A fusion protein derived from plants holds promising potential as a new oral therapy for type 2 diabetes.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Plant Biotechnology Journal

• Publication date

  2014-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/pbi.12149PMID 24373324
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Inhibition of Gsk3β activity improves β-cell function in c-KitWv/+ male mice

  2012cited by this paper
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• Caco‐2 Cells as a Model for Intestinal Absorption

  2011cited by this paper
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  2011cited by this paper
• Endocrine disruptors in the etiology of type 2 diabetes mellitus

  2011cited by this paper
• Long-Acting Glucagon-Like Peptide 1 Receptor Agonists

  2011influential reference
• Cardiovascular complications in diabetes: lessons from animal models.

  2011cited by this paper
• Developing risk prediction models for type 2 diabetes: a systematic review of methodology and reporting

  2011cited by this paper
• Incretin-based therapy: a powerful and promising weapon in the treatment of type 2 diabetes mellitus

  2011cited by this paper
• Global healthcare expenditure on diabetes for 2010 and 2030.

  2010cited by this paper
• Exenatide Use in the Management of Type 2 Diabetes Mellitus

  2010cited by this paper
• Human growth hormone-transferrin fusion protein for oral delivery in hypophysectomized rats.

  2010cited by this paper
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  2010cited by this paper
• Transferrin Fusion Technology: A Novel Approach to Prolonging Biological Half-Life of Insulinotropic Peptides

  2010cited by this paper
• Plant-derived recombinant human serum transferrin demonstrates multiple functions.

  2010cited by this paper
• Expression, purification, and characterization of recombinant human transferrin from rice (Oryza sativa L.).

  2010cited by this paper
• Use of Antimicrobial and Genotoxicity Potentiality for Evaluation of Essential Oils as Food Preservatives

  2009cited by this paper
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  2009cited by this paper
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  2009cited by this paper
• Tobacco, a highly efficient green bioreactor for production of therapeutic proteins

  2009cited by this paper
• A review of exenatide as adjunctive therapy in patients with type 2 diabetes

  2009cited by this paper
• Incretin-based therapies for type 2 diabetes mellitus

  2009cited by this paper
• Protein and Peptide Drug Delivery: Oral Approaches

  2008cited by this paper
• Incretin based therapies for type 2 diabetes mellitus.

  2008cited by this paper
• Exendin-4 modulates diabetes onset in nonobese diabetic mice.

  2008cited by this paper
• A novel platform for biologically active recombinant human interleukin-13 production.

  2008cited by this paper
• Tumor cell targeting of transferrin-PEG-TNF-alpha conjugate via a receptor-mediated delivery system: design, synthesis, and biological evaluation.

  2007cited by this paper
• Exploiting the pleiotropic actions of GLP-1 for the management of type 2 diabetes mellitus and its complications

  2007cited by this paper
• Recombinant granulocyte colony-stimulating factor-transferrin fusion protein as an oral myelopoietic agent.

  2005cited by this paper
• Production of biologically active human interleukin-4 in transgenic tobacco and potato.

  2005cited by this paper
• Drug delivery: Transferrin' the load

  2005cited by this paper
• Induction of oral tolerance to prevent diabetes with transgenic plants requires glutamic acid decarboxylase (GAD) and IL-4.

  2004cited by this paper
• Role of incretin hormones in the regulation of insulin secretion in diabetic and nondiabetic humans.

  2004influential reference
• Molecular mechanism of RNA silencing suppression mediated by p19 protein of tombusviruses

  2004cited by this paper
• Minimizing the immunogenicity of protein therapeutics.

  2004cited by this paper
• Optimization of codon pair use within the (GGGGS)3 linker sequence results in enhanced protein expression.

  2004cited by this paper
• Molecular farming in plants: host systems and expression technology.

  2003cited by this paper
• Hepatocyte growth factor stimulates proliferation of pancreatic beta-cells particularly in the presence of subphysiological glucose concentrations.

  2002cited by this paper
• Transferrin/transferrin receptor‐mediated drug delivery

  2002cited by this paper
• Isolation and Sequence Analysis of a Barley a-Amylase cDNA Clone*

  2001cited by this paper
• Protein kinase Czeta activation mediates glucagon-like peptide-1-induced pancreatic beta-cell proliferation.

  2001cited by this paper
• Glucagon-like peptide 1 induces differentiation of islet duodenal homeobox-1-positive pancreatic ductal cells into insulin-secreting cells.

  2001cited by this paper
• Biological activities of glucagon-like peptide-1 analogues in vitro and in vivo.

  2001cited by this paper
• Protein Kinase Cζ Activation Mediates Glucagon-Like Peptide-1–Induced Pancreatic β-Cell Proliferation

  2001cited by this paper
• Hypoglycemic effect of insulin-transferrin conjugate in streptozotocin-induced diabetic rats.

