Draft toxicological profile for perfluoroalkyls

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Unknown venue

• Publication date

  2009-05-01

• Fields of study

  Medicine, Chemistry, Engineering, Environmental Science

• Identifiers

  No identifiers available.

• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Physiologically Based Pharmacokinetic Modelling

  2009cited by this paper
• Perfluorinated compounds--exposure assessment for the general population in Western countries.

  2009cited by this paper
• The relationship between birth weight, gestational age and perfluorooctanoic acid (PFOA)-contaminated public drinking water.

  2009cited by this paper
• Preliminary observations on perfluorinated compounds in plasma samples (1977-2004) of young German adults from an area with perfluorooctanoate-contaminated drinking water.

  2009cited by this paper
• Contribution to the evaluation of reference values for PFOA and PFOS in plasma of children and adults from Germany.

  2009cited by this paper
• Polyfluorinated chemicals in a spatially and temporally integrated food web in the Western Arctic.

  2008cited by this paper
• Perfluorooctane sulfonate and other fluorochemicals in waterbird eggs from south China.

  2008cited by this paper
• Spatial trends of perfluoroalkyl compounds in ringed seals (Phoca hispida) from the Canadian Arctic

  2008cited by this paper
• Existence of nonpoint source of perfluorinated compounds and their loads in the Tsurumi River basin, Japan.

  2008cited by this paper
• Analysis of perfluorinated carboxylic acids in soils II: optimization of chromatography and extraction.

  2008cited by this paper
• Assessment and Management of the First German Case of a Contamination with Perfluorinated Compounds (PFC) in the Region Sauerland, North Rhine-Westphalia

  2008cited by this paper
• Neonatal exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) causes neurobehavioural defects in adult mice.

  2008influential reference
• The pKa values of PFOA and other highly fluorinated carboxylic acids.

  2008cited by this paper
• Lipid homeostasis and oxidative stress in the liver of male rats exposed to perfluorododecanoic acid.

  2008cited by this paper
• Time dependencies in perfluorooctylacids disposition in rat and monkeys: a kinetic analysis.

  2008influential reference
• Perfluorooctanoic Acid–Induced Immunomodulation in Adult C57BL/6J or C57BL/6N Female Mice

  2008cited by this paper
• Biomonitoring of Perfluorinated Compounds in Children and Adults Exposed to Perfluorooctanoate-Contaminated Drinking Water

  2008cited by this paper
• Application of the OECD 301F respirometric test for the biodegradability assessment of various potential endocrine disrupting chemicals.

  2008cited by this paper
• Occupational Medicine Forum

  2008cited by this paper
• Perfluorooctanoic acid-induced hepatic toxicity following 21-day oral exposure in mice

  2008influential reference
• Perfluorinated compounds in house dust from Ohio and North Carolina, USA.

  2008cited by this paper
• Effects of perfluorobutyrate exposure during pregnancy in the mouse.

  2008influential reference
• Do perfluoropolymers biodegrade into PFOA?

  2008cited by this paper
• Perfluorinated compounds in human milk from Massachusetts, U.S.A.

  2008cited by this paper
• Prenatal Exposure to Perfluorooctanoate (PFOA) and Perfluorooctanesulfonate (PFOS) and Maternally Reported Developmental Milestones in Infancy

  2008cited by this paper
• Perfluoroalkyl acids and related chemistries--toxicokinetics and modes of action.

  2008cited by this paper
• Comparative pharmacokinetics of perfluorobutyrate in rats, mice, monkeys, and humans and relevance to human exposure via drinking water.

  2008cited by this paper
• Perfluorooctane sulphonate (PFOS) and perfluorooctanoic acid (PFOA) in human breast milk: results of a pilot study.

  2008cited by this paper
• Gestational exposure to perfluorooctane sulfonate suppresses immune function in B6C3F1 mice.

  2008cited by this paper
• Toxicogenomic dissection of the perfluorooctanoic acid transcript profile in mouse liver: evidence for the involvement of nuclear receptors PPAR alpha and CAR.

