Recent developments in the understanding of the pathophysiology of osteopetrosis.

No abstract is available for this paper.

• Publication year

  1996

• Venue

  European Journal of Endocrinology

• Publication date

  1996-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1530/EJE.0.1340143PMID 8630510
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Biochemical evidence of disturbed bone metabolism and calcium homeostasis in two types of autosomal dominant osteopetrosis.

  2009cited by this paper
• Defective macrophage chemotaxis in osteopetrotic mice

  2006cited by this paper
• Colony-stimulating factor-1 injections improve but do not cure skeletal sclerosis in osteopetrotic (op) mice.

  1995cited by this paper
• Detection of transcripts and binding sites for colony-stimulating factor-1 during bone development.

  1995cited by this paper
• Expression of Mac‐2 antigen in the preosteoclast and osteoclast identified in the op/op mouse injected with macrophage colony‐stimulating factor

  1994cited by this paper
• Role of colony stimulating factor-1 in the establishment and regulation of tissue macrophages during postnatal development of the mouse.

  1994cited by this paper
• c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodeling.

  1994cited by this paper
• Macrophage colony‐stimulating factor restores bone resorption in op/op bone in vitro in conjunction with parathyroid hormone or 1,25‐dihydroxyvitamin D3

  1994cited by this paper
• Granulocyte-macrophage colony-stimulating factor corrects macrophage deficiencies, but not osteopetrosis, in the colony-stimulating factor-1-deficient op/op mouse.

  1994cited by this paper
• Neonatal reductions in osteoclast number and function account for the transient nature of osteopetrosis in the rat mutation microphthalmia blanc (mib).

  1994cited by this paper
• Transient recruitment of osteoclasts and expression of their function in osteopetrotic (op/op) mice by a single injection of macrophage colony‐stimulating factor

  1993cited by this paper
• Bone marrow-derived osteoclast-like cells from a patient with craniometaphyseal dysplasia lack expression of osteoclast-reactive vacuolar proton pump.

  1993cited by this paper
• Delayed hematopoietic development in osteopetrotic (op/op) mice

  1993cited by this paper
• Activation of Src family kinases by colony stimulating factor‐1, and their association with its receptor.

  1993cited by this paper
• The skeletal effects of colony-stimulating factor-1 in toothless (osteopetrotic) rats: persistent metaphyseal sclerosis and the failure to restore subepiphyseal osteoclasts.

  1993cited by this paper
• Osteopetrosis in Src-deficient mice is due to an autonomous defect of osteoclasts.

  1993cited by this paper
• Macrophage colony‐stimulating factor release and receptor expression in bone cells

  1993cited by this paper
• Ultrastructural investigations of bone resorptive cells in two types of autosomal dominant osteopetrosis.

  1993cited by this paper
• Macrophage colony-stimulating factor is indispensable for both proliferation and differentiation of osteoclast progenitors.

  1993cited by this paper
• Experimental studies of osteopetrosis in laboratory animals.

  1993cited by this paper
• Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein.

  1993cited by this paper
• Macrophage colony-stimulating factor stimulates survival and chemotactic behavior in isolated osteoclasts

  1993cited by this paper
• Biology and Physiology of the Osteoclast

  1992cited by this paper
• Lack of bone resorption in osteosclerotic (oc/oc) mice is due to a defect in osteoclast progenitors rather than the local microenvironment provided by osteoblastic cells.

  1992cited by this paper
• Osteoclasts express high levels of pp60c-src in association with intracellular membranes

  1992cited by this paper
• Bone and haematopoietic defects in mice lacking c-fos

  1992cited by this paper
• CSF-1 deficiency in the op/op mouse has differential effects on macrophage populations and differentiation stages.

  1992cited by this paper
• Requirement of pp60c-src expression for osteoclasts to form ruffled borders and resorb bone in mice.

  1992cited by this paper
• Osteoclasts express high levels of p60c‐src , preferentially on ruffled border membranes

  1992cited by this paper
• Effect of macrophage colony-stimulating factor on in vitro osteoclast generation and bone resorption.

  1992cited by this paper
• Modulation of osteoclast differentiation.

  1992cited by this paper
• Detection of transcripts for the receptor for macrophage colony-stimulating factor, c-fms, in murine osteoclasts.

  1992cited by this paper
• Circulating macrophage colony-stimulating factor is not reduced in malignant osteopetrosis.

  1992cited by this paper
• Recombinant human interferon gamma therapy for osteopetrosis.

  1992cited by this paper
• Administration of colony stimulating factor-1 corrects some macrophage, dental, and skeletal defects in an osteopetrotic mutation (toothless, tl) in the rat.

  1992cited by this paper
• Identification of a high molecular weight macrophage colony-stimulating factor as a glycosaminoglycan-containing species.

  1992cited by this paper
• Molecular basis of human carbonic anhydrase II deficiency.

  1992cited by this paper
• Pleiotropic effects of a null mutation in the c-fos proto-oncogene.

  1992cited by this paper
• The predominant form of secreted colony stimulating factor-1 is a proteoglycan.

