Hypothalamic neurohormones and immune responses

The aim of this review is to provide a comprehensive examination of the current literature describing the neural-immune interactions, with emphasis on the most recent findings of the effects of neurohormones on immune system. Particularly, the role of hypothalamic hormones such as Thyrotropin-releasing hormone (TRH), Corticotropin-releasing hormone (CRH) and Gonadotropin-releasing hormone (GnRH). In the past few years, interest has been raised in extrapituitary actions of these neurohormones due to their receptors have been found in many non-pituitary tissues. Also, the receptors are present in immune cells, suggesting an autocrine or paracrine role within the immune system. In general, these neurohormones have been reported to exert immunomodulatory effects on cell proliferation, immune mediators release and cell function. The implications of these findings in understanding the network of hypothalamic neuropeptides and immune system are discussed.

• Publication year

  2013

• Venue

  Frontiers in Integrative Neuroscience

• Publication date

  2013-08-13

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3389/fnint.2013.00056PMID 23964208PMCID 3741963
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Gonadotropin-releasing hormone receptors as molecular therapeutic targets in prostate cancer: Current options and emerging strategies.

  2013cited by this paper
• Corticotropin releasing hormone activates CD14+ cells to induce endothelial barrier dysfunction

  2013cited by this paper
• Is It Really a Matter of Simple Dualism? Corticotropin-Releasing Factor Receptors in Body and Mental Health

  2013cited by this paper
• Ingested (oral) thyrotropin releasing factor (TRH) inhibits EAE.

  2013cited by this paper
• Desensitization, Trafficking, and Resensitization of the Pituitary Thyrotropin-Releasing Hormone Receptor

  2012influential reference
• Gonadotropin-releasing hormone treatment improves locomotor activity, urinary function and neurofilament protein expression after spinal cord injury in ovariectomized rats.

  2012cited by this paper
• Visualizing corticotropin‐releasing hormone receptor type 1 expression and neuronal connectivities in the mouse using a novel multifunctional allele

  2012cited by this paper
• Leuprolide Acetate, a GnRH Agonist, Improves Experimental Autoimmune Encephalomyelitis: A Possible Therapy for Multiple Sclerosis

  2012cited by this paper
• Gonadotropin-releasing hormone plasticity: a comparative perspective.

  2012cited by this paper
• Biochemistry, molecular biology and cell biology of gonadotropin-releasing hormone antagonists

  2011cited by this paper
• Gonadotropin-releasing hormone reduces the severity of experimental autoimmune encephalomyelitis, a model of multiple sclerosis.

  2011cited by this paper
• Novel thyrotropin-releasing hormone analogs: a patent review

  2011influential reference
• Gonadotropin releasing hormone agonists: Expanding vistas

  2011cited by this paper
• Lipopolysaccharide upregulates the expression of corticotropin-releasing hormone via MAP kinase pathway in rat peritoneal macrophages

  2011influential reference
• Neuropeptides

  2011cited by this paper
• Neuroimmunomodulation by gonadotropin releasing hormone

  2011cited by this paper
• Gonadotropin-releasing hormone/gonadotropin-releasing hormone receptor signaling in the placenta

  2011cited by this paper
• TRH-like peptides.

  2011cited by this paper
• Synthesis, Receptor Binding, and CNS Pharmacological Studies of New Thyrotropin‐Releasing Hormone (TRH) Analogues

  2011cited by this paper
• Changes in tissue inflammation, angiogenesis and apoptosis in endometriosis, adenomyosis and uterine myoma after GnRH agonist therapy.

  2010cited by this paper
• Neuroendocrine regulation of GnRH release and expression of GnRH and GnRH receptor genes in the hypothalamus-pituitary unit in different physiological states.

  2010cited by this paper
• Gonadotropin-releasing hormone receptor in spinal cord neurons of embryos and adult rats.

  2009cited by this paper
• Luteinizing Hormone-Releasing Hormone Enhances T Cell Recovery following Allogeneic Bone Marrow Transplantation1

  2009cited by this paper
• The thyrotropin-releasing hormone (TRH)-immune system homeostatic hypothesis.

  2009cited by this paper
• Gonadotropin-releasing hormone-regulated chemokine expression in human placentation.

  2009cited by this paper
• Trafficking and quality control of the gonadotropin releasing hormone receptor in health and disease.