  2008cited by this paper
• Genomic Profiling Reveals an Alternate Mechanism for Hepatic Tumor Promotion by Perfluorooctanoic Acid in Rainbow Trout

  2008cited by this paper
• Perfluorinated acids as novel chemical tracers of global circulation of ocean waters.

  2008cited by this paper
• Analysis of perfluorooctanoate (PFOA) and other perfluorinated compounds (PFCs) in the River Po watershed in N-Italy.

  2008cited by this paper
• Correlations between Prenatal Exposure to Perfluorinated Chemicals and Reduced Fetal Growth

  2008influential reference
• Accumulation of perfluorooctane sulfonate (PFOS) in the food chain of the Western Scheldt estuary: Comparing field measurements with kinetic modeling.

  2008cited by this paper
• Human exposure to perfluorinated chemicals through the diet: intake of perfluorinated compounds in foods from the Catalan (Spain) market.

  2008cited by this paper
• Fetal growth indicators and perfluorinated chemicals: a study in the Danish National Birth Cohort.

  2008cited by this paper
• An interlaboratory study of perfluorinated alkyl compound levels in human plasma.

  2008influential reference
• Thyroid hormone status and pituitary function in adult rats given oral doses of perfluorooctanesulfonate (PFOS).

  2008cited by this paper
• Estimating Consumer Exposure to PFOS and PFOA

  2008influential reference
• New Jersey dives into PFOA water guidance.

  2007cited by this paper
• Assessment of lipid, hepatic, and thyroid parameters with serum perfluorooctanoate (PFOA) concentrations in fluorochemical production workers

  2007cited by this paper
• Behavioral effects in adult mice exposed to perfluorooctane sulfonate (PFOS).

  2007cited by this paper
• Perfluorinated acids in air, rain, snow, surface runoff, and lakes: relative importance of pathways to contamination of urban lakes.

  2007influential reference
• Perfluorinated Chemicals and Fetal Growth: A Study within the Danish National Birth Cohort

  2007influential reference
• Riverine discharge of perfluorinated carboxylates from the European continent.

  2007cited by this paper
• Quantitation of gas-phase perfluoroalkyl surfactants and fluorotelomer alcohols released from nonstick cookware and microwave popcorn bags.

  2007cited by this paper
• Negative bias from analog methods used in the analysis of free thyroxine in rat serum containing perfluorooctanesulfonate (PFOS).

  2007cited by this paper
• Combining perfluoroalkane acid exposure levels for risk assessment.

  2007cited by this paper
• Comparison of human whole blood, plasma, and serum matrices for the determination of perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), and other fluorochemicals.

  2007cited by this paper
• A global mass balance analysis of the source of perfluorocarboxylic acids in the Arctic Ocean.

  2007influential reference
• Bioaccumulation of perfluorochemicals in sediments by the aquatic oligochaete Lumbriculus variegatus.

  2007cited by this paper
• In vitro metabolism of 8-2 fluorotelomer alcohol: interspecies comparisons and metabolic pathway refinement.

  2007cited by this paper
• Polyfluoroalkyl Chemicals in the U.S. Population: Data from the National Health and Nutrition Examination Survey (NHANES) 2003–2004 and Comparisons with NHANES 1999–2000

  2007cited by this paper
• PFOS levels in the blood and liver of a small insectivorous songbird near a fluorochemical plant.

  2007cited by this paper
• The Environmental Specimen Bank for Human Tissues as part of the German Environmental Specimen Bank.

  2007cited by this paper
• Rapid response of Arctic ringed seals to changes in perfluoroalkyl production.

  2007cited by this paper
• Identification and pattern of perfluorooctane sulfonate (PFOS) isomers in human serum and plasma.

  2007cited by this paper
• Trends of perfluorinated alkyl substances in herring gull eggs from two coastal colonies in northern Norway: 1983-2003.

