Bone metastasis in prostate cancer: molecular and cellular mechanisms (Review).

No abstract is available for this paper.

• Publication year

  2007

• Venue

  International Journal of Molecular Medicine

• Publication date

  2007-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3892/IJMM.20.1.103PMID 17549396
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Hepatocyte growth factor up-regulates the expression of the bone morphogenetic protein (BMP) receptors, BMPR-IB and BMPR-II, in human prostate cancer cells.

  2007cited by this paper
• Bone morphogenetic proteins and their receptor signaling in prostate cancer.

  2007cited by this paper
• The central role of osteoblasts in the metastasis of prostate cancer

  2007cited by this paper
• Dickkopf homolog 1 mediates endothelin-1-stimulated new bone formation.

  2007cited by this paper
• Basic Mechanisms Responsible for Osteolytic and Osteoblastic Bone Metastases

  2006cited by this paper
• Increased expression of osteopontin contributes to the progression of prostate cancer.

  2006cited by this paper
• Cytokines regulating osteoclast formation and function

  2006cited by this paper
• Biglycan is a positive modulator of BMP-2 induced osteoblast differentiation.

  2006cited by this paper
• Role of wnts in prostate cancer bone metastases

  2006cited by this paper
• Targeting Factors Involved in Bone Remodeling as Treatment Strategies in Prostate Cancer Bone Metastasis

  2006cited by this paper
• Pathogenesis of bone metastasis: a review.

  2006cited by this paper
• IGF‐I secretion by prostate carcinoma cells does not alter tumor‐bone cell interactions in vitro or in vivo

  2006cited by this paper
• Expression of recombinant MDA-BF-1 with a kinase recognition site and a 7-histidine tag for receptor binding and purification.

  2005cited by this paper
• Hepatocyte growth factor, its receptor, and their potential value in cancer therapies.

  2005cited by this paper
• Beta ig-h3 mediates osteoblast adhesion and inhibits differentiation.

  2005cited by this paper
• Increased osteoblastogenesis and decreased bone resorption protect against ovariectomy-induced bone loss in thrombospondin-2-null mice.

  2005cited by this paper
• Gonadotropin-releasing hormone agonists and fracture risk: a claims-based cohort study of men with nonmetastatic prostate cancer.

  2005cited by this paper
• Differential regulation of platelet‐derived growth factor stimulated migration and proliferation in osteoblastic cells

  2004cited by this paper
• Regulation, regulatory activities, and function of biglycan.

  2004cited by this paper
• Metastatic Properties of Prostate Cancer Cells are Controlled by VEGF

  2004cited by this paper
• Natural history of bone complications in men with prostate carcinoma initiating androgen deprivation therapy

  2004cited by this paper
• Vascular Endothelial Growth Factor Contributes to the Prostate Cancer-Induced Osteoblast Differentiation Mediated by Bone Morphogenetic Protein

  2004cited by this paper
• The small leucine‐rich proteoglycan biglycan modulates BMP‐4‐induced osteoblast differentiation

  2004cited by this paper
• Mechanisms of bone metastasis.

  2004cited by this paper
• [Bone sialoprotein].

  2004cited by this paper
• Mechanisms of bone metastasis.

  2004cited by this paper
• Down‐regulation of macrophage inhibitory cytokine‐1/prostate derived factor in benign prostatic hyperplasia

  2004cited by this paper
• Up‐regulation of MDA‐BF‐1, a secreted isoform of ErbB3, in metastatic prostate cancer cells and activated osteoblasts in bone marrow

  2004cited by this paper
• Up-regulation of Wnt-1 and beta-catenin production in patients with advanced metastatic prostate carcinoma: potential pathogenetic and prognostic implications.

  2004cited by this paper
• Loss of expression of bone morphogenetic protein receptor type II in human prostate cancer cells

  2004cited by this paper
• Intraosseous growth of human prostate cancer in implanted adult human bone: Relationship of prostate cancer cells to osteoclasts in osteoblastic metastatic lesions

  2004cited by this paper
• Over-expression of bone sialoprotein enhances bone metastasis of human breast cancer cells in a mouse model.

