Paneth cell defensins: Endogenous peptide components of intestinal host defense

No abstract is available for this paper.

• Publication year

  1996

• Venue

  The FASEB Journal

• Publication date

  1996-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1096/fasebj.10.11.8836041PMID 8836041
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Effect of live and heat-killed bacteria on the secretory activity of Paneth cells in germ-free mice

  2004cited by this paper
• Positional specificity of defensin gene expression reveals Paneth cell heterogeneity in mouse small intestine.

  1996cited by this paper
• Human Enteric Defensins

  1996cited by this paper
• Human enteric defensin genes: chromosomal map position and a model for possible evolutionary relationships.

  1996cited by this paper
• Structure, function, and membrane integration of defensins.

  1995cited by this paper
• Defensins in granules of phagocytic and non-phagocytic cells.

  1995influential reference
• The pro region of human neutrophil defensin contains a motif that is essential for normal subcellular sorting.

  1995cited by this paper
• Cathelicidins: a novel protein family with a common proregion and a variable C‐terminal antimicrobial domain

  1995cited by this paper
• Defensins and other endogenous peptide antibiotics of vertebrates

  1995cited by this paper
• Bactericidal properties of murine intestinal phospholipase A2.

  1995cited by this paper
• Killing of Giardia lamblia by cryptdins and cationic neutrophil peptides

  1994cited by this paper
• Interactions between human defensins and lipid bilayers: Evidence for formation of multimeric pores

  1994influential reference
• Structure and diversity of the murine cryptdin gene family.

  1994cited by this paper
• Defensins.

  1994cited by this paper
• Structure and dynamics of the neutrophil defensins NP‐2, NP‐5, and HNP‐1: NMR studies of amide hydrogen exchange kinetics

  1994cited by this paper
• A family of defensin-like genes codes for diverse cysteine-rich peptides in mouse Paneth cells.

  1994influential reference
• Individual and synergistic effects of rabbit granulocyte proteins on Escherichia coli.

  1994cited by this paper
• Defensins: a family of antimicrobial and cytotoxic peptides.

  1994cited by this paper
• Mouse Paneth cell defensins: primary structures and antibacterial activities of numerous cryptdin isoforms

  1994influential reference
• Paneth cell differentiation in the developing intestine of normal and transgenic mice.

  1994influential reference
• Enhancing factor, a Paneth cell specific protein from mouse small intestines: predicted amino acid sequence from RT-PCR amplified cDNA and its expression.

  1993cited by this paper
• Investigational approaches for studying the structures and biological functions of myeloid antimicrobial peptides.

  1993cited by this paper
• Defensin‐6 mRNA in human Paneth cells: implications for antimicrobia peptides in host defense of the human bowel

  1993cited by this paper
• Enhancing factor, a Paneth cell specific protein from mouse small intestines: predicted amino acid sequence from RT-PCR amplified cDNA and its expression.

  1993cited by this paper
• Detection of CD1 mRNA in Paneth cells of the mouse intestine by in situ hybridization.

  1992cited by this paper
• Posttranslational processing of defensins in immature human myeloid cells.

  1992cited by this paper
• Cryptdins: antimicrobial defensins of the murine small intestine

  1992cited by this paper
• NMR studies of defensin antimicrobial peptides. 2. Three-dimensional structures of rabbit NP-2 and human HNP-1.

  1992cited by this paper
• The defensin-related murine CRS1C gene: expression in Paneth cells and linkage to Defcr, the cryptdin locus.

  1992cited by this paper
• Paneth cells of the human small intestine express an antimicrobial peptide gene.

  1992cited by this paper
• Cationic defensins arise from charge‐neutralized propeptides: a mechanism for avoiding leukocyte autocytotoxicity?

  1992cited by this paper
• Enteric defensins: antibiotic peptide components of intestinal host defense

  1992influential reference
• Antibacterial peptides: key components needed in immunity.

  1991cited by this paper
• Epithelial cell differentiation in normal and transgenic mouse intestinal isografts

  1991cited by this paper
• Crystal structure of defensin HNP-3, an amphiphilic dimer: mechanisms of membrane permeabilization.

  1991cited by this paper
• Human intestine matures as nude mouse xenograft.

  1991cited by this paper
• A novel mouse gene family coding for cationic, cysteine-rich peptides. Regulation in small intestine and cells of myeloid origin.

  1990cited by this paper
• Interaction of human defensins with Escherichia coli. Mechanism of bactericidal activity.

  1989cited by this paper
• Determination of the disulfide array in the human defensin HNP-2. A covalently cyclized peptide.