  2007cited by this paper
• Occurrence of perfluorinated substances in an adult German population in southern Bavaria

  2007cited by this paper
• Perfluorinated compounds in some terrestrial and aquatic wildlife species from Poland

  2007cited by this paper
• Serum PFOA Levels in Residents of Communities Near a Teflon-Production Facility

  2007cited by this paper
• High-resolution atmospheric modeling of fluorotelomer alcohols and perfluorocarboxylic acids in the North American troposphere.

  2007cited by this paper
• Perfluoroalkyl sulfonates and perfluorocarboxylates in two wastewater treatment facilities in Kentucky and Georgia.

  2007cited by this paper
• Exposure of an adult population to perfluorinated substances using duplicate diet portions and biomonitoring data.

  2007cited by this paper
• Partitioning and removal of perfluorooctanoate during rain events: the importance of physical-chemical properties.

  2007influential reference
• Half-Life of Serum Elimination of Perfluorooctanesulfonate,Perfluorohexanesulfonate, and Perfluorooctanoate in Retired Fluorochemical Production Workers

  2007cited by this paper
• Negative results ofumu genotoxicity test of fluorotelomer alcohols and perfluorinated alkyl acids

  2007cited by this paper
• Production of perfluorinated carboxylic acids (PFCAs) from the biotransformation of polyfluoroalkyl phosphate surfactants (PAPS): exploring routes of human contamination.

  2007cited by this paper
• Analysis of per- and polyfluorinated alkyl substances in air samples from Northwest Europe.

  2007influential reference
• Exposure to the immunosuppressant, perfluorooctanoic acid, enhances the murine IgE and airway hyperreactivity response to ovalbumin.

  2007influential reference
• Transplacental exposure of neonates to perfluorooctanesulfonate and perfluorooctanoate: a pilot study

  2007influential reference
• Longitudinal Study of Serum Lipids and Liver Enzymes in Workers With Occupational Exposure to Ammonium Perfluorooctanoate

  2007cited by this paper
• Estrogen‐like properties of perfluorooctanoic acid as revealed by expressing hepatic estrogen‐responsive genes in rare minnows (Gobiocypris rarus)

  2007cited by this paper
• Perfluoroalkyl acids: a review of monitoring and toxicological findings.

  2007cited by this paper
• Self-Reported Medical Conditions in Perfluorooctanesulfonyl Fluoride Manufacturing Workers

  2007cited by this paper
• Serum concentrations of 11 polyfluoroalkyl compounds in the u.s. population: data from the national health and nutrition examination survey (NHANES).

  2007cited by this paper
• Historical and geographical aspects of the increasing perfluorooctanoate and perfluorooctane sulfonate contamination in human serum in Japan.

  2007cited by this paper
• PERFLUOROALKYL ACIDS: What Is the Evidence Telling Us?

  2007cited by this paper
• Development and application of a simplified sampling method for volatile polyfluorinated alkyl substances in indoor and environmental air.

  2007cited by this paper
• Cross-Sectional Study of Lipids and Liver Enzymes Related to a Serum Biomarker of Exposure (ammonium perfluorooctanoate or APFO) as Part of a General Health Survey in a Cohort of Occupationally Exposed Workers

  2007cited by this paper
• Gene expression profiling in the lung and liver of PFOA-exposed mouse fetuses.

  2007cited by this paper
• Analysis of structure-cytotoxicity in vitro relationship (SAR) for perfluorinated carboxylic acids.

  2007cited by this paper
• Perfluorinated compounds in the Cape Fear Drainage Basin in North Carolina.

  2007influential reference
• Transport of ammonium perfluorooctanoate in environmental media near a fluoropolymer manufacturing facility.

  2007influential reference
• Biotransformation of 8:2 fluorotelomer alcohol in soil and by soil bacteria isolates.

  2007cited by this paper
• Clinical epidemiological study of employees exposed to surfactant blend containing perfluorononanoic acid

  2007influential reference
• PFOA in people.

  2007cited by this paper
• Occurrence of perfluorooctane sulfonate and other perfluorinated alkylated substances in harbor porpoises from the Black Sea.