  2000cited by this paper
• The glucagon-like peptides.

  1999cited by this paper
• Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells

  1999cited by this paper
• Different degradation pathways for heterologous glycoproteins in yeast

  1998cited by this paper
• Molecular Cloning of the Helodermin and Exendin-4 cDNAs in the Lizard

  1998cited by this paper
• Insulin-like Growth Factor I (IGF-I)-stimulated Pancreatic β-Cell Growth Is Glucose-dependent

  1998cited by this paper
• Cholera toxin and cholera toxin B subunit induce IgA switching through the action of TGF-beta 1.

  1998cited by this paper
• Insulin-like growth factor I (IGF-I)-stimulated pancreatic beta-cell growth is glucose-dependent. Synergistic activation of insulin receptor substrate-mediated signal transduction pathways by glucose and IGF-I in INS-1 cells.

  1998cited by this paper
• Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines.

  1992cited by this paper
• Cap-independent enhancement of translation by a plant potyvirus 5' nontranslated region

  1990cited by this paper
• The physiology of transferrin and transferrin receptors.

  1987cited by this paper
• A simple and general method for transferring genes into plants.

  1985cited by this paper
• Human transferrin: cDNA characterization and chromosomal localization.

  1984cited by this paper
• Isolation and sequence analysis of a barley alpha-amylase cDNA clone.

  1983cited by this paper
• Receptor-mediated endocytosis of transferrin in developmentally totipotent mouse teratocarcinoma stem cells.

  1981influential reference
• Is Incretin-Based Therapy Ready for the Care of Hospitalized Patients With Type 2 Diabetes? Insulin therapy has proven itself and is considered the mainstay of treatment

  year unknowncited by this paper

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• Plastid transformation: Advances and challenges for its implementation in agricultural crops

  2021cites this paper
• Recent Advances in Half-life Extension Strategies for Therapeutic Peptides and Proteins.

  2019cites this paper
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  2019cites this paper
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  2018cites this paper
• Sialic-Acid-Anchored Micelles: A Hierarchical Targeting Device for Enhanced Tumor Tissue Accumulation and Cellular Internalization.

  2018cites this paper
• Current Status and Perspectives of the Molecular Farming Landscape

  2018cites this paper
• Intranasal basic fibroblast growth factor attenuates endoplasmic reticulum stress and brain injury in neonatal hypoxic-ischaemic injury.

  2017cites this paper
• Melatonin protects against blood-brain barrier damage by inhibiting the TLR4/ NF-κB signaling pathway after LPS treatment in neonatal rats

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• Dl‐3‐n‐butylphthalide attenuates acute inflammatory activation in rats with spinal cord injury by inhibiting microglial TLR4/NF‐κB signalling

  2017cites this paper
• Melatonin reduces hypoxic-ischaemic (HI) induced autophagy and apoptosis: An in vivo and in vitro investigation in experimental models of neonatal HI brain injury.

  2017cites this paper
• Inhibiting endoplasmic reticulum stress by lithium chloride contributes to the integrity of blood-spinal cord barrier and functional recovery after spinal cord injury.

  2017influential citation
• Expression and functional evaluation of biopharmaceuticals made in plant chloroplasts.

  2017cites this paper
• Emerging technologies to achieve oral delivery of GLP-1 and GLP-1 analogs for treatment of type 2 diabetes mellitus (T2DM)

  2017cites this paper
• Inhibition of endoplasmic reticulum stress is involved in the neuroprotective effect of aFGF in neonatal hypoxic-ischaemic brain injury

  2017cites this paper
• Astragalus polysaccharides protect against dextran sulfate sodium-induced colitis by inhibiting NF-κВ activation.

  2017cites this paper
• Nerve growth factor-induced Akt/mTOR activation protects the ischemic heart via restoring autophagic flux and attenuating ubiquitinated protein accumulation

  2016cites this paper
• Companion Protease Inhibitors for the In Situ Protection of Recombinant Proteins in Plants.

  2016cites this paper
• Oral Delivery of Protein Drugs Bioencapsulated in Plant Cells

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• Diversion dirigée du métabolisme cellulaire chez le tabac sauvage Nicotiana benthamiana utilisé comme hôte pour l'expression hétérologue de protéines d'intérêt clinique

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• Low-cost oral delivery of protein drugs bioencapsulated in plant cells.

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• Fusion Proteins for Half-Life Extension of Biologics as a Strategy to Make Biobetters

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• Plant-based oral delivery of β-glucocerebrosidase as an enzyme replacement therapy for Gaucher's disease.

  2015cites this paper
• The increasing value of plant-made proteins.

  2015cites this paper
• Transgenic Plants as Novel Bioreactors to Produce Human Protein

  2014cites this paper
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  2014cites this paper