  1989cited by this paper
• Assignment of defensin gene(s) to human chromosome 8p23.

  1989cited by this paper
• Localization of the cryptdin locus on mouse chromosome 8.

  1989cited by this paper
• Developmental regulation of cryptdin, a corticostatin/defensin precursor mRNA in mouse small intestinal crypt epithelium

  1989cited by this paper
• Concurrent assessment of inner and outer membrane permeabilization and bacteriolysis in E. coli by multiple-wavelength spectrophotometry.

  1988cited by this paper
• Immunohistochemical observations of lysozyme in the Paneth cells of specific-pathogen-free and germ-free mice.

  1988cited by this paper
• Antibacterial activity of microbicidal cationic proteins 1 and 2, natural peptide antibiotics of rabbit lung macrophages

  1983cited by this paper
• The Paneth cell: a source of intestinal lysozyme.

  1975cited by this paper
• Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. IV. Paneth cells.

  1974cited by this paper
• Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. V. Unitarian Theory of the origin of the four epithelial cell types.

  1974cited by this paper
• Lysozyme in Paneth cell secretions.

  1973cited by this paper
• Paneth cell function: phagocytosis and intracellular digestion of intestinal microorganisms. I. Hexamita muris.

  1972cited by this paper
• Paneth cell function: phagocytosis and intracellular digestion of intestinal microorganisms. II. Spiral microorganism.

  1972cited by this paper
• PANETH AND GOBLET CELL RENEWAL IN MOUSE DUODENAL CRYPTS

  1969cited by this paper
• Renewal of Paneth cells in the small intestine of the mouse.

  1969cited by this paper
• Pattern of Secretion of Paneth Cells of the Small Intestine of Mice

  1967cited by this paper
• LOCALIZATION OF SULFHYDRYL AND DISULFIDE GROUPS OF PROTEIN IN PANETH CELL SECRETION OF THE MOUSE INTESTINE

  1962cited by this paper
• Ueber die secernirenden Zellen des Dünndarm-Epithels

  1887cited by this paper

• Chronic Heat Stress Can Induce Conjugation of a Novel ermB-Containing ICEFZMF, Increasing Resistance to Erythromycin Among Enterococcus Strains in Diverse Intestinal Segments in the Mouse Model

  2025cites this paper
• Recent advances in biomarkers for senescence: Bridging basic research to clinic

  2025cites this paper
• The underlying mechanism of nuclear and mitochondrial DNA damages in triggering cancer incidences: Insights into proteomic and genomic sciences.

  2024cites this paper
• Genetic variance in the murine defensin locus modulates glucose homeostasis

  2024cites this paper
• Design of Potent and Salt-Insensitive Antimicrobial Branched Peptides

  2023cites this paper
• Antimicrobial Peptides (AMPs): Potential Therapeutic Strategy against Trypanosomiases?

  2023cites this paper
• The impact of gut microbiota on vascularization of the small intestine

  2023cites this paper
• Antimicrobial Properties and Mode of Action of Cryptdin-4, a Mouse α-Defensin Regulated by Peptide Redox Structures and Bacterial Cultivation Conditions

  2023cites this paper
• Gut Microbiota Modulation for Therapeutic Management of Various Diseases: A New Perspective Using Stem Cell Therapy.

  2022cites this paper
• Mouse α-Defensins: Structural and Functional Analysis of the 17 Cryptdin Isoforms Identified from a Single Jejunal Crypt

  2022cites this paper
• Microbiota and Metabolites as Factors Influencing Blood Pressure Regulation.

  2021cites this paper
• General Concepts of Immunity

  2021cites this paper
• Effect of a High-Fat Diet on the Small-Intestinal Environment and Mucosal Integrity in the Gut-Liver Axis

  2021cites this paper
• Structure and Function of the Immune System

  2021cites this paper
• Microbial recognition regulates intestinal epithelial growth in homeostasis and disease

  2021cites this paper
• Mechanism of deoxynivalenol mediated gastrointestinal toxicity: Insights from mitochondrial dysfunction.

  2021cites this paper
• Insight into the Animal Models for Microbiome Studies

  2021cites this paper
• Links between Nutrition, Infectious Diseases, and Microbiota: Emerging Technologies and Opportunities for Human-Focused Research

  2020cites this paper
• Immune modulations and survival strategies of evolved hypervirulent Salmonella Typhimurium strains.

  2020cites this paper
• A role of PSA-NCAM in the survival of retinal ganglion cells (RGCs) after kainic acid damage.