  2007cited by this paper
• Determinants of fetal exposure to polyfluoroalkyl compounds in Baltimore, Maryland.

  2007cited by this paper
• Perfluorinated acids in Arctic snow: new evidence for atmospheric formation.

  2007cited by this paper
• Spatial distribution of perfluoroalkyl contaminants in lake trout from the Great Lakes.

  2007cited by this paper
• Light-induced degradation of perfluorocarboxylic acids in the presence of titanium dioxide.

  2007cited by this paper
• Latitudinal gradient of airborne polyfluorinated alkyl substances in the marine atmosphere between Germany and South Africa (53 degrees N-33 degrees S).

  2007cited by this paper
• Alterations in gene expression and testosterone synthesis in the testes of male rats exposed to perfluorododecanoic acid.

  2007influential reference
• Perfluorooctanoic acid induced developmental toxicity in the mouse is dependent on expression of peroxisome proliferator activated receptor-alpha.

  2007influential reference
• Cord Serum Concentrations of Perfluorooctane Sulfonate (PFOS) and Perfluorooctanoate (PFOA) in Relation to Weight and Size at Birth

  2007cited by this paper
• Bladder cancer in perfluorooctanesulfonyl fluoride manufacturing workers.

  2007cited by this paper
• Tissue distribution and hepatic subcellular distribution of perfluorooctanoic acid at low dose are different from those at high dose in rats.

  2007influential reference
• Dietary exposure of Canadians to perfluorinated carboxylates and perfluorooctane sulfonate via consumption of meat, fish, fast foods, and food items prepared in their packaging.

  2007cited by this paper

• Cyclodextrins for the removal of per- and polyfluoroalkyl substances: a review

  2025cites this paper
• Distribution and potential health risks of perfluoroalkyl substances (PFAS) in dairy and egg products in Guangzhou

  2025cites this paper
• Can four decades of experience with dioxins inform scientists and regulatory agencies about how to regulate PFAS chemicals?

  2025cites this paper
• The relationship between PFAS exposure and dyslipidemia: an updated review, meta-analysis, and evaluation of bias

  2025cites this paper
• Assessing per- and polyfluoroalkyl substances (PFAS) in sediments and fishes in a large, urbanized estuary and the potential human health implications

  2022influential citation
• An Environmentally Relevant Mixture of Perfluorooctanesulfonic Acid and Perfluorohexanesulfonic Acid Does Not Conform to Additivity in Northern Leopard Frogs Exposed Through Metamorphosis

  2022cites this paper
• Perfluoroalkyl and polyfluoroalkyl substances, bisphenol and paraben compounds in dust collected from residential homes in Klang Valley, Malaysia

  2022cites this paper
• Modelling the transport of PFOS from single lined municipal solid waste landfill

  2021cites this paper
• Comparative toxicometabolomics of perfluorooctanoic acid (PFOA) and next-generation perfluoroalkyl substances.

  2020cites this paper
• Emerging and legacy per- and polyfluoroalkyl substances in house dust from South China: Contamination status and human exposure assessment.

  2020cites this paper
• PFAS concentration during pregnancy in relation to cardiometabolic health and birth outcomes.

  2020cites this paper
• Associations of Perfluoroalkyl substances with blood lipids and Apolipoproteins in lipoprotein subspecies: the POUNDS-lost study

  2020cites this paper
• A Simple and Rapid Method for Quantitative HPLC MS/MS Determination of Selected Perfluorocarboxylic Acids and Perfluorosulfonates in Human Serum

  2020cites this paper
• Severity of COVID-19 at elevated exposure to perfluorinated alkylates

  2020cites this paper
• Perfluorooctanesulfonate (PFOS), Its Occurrence, Fate, Transport and Removal in Various Environmental Media: A Review

  2020cites this paper
• Per- and polyfluoroalkyl substances (PFAS) serum levels among a group of New Jersey volunteer firefighters and comparison with the US National Health and Nutrition Examination Survey (NHANES) (2015-16)

  2020cites this paper
• Concentration, distribution and sources of perfluoroalkyl substances and organochlorine pesticides in surface sediments of the northern Bering Sea, Chukchi Sea and adjacent Arctic Ocean.