  2009cited by this paper
• Gonadotropin-Releasing Hormone Modulates Immune System Function via the Nuclear Factor-κB Pathway in Murine Raw264.7 Macrophages

  2009cited by this paper
• Minireview: Thyrotropin-releasing hormone and the thyroid hormone feedback mechanism.

  2009cited by this paper
• Neurotransmitters activate T-cells and elicit crucial functions via neurotransmitter receptors.

  2008cited by this paper
• Enhanced Immune System Regeneration in Humans Following Allogeneic or Autologous Hemopoietic Stem Cell Transplantation by Temporary Sex Steroid Blockade

  2008cited by this paper
• Leuprolide--a GnRH agonist--prevents restraint stress-induced immunosuppression via sex steroid-independent peripheral mechanism in mice.

  2008cited by this paper
• Gonadotropin‐releasing hormone: GnRH receptor signaling in extrapituitary tissues

  2008cited by this paper
• Type 1 corticotropin‐releasing factor receptor expression reported in BAC transgenic mice: Implications for reconciling ligand‐receptor mismatch in the central corticotropin‐releasing factor system

  2008influential reference
• Luteinizing Hormone-Releasing Hormone I (LHRH-I) and Its Metabolite in Peripheral Tissues

  2008cited by this paper
• Leuprolide acetate: a drug of diverse clinical applications

  2007cited by this paper
• Effects of hypoxia on glucose, insulin, glucagon, and modulation by corticotropin-releasing factor receptor type 1 in the rat.

  2007cited by this paper
• Corticotropin‐releasing factor, urocortin 1, and their receptors in the mouse spinal cord

  2007cited by this paper
• Neuroendocrine control of reproductive aging: roles of GnRH neurons.

  2006cited by this paper
• Low Affinity Analogs of Thyrotropin-releasing Hormone Are Super-agonists*

  2006cited by this paper
• Role of beta-endorphin, corticotropin-releasing hormone, and autonomic nervous system in mediation of the effect of chronic ethanol on natural killer cell cytolytic activity.

  2006cited by this paper
• Corticotropin Releasing Hormone And The Immune/Inflammatory Response

  2006cited by this paper
• [Luteinizing hormone].

  2005cited by this paper
• GnRHs and GnRH receptors.

  2005cited by this paper
• GnRH‐I and GnRH‐II have differential modulatory effects on human peripheral blood mononuclear cell proliferation and interleukin‐2 receptor γ‐chain mRNA expression in healthy males

  2005cited by this paper
• Human Mast Cells Express Corticotropin-Releasing Hormone (CRH) Receptors and CRH Leads to Selective Secretion of Vascular Endothelial Growth Factor1

  2005cited by this paper
• Synthesis and secretion of GnRH.

  2005cited by this paper
• Molecular biology of gonadotropin-releasing hormone (GnRH)-I, GnRH-II, and their receptors in humans.

  2005cited by this paper
• Hypothalamic hormones a.k.a. hypothalamic releasing factors.

  2005influential reference
• The corticotropin-releasing factor (CRF) family of neuropeptides in inflammation: potential therapeutic applications.

  2005cited by this paper
• Gonadotropin-releasing hormone and its receptor in normal and malignant cells.

  2004cited by this paper
• Critical role of mast cells in inflammatory diseases and the effect of acute stress.

  2004cited by this paper
• Corticotropin-releasing hormone and its structurally related urocortin are synthesized and secreted by human mast cells.

  2004cited by this paper
• In vitro effect of gonadotropin-releasing hormone agonist on natural killer cell cytolysis in women with and without endometriosis.

  2004cited by this paper
• Modulation of diabetes with gonadotropin-releasing hormone antagonists in the nonobese mouse model of autoimmune diabetes.

  2004cited by this paper
• Mast cells

  2004cited by this paper
• CRF and CRF receptors: role in stress responsivity and other behaviors.

  2004cited by this paper
• Mast cells in the rat brain synthesize gonadotropin-releasing hormone.

  2003cited by this paper
• Differential profile of CRF receptor distribution in the rat stomach and duodenum assessed by newly developed CRF receptor antibodies

  2003cited by this paper
• Use of a Highly Specific Monoclonal Antibody Against the Central Variable Amino Acid Sequence of Mammalian Gonadotropin Releasing Hormone to Evaluate GnRH‐I Tissue Distribution Compared With GnRH‐I Binding Sites in Adult Male Rats

  2003cited by this paper
• Thyrotropin-releasing hormone receptors -- similarities and differences.