  2003cited by this paper
• Mechanisms of Tumor Metastasis to the Bone: Challenges and Opportunities

  2003cited by this paper
• Stromal factors involved in prostate carcinoma metastasis to bone

  2003cited by this paper
• Effect of endothelin-A receptor blockade with atrasentan on tumor progression in men with hormone-refractory prostate cancer: a randomized, phase II, placebo-controlled trial.

  2003cited by this paper
• Prostate cancer cells-osteoblast interaction shifts expression of growth/survival-related genes in prostate cancer and reduces expression of osteoprotegerin in osteoblasts.

  2003cited by this paper
• A causal role for endothelin-1 in the pathogenesis of osteoblastic bone metastases

  2003cited by this paper
• Increased expression of bone morphogenetic protein‐7 in bone metastatic prostate cancer

  2003cited by this paper
• Mechanisms of osteoblastic metastases: role of endothelin-1.

  2003cited by this paper
• Bone matrix proteins: their function, regulation, and relationship to osteoporosis

  2003cited by this paper
• The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma.

  2003cited by this paper
• Integrin alpha v beta 3 as a therapeutic target for blocking tumor-induced angiogenesis.

  2003cited by this paper
• The New Bisphosphonate, Zometa® (Zoledronic Acid), Decreases Skeletal Complications in Both Osteolytic and Osteoblastic Lesions: A Comparison to Pamidronate

  2002cited by this paper
• Tumor-derived platelet-derived growth factor-BB plays a critical role in osteosclerotic bone metastasis in an animal model of human breast cancer.

  2002cited by this paper
• Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover

  2002cited by this paper
• Insulin-like growth factor-I (IGF-I) and IGF binding protein-3 as predictors of advanced-stage prostate cancer.

  2002cited by this paper
• The role of alpha(v)beta(3) in prostate cancer progression.

  2002cited by this paper
• The potential role of bisphosphonates in prostate cancer

  2002cited by this paper
• Resistance to Unloading‐Induced Three‐Dimensional Bone Loss in Osteopontin‐Deficient Mice

  2002cited by this paper
• Association of preoperative plasma levels of insulin-like growth factor I and insulin-like growth factor binding proteins-2 and -3 with prostate cancer invasion, progression, and metastasis.

  2002cited by this paper
• The Secreted Protein Thrombospondin 2 Is an Autocrine Inhibitor of Marrow Stromal Cell Proliferation

  2002cited by this paper
• A functional thrombin receptor (PAR1) is expressed on bone-derived prostate cancer cell lines.

  2002cited by this paper
• Placental bone morphogenetic protein (PLAB) gene expression in normal, pre‐malignant and malignant human prostate: Relation to tumor development and progression

  2001cited by this paper
• Epigenetic Regulation of Human Bone Morphogenetic Protein 6 Gene Expression in Prostate Cancer

  2001cited by this paper
• Bone sialoprotein, bone morphogenetic protein 6 and thymidine phosphorylase expression in localized human prostatic adenocarcinoma as predictors of clinical outcome: a clinicopathological and immunohistochemical study of 43 cases.

  2001cited by this paper
• Parathyroid Hormone-induced Bone Resorption Does Not Occur in the Absence of Osteopontin*

  2001cited by this paper
• Preoperative plasma levels of transforming growth factor beta(1) (TGF-beta(1)) strongly predict progression in patients undergoing radical prostatectomy.

  2001cited by this paper
• The Role of Vascular Endothelial Growth Factor in the Tissue Specific in Vivo Growth of Prostate Cancer Cells

  2001cited by this paper
• Role of osteopontin in cellular signaling and toxicant injury.

  2001cited by this paper
• Pamidronate to prevent bone loss during androgen-deprivation therapy for prostate cancer.

  2001cited by this paper
• Biology of bone and how it orchestrates the form and function of the skeleton

  2001cited by this paper
• Endothelin‐1 production by prostate cancer cell lines is up‐regulated by factors involved in cancer progression and down‐regulated by androgens

  2001cited by this paper
• A N‐terminal PTHrP peptide fragment void of a PTH/PTHrP‐receptor binding domain activates cardiac ETA receptors

  2001cited by this paper
• The sentinel lymph node concept in prostate cancer: first results of gamma probe-guided sentinel lymph node identification.