  2019cites this paper
• Metabolomics of childhood exposure to perfluoroalkyl substances: a cross-sectional study

  2019cites this paper
• Renal function and isomers of perfluorooctanoate (PFOA) and perfluorooctanesulfonate (PFOS): Isomers of C8 Health Project in China.

  2019cites this paper
• Perfluoroalkyl substances (PFASs) in edible fish species from Charleston Harbor and tributaries, South Carolina, United States: Exposure and risk assessment

  2019cites this paper
• Interspecies differences in perfluoroalkyl substances (PFAS) toxicokinetics and application to health-based criteria.

  2019cites this paper
• Associations of Perfluoroalkyl Substances (PFASs) with Lower Birth Weight: An Evaluation of Potential Confounding by Glomerular Filtration Rate Using a Physiologically Based Pharmacokinetic Model (PBPK)

  2019cites this paper
• Legacy and alternative per- and polyfluoroalkyl substances in the U.S. general population: Paired serum-urine data from the 2013-2014 National Health and Nutrition Examination Survey.

  2019cites this paper
• Ableitung von HBM-I-Werten für Perfluoroktansäure (PFOA) und Perfluoroktansulfonsäure (PFOS) – Stellungnahme der Kommission „Humanbiomonitoring“ des Umweltbundesamts

  2018cites this paper
• Per- and polyfluoroalkyl substances in sera from children 3 to 11 years of age participating in the National Health and Nutrition Examination Survey 2013-2014.

  2018cites this paper
• Fate of bisphenol A, perfluorooctanoic acid and perfluorooctanesulfonate in two different types of sewage treatment works in Hong Kong.

  2018cites this paper
• Per- and polyfluoroalkyl substances and fluorinated alternatives in urine and serum by on-line solid phase extraction-liquid chromatography-tandem mass spectrometry.

  2018cites this paper
• Delayed discovery, dissemination, and decisions on intervention in environmental health: a case study on immunotoxicity of perfluorinated alkylate substances

  2018cites this paper
• Environmental contaminants and child’s growth

  2018cites this paper
• Per- and polyfluoroalkyl substance (PFAS) exposure assessment in a community exposed to contaminated drinking water, New Hampshire, 2015.

  2018cites this paper
• Perfluoroalkyl substances and fish consumption

  2017cites this paper
• Recent experimental results of effects of perfluoroalkyl substances in laboratory animals - Relation to current regulations and guidance values.

  2017cites this paper
• Lessons Learned from Legacy Contaminants of Emerging Concern: Perfluoroalkyl Compounds (PFCs) in the Village of Hoosick Falls, Rensselaer County, New York

  2017cites this paper
• Metal exposures from aluminum cookware: An unrecognized public health risk in developing countries.

  2017cites this paper
• Persistent alterations in immune cell populations and function from a single dose of perfluorononanoic acid (PFNA) in C57Bl/6 mice.

  2017cites this paper
• Recent developments in polyfluoroalkyl compounds research: a focus on human/environmental health impact, suggested substitutes and removal strategies

  2017cites this paper
• Prenatal concentrations of Perfluoroalkyl substances and early communication development in British girls.

  2017cites this paper
• PFAS – Questions and Answers

  2017cites this paper
• Persistente organische Kontaminanten in Lebensmitteln

  2017cites this paper
• Integration of Life-Stage Physiologically Based Pharmacokinetic Models with Adverse Outcome Pathways and Environmental Exposure Models to Screen for Environmental Hazards.

  2016cites this paper
• Levels of persistent contaminants in relation to fish consumption among older male anglers in Wisconsin.

  2016cites this paper
• Maternal exposure to perfluoroalkyl acids measured in whole blood and birth outcomes in offspring.

