Nuclear translocation of EndoG at the initiation of disuse muscle atrophy and apoptosis is specific to myonuclei.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  American Journal of Physiology. Regulatory Integrative and Comparative Physiology

• Publication date

  2006-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1152/AJPREGU.00176.2006PMID 16873557
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Apoptotic responses to hindlimb suspension in gastrocnemius muscles from young adult and aged rats.

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• Age-related differences in apoptosis with disuse atrophy in soleus muscle.

  2005influential reference
• Hindlimb casting decreases muscle mass in part by proteasome-dependent proteolysis but independent of protein synthesis.

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• Aging influences cellular and molecular responses of apoptosis to skeletal muscle unloading.

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• Mechanisms of disuse muscle atrophy: role of oxidative stress.

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• Regulation of muscle protein degradation: coordinated control of apoptotic and ubiquitin-proteasome systems by phosphatidylinositol 3 kinase.

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• Skeletal muscle atrophy leads to loss and dysfunction of muscle precursor cells.

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• Molecular mechanisms modulating muscle mass.

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• Signalling pathways that mediate skeletal muscle hypertrophy and atrophy

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• FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons

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• Apoptosis in skeletal muscle with aging.

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• Mechanisms leading to restoration of muscle size with exercise and transplantation after spinal cord injury.

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• Activated satellite cells fail to restore myonuclear number in spinal cord transected and exercised rats.

  1999influential reference
• Differential microvascular response to disuse in rat hindlimb skeletal muscles.

  1999cited by this paper
• Molecular characterization of mitochondrial apoptosis-inducing factor

  1999cited by this paper
• Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor.

  1999cited by this paper
• Early changes in muscle fiber size and gene expression in response to spinal cord transection and exercise.

  1998cited by this paper
• Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis

  1998cited by this paper
• Transcription occurs in pulses in muscle fibers.

  1998cited by this paper
• Growth hormone/IGF-I and/or resistive exercise maintains myonuclear number in hindlimb unweighted muscles.

  1997cited by this paper
• Effects of chronic low frequency stimulation on contractile and elastic properties of hindlimb suspended rat soleus muscle

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• Apoptosis: a mechanism contributing to remodeling of skeletal muscle in response to hindlimb unweighting.

  1997influential reference
• Myonuclear number and myosin heavy chain expression in rat soleus single muscle fibers after spaceflight.

  1996cited by this paper
• Satellite cells and myonuclei in long‐term denervated rat muscles

  1995cited by this paper
• Plasticity of myonuclear number in hypertrophied and atrophied mammalian skeletal muscle fibers.

  1995cited by this paper
• Mechanism of oxidative stress in skeletal muscle atrophied by immobilization.

  1993cited by this paper
• Primers for mitochondrial DNA replication generated by endonuclease G.

  1993cited by this paper
• Angiogenesis in skeletal and cardiac muscle.

  1992cited by this paper
• Atrophy of the soleus muscle by hindlimb unweighting.

  1990cited by this paper
• Spherical reflector as an electromagnetic‐missile launcher

  1990cited by this paper
• Protein metabolism and beta-myosin heavy-chain mRNA in unweighted soleus muscle.

  1989cited by this paper
• Localization of muscle gene products in nuclear domains

  1989cited by this paper
• Cytochrome c protein-synthesis rates and mRNA contents during atrophy and recovery in skeletal muscle.

  1987cited by this paper
• Changes in actin synthesis and alpha-actin-mRNA content in rat muscle during immobilization.

  1984cited by this paper
• A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

  1976cited by this paper

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