  2003cited by this paper
• The human neuroendocrine thyrotropin-releasing hormone receptor promoter is activated by the haematopoietic transcription factor c-Myb.

  2003cited by this paper
• Gonadotropin-Releasing Hormone Alters the T Helper Cytokine Balance in the Pregnant Rat1

  2003cited by this paper
• Human Urocortin II, a Selective Agonist for the Type 2 Corticotropin-Releasing Factor Receptor, Decreases Feeding and Drinking in the Rat

  2003cited by this paper
• Involvement of corticotropin‐releasing hormone receptor subtypes 1 and 2 in peripheral opioid‐mediated inhibition of inflammatory pain

  2003cited by this paper
• Corticotropin-releasing hormone causes vasodilation in human skin via mast cell-dependent pathways.

  2003cited by this paper
• The Thyrotropin-Releasing Hormone (TRH) Hypothesis of Homeostatic Regulation: Implications for TRH-Based Therapeutics

  2003cited by this paper
• Gonadotropin-releasing hormone attenuates pregnancy-associated thymic involution and modulates the expression of antiproliferative gene product prohibitin.

  2003cited by this paper
• The hypothalamic-pituitary-gonadal axis: immune function and autoimmunity.

  2003cited by this paper
• Signalling, cycling and desensitisation of gonadotrophin-releasing hormone receptors.

  2002cited by this paper
• The neuropeptides GnRH-II and GnRH-I are produced by human T cells and trigger laminin receptor gene expression, adhesion, chemotaxis and homing to specific organs

  2002cited by this paper
• Corticotropin-Releasing Hormone and Brain Mast Cells Regulate Blood-Brain-Barrier Permeability Induced by Acute Stress

  2002cited by this paper
• Probing the roles of mast cells and basophils in natural and acquired immunity, physiology and disease.

  2002cited by this paper
• Functional characteristics of CRH receptors and potential clinical applications of CRH-receptor antagonists.

  2002cited by this paper
• Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor

  2001cited by this paper
• Expression of CRHR1 and CRHR2 in mouse pituitary and adrenal gland: implications for HPA system regulation.

  2001cited by this paper
• Corticotropin-releasing hormone signaling in synovial tissue from patients with early inflammatory arthritis is mediated by the type 1 alpha corticotropin-releasing hormone receptor.

  2001cited by this paper
• Immunomodulatory role of the corticotropin-releasing factor.

  2001influential reference
• Expression of CRHR1 and CRHR2 in Mouse Pituitary and Adrenal Gland: Implications for HPA System Regulation.

  2001cited by this paper
• Immunomodulatory role of the corticotropin-releasing factor.

  2001cited by this paper
• Luteinizing hormone-releasing hormone induces nuclear factor kappaB-activation and inhibits apoptosis in ovarian cancer cells.

  2000cited by this paper
• Peripheral corticotropin-releasing factor and stress-stimulated colonic motor activity involve type 1 receptor in rats.

  2000cited by this paper
• Endocrine–Immune Interaction: Alterations in Immune Function Resulting From Neonatal Treatment with a GnRH Antagonist and Seasonality in Male Primates

  2000cited by this paper
• mRNA expression profiles for corticotrophin-releasing factor (CRF), urocortin, CRF receptors and CRF-binding protein in peripheral rat tissues.

  2000cited by this paper
• Human mast cells and basophils as sources of cytokines

  2000cited by this paper
• The biology of pro-thyrotropin-releasing hormone-derived peptides.

  1999influential reference
• Early Activation of Thyrotropin-Releasing-Hormone and Prolactin Plays a Critical Role during a T Cell-Dependent Immune Response.

  1999cited by this paper
• Increased Natural Killer Cell Activities in Patients Treated with Gonadotropin Releasing Hormone Agonist

  1999cited by this paper
• Early activation of thyrotropin-releasing-hormone and prolactin plays a critical role during a T cell-dependent immune response.

  1999cited by this paper
• Human peripheral blood mononuclear cells express gonadotropin-releasing hormone (GnRH), GnRH receptor, and interleukin-2 receptor gamma-chain messenger ribonucleic acids that are regulated by GnRH in vitro.

  1999cited by this paper
• Expression analysis of the thyrotropin‐releasing hormone receptor (TRHR) in the immune system using agonist anti‐TRHR monoclonal antibodies

  1999cited by this paper
• A role for corticotropin releasing factor and urocortin in behavioral responses to stressors.

