF-induced vascular permeability in vivo

  2011cited by this paper
• Mechanisms of leukocyte transendothelial migration.

  2011cited by this paper
• Stabilizing the VE‐cadherin–catenin complex blocks leukocyte extravasation and vascular permeability

  2011cited by this paper
• Src-induced Tyrosine Phosphorylation of VE-cadherin Is Not Sufficient to Decrease Barrier Function of Endothelial Monolayers*♦

  2010influential reference
• Role of protein tyrosine phosphatase SHP2 in barrier function of pulmonary endothelium.

  2010cited by this paper
• Transcriptional profiling reveals a critical role for tyrosine phosphatase VE‐PTP in regulation of VEGFR2 activity and endothelial cell morphogenesis

  2009cited by this paper
• Density-enhanced Phosphatase 1 Regulates Phosphorylation of Tight Junction Proteins and Enhances Barrier Function of Epithelial Cells*

  2009cited by this paper
• The Regulation of Vascular Endothelial Growth Factor-induced Microvascular Permeability Requires Rac and Reactive Oxygen Species*

  2009influential reference
• VE-PTP controls blood vessel development by balancing Tie-2 activity

  2009cited by this paper
• Cell adhesion dynamics at endothelial junctions: VE-cadherin as a major player.

  2009cited by this paper
• p120-Catenin regulates leukocyte transmigration through an effect on VE-cadherin phosphorylation.

  2008cited by this paper
• Structurally distinct phosphatases CD45 and CD148 both regulate B cell and macrophage immunoreceptor signaling.

  2008cited by this paper
• Phosphorylation of vascular endothelial cadherin controls lymphocyte emigration

  2008cited by this paper
• Role of Protein Tyrosine Phosphatase 1B in Vascular Endothelial Growth Factor Signaling and Cell–Cell Adhesions in Endothelial Cells

  2008cited by this paper
• Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell–cell and cell–matrix contacts

  2008cited by this paper
• The role of adherens junctions and VE-cadherin in the control of vascular permeability

  2008cited by this paper
• VE-PTP maintains the endothelial barrier via plakoglobin and becomes dissociated from VE-cadherin by leukocytes and by VEGF

  2008cited by this paper
• The role of junctional adhesion molecules in vascular inflammation

  2007cited by this paper
• Getting to the site of inflammation: the leukocyte adhesion cascade updated

  2007cited by this paper
• Vascular endothelial tyrosine phosphatase (VE-PTP)-null mice undergo vasculogenesis but die embryonically because of defects in angiogenesis

  2007influential reference
• A CD99-related antigen on endothelial cells mediates neutrophil but not lymphocyte extravasation in vivo.

  2007cited by this paper
• Adhesion and signaling molecules controlling the transmigration of leukocytes through endothelium

  2007cited by this paper
• JAM-A regulates permeability and inflammation in the intestine in vivo

  2007cited by this paper
• Src kinase phosphorylates vascular endothelial-cadherin in response to vascular endothelial growth factor: identification of tyrosine 685 as the unique target site

  2007cited by this paper
• Angiopoietin-1 Requires p190 RhoGAP to Protect against Vascular Leakage in Vivo*

  2007cited by this paper
• ICAM-1-Mediated, Src- and Pyk2-Dependent Vascular Endothelial Cadherin Tyrosine Phosphorylation Is Required for Leukocyte Transendothelial Migration1

  2007influential reference
• JAM family and related proteins in leukocyte migration (Vestweber series).

  2007cited by this paper
• Junctional adhesion molecule-C regulates vascular endothelial permeability by modulating VE-cadherin–mediated cell–cell contacts

  2006cited by this paper
• TNF-alpha increases tyrosine phosphorylation of vascular endothelial cadherin and opens the paracellular pathway through fyn activation in human lung endothelia.

  2006cited by this paper
• ESAM supports neutrophil extravasation, activation of Rho, and VEGF-induced vascular permeability

  2006cited by this paper
• Modulation of α-catenin Tyr phosphorylation by SHP2 positively effects cell transformation induced by the constitutively active FGFR3

  2006cited by this paper
• Vascular endothelial cell–specific phosphotyrosine phosphatase (VE-PTP) activity is required for blood vessel development

  2006cited by this paper
• Vascular endothelial cell-specific phosphotyrosine phosphatase (VE-PTP) activity is required for blood vessel development.

