DEGRANULATION OF POLYMORPHONUCLEAR LEUCOCYTES FOLLOWING PHAGOCYTOSIS OF MICROORGANISMS

A marked reduction in numbers of cytoplasmic granules in rabbit and human polymorphonuclear leucocytes takes place following ingestion of various microorganisms or of a yeast cell wall preparation. The degranulation occurs within 30 minutes of phagocytosis, and is directly related to the quantity of material engulfed. White cells completely degranulated following phagocytosis of large numbers of microorganisms remain viable for at least 1 hour. The granules of polymorphonuclear leucocytes contain the antimicrobial agent, phagocytin, and various digestive enzymes. These substances thus are released into the cytoplasm or into vacuoles following ingestion of foreign material. The granule system and granule lysis mechanism may well play a central role in the primary function of these specialized cells; namely, that of destroying invading microorganisms.

• Publication year

  1960

• Venue

  Journal of Experimental Medicine

• Publication date

  1960-11-30

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1084/JEM.112.6.1005PMID 13714579PMCID 2137318
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• STUDIES OF PHAGOCYTOSIS OF GROUP A STREPTOCOCCI BY POLYMORPHONUCLEAR LEUCOCYTES IN VITRO

  1960cited by this paper
• THE ISOLATION AND PROPERTIES OF THE SPECIFIC CYTOPLASMIC GRANULES OF RABBIT POLYMORPHONUCLEAR LEUCOCYTES

  1960cited by this paper
• Antimicrobial factors in tissues and phagocytic cells.

  1960cited by this paper
• The physiology of granulocytic cells in normal and leukemic states.

  1960cited by this paper
• FUNCTIONAL AND METABOLIC PROPERTIES OF POLYMORPHONUCLEAR LEUCOCYTES

  1960cited by this paper
• FUNCTIONAL AND METABOLIC PROPERTIES OF POLYMORPHONUCLEAR LEUCOCYTES

  1960cited by this paper
• Phagocytosis of M. tuberculosis and M. smegmatis stained with indicator dyes.

  1956cited by this paper
• THE RELATIVE REACTION WITHIN LIVING MAMMALIAN TISSUES

  1926cited by this paper
• THE RELATIVE REACTION WITHIN LIVING MAMMALIAN-TISSUES

  1925cited by this paper

• Local inflammation at the salmon louse (Lepeophtheirus salmonis) attachment site contributes to copepodid rejection in coho salmon (Oncorhynchus kisutch)

  2025cites this paper
• Two-component macrophage model for active phagocytosis with pseudopod formation.

  2024cites this paper
• Conceptual Contextualization of Neutrophilic Dermatoses

  2024cites this paper
• Trypanosoma brucei Lipophosphoglycan Activates Host Immune Responses via the TLR-mediated p38 MAP Kinase and NF-κB Pathways

  2023cites this paper
• A short history of innate immunity

  2023cites this paper
• Protrudin-mediated ER-endosome contact sites promote phagocytosis

  2023cites this paper
• On neutrophil extracellular traps in leukocyte-dependent inflammation

  2022cites this paper
• The Role of the Oral Immune System in Oropharyngeal Candidiasis-Facilitated Invasion and Dissemination of Staphylococcus aureus

  2022cites this paper
• DNA Repair in Staphylococcus aureus

  2021cites this paper
• Modulation of Immune Responses by Particle Size and Shape

  2021cites this paper
• Physical Constraints and Forces Involved in Phagocytosis

  2020cites this paper
• Imaging the neutrophil: Intravital microscopy provides a dynamic view of neutrophil functions in host immunity.

  2020cites this paper
• Staphylococcal DNA Repair Is Required for Infection

  2020cites this paper
• Staphylococcal DNA repair confers tolerance of the bactericidal activity of both 2 neutrophils and antibiotics 3 4

  2020cites this paper
• Combating Implant Infections: Shifting Focus from Bacteria to Host

  2020cites this paper
• Myeloperoxidase - A bridge linking inflammation and oxidative stress with cardiovascular disease.

  2019cites this paper
• Cytosolic Fe-superoxide dismutase safeguards Trypanosoma cruzi from macrophage-derived superoxide radical

  2019cites this paper
• Reactive Oxygen Species Generation in Neutrophils: Modulation by Nitric Oxide

  2019cites this paper
• MPO (Myeloperoxidase) Caused Endothelial Dysfunction.

  2018cites this paper
• GSDMB promotes non-canonical pyroptosis by enhancing caspase-4 activity.

  2018cites this paper
• F4/80 as a Major Macrophage Marker: The Case of the Peritoneum and Spleen

  2017cites this paper
• Neutrophils and Ly6Chi monocytes collaborate in generating an optimal cytokine response that protects against pulmonary Legionella pneumophila infection

  2017cites this paper
• F4/80 as a Major Macrophage Marker: The Case of the Peritoneum and Spleen.