  2000cited by this paper
• Pathogenesis of Bone Metastases: Role of Tumor‐Related Proteins

  2000cited by this paper
• Metastatic patterns of prostate cancer: an autopsy study of 1,589 patients.

  2000cited by this paper
• Osteopenia and decreased bone formation in osteonectin-deficient mice

  2000cited by this paper
• Endothelin-1 from prostate cancer cells is enhanced by bone contact which blocks osteoclastic bone resorption

  2000cited by this paper
• Markers of bone turnover for the management of patients with bone metastases from prostate cancer

  2000cited by this paper
• Thrombospondin 2, a matricellular protein with diverse functions.

  2000cited by this paper
• Osteopenia and decreased bone formation in osteonectin-deficient mice.

  2000cited by this paper
• The Roles of Osteoprotegerin and Osteoprotegerin Ligand in the Paracrine Regulation of Bone Resorption

  2000cited by this paper
• The Sentinel Lymph Node Concept in Prostate Cancer – First Results of Gamma Probe-Guided Sentinel Lymph Node Identification

  1999cited by this paper
• Bone sialoprotein.

  1999cited by this paper
• Osteonectin promotes prostate cancer cell migration and invasion: a possible mechanism for metastasis to bone.

  1999cited by this paper
• VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation

  1999cited by this paper
• Systemic Administration of Acidic Fibroblast Growth Factor (FGF‐1) Prevents Bone Loss and Increases New Bone Formation in Ovariectomized Rats

  1999cited by this paper
• Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study.

  1998cited by this paper
• Bone morphogenetic protein 6 in skeletal metastases from prostate cancer and other common human malignancies.

  1998cited by this paper
• Preferential adhesion of prostate cancer cells to a human bone marrow endothelial cell line.

  1998cited by this paper
• Exfoliated ductal epithelial cells in human breast milk: a source of target tissue DNA for molecular epidemiologic studies of breast cancer.

  1998cited by this paper
• Fibronectin is a survival factor for differentiated osteoblasts.

  1998cited by this paper
• Androgen‐dependent gene expression of bone morphogenetic protein 7 in mouse prostate

  1998cited by this paper
• Osteoprotegerin: a novel secreted protein involved in the regulation of bone density.

  1997cited by this paper
• Interactions between integrin receptors and fibronectin are required for calvarial osteoblast differentiation in vitro.

  1997cited by this paper
• Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein

  1997cited by this paper
• Growth regulation of human prostate cancer cells by bone morphogenetic protein-2.

  1997cited by this paper
• Fibronectin regulates calvarial osteoblast differentiation.

  1996cited by this paper
• Endothelin-1 production and decreased endothelin B receptor expression in advanced prostate cancer.

  1996cited by this paper
• Increased bone formation in osteocalcin-deficient mice

  1996cited by this paper
• Prostate specific antigen cleaves parathyroid hormone-related protein in the PTH-like domain: inactivation of PTHrP-stimulated cAMP accumulation in mouse osteoblasts.

  1996cited by this paper
• Identification of endothelin–1 in the pathophysiology of metastatic adenocarcinoma of the prostate

  1995cited by this paper
• Urokinase overproduction results in increased skeletal metastasis by prostate cancer cells in vivo.

  1994cited by this paper
• Biological effects of prostate specific antigen as an insulin-like growth factor binding protein-3 protease.

  1994cited by this paper
• Vasculotropin/vascular endothelial growth factor induces differentiation in cultured osteoblasts.

  1994cited by this paper
• beta ig-h3: a transforming growth factor-beta-responsive gene encoding a secreted protein that inhibits cell attachment in vitro and suppresses the growth of CHO cells in nude mice.

  1994cited by this paper
• Nucleation of hydroxyapatite by bone sialoprotein.

  1993cited by this paper
• Mitogenic response of osteoblast cells to prostate-specific antigen suggests an activation of latent TGF-beta and a proteolytic modulation of cell adhesion receptors.