  1999cited by this paper
• Time of Day-Dependent Effects of Thyroliberin and Thyrotropin on Thymocyte Proliferation in Rats

  1999cited by this paper
• Corticotropin-releasing factor receptor 1 in mouse spleen: expression after immune stimulation and identification of receptor-bearing cells.

  1999cited by this paper
• Cloning of thyrotropin-releasing hormone precursor and receptor in rat thymus, adrenal gland, and testis.

  1999influential reference
• The effect of LHRH and TRH on human interferon-gamma production in vivo and in vitro.

  1998cited by this paper
• Localization of corticotropin-releasing factor in primary and secondary lymphoid organs of the rat.

  1998cited by this paper
• The anti-gonadotropic effects of cytokines: the role of neuropeptides.

  1998cited by this paper
• Mast cells in the neonate musk shrew brain: implications for neuroendocrine immune interactions.

  1998cited by this paper
• Static and dynamic roles of extracellular loops in G-protein-coupled receptors: a mechanism for sequential binding of thyrotropin-releasing hormone to its receptor.

  1998cited by this paper
• Local Hormone Networks and Intestinal T Cell Homeostasis

  1997cited by this paper

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  2025cites this paper
• Conditioned immune responses and the neural-immune connection in animals and humans.

  2025cites this paper
• Decoding sex differences in human immunity through systems immunology

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• CRH upregulates supervillin through ERK and AKT pathways to promote bladder cancer cell migration

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• Mass Spectrometry-Based Metabolomics Reveals a Salivary Signature for Low-Severity COVID-19

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• New onset of Graves' disease after controlled ovarian stimulation: A case report and brief literature review

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• Gonadotropin-Releasing Hormone and Organs of the Immune System

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• Effect of Leuprolide Acetate, a GnRH Agonist, on Neuroinflammation and Anxiety-Like Behavior after Mild Hypoxic-Ischemic Encephalopathy in Rat Model

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• The Effect of Craniosacral Therapy on Blood Levels of Stress Hormones in Male Firefighter Cadets: A Randomized Clinical Trial

  2023cites this paper
• Hypothyroidism‐associated immunosuppression involves induction of galectin‐1‐producing regulatory T cells

  2023cites this paper
• Crosstalk between reproductive and immune systems: the teleostean perspective.

  2022cites this paper
• Thyroid Dysfunction after Gonadotropin-Releasing Hormone Agonist Administration in Women with Thyroid Autoimmunity

  2022cites this paper
• Relationship Between Immune Response and Some Reproductive Hormones in Chickens

  2021cites this paper
• Single-cell analysis reveals altered tumor microenvironments of relapse- and remission-associated pediatric acute myeloid leukemia

  2021cites this paper
• Comparative profiling of immune genes improves the prognoses of lower grade gliomas

  2021cites this paper
• Acute Corticotropin-Releasing Factor Receptor Type 2 Agonism Results in Sustained Symptom Improvement in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

  2021cites this paper
• Behavioral assessment of children and adolescents with Graves’ disease: A prospective study

  2021cites this paper
• Thyrotropin-Releasing Hormone (TRH) and Somatostatin (SST), but not Growth Hormone-Releasing Hormone (GHRH) nor Ghrelin (GHRL), Regulate Expression and Release of Immune Growth Hormone (GH) from Chicken Bursal B-Lymphocyte Cultures

  2020cites this paper
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  2020cites this paper
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  2020cites this paper
• Pharmacology of Neuropeptides: Substance P, Vasoactive Intestinal Peptides, Neuropeptide Y, Calcitonin Peptides and Their Receptors

  2020cites this paper
• Mechanisms of Reciprocal Regulation of Gonadotropin-Releasing Hormone (GnRH)-Producing and Immune Systems: The Role of GnRH, Cytokines and Their Receptors in Early Ontogenesis in Normal and Pathological Conditions

  2020cites this paper
• Cancer-Specific Loss of Urocortin 3 in Human Renal Cancer

  2019cites this paper
• Fish pituitary show an active immune response after in vitro stimulation with Vibrio bacterin.

  2019cites this paper
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  2019cites this paper
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  2018cites this paper
• Black/White disparities in pregnant women in the United States: An examination of risk factors associated with Black/White racial identity

  2018cites this paper
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  2017cites this paper
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  2017cites this paper
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  2015cites this paper
• Molecular mechanisms of amitraz mammalian toxicity: a comprehensive review of existing data.

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• Beyond the borders: the gates and fences of neuroimmune interaction

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