  2017cites this paper
• The μ-calpain-ezrin axis : a potential target for therapy in inflammatory disease

  2017cites this paper
• Neutrophil killing of Staphylococcus aureus In Sepsis

  2017cites this paper
• Myeloperoxidase: A new player in autoimmunity.

  2017cites this paper
• Differential Signalling and Kinetics of Neutrophil Extracellular Trap Release Revealed by Quantitative Live Imaging

  2017cites this paper
• Evasion of Neutrophil Killing by Staphylococcus aureus

  2016cites this paper
• The impact of antipsychotic drugs on the expression of genes associated with obesity

  2016cites this paper
• TREM‐like transcript 2 is stored in human neutrophil primary granules and is up‐regulated in response to inflammatory mediators

  2016cites this paper
• Release of Histamine from Human Basophils

  2016cites this paper
• Placental histology and neutrophil extracellular traps in lupus and pre-eclampsia pregnancies

  2016cites this paper
• Staphylococcus Aureus Biofilms Interfere With Macrophage Antimicrobial Responses Through Differential Gene Regulation, Toxin Production, and Purine Metabolism

  2016cites this paper
• Synthesis of oxidant prone nanosilver to develop H2O2 responsive drug delivery system.

  2015cites this paper
• Biomarkers of urinary tract infections: state of the art, and promising applications for rapid strip-based chemical sensors

  2015cites this paper
• Redox State Of Erythrocyte Peroxiredoxin 2 During Oxidative Stress And Its Effect On Membrane Binding

  2015cites this paper
• Do neutrophil extracellular traps contribute to the heightened risk of thrombosis in inflammatory diseases?

  2015cites this paper
• Neutrophil priming and host inflammation: The roles of NOX2 and toll-like receptors

  2014cites this paper
• Redox Reactions and Microbial Killing in the Neutrophil Phagosome

  2013cites this paper
• Aus der Klinik für Allgemeine und Interventionelle Kardiologie des Universitären

  2013cites this paper
• Myeloperoxidase: a front‐line defender against phagocytosed microorganisms

  2013cites this paper
• α‐Defensins in human innate immunity

  2012cites this paper
• The historical milestones in the understanding of leukocyte biology initiated by Elie Metchnikoff

  2011cites this paper
• Neutrophils in innate host defense against Staphylococcus aureus infections

  2011cites this paper
• Small molecule inhibition of Staphylococcus aureus virulence

  2011cites this paper
• Activated human neutrophil response to perfluorocarbon nanobubbles: oxygen-dependent and -independent cytotoxic responses.

  2011cites this paper
• Genetic and dietary effects on chicken heterophil function and immune response to Salmonella enteritidis

  2010cites this paper
• Aktivierung von neutrophilen Granulozyten ist ein zeitlicher Vorläufer von myokardialen Zellschäden bei akutem Myokardinfarkt

  2010cites this paper
• Contribution of serum and cellular factors in host defense reactions. II. Cellular factors in host resistance.

  2010cites this paper
• Phagocytosis of Salmonella typhimurium 395 MR10 by rabbit polymorphonuclear leucocytes: formation of phagolysosomes demonstrated by zonal separation.

  2009cites this paper
• INTERNAL DEFENSES OF CRUSTACEA : A REVIEWl

  2009cites this paper
• Host defense and pathogenesis in Staphylococcus aureus infections.

  2009cites this paper
• The distribution of some hydrolytic enzymes in the cells of the digestive gland of certain lamellibranchs and gastropods

  2009cites this paper
• Cationic proteins of human granulocytes. I. Isolation of the cationic proteins from the granules of leukaemic myeloid cells.

  2009cites this paper
• Influence of the cell surface lipopolysaccharide structure of Salmonella typhimurium on resistance to intracellular bactericidal systems.

  2009cites this paper
• STUDIES ON HUMAN LEUKOCYTE MOTILITY . II . EFFECTS OF BACTERIAL ENDOTOXIN ON LEUKOCYTE MIGRATION , ADHESIVENESS , AND AGGREGATIONt While polymorphonuclear leukocytes

  2008cites this paper
• Inflammation and tissue destruction in arthritides and periodontal disease

  2008cites this paper
• Overview of Immunity

  2008cites this paper
• The role of chloride anion and CFTR in killing of Pseudomonas aeruginosa by normal and CF neutrophils

  2008cites this paper
• Voltage-gated proton channels

  2008cites this paper
• AN ELECTRON-MICROSCOPE STUDY OF NATURALLY OCCURRING AND CULTURED CELLS OF NEZSSERZA

  2008cites this paper
• Defensyny i katelicydyny jako naturalne antybiotyki peptydowe Defensins and cathelicidins as natural peptide antibiotics

  2008cites this paper
• DISSEMINATED INTRAVASCULAR COAGULATION I N COCCAL ENDOTOXIN A N D MATERIALS EGESTED F R O M LEUCOCYTES CONTAINING MENINGOCOCCI RABBITS: SYNERGISTIC ACTIVITY O F MENINGO-

  2008cites this paper
• [Defensins and cathelicidins as natural peptide antibiotics].