  1992cited by this paper
• Identification and characterization of a novel cytoskeleton-associated pp60src substrate

  1991cited by this paper
• Colony-Stimulating Factor 1 (Macrophage Colony-Stimulating-Factor)

  1991cited by this paper
• Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice.

  1991cited by this paper
• Abnormal differentiation of tissue macrophage populations in 'osteopetrosis' (op) mice defective in the production of macrophage colony-stimulating factor.

  1991cited by this paper
• Deficiency of osteoclasts in osteopetrotic mice is due to a defect in the local microenvironment provided by osteoblastic cells.

  1991cited by this paper
• The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation.

  1991cited by this paper
• A novel target cell for c‐fos‐induced oncogenesis: development of chondrogenic tumours in embryonic stem cell chimeras.

  1991cited by this paper
• Medullary bone of piglets.

  1991cited by this paper
• Tibial dimensions before and during the recovery phase in the osteopetrotic mutant mouse.

  1991cited by this paper
• Macrophage colony stimulating factor (M-CSF) is essential for osteoclast formation in vitro.

  1991cited by this paper
• IgG response is impaired in H2-c-fos transgenic mice.

  1991cited by this paper
• Congenitally osteosclerotic (os/os) rabbits are not cured by bone marrow transplantation from normal littermates.

  1991cited by this paper
• Congenital osteoclast deficiency in osteopetrotic (op/op) mice is cured by injections of macrophage colony-stimulating factor

  1991cited by this paper
• Transient infantile osteopetrosis.

  1991cited by this paper
• Oncogenes and signal transduction.

  1991cited by this paper
• Macrophage colony stimulating factor restores in vivo bone resorption in the op/op osteopetrotic mouse.

  1990cited by this paper
• Comparison of bone and parathyroid hormone as stimulators of osteoclast development and activity in calvarial cell cultures from normal and osteopetrotic (mi/mi) mice

  1990cited by this paper
• Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic (op/op) mouse.

  1990cited by this paper
• Association between the PDGF receptor and members of the src family of tyrosine kinases.

  1990cited by this paper
• Osteopetrotic (grey-lethal) bone produces collagenase and TIMP in organ culture: regulation by vitamin A.

  1990cited by this paper
• Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo.

  1990cited by this paper
• Effects of 1,25 dihydroxyvitamin D on osteoclast number and cytochemistry in normal and osteopetrotic (os) rabbits.

  1990cited by this paper
• The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene

  1990cited by this paper
• Congenital Osteopetrosis in White-tailed Deer (Odocoileus Virginianus)

  1990cited by this paper
• Rapid publication: Impairment of macrophage colony‐stimulating factor production and lack of resident bone marrow macrophages in the osteopetrotic op/op Mouse

  1990cited by this paper
• Successful treatment of infantile malignant osteopetrosis by bone marrow transplantation: A case report

  1989cited by this paper
• Structural and histomorphometric studies of iliac crest trabecular and cortical bone in autosomal dominant osteopetrosis: a study of two radiological types.

  1989cited by this paper
• Osteoclast biology in the osteopetrotic (op) rat.

  1989cited by this paper
• c-fos expression induces bone tumors in transgenic mice.

  1989cited by this paper
• Stimulation of collagenolytic enzyme release from cultured bone cells of normal and osteopetrotic (mi/mi) mice by parathyroid hormone and lipopolysaccharide.

  1989cited by this paper
• Expression of the c-fms proto-oncogene and of the cytokine, CSF-1, during mouse embryogenesis.

  1989cited by this paper
• Effects of bone marrow transplantation on impacted dental germs in osteopetrotic op/op rats.

  1989cited by this paper
• Osteoclast formation from cloned pluripotent hemopoietic stem cells.

  1989cited by this paper
• Treatment of congenital osteopetrosis in the rabbit with high‐dose 1,25‐dihydroxyvitamin D

  1989cited by this paper
• Autosomal dominant osteopetrosis: bone metabolism and epidemiological, clinical, and hormonal aspects.

  1989cited by this paper
• Successful treatment of infantile malignant osteopetrosis by bone-marrow transplantation. A case report.

  1988cited by this paper
• Stromal stem cells: marrow-derived osteogenic precursors.

  1988cited by this paper
• Skeletal biology in the toothless (osteopetrotic) rat.

  1988cited by this paper
• Osteoblastic cells are involved in osteoclast formation.

  1988cited by this paper
• Synthesis of membrane-bound colony-stimulating factor 1 (CSF-1) and downmodulation of CSF-1 receptors in NIH 3T3 cells transformed by cotransfection of the human CSF-1 and c-fms (CSF-1 receptor) genes

  1987cited by this paper
• Apparent role of the macrophage growth factor, CSF-1, in placental development

  1987cited by this paper
• The osteopetrotic rabbit: skeletal cytology and ultrastructure.

  1987cited by this paper
• Elevated serum 1,25-dihydroxyvitamin D in osteopetrotic mutations in three species.

  1987cited by this paper
• 1,25-Dihydroxyvitamin D3 stimulates rat osteoblastic cells to release a soluble factor that increases osteoclastic bone resorption.