  2019cites this paper
• Microbial Infections as a Trigger for Acute-on-Chronic Liver Failure: A Review

  2019cites this paper
• Paneth Cells during Viral Infection and Pathogenesis

  2018cites this paper
• Expression of α-Defensins, CD20+ B-lymphocytes, and Intraepithelial CD3+ T-lymphocytes in the Intestinal Mucosa of Patients with Liver Cirrhosis: Emerging Mediators of Intestinal Barrier Function

  2018cites this paper
• 6 Defensins in Ulcerative Colitis

  2018cites this paper
• Characterization of a Gloverin-Like Antimicrobial Peptide Isolated from Muga Silkworm, Antheraea assamensis

  2018cites this paper
• Human Antimicrobial Peptides in Bodily Fluids: Current Knowledge and Therapeutic Perspectives in the Postantibiotic Era

  2017cites this paper
• Gut Microbial Influences on the Mammalian Intestinal Stem Cell Niche

  2017cites this paper
• Convergent evolution of defensin sequence, structure and function

  2017cites this paper
• Mechanisms of angiogenesis in microbe-regulated inflammatory and neoplastic conditions

  2017cites this paper
• Food quality affects the expression of antimicrobial peptide genes upon simulated parasite attack in the larvae of greater wax moth

  2017cites this paper
• Antimicrobial peptides as an alternative to anti-tuberculosis drugs.

  2017cites this paper
• Engineering the Niche for Intestinal Regeneration

  2017cites this paper
• Transfer of Maternal Immune Cells by Breastfeeding: Maternal Cytotoxic T Lymphocytes Present in Breast Milk Localize in the Peyer’s Patches of the Nursed Infant

  2016cites this paper
• Characterization of the antimicrobial peptide family defensins in the Tasmanian devil (Sarcophilus harrisii), koala (Phascolarctos cinereus), and tammar wallaby (Macropus eugenii)

  2016cites this paper
• the mucosal barrier IV. Paneth cell antimicrobial peptides and the biology of

  2016cites this paper
• Tissue- and age-dependent expression of the bovine DEFB103 gene and protein

  2016cites this paper
• Mechanisms and consequences of bacterial resistance to antimicrobial peptides.

  2016cites this paper
• An investigation of the effects of an antimicrobial peptide on the survival of Acanthamoeba and intracellular bacteria associated with cystic fibrosis

  2016cites this paper
• Molecular Evolutionary Analysis of β-Defensin Peptides in Vertebrates

  2015cites this paper
• Peptides and Peptidomimetics for Antimicrobial Drug Design

  2015cites this paper
• The Tumor Suppressor RASSF1A Links Inflammation and Cancer

  2015cites this paper
• Characterization of natural antimicrobial peptides adsorbed to different matrices

  2015cites this paper
• Molecular Characterization and In Silico Analysis of Defensin From Tor putitora (Hamilton)

  2015cites this paper
• The First Line of Defense

  2015cites this paper
• Apoptotic human neutrophil peptide-1 anti-tumor activity revealed by cellular biomechanics.

  2015cites this paper
• How informative is the mouse for human gut microbiota research?

  2015cites this paper
• 4 – Innate (General or Nonspecific) Host Defense Mechanisms

  2015cites this paper
• Correction for Herrera et al., The Vibrio cholerae VprA-VprB Two-Component System Controls Virulence through Endotoxin Modification

  2015cites this paper
• Cinética de expresión de inmunoglobulina a en el epitelio intestinal de crías de alpaca (Vicugna pacos)

  2014cites this paper
• Macaque Small Intestine -Defensins from Rhesus α

  2014cites this paper
• Evolutionary Divergence in Human Versus Mouse Innate Immune Gene Regulation and Function

  2014cites this paper
• IL-25 Improves Luminal Innate Immunity and Barrier Function During Parenteral Nutrition

  2014cites this paper
• Evolution of primate α and θ defensins revealed by analysis of genomes

  2014cites this paper
• The Vibrio cholerae VprA-VprB Two-Component System Controls Virulence through Endotoxin Modification

  2014cites this paper
• INTERNATIONAL JOURNAL OF CURRENT RESEARCH IN CHEMISTRY AND PHARMACEUTICAL SCIENCES

  2014cites this paper
• Insights into Vibrio cholerae Intestinal Colonization from Monitoring Fluorescently Labeled Bacteria

  2014cites this paper
• ANTIMICROBIAL PEPTIDES FORM MICROBES - REVIEW

  2014cites this paper
• Defensins: antifungal lessons from eukaryotes

  2014cites this paper
• The Enteric Nervous System Neuropeptide, Bombesin, Reverses Innate Immune Impairments During Parenteral Nutrition

  2014cites this paper
• Parenteral nutrition decreases paneth cell function and intestinal bactericidal activity while increasing susceptibility to bacterial enteroinvasion.