  2008cites this paper
• Cellular Inflammation in Models of Acute Gout

  2008cites this paper
• Die Rolle der polymorphzelligen Leukozyten bei der Schädigung der Lunge durch Endotoxin

  2007cites this paper
• Streptococcus pyogenes bacteria modulate membrane traffic in human neutrophils and selectively inhibit azurophilic granule fusion with phagosomes

  2006cites this paper
• Untersuchungen zur LE-Zellgenese im Supravitalpräparat

  2005cites this paper
• The polymorphonuclear leukocyte

  2005cites this paper
• Neutrophilic Function in Animals with the Chediak-Higashi Syndrome

  2005cites this paper
• Release of Histamine from Human Basophils

  2005cites this paper
• BIOPHYSICAL ASPECTS OF MICROSPHERE ENGULFMENT

  2005cites this paper
• Oxidative cytochemistry in phagocytosis: the interface between structure and function

  2005cites this paper
• Myeloperoxidase: friend and foe

  2005cites this paper
• Die Bildung zytoplasmatischer Vakuolen phagozytierender neutrophiler Granulozyten während Sauerstoff- und Stickstoff-Begasung im in vitro-Versuch

  2005cites this paper
• Cathepsin G and elastase in synovial fluid and peripheral blood in reactive and rheumatoid arthritis

  2005cites this paper
• Neutrophils in the innate immune response.

  2005cites this paper
• Membrane retrieval in neutrophils during phagocytosis: inhibition by M protein‐expressing S. pyogenes bacteria

  2004cites this paper
• Light and electron microscopy of the leucocytes of Crassostrea virginica (Mollusca: Pelecypoda)

  2004cites this paper
• Die Wirkung von Melittin auf isolierte lysosomale Granula und polymorphkernige Leukocyten in vitro

  2004cites this paper
• Electron microscopic study of the in vivo erythrophagocytosis by alveolar macrophages of the cat

  2004cites this paper
• Electron microscopic study of the in vivo erythrophagocytosis by alveolar macrophages of the cat

  2004cites this paper
• KLI NISCHE WOCHEN SCHRIFT

  2004cites this paper
• Scanning electron microscopic observations of early stages of phagocytosis of E. coli by human neutrophils

  2004cites this paper
• Fine structure of germ cells and Sertoli cells during the cycle of the seminiferous epithelium in the rat

  2004cites this paper
• Bacterial responses to neutrophil phagocytosis

  2004cites this paper
• Primate defensins

  2004cites this paper
• IODINATION OF BACTERIA Materials and Methods Determination of Bactericidal Effect

  2003cites this paper
• THE ENHANCEMENT OF BACTERIAL PHAGOCYTOSIS BY SERUM THE ROLE OF COMPLEMENT COMPONENTS AND TWO COFACTORS

  2003cites this paper
• FATE OF STAPHYLOCOCCI WITHIN HUMAN LEUKOCYTES* Bx MARIAN ANN MELLY,

  2003cites this paper
• ACCESSORY PLASMA FACTORS INVOLVED IN THE BACTERICIDAL TEST FOR TYPE-SPECIFIC ANTIBODY TO GROUP A STREPTOCOCCI* I. ATYPICAL BEHAVIOR OF SOME HUMAN AND RABBIT BLOODS

  2003cites this paper
• THE FATE OF BACTERIA WITHIN PHAGOCYTIC CELLS III. DESTRUCTION OF AN ESCHERICHIA COLI AGOLUTINOGEN WITHIN POLYMORPHONUCLEAR LEUCOCYTES AND I~IACROPHAGES* BY ZANVIL

  2003cites this paper
• Pkagocyt ~ c Properties of BCG-Induced Alveolar Macrophages

  2003cites this paper
• T H E FATE OF BACTERIA W I T H I N PHAGOCYTIC CELLS I. THE DEGRADATION OF ISOTOPICALLY LABELED BACTERIA BY POLYMORPHONUCLEAR LEUCOCYTES

  2003cites this paper
• Factors involved in the pathogenesis of neutrophilic vasculitis in MRL/Mp-lpr/lpr mice: a model for human microscopic angiitis.

  1999cites this paper
• Acidification of the phagosome in Crassostrea virginica hemocytes following engulfment of zymosan.

  1999cites this paper
• Origins and development of peptide antibiotic research

  1998cites this paper
• Inside the neutrophil phagosome: oxidants, myeloperoxidase, and bacterial killing.

  1998cites this paper
• Identification of glyceraldehyde‐3‐phosphate dehydrogenase as a Ca2+‐dependent fusogen in human neutrophil cytosol

  1998cites this paper
• Video-rate dynamics of exocytotic events associated with phagocytosis in neutrophils.

  1997cites this paper