  1993cited by this paper
• Distribution of integrin subunits on rat metaphyseal osteoclasts and osteoblasts.

  1993cited by this paper
• Osteoblastic metastasis in advanced prostate cancer.

  1993cited by this paper

• High Frequency Loss of 17q11.2 and Downregulation of the Cancer Metastasis Suppression microRNA miR-193a-3p in Prostate Cancer Bone Metastasis

  2026cites this paper
• Volumetric 68 Ga- prostate-specific membrane antigen PET/computed tomography analysis of bone metastasis subtypes in prostate cancer: correlation with prostate-specific antigen and International Society of Urological Pathology grade.

  2025cites this paper
• Molecular targeted therapies, omics, and AI based theranostics approaches for the treatment of prostate cancer.

  2025cites this paper
• Intraindividual comparison of 99mTc-HYNIC-PSMA-11 and 99mTc-MDP bone scan with SPECT/CT for detecting skeletal metastases in prostate cancer: a prospective concordance study.

  2025cites this paper
• The Recruitment and Immune Suppression Mechanisms of Myeloid‐Derived Suppressor Cells and Their Impact on Bone Metastatic Cancer

  2025cites this paper
• Genome-wide long non-coding RNA expression profile and its regulatory role in the ileocecal valve from Mycobacterium avium subsp. paratuberculosis-infected cattle

  2025cites this paper
• Bone-metastatic lung adenocarcinoma cells bearing CD74-ROS1 fusion interact with macrophages to promote their dissemination

  2024cites this paper
• A case report on the atypical metastatic pathway of prostate cancer to the kidney and stomach

  2024cites this paper
• Research Progress on the Bone Metastasis Mechanism of Prostate Cancer and Bone-Targeted Drugs

  2024cites this paper
• Prostate Cancer Skeletal Metastasis: A Spontaneous Evolution from Osteolytic to Osteoblastic Morphology without Treatment

  2023cites this paper
• MDA-9/Syntenin in the tumor and microenvironment defines prostate cancer bone metastasis.

  2023cites this paper
• Iron supplementation enhances RSL3-induced ferroptosis to treat naïve and prevent castration-resistant prostate cancer

  2023cites this paper
• Metabolic control of cancer metastasis: role of amino acids at secondary organ sites

  2023cites this paper
• An Impressive Approach in Nuclear Medicine: Theranostics.

  2021cites this paper
• Tissue engineered scaffolds as 3D models for prostate cancer metastasis to bone

  2021cites this paper
• DOTA-ZOL: A Promising Tool in Diagnosis and Palliative Therapy of Bone Metastasis—Challenges and Critical Points in Implementation into Clinical Routine

  2020cites this paper
• Calcium and phosphorus disorders

  2020cites this paper
• Bone morphogenetic proteins mediate crosstalk between cancer cells and the tumour microenvironment at primary tumours and metastases (Review).

  2020cites this paper
• Breaking the vicious cycle between tumor cell proliferation and bone resorption by chloroquine-loaded and bone-targeted polydopamine nanoparticles

  2020cites this paper
• Dysregulation of cystathionine γ‐lyase promotes prostate cancer progression and metastasis

  2019cites this paper
• The Osteoclast in Bone Metastasis: Player and Target

  2018cites this paper
• Basement membrane extract attenuates the more malignant gene expression profile accentuated by fibronectin in prostate cancer cells

  2018cites this paper
• Osteoblast-secreted WISP-1 promotes adherence of prostate cancer cells to bone via the VCAM-1/integrin α4β1 system.

  2018cites this paper
• Recombinant MDA-7/IL24 Suppresses Prostate Cancer Bone Metastasis through Downregulation of the Akt/Mcl-1 Pathway

  2018cites this paper
• Where Hematopoietic Stem Cells Live: The Bone Marrow Niche

  2018cites this paper
• A proposed link between spinal epidural lipomatosis, prostate cancer and androgen deprivation therapy

  2018cites this paper
• Role of hepcidin and iron metabolism in the onset of prostate cancer.