  1987cited by this paper
• Tumor necrosis factors alpha and beta induce osteoblastic cells to stimulate osteoclastic bone resorption.

  1987cited by this paper
• Hormonal regulation of the production of collagenase and a collagenase inhibitor activity by rat osteogenic sarcoma cells.

  1987cited by this paper
• Congenitally osteosclerotic (oc/oc) mice are resistant to cure by transplantation of bone marrow or spleen cells from normal littermates.

  1987cited by this paper
• [Experimental osteopetrosis].

  1987cited by this paper
• Congenital murine osteopetrosis inherited with osteosclerotic (oc) gene: hematological characterization.

  1986cited by this paper
• Osteoblasts mediate interleukin 1 stimulation of bone resorption by rat osteoclasts

  1986cited by this paper
• The osteopetrotic rabbit: general and skeletal features of a new outbred stock.

  1986cited by this paper
• In vitro osteoclast generation from different bone marrow fractions, including a highly enriched haematopoietic stem cell population

  1986cited by this paper
• Osteoblast-like cells in the presence of parathyroid hormone release soluble factor that stimulates osteoclastic bone resorption.

  1986cited by this paper
• Differentiation kinetics of osteoclasts in the periosteum of embryonic bones in vivo and in vitro

  1986cited by this paper
• Neutrophil defect associated with malignant infantile osteopetrosis.

  1986cited by this paper
• Abundant calcitonin receptors in isolated rat osteoclasts. Biochemical and autoradiographic characterization.

  1986cited by this paper
• Fusion disability of embryonic osteoclast precursor cells and macrophages in the microphthalmic osteopetrotic mouse.

  1985cited by this paper
• Morphological evidence of reduced bone resorption in the osteosclerotic (oc) mouse.

  1985cited by this paper
• Osteoclast populations in congenital osteopetrosis: additional evidence of heterogeneity.

  1984cited by this paper
• Mouse osteoblasts synthesize collagenase in response to bone resorbing agents.

  1984cited by this paper
• Congenitally osteopetrotic (oplop) mice are not cured by transplants of spleen or bone marrow cells from normal littermates.

  1984cited by this paper

• Tissue adaptation of CD4 T lymphocytes in homeostasis and cancer.

  2024cites this paper
• Differential osteoblastic activity in primary metaphyseal trabecular and secondary trabeculae of c-fos deficient mice.

  2023cites this paper
• Carbonic anhydrase II deficiency.

  2023cites this paper
• Calcium released by osteoclastic resorption stimulates autocrine/paracrine activities in local osteogenic cells to promote coupled bone formation.

  2022cites this paper
• A cross-sectional nationwide survey of osteosclerotic skeletal dysplasias in Japan.

  2021cites this paper
• Visualization of mandibular movement relative to the maxilla during mastication in mice: integration of kinematic analysis and reconstruction of a three-dimensional model of the maxillofacial structure

  2021cites this paper
• Inhibition of osteogenic and adipogenic potential in bone marrow-derived mesenchymal stem cells under osteoporosis.

  2020cites this paper
• Neurosurgical considerations in osteopetrosis

  2020cites this paper
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• Visual Function Improvement After Optic Nerve Sheath Fenestration in Osteopetrosis Patients with Optic Canal Stenosis: A Report of Two Cases

  2018cites this paper
• Impact of hematopoietic stem cell transplant on VEP and ABR values of the patients with malignant infantile osteopetrosis.

  2018cites this paper
• Histochemical assessment for osteoblastic activity coupled with dysfunctional osteoclasts in c-src deficient mice.

  2017cites this paper
• Decreased bone mineral density in experimental myasthenia gravis in C57BL/6 mice

  2017cites this paper
• Osteomyelitis In Mandible in A Case of Infantile Osteopetrosis : A Case Report And Review of Literature

  2017cites this paper
• Extracellular Iron is a Modulator of the Differentiation of Osteoclast Lineage Cells

  2016cites this paper
• [Malignant infantile osteopetrosis revealed by choanal atresia: A case report].

  2016cites this paper
• Osteoblasts in the Vicinity of Osteoclasts in a Case of Infantile Osteopetrosis

  2016cites this paper
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  2015cites this paper
• Infant cynomolgus monkeys exposed to denosumab in utero exhibit an osteoclast-poor osteopetrotic-like skeletal phenotype at birth and in the early postnatal period.

  2014cites this paper
• Impact of Dietary Aromatic Amino Acids on Osteoclastic Activity

  2014cites this paper
• anhydrase II deficiency syndrome Bone marrow transplantation corrects osteopetrosis in the carbonic

  2013cites this paper
• Association of possible osteopetrosis with acute myeloid leukaemia in a child

  2013cites this paper
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  2013cites this paper
• The Role of Src Kinase in Macrophage-Mediated Inflammatory Responses

  2012cites this paper
• A Case Report of Malignant Infantile Osteopetrosis

  2012cites this paper
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  2011cites this paper
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  2004cites this paper
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  2004cites this paper
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  2004cites this paper
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  2004cites this paper
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  2004cites this paper
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  2004cites this paper
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  2004cites this paper
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  2004cites this paper
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  2003cites this paper
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