MiRNA 34a: a therapeutic target for castration-resistant prostate cancer

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Expert opinion on therapeutic targets

• Publication date

  2016-03-28

• Fields of study

  Medicine

• Identifiers
  DOI 10.1517/14728222.2016.1162294PMID 26942553
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Regulation of PD-L1: a novel role of pro-survival signalling in cancer.

  2016influential reference
• Epithelial mesenchymal-like transition occurs in a subset of cells in castration resistant prostate cancer bone metastases

  2016cited by this paper
• Using routinely collected data to stratify prostate cancer patients into phases of care in the United Kingdom: implications for resource allocation and the cancer survivorship programme

  2015influential reference
• miRNAs dysregulated in association with Gleason grade regulate extracellular matrix, cytoskeleton and androgen receptor pathways

  2015cited by this paper
• Active surveillance of prostate cancer: a questionnaire survey of urologists, clinical oncologists and urology nurse specialists across three cancer networks in the United Kingdom

  2015cited by this paper
• LncRNA HOTAIR Enhances the Androgen-Receptor-Mediated Transcriptional Program and Drives Castration-Resistant Prostate Cancer

  2015cited by this paper
• Runx2–smad signaling impacts the progression of tumor‐induced bone disease

  2015cited by this paper
• Chitosan nanoparticle-mediated delivery of miRNA-34a decreases prostate tumor growth in the bone and its expression induces non-canonical autophagy

  2015cited by this paper
• Microdissecting the role of microRNAs in the pathogenesis of prostate cancer.

  2015cited by this paper
• Current and emerging therapies for bone metastatic castration-resistant prostate cancer.

  2015cited by this paper
• The role of microRNA in castration-resistant prostate cancer.

  2014cited by this paper
• A Short Antisense Oligonucleotide Ameliorates Symptoms of Severe Mouse Models of Spinal Muscular Atrophy

  2014cited by this paper
• miR‐34a is an intracellular and exosomal predictive biomarker for response to docetaxel with clinical relevance to prostate cancer progression

  2014cited by this paper
• Molecular Regulation of Bone Marrow Metastasis in Prostate and Breast Cancer

  2014cited by this paper
• MicroRNAs and Bone Metastasis: A New Challenge

  2014influential reference
• Bone metastatic prostate cancer and resistance to tyrosine kinase inhibitors: an intimate relationship between loss of miR-203 and up-regulation of EGFR signaling

  2014cited by this paper
• Transforming growth factor-β promotes prostate bone metastasis through induction of microRNA-96 and activation of the mTOR pathway

  2014cited by this paper
• MicroRNAs in the control of metastatic bone disease.

  2014cited by this paper
• Loss of miR-100 enhances migration, invasion, epithelial-mesenchymal transition and stemness properties in prostate cancer cells through targeting Argonaute 2.

  2014cited by this paper
• MicroRNA-34a regulates WNT/TCF7 signaling and inhibits bone metastasis in Ras-activated prostate cancer

  2014influential reference
• MicroRNAs in the Regulation of MMPs and Metastasis

  2014influential reference
• Molecular pathways and targets in prostate cancer

  2014influential reference
• MicroRNA-34a: a potential therapeutic target in human cancer

  2014cited by this paper
• Mir-34: A New Weapon Against Cancer?

  2014influential reference
• The p53/miR-34 axis in development and disease.

  2014influential reference
• SATB2 enhances migration and invasion in osteosarcoma by regulating genes involved in cytoskeletal organization

  2014cited by this paper
• miR-34a Blocks Osteoporosis and Bone Metastasis by Inhibiting Osteoclastogenesis and Tgif2

  2014cited by this paper
• Prostate Cancer and Bone: The Elective Affinities

  2014cited by this paper
• MicroRNAs in osteosarcoma: From biological players to clinical contributors, a review

  2013cited by this paper
• Up-regulated microRNA-143 in cancer stem cells differentiation promotes prostate cancer cells metastasis by modulating FNDC3B expression

  2013cited by this paper
• MicroRNA-34 suppresses breast cancer invasion and metastasis by directly targeting Fra-1

  2013cited by this paper
• The role of micro RNAs let7c, 100 and 218 expression and their target RAS, C-MYC, BUB1, RB, SMARCA5, LAMB3 and Ki-67 in prostate cancer

  2013influential reference
• Comprehensive molecular oncogenomic profiling and miRNA analysis of prostate cancer.

  2013cited by this paper
• The efficiency of the serum prostate specific antigen levels in diagnosing prostatic enlargements.