  2006cited by this paper
• Genetic Ablation of Ptprj, a Mouse Cancer Susceptibility Gene, Results in Normal Growth and Development and Does Not Predispose to Spontaneous Tumorigenesis

  2006cited by this paper
• VEGF controls endothelial-cell permeability by promoting the β-arrestin-dependent endocytosis of VE-cadherin

  2006cited by this paper
• The HSPGs Syndecan and Dallylike bind the receptor phosphatase LAR and exert distinct effects on synaptic development.

  2006cited by this paper
• Signaling mechanisms regulating endothelial permeability.

  2006cited by this paper
• Proline-rich Tyrosine Kinase 2 (Pyk2) Mediates Vascular Endothelial-Cadherin-based Cell-Cell Adhesion by Regulating β-Catenin Tyrosine Phosphorylation*

  2005cited by this paper
• Association of Csk to VE‐cadherin and inhibition of cell proliferation

  2005cited by this paper
• Receptor protein tyrosine phosphatase micro regulates the paracellular pathway in human lung microvascular endothelia.

  2005cited by this paper
• Receptor Protein Tyrosine Phosphatase Regulates the Paracellular Pathway in Human Lung Microvascular Endothelia

  2005cited by this paper
• The regulation of cadherin-mediated adhesion by tyrosine phosphorylation/dephosphorylation of beta-catenin.

  2005cited by this paper
• Tyrosine phosphatases in vessel wall signaling.

  2005cited by this paper
• Platelet‐activating factor increases VE‐cadherin tyrosine phosphorylation in mouse endothelial cells and its association with the PtdIns3′‐kinase

  2005cited by this paper
• Src blockade stabilizes a Flk/cadherin complex, reducing edema and tissue injury following myocardial infarction.

  2004cited by this paper
• Mouse CD99 participates in T-cell recruitment into inflamed skin.

  2004cited by this paper
• ReviewProtein Tyrosine Phosphatases in the Human

  2004cited by this paper
• A transmigratory cup in leukocyte diapedesis both through individual vascular endothelial cells and between them

  2004cited by this paper
• Protein tyrosine phosphatases in the human genome.

  2004cited by this paper
• Protein kinase C modifications of VE-cadherin, p120, and beta-catenin contribute to endothelial barrier dysregulation induced by thrombin.

  2003cited by this paper
• Faculty Opinions recommendation of Contact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, beta-catenin, and the phosphatase DEP-1/CD148.

  2003cited by this paper
• Contact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, β-catenin, and the phosphatase DEP-1/CD148

  2003cited by this paper
• Faculty Opinions recommendation of Tyrosine phosphorylation of plakoglobin causes contrary effects on its association with desmosomes and adherens junction components and modulates beta-catenin-mediated transcription.

  2003cited by this paper
• p120 Catenin-Associated Fer and Fyn Tyrosine Kinases Regulate β-Catenin Tyr-142 Phosphorylation and β-Catenin-α-Catenin Interaction

  2003cited by this paper
• Protein tyrosine phosphatase activity regulates endothelial cell-cell interactions, the paracellular pathway, and capillary tube stability.

  2003cited by this paper
• p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction.

  2003cited by this paper
• A Mutant Receptor Tyrosine Phosphatase, CD148, Causes Defects in Vascular Development

  2003cited by this paper
• Tyrosine Phosphorylation of Plakoglobin Causes Contrary Effects on Its Association with Desmosomes and Adherens Junction Components and Modulates β-Catenin-Mediated Transcription

  2003cited by this paper
• Signal transduction pathways mediated by PECAM-1: new roles for an old molecule in platelet and vascular cell biology.

  2003cited by this paper
• CD99 plays a major role in the migration of monocytes through endothelial junctions

  2002cited by this paper
• VE‐PTP and VE‐cadherin ectodomains interact to facilitate regulation of phosphorylation and cell contacts

  2002cited by this paper
• Heparan sulfate proteoglycans are ligands for receptor protein tyrosine phosphatase sigma.

  2002cited by this paper
• Heparan Sulfate Proteoglycans Are Ligands for Receptor Protein Tyrosine Phosphatase σ

  2002cited by this paper
• An extracellular ligand increases the specific activity of the receptor-like protein tyrosine phosphatase DEP-1

  2001cited by this paper
• Regulation of β-catenin structure and activity by tyrosine phosphorylation.