  2016cites this paper
• Accumulation of persistent organic pollutants in consumers of eel from polluted rivers compared to marketable eel.

  2016cites this paper
• Poly- and perfluoroalkylated substances (PFASs) in water, sediment and fish muscle tissue from Lake Tana, Ethiopia and implications for human exposure.

  2016cites this paper
• Determination of perfluorinated compounds (PFCs) in the fine particulate matter (PM2.5) in China

  2016cites this paper
• Producing Fluoromonomers, Fluoropolymers, and Fluoropolymer Finishing

  2016cites this paper
• Possible role of serotonin and neuropeptide Y on the disruption of the reproductive axis activity by perfluorooctane sulfonate.

  2015cites this paper
• Karst Influence in the Creation of a PFC Megaplume

  2015cites this paper
• Maternal exposure to perfluorinated chemicals and reduced fecundity: the MIREC study

  2015cites this paper
• Associations of Perfluoroalkyl Substances (PFAS) with Lower Birth Weight: An Evaluation of Potential Confounding by Glomerular Filtration Rate Using a Physiologically Based Pharmacokinetic Model (PBPK)

  2015cites this paper
• 7 – Polymerization Surfactants

  2015cites this paper
• Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA): emerging contaminants of increasing concern in fish from Lake Varese, Italy

  2015cites this paper
• The Navigation Guide—Evidence-Based Medicine Meets Environmental Health: Systematic Review of Nonhuman Evidence for PFOA Effects on Fetal Growth

  2014cites this paper
• Fish consumption as a source of human exposure to perfluorinated alkyl substances in Italy: analysis of two edible fish from Lake Maggiore.

  2014cites this paper
• Toxic Interactions of Perfluorinated Compounds (PFCs) with Heavy Metals Using Vibrio fischeri

  2014cites this paper
• Foodstuff analyses show that seafood and water are major perfluoroalkyl acids (PFAAs) sources to humans in Korea.

  2014cites this paper
• Quantifizierung der Auswirkungen verschiedener Umweltbelastungen auf die Gesundheit der Menschen in Deutschland unter Berücksichtigung der bevölkerungsbezogenen Expositionsermittlung - (Verteilungsbasierte Analyse gesundheitlicher Auswirkungen von Umwelt-Stressoren, VegAS)

  2013cites this paper
• Effects of acute and chronic exposure to perfluorodecanoic acid (PFDA) and perfluorotridecanoic acid (PFTrDA) in Daphnia magna and Zebrafish (Danio rerio) with endocrine disruption potential

  2013cites this paper
• Tissue distribution studies and risk assessment of perfluoroalkylated and polyfluoroalkylated substances (pfass)

  2013cites this paper
• Nanofiltration and granular activated carbon treatment of perfluoroalkyl acids.

  2013cites this paper
• Immunotoxicity of perfluorinated alkylates: calculation of benchmark doses based on serum concentrations in children

  2013cites this paper
• In situ air-water and particle-water partitioning of perfluorocarboxylic acids, perfluorosulfonic acids and perfluorooctyl sulfonamide at a wastewater treatment plant.

  2013cites this paper
• Maternal Concentrations of Polyfluoroalkyl Compounds during Pregnancy and Fetal and Postnatal Growth in British Girls

  2012cites this paper
• Environmental and Health Risk Assessment of Perfluoroalkylated and Polyfluoroalkylated Substances (PFASs) in Sweden

  2012influential citation
• Assessment of perfluorinated compounds (PFCs) in plasma of bottlenose dolphins from two southeast US estuarine areas: relationship with age, sex and geographic locations.

  2012cites this paper
• Committee for Risk Assessment (RAC) Committee for Socio-economic Analysis (SEAC)

  2011cites this paper
• Perfluorooctanoic acid, perfluorooctanesulfonate, and serum lipids in children and adolescents: results from the C8 Health Project.

  2010cites this paper
• ENVIRONMENT Case studies: applications of physiologically-based pharmacokinetic (PBPK) modelling in human health risk assessment.

  year unknowninfluential citation