Paradoxical Decision-Making: A Framework for Understanding Cognition in Parkinson's Disease.

People with Parkinson's disease (PD) show impaired decision-making when sensory and memory information must be combined. This recently identified impairment results from an inability to accumulate the proper amount of information needed to make a decision and appears to be independent of dopamine tone and reinforcement learning mechanisms. Although considerable work focuses on PD and decisions involving risk and reward, in this Opinion article we propose that the emerging findings in perceptual decision-making highlight the multisystem nature of PD, and that unraveling the neuronal circuits underlying perceptual decision-making impairment may help in understanding other cognitive impairments in people with PD. We also discuss how a decision-making framework may be extended to gain insights into mechanisms of motor impairments in PD.

• Publication year

  2018

• Venue

  Trends in Neurosciences

• Publication date

  2018-08-01

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1016/j.tins.2018.04.006PMID 29747856PMCID PMC6124671
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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