  2001cited by this paper
• Regulation of beta-catenin structure and activity by tyrosine phosphorylation.

  2001cited by this paper
• SHP2 Association with VE-Cadherin Complexes in Human Endothelial Cells Is Regulated by Thrombin*

  2000cited by this paper
• Angiopoietin-1 Is an Antipermeability and Anti-Inflammatory Agent In Vitro and Targets Cell Junctions

  2000cited by this paper
• Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands.

  1999cited by this paper
• Histamine induces tyrosine phosphorylation of endothelial cell-to-cell adherens junctions.

  1999influential reference
• Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1.

  1999cited by this paper
• Role of vascular endothelial-cadherin in vascular morphogenesis.

  1999cited by this paper
• Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis.

  1999cited by this paper
• Vascular endothelial-cadherin is an important determinant of microvascular integrity in vivo.

  1999cited by this paper
• Functional interaction of vascular endothelial-protein-tyrosine phosphatase with the Angiopoietin receptor Tie-2

  1999influential reference
• Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability.

  1999cited by this paper
• Junctional Adhesion Molecule, a Novel Member of the Immunoglobulin Superfamily That Distributes at Intercellular Junctions and Modulates Monocyte Transmigration

  1998cited by this paper
• Dynamic Interaction of PTPμ with Multiple Cadherins In Vivo

  1998cited by this paper
• Neutrophils Emigrate from Venules by a Transendothelial Cell Pathway in Response to FMLP

  1998cited by this paper
• Regulation of Mouse PECAM-1 Tyrosine Phosphorylation by the Src and Csk Families of Protein-tyrosine Kinases*

  1998cited by this paper
• The Nonreceptor Protein Tyrosine Phosphatase PTP1B Binds to the Cytoplasmic Domain of N-Cadherin and Regulates the Cadherin–Actin Linkage

  1998cited by this paper
• A Single Gene Product, Claudin-1 or -2, Reconstitutes Tight Junction Strands and Recruits Occludin in Fibroblasts

  1998cited by this paper
• Vascular Endothelial Growth Factor Induces Endothelial Fenestrations In Vitro

  1998influential reference

• A Machine Learning–3D Microvessel Platform Identifies Kinase Targets Restoring Blood-Brain-Barrier Endothelial Integrity

  2025cites this paper
• Vascular Endothelium at the Molecular Level: From Fundamental Knowledge Toward Medical Implementation

  2024cites this paper
• Myocardial Oedema as a Consequence of Viral Infection and Persistence—A Narrative Review with Focus on COVID-19 and Post COVID Sequelae

  2024cites this paper
• Systems-level reconstruction of kinase phosphosignaling networks regulating endothelial barrier integrity using temporal data

  2024cites this paper
• Interrogating endothelial barrier regulation by temporally resolved kinase network generation

  2023cites this paper
• Therapeutic targeting of angiopoietins in tumor angiogenesis and cancer development.

  2023cites this paper
• Agonists for Bitter Taste Receptors T2R10 and T2R38 Attenuate LPS-Induced Permeability of the Pulmonary Endothelium in vitro

  2022cites this paper
• βIV-spectrin as a stalk cell-intrinsic regulator of VEGF signaling

  2022cites this paper
• Renal microvascular endothelial cell responses in sepsis-induced acute kidney injury

  2021cites this paper
• SMAD6 transduces endothelial cell flow responses required for blood vessel homeostasis

  2021cites this paper
• RNA-Seq unveiled section-specific host response to lack of gut microbiota in mouse intestine.

  2021cites this paper
• Autoregulatory “Multitasking” at Endothelial Cell Junctions by Junction-Associated Intermittent Lamellipodia Controls Barrier Properties

  2021cites this paper
• Exploiting polypharmacology to dissect host kinases and kinase inhibitors that modulate endothelial barrier integrity.

  2021cites this paper
• Development of an Image-Based HCS-Compatible Method for Endothelial Barrier Function Assessment

  2021cites this paper
• SMAD6 transduces endothelial cell flow responses required for blood vessel homeostasis

  2021cites this paper
• Molecular Mechanisms of Vascular Damage During Lung Injury.