  2018cites this paper
• Potential use of Aneustat for improvement of docetaxel-based therapy of advanced prostate cancer

  2017influential citation
• Mechanisms involved in the development of androgen independent prostate: Androgen receptor activation leads to a dissociation of E2F1:PHB in prostate cancer

  2017cites this paper
• Identification of the genetic alterations in prostate cancer metastases

  2017influential citation
• High uric acid (UA) downregulates bone alkaline phosphatase (BALP) expression through inhibition of its promoter activity

  2017cites this paper
• Dramatic mixed response of lymphangitic pulmonary metastases in newly diagnosed prostate cancer

  2017cites this paper
• Circulating steroid hormone variations throughout different stages of prostate cancer.

  2017cites this paper
• Identification of FBXL4 as a Metastasis Associated Gene in Prostate Cancer

  2017cites this paper
• Perlecan/HSPG2 and matrilysin/MMP-7 as indices of tissue invasion: tissue localization and circulating perlecan fragments in a cohort of 288 radical prostatectomy patients

  2016cites this paper
• Hypocalcaemia of malignancy.

  2016cites this paper
• Nuclear transcription factor Nrf2 suppresses prostate cancer cells growth and migration through upregulating ferroportin

  2016cites this paper
• MiRNA 34a: a therapeutic target for castration-resistant prostate cancer

  2016cites this paper
• Inhibition of Survivin Is Associated with Zoledronic Acid-induced Apoptosis of Prostate Cancer Cells.

  2016cites this paper
• Molecular Mechanisms of Bone Metastasis.

  2016cites this paper
• MicroRNA-335 and -543 suppress bone metastasis in prostate cancer via targeting endothelial nitric oxide synthase.

  2015cites this paper
• Optimal sequence of bone target drugs in metastatic prostatic cancer

  2015cites this paper
• Significance of S 100 A 4 expression in prostatic adenocarcinoma

  2015cites this paper
• Decreased expression of ferroportin in prostate cancer.

  2015cites this paper
• Computer-Aided Detection and diagnosis for prostate cancer based on mono and multi-parametric MRI: A review

  2015cites this paper
• Inorganic Arsenic–Related Changes in the Stromal Tumor Microenvironment in a Prostate Cancer Cell–Conditioned Media Model

  2015cites this paper
• Association of Gleason Risk Groups with Metastatic Sites in Prostate Cancer

  2015cites this paper
• Simultaneous Occurrence of Periodontal and Skin Abscesses in a Nigerian Girl: Case Report

  2015cites this paper
• Identification of novel androgen receptor inhibitors for the treatment of castration resistant prostate cancer

  2015cites this paper
• Sunitinib reduces tumor hypoxia and angiogenesis, and radiosensitizes prostate cancer stem‐like cells

  2015cites this paper
• Recent advances in bone-targeted therapies of metastatic prostate cancer.

  2014influential citation
• Delayed Diagnosis of a 67-Year-Old Man with an Atypical Presentation of Prostate Cancer: A Case Report

  2014cites this paper
• Diminished expression of h2-calponin in prostate cancer cells promotes cell proliferation, migration and the dependence of cell adhesion on substrate stiffness

  2014cites this paper
• Epithelial and Stromal Ron Receptor Expression Promotes Tumor Growth in a Murine Model of Prostate Cancer

  2013cites this paper
• Biología molecular de la metástasis óseas.

  2013cites this paper
• EUROPEAN ACADEMIC RESEARCH, VOL

  2013cites this paper
• [Molecular biology of bone metastases].

  2013cites this paper
• Solid Tumours Show Osteotropism: Mechanisms of Bone Metastases

  2013cites this paper
• Search for a cause of disseminated intravascular coagulopathy resulted in finding metastatic prostate cancer

  2013cites this paper
• MicroRNA-4723 Inhibits Prostate Cancer Growth through Inactivation of the Abelson Family of Nonreceptor Protein Tyrosine Kinases

  2013cites this paper
• The Osteoblastic and Osteoclastic Interactions in Spinal Metastases Secondary to Prostate Cancer

  2013cites this paper
• Pathobiology and management of prostate cancer-induced bone pain: recent insights and future treatments

  2013cites this paper
• Electric Cell-Substrate Impedance Sensing and Cancer Metastasis

  2012cites this paper
• The Interplay between the Androgen Receptor, Soluble Factors and Tumour Microenvironment

  2012cites this paper
• Novel approaches in the pharmacotherapy of skeletal-related events in metastatic castrate-resistant prostate cancer.