  2014cites this paper
• Prevention of Osteoporosis by Physical Signals

  2013cites this paper
• Analysis of intestinal factors contributing to the age-dependency of systemic neuropathogenic Escherichia coli K1 infection in the neonatal rat

  2013cites this paper
• Interactions of intestinal epithelial cells with bacterial extracellular products

  2013influential citation
• Cellular Response to Trypanosoma cruzi Infection Induces Secretion of Defensin α-1, Which Damages the Flagellum, Neutralizes Trypanosome Motility, and Inhibits Infection

  2013cites this paper
• JAK-STAT and intestinal mucosal immunology

  2013cites this paper
• Midkine - a host defence protein

  2013cites this paper
• Behavioral and genetic characteristics of intestinal cell lineages in health and disease

  2013cites this paper
• Tumor-Infiltrating Immune Cells Promoting Tumor Invasion and Metastasis: Existing Theories

  2013cites this paper
• Parenteral nutrition increases susceptibility of ileum to invasion by E coli.

  2013cites this paper
• Study of the effects of the antifungal defensin Psd1 in Candida albicans using atomic force microscopy and flow cytometry

  2013cites this paper
• Parenteral nutrition suppresses the bactericidal response of the small intestine.

  2013cites this paper
• Cranberry proanthocyanidins improve the gut mucous layer morphology and function in mice receiving elemental enteral nutrition.

  2013cites this paper
• Study of the effects of the antifungal defensin Psd1 in Candida albicans using atomic force microscopy and flow cytometry

  2013cites this paper
• Cationic Host Defence Peptides: Potential as Antiviral Therapeutics

  2013cites this paper
• Microbial Programming of the Neonatal Pig

  2013cites this paper
• Functional interactions between matrix metalloproteinases and glycosaminoglycans

  2013cites this paper
• Antibacterial activity of protein extract of marine Pseudomonas aeruginosa against bacterial pathogens

  2013cites this paper
• Isolation, evaluation and purification of antibacterial peptides from rhinoceros beetle, Oryctes rhinoceros (L.)

  2012cites this paper
• Biotic stress resistance in agriculture through antimicrobial peptides.

  2012cites this paper
• Efficiency of Probiotics in Farm Animals

  2012cites this paper
• Route and Type of Nutrition and Surgical Stress Influence Secretory Phospholipase A2 (sPLA2) Secretion of the Murine Small Intestine

  2012cites this paper
• Leishmania major Infection in Humanized Mice Induces Systemic Infection and Provokes a Nonprotective Human Immune Response

  2012cites this paper
• α-Defensins and hsCRP levels in inflammatory response of standard and laparoendoscopic single-site cholecystectomy

  2012cites this paper
• Desarrollo del epitelio del tracto intestinal y su participación en la defensa del organismo en mamíferos

  2012cites this paper
• Route and type of nutrition and surgical stress influence secretory phospholipase A2 secretion of the murine small intestine.

  2011cites this paper
• Modelling intestinal cancer development and progression in the mouse

  2011cites this paper
• Antimicrobial peptides in healthy skin and atopic dermatitis.

  2011cites this paper
• Defensins in Ulcerative Colitis

  2011cites this paper
• Antimicrobial peptide killing of African trypanosomes

  2011cites this paper
• Impaired Pulmonary Host Defense Against Pseudomonas aeruginosa Following Bone Marrow Transplantation.

  2011cites this paper
• Antibacterial Proteins and Peptides in Nurse Shark ( Ginglymostoma Cirratum ) Peripheral Blood Leukocytes

  2011cites this paper
• Antimicrobial peptides and proteins of the horse - insights into a well-armed organism

  2011cites this paper
• α-Defensin Expression of Inflammatory Response in Open and Laparoscopic Colectomy for Colorectal Cancer

  2011cites this paper
• Mouse and human intestinal immunity: same ballpark, different players; different rules, same score

  2011cites this paper
• Antimicrobial peptides and their use in medicine

  2010cites this paper
• Intestinal epithelial cells and their role in innate mucosal immunity

  2010cites this paper
• [Zinc and the secretory material content in blood granulocytes and in basal parts of intestine crypts during stress].

  2010cites this paper
• Antimicrobial anxiety: the impact of stress on antimicrobial immunity

  2010cites this paper
• Toxoplasma gondii Intestinal {alpha}-Defensins by TLR9-Dependent Induction of

  2010cites this paper
• TLR9-Dependent Induction of Intestinal α-Defensins by Toxoplasma gondii

  2010cites this paper