  2021cites this paper
• SMAD6 Integrates Endothelial Cell Homeostatic Flow Responses Downstream of Notch

  2020cites this paper
• Flow-Induced Transcriptomic Remodeling of Endothelial Cells Derived From Human Induced Pluripotent Stem Cells

  2020cites this paper
• Development and validation of an in vitro human model of drug-induced vascular injury

  2019cites this paper
• Atorvastatin enhances endothelial adherens junctions through promoting VE-PTP gene transcription and reducing VE-cadherin-Y731 phosphorylation.

  2019cites this paper
• Helium-mediated regulation of endothelial permeability: involvement of Caveolin-1, VE-Cadherin and Connexin-43

  2019cites this paper
• Cysteine Glutathionylation Acts as a Redox Switch in Endothelial Cells

  2019cites this paper
• IL‐1&bgr; promotes transendothelial migration of PBMCs by upregulation of the FN/&agr;5&bgr;1 signalling pathway in immortalised human brain microvascular endothelial cells

  2018cites this paper
• Mind the gap: mechanisms regulating the endothelial barrier

  2018cites this paper
• SHP2 protects endothelial cell barrier through suppressing VE‐cadherin internalization regulated by MET‐ARF1

  2018cites this paper
• Interleukin-6 promotes a sustained loss of endothelial barrier function via Janus kinase-mediated STAT3 phosphorylation and de novo protein synthesis.

  2018cites this paper
• Lonidamine-ethyl ester-mediated remodelling of the Sertoli cell cytoskeleton induces phosphorylation of plakoglobin and promotes its interaction with ?-catenin at the blood?testis barrier.

  2017cites this paper
• Activation of the sweet taste receptor, T1R3, by the artificial sweetener sucralose regulates the pulmonary endothelium

  2017cites this paper
• VE-Cadherin–Mediated Epigenetic Regulation of Endothelial Gene Expression

  2017cites this paper
• The molecular basis of endothelial cell plasticity

  2017cites this paper
• Endothelial cell-cell adhesion and signaling

  2017cites this paper
• Annexin A2 supports pulmonary microvascular integrity by linking vascular endothelial cadherin and protein tyrosine phosphatases

  2017cites this paper
• Stepping out of the shadows: Oncogenic and tumor-promoting protein tyrosine phosphatases.

  2017cites this paper
• Mesenchymal state of intimal cells may explain higher propensity to ascending aortic aneurysm in bicuspid aortic valves

  2016cites this paper
• The Journal of Clinical Investigation

  2016cites this paper
• Translational Research in Acute Lung Injury and Pulmonary Fibrosis Using cultured endothelial cells to study endothelial barrier dysfunction : Challenges and opportunities

  2016cites this paper
• Src Family Kinases Modulate the Loss of Endothelial Barrier Function in Response to TNF-α: Crosstalk with p38 Signaling

  2016cites this paper
• VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread

  2016cites this paper
• The Role of Paladin in Endothelial Cell Signaling and Angiogenesis

  2016cites this paper
• Unraveling Interactions Between Anesthetics and the Endothelium: Update and Novel Insights

  2016cites this paper
• Mechanisms and regulation of endothelial VEGF receptor signalling

  2016cites this paper
• VEGF receptor signal transduction - A brief update.

  2016cites this paper
• Brain barriers: Crosstalk between complex tight junctions and adherens junctions

  2015cites this paper
• VE-cadherin in vascular development: a coordinator of cell signaling and tissue morphogenesis.

  2015cites this paper
• Regulation of Endothelial Adherens Junctions by Tyrosine Phosphorylation

  2015cites this paper
• The angiopoietin-Tie2 signaling axis in the vascular leakage of systemic inflammation

  2015cites this paper
• R3 receptor tyrosine phosphatases: conserved regulators of receptor tyrosine kinase signaling and tubular organ development.

  2015cites this paper
• HIF2α signaling inhibits adherens junctional disruption in acute lung injury.

  2015cites this paper
• Brain barriers: Crosstalk between complex tight junctions and adherens junctions

  2015cites this paper
• Neuroprotective effect of ischemic preconditioning in focal cerebral infarction: relationship with upregulation of vascular endothelial growth factor

  2014cites this paper
• Between sealing and leakiness: molecular dynamics of the endothelium to maintain and regulate barrier function

  2014cites this paper
• c-Src mediated tyrosine phosphorylation of plakophilin 3 as a new mechanism to control desmosome composition in cells exposed to oxidative stress

  2014cites this paper