  2012cites this paper
• Atypical Presentation of Prostate Cancer and the Workup of an Adenocarcinoma of Unknown Primary

  2012cites this paper
• Targeting bone-microenvironment-tumour cell interactions : IGF-1 receptor kinase inhibitors

  2012cites this paper
• Current and Future Applications of ECIS Models to Study Bone Metastasis

  2012cites this paper
• Radiopharmaceuticals for Bone Metastasis Therapy and Beyond: A Voyage from the Past to the Present and a Look to the Future

  2012cites this paper
• Evaluating the effects of mixed osteolytic/osteoblastic metastasis on vertebral bone quality in a new rat model

  2012cites this paper
• Elucidating Zinc Distribution In Cancerous Prostate Cells Using Novel FRET Sensors

  2012cites this paper
• First-Line Chemotherapy with Anthracycline and Taxane Combination in Metastatic Breast Cancer. Detection of bone metastases with TRACP 5b

  2011cites this paper
• N-cadherin mediates angiogenesis by regulating monocyte chemoattractant protein-1 expression via PI3K/Akt signaling in prostate cancer cells.

  2011cites this paper
• Identification of miRs-143 and -145 that Is Associated with Bone Metastasis of Prostate Cancer and Involved in the Regulation of EMT

  2011cites this paper
• Bone morphogenetic protein and bone metastasis, implication and therapeutic potential.

  2011cites this paper
• Potential prognostic value of repulsive guidance molecules in breast cancer.

  2011cites this paper
• Blockade of transforming growth factor‐beta (TGFβ) signaling inhibits osteoblastic tumorigenesis by a novel human prostate cancer cell line

  2011cites this paper
• Understanding and Optimizing Bone Health in Breast Cancer

  2010cites this paper
• Pathogenesis of osteoblastic bone metastases from prostate cancer

  2010cites this paper
• Post-treatment circulating plasma BMP6 mRNA and H3K27 methylation levels discriminate metastatic prostate cancer from localized disease.

  2010cites this paper
• Examining the metastatic niche: targeting the microenvironment.

  2010cites this paper
• Increased anti-tumour effects of doxorubicin and zoledronic acid in prostate cancer cells in vitro: supporting the benefits of combination therapy

  2010cites this paper
• Therapeutic Potential of Adult Bone Marrow–Derived Mesenchymal Stem Cells in Prostate Cancer Bone Metastasis

  2009cites this paper
• Curcumin blocks CCL2-induced adhesion, motility and invasion, in part, through down-regulation of CCL2 expression and proteolytic activity.

  2009cites this paper
• Metastatic patterns of cancers: results from a large autopsy study.

  2009cites this paper
• Characterization and Cloning of the Human Perlecan Promoter Region

  2009influential citation
• Prostatic tumor stroma: a key player in cancer progression.

  2008cites this paper
• POST-TRANSLATIONAL REGULATION OF GALECTIN-3 IN HUMAN SEMINAL PLASMA

  2008cites this paper
• BMP‐6 over‐expression in prostate cancer is associated with increased Id‐1 protein and a more invasive phenotype

  2008cites this paper
• Metabolic targeting of cancer cells: Two molecular mechanisms involving glucose metabolism

  2008cites this paper
• Bone metastasis: pathogenesis and therapeutic implications

  2007cites this paper
• Regulation Of Membrane-Type 1 Matrix Metalloproteinase In Prostate Cancer

  2007cites this paper
• Interactions of Prostate Cancer Cells to Human Microvascular Endothelial Cells Under Shear Stress Conditions

  2007cites this paper
• Duke University Dissertation Template

  2007cites this paper