  2013cited by this paper
• Multifunctional properties of RANKL/RANK in cell differentiation, proliferation and metastasis.

  2013cited by this paper
• Genistein Inhibits Prostate Cancer Cell Growth by Targeting miR-34a and Oncogenic HOTAIR

  2013cited by this paper
• The Antiapoptotic Function of miR-96 in Prostate Cancer by Inhibition of FOXO1

  2013cited by this paper
• Androgen receptors in hormone-dependent and castration-resistant prostate cancer.

  2013cited by this paper
• Erratum: Epigenetic silencing of miR-34a in human prostate cancer cells and tumor tissue specimens can be reversed by BR-DIM treatment.

  2013cited by this paper
• Targeting Bone Metastases: New Drugs for New Targets

  2013cited by this paper
• miR-34 – a microRNA replacement therapy is headed to the clinic

  2012influential reference
• Docetaxel-Resistance in Prostate Cancer: Evaluating Associated Phenotypic Changes and Potential for Resistance Transfer via Exosomes

  2012cited by this paper
• MicroRNA control of bone formation and homeostasis

  2012influential reference
• Cancer stem cells, microRNAs, and therapeutic strategies including natural products

  2012influential reference
• The Mutational Landscape of Lethal Castrate Resistant Prostate Cancer

  2012cited by this paper
• In situ forming implants for local chemotherapy and hyperthermia of bone tumors

  2012cited by this paper
• MicroRNA-34a Inhibits the Proliferation and Metastasis of Osteosarcoma Cells Both In Vitro and In Vivo

  2012influential reference
• Regular Exercise, Subjective Wellbeing, and Internalizing Problems in Adolescence: Causality or Genetic Pleiotropy?

  2012cited by this paper
• Lifestyle and dietary factors in the prevention of lethal prostate cancer.

  2012cited by this paper
• MicroRNA-34a and microRNA-21 play roles in the chemopreventive effects of 3,6-dihydroxyflavone on 1-methyl-1-nitrosourea-induced breast carcinogenesis

  2012influential reference
• Epigenetic silencing of miR-34a in human prostate cancer cells and tumor tissue specimens can be reversed by BR-DIM treatment.

  2012influential reference
• Recent updates on the role of microRNAs in prostate cancer

  2012cited by this paper
• miR-34s inhibit osteoblast proliferation and differentiation in the mouse by targeting SATB2

  2012cited by this paper
• An overview of the c-MET signaling pathway

  2011cited by this paper
• MicroRNA biogenesis and regulation of bone remodeling

  2011influential reference
• Cancer to bone: a fatal attraction

  2011cited by this paper
• Mechanisms of cancer cell metastasis to the bone: a multistep process.

  2011influential reference
• A Perspective on Cancer Cell Metastasis

  2011cited by this paper
• Canonical and non-canonical autophagy: variations on a common theme of self-eating?

  2011cited by this paper
• The microRNA miR-34 a inhibits prostate cancer stem cells and metastasis by directly repressing CD 44

  2011influential reference
• From Prostate to Bone: Key Players in Prostate Cancer Bone Metastasis

  2011cited by this paper
• p53, Stem Cells, and Reprogramming: Tumor Suppression beyond Guarding the Genome.

  2011influential reference
• Runx2 and Osterix Gene Expression in Human B one Marrow Stromal Cells Are Mediated by Far2Infrared Radiation

  2011cited by this paper
• Steps in prostate cancer progression that lead to bone metastasis

  2011influential reference
• Novel targeted therapeutics for metastatic castration-resistant prostate cancer.

  2010cited by this paper
• Identification of miR-34a as a potent inhibitor of prostate cancer progenitor cells and metastasis by directly repressing CD44

  2010cited by this paper
• Current management of castrate-resistant prostate cancer.

  2010cited by this paper
• Pathogenesis of osteoblastic bone metastases from prostate cancer

  2010cited by this paper
• miR-143 decreases prostate cancer cells proliferation and migration and enhances their sensitivity to docetaxel through suppression of KRAS

  2010cited by this paper
• p53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC

  2010cited by this paper
• Regulatory Role of mir-203 in Prostate Cancer Progression and Metastasis

  2010cited by this paper
• Roles of TGFβ in metastasis

  2009cited by this paper
• MicroRNAs — the micro steering wheel of tumour metastases

  2009cited by this paper
• Post-translational Regulation of Runx2 in Bone and Cartilage

  2009cited by this paper
• Prostate Cancer: Biology, Genetics, and the New Therapeutics, 2nd Edition

  2009cited by this paper
• PTH and PTHrP signaling in osteoblasts.

  2009cited by this paper
• The basics of epithelial-mesenchymal transition.

  2009influential reference
• Gene therapy for the treatment of cancer: From laboratory to bedside

  2008cited by this paper
• Mechanisms of bone metastasis in prostate cancer: clinical implications.

  2008influential reference
• Tumor expressed PTHrP facilitates prostate cancer‐induced osteoblastic lesions

  2008cited by this paper
• Molecular biology of bone metastasis.

  2008cited by this paper
• Prostate Cancer: Biology, Genetics and the New Therapeutics

  2008cited by this paper
• Anatomy of the prostate gland and surgical pathology of prostate cancer

  2008cited by this paper
• Bone metastasis in prostate cancer: molecular and cellular mechanisms (Review).

  2007cited by this paper
• The pivotal role of CXCL12 (SDF-1)/CXCR4 axis in bone metastasis

  2007cited by this paper
• Mechanisms of osteopontin and CD44 as metastatic principles in prostate cancer cells

  2007influential reference
• Transcriptional activation of miR-34a contributes to p53-mediated apoptosis.

  2007cited by this paper
• Tumor microenvironment promotes cancer progression, metastasis, and therapeutic resistance.

  2007influential reference
• Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis.

  2007cited by this paper
• Selectins and selectin ligands in extravasation of cancer cells and organ selectivity of metastasis

  2007cited by this paper
• Therapeutic potential for microRNAs.

  2007influential reference
• Human osteocalcin: a strong promoter for nitric oxide synthase gene therapy, with specificity for hormone refractory prostate cancer

  2007influential reference
• beta2-microglobulin is a signaling and growth-promoting factor for human prostate cancer bone metastasis.

  2006cited by this paper
• Regulatory roles of Runx2 in metastatic tumor and cancer cell interactions with bone

  2006influential reference
• Clinical Features of Metastatic Bone Disease and Risk of Skeletal Morbidity

  2006influential reference
• β2-Microglobulin Is a Signaling and Growth-Promoting Factor for Human Prostate Cancer Bone Metastasis

  2006cited by this paper
• Osteoblasts in prostate cancer metastasis to bone

  2005influential reference
• Current management of hormone-refractory prostate cancer.

  2004cited by this paper
• Pathophysiology of Bone Metastases in Prostate Cancer

  2004influential reference
• Mechanisms of bone metastasis.

  2004cited by this paper

• MiRNA based liquid biopsy for castration-resistant prostate cancer diagnostics.

  2026cites this paper
• Synergistic targeting strategies for prostate cancer

  2025cites this paper
• Research on drug treatment and the novel signaling pathway of chronic atrophic gastritis.

  2024cites this paper
• NF-κB signaling in therapy resistance of breast cancer: Mechanisms, approaches, and challenges.

  2024cites this paper
• Targeting Castration-Resistant Prostate Cancer Using Mesenchymal Stem Cell Exosomes for Therapeutic MicroRNA-let-7c Delivery.

  2022cites this paper
• Printed Electrochemical Strip for the Detection of miRNA-29a: A Possible Biomarker Related to Alzheimer’s Disease

  2022cites this paper
• Combination therapy with miR34a and doxorubicin synergistically inhibits Dox-resistant breast cancer progression via down-regulation of Snail through suppressing Notch/NF-κB and RAS/RAF/MEK/ERK signaling pathway

  2021cites this paper
• MicroRNAs in treatment-induced neuroendocrine differentiation in prostate cancer

  2020cites this paper
• Exploring the Potential of MicroRNA Let-7c as a Therapeutic for Prostate Cancer

  2019cites this paper
• Isolation, structure elucidation, and synthesis of (±)-millpuline A with a suppressive effect in miR-144 expression

  2019cites this paper
• MiR-34a overexpression enhances the inhibitory effect of doxorubicin on HepG2 cells

  2019cites this paper
• PAMAM dendrimer modified screen printed electrodes for impedimetric detection of miRNA-34a

  2019cites this paper
• Impedimetric detection of miRNA-34a using graphene oxide modified chemically activated graphite electrodes

  2018cites this paper
• Implications of microRNA dysregulation in the development of prostate cancer.

  2017cites this paper
• Influence of alginate backbone on efficacy of thermo-responsive alginate-g-P(NIPAAm) hydrogel as a vehicle for sustained and controlled gene delivery.

  2017cites this paper
• Mechanistic roles of microRNAs in hepatocarcinogenesis: A study of thioacetamide with multiple doses and time-points of rats

  2017cites this paper