Human Urocortin II, a Selective Agonist for the Type 2 Corticotropin-Releasing Factor Receptor, Decreases Feeding and Drinking in the Rat

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Journal of Pharmacology and Experimental Therapeutics

• Publication date

  2003-04-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1124/JPET.102.047712PMID 12649393
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2002cited by this paper
• Human urocortin II: mild locomotor suppressive and delayed anxiolytic-like effects of a novel corticotropin-releasing factor related peptide.

  2002influential reference
• Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor

  2001cited by this paper
• Urocortin II: A member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors

  2001influential reference
• Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor

  2001cited by this paper
• Intrameal hepatic-portal infusion of glucose reduces spontaneous meal size in rats.

  2001cited by this paper
• A Novel Selective Melanocortin-4 Receptor Agonist Reduces Food Intake in Rats and Mice without Producing Aversive Consequences

  2000influential reference
• Role of corticotropin-releasing factor (CRF) receptors in the anorexic syndrome induced by CRF.

  2000cited by this paper
• Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress

  2000cited by this paper
• Distribution of mRNAs encoding CRF receptors in brain and pituitary of rat and mouse

  2000cited by this paper
• Abnormal adaptations to stress and impaired cardiovascular function in mice lacking corticotropin-releasing hormone receptor-2

  2000influential reference
• Dissociation of locomotor activation and suppression of food intake induced by CRF in CRFR1-deficient mice.

  2000cited by this paper
• The inhibitory effect of hormones associated with stress on Na appetite of sheep.

  2000cited by this paper
• The Role of CNS Glucagon-Like Peptide-1 (7-36) Amide Receptors in Mediating the Visceral Illness Effects of Lithium Chloride

  2000influential reference
• Do Centrally Administered Neuropeptides Access Cognate Receptors?: An Analysis in the Central Corticotropin-Releasing Factor System

  2000influential reference
• Dissociation of Locomotor Activation and Suppression of Food Intake Induced by CRF in CRFR1-Deficient Mice.

  2000cited by this paper
• Corticotropin Releasing Factor Receptors and Their Ligand Family

  1999cited by this paper
• A role for corticotropin releasing factor and urocortin in behavioral responses to stressors.

  1999influential reference
• Cholecystokinin: proofs and prospects for involvement in control of food intake and body weight.

  1999cited by this paper
• Printed in U.S.A. Copyright © 2000 by The Endocrine Society Modulation of Urocortin-Induced Hypophagia and Weight Loss by Corticotropin-Releasing Factor Receptor 1 Deficiency in Mice*

  1999influential reference
• Central infusion of melanocortin agonist MTII in rats: assessment of c-Fos expression and taste aversion.

  1998influential reference
• Hypothalamic effector neurons and extended circuitries activated in “neurogenic” stress: A comparison of footshock effects exerted acutely, chronically, and in animals with controlled glucocorticoid levels

  1998cited by this paper
• d-fenfluramine anorexia: dissociation of ingestion rate, meal duration, and meal size effects.

  1997cited by this paper
• Conditioned taste aversion and c‐fos expression in the rat brainstem after administration of various USs

  1997cited by this paper
• Appetite-Suppressing Effects of Urocortin, a CRF-Related Neuropeptide

  1996cited by this paper
• Central infusions of leptin and GLP-1-(7-36) amide differentially stimulate c-FLI in the rat brain.

  1996cited by this paper
• Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor

  1995influential reference
• Corticotropin releasing factor, stress and behavior

  1994cited by this paper
• Spatially and temporally differentiated patterns of c‐fos expression in brainstem catecholamilriergic cell groups induced by cardiovascular challenges in the rat

  1994cited by this paper
• Evidence that cholecystokinin induces immediate early gene expression in the brainstem, hypothalamus and amygdala of the rat by a CCKA receptor mechanism.

  1994influential reference
• Lithium chloride and inescapable, unsignaled tail shock differentially affect meal patterns of rats.

  1994cited by this paper
• Dexfenfluramine induces Fos-like immunoreactivity in discrete brain regions in rats.

  1993cited by this paper
• Pica in rats is analogous to emesis: an animal model in emesis research.

  1993cited by this paper
• Corticotropin-releasing factor enhances sodium and water intake/excretion in rabbits.

  1991cited by this paper
• Both conditioned taste preference and aversion induced by corticotropin-releasing factor.

  1991influential reference
• Lithium chloride, cholecystokinin and meal patterns: evidence that cholecystokinin suppresses meal size in rats without causing malaise.

  1987influential reference
• Serotonin manipulations and the structure of feeding behaviour.

  1986cited by this paper
• Pericardiectomy: current indications, concepts, and results in a university center.

  1982cited by this paper
• THE EFFECT OF FENFLURAMINE ON THE MICROSTRUCTURE OF FEEDING AND DRINKING IN THE RAT

  1981cited by this paper
• Effects of d-amphetamine and fenfluramine on feeding pattens and activity of obese and lean Zucker rats.

  1980cited by this paper
• A Stereotaxic Atlas of the Rat Brain

  1980influential reference
• Conditioned taste aversions: Two-stimulus tests are more sensitive than one-stimulus tests

  1971influential reference
• A stereotaxic atlas of the rat brain

  1967cited by this paper

• The metabolic role of corticotropin-releasing hormone receptor 2 and its UCN peptides: emerging therapeutic potential

  2025cites this paper
• Edinger-Westphal Urocortin-1 neurons regulate consumption and affect

  2025cites this paper
• The Role of Corticotropin-Releasing Factor (CRF) and CRF-Related Peptides in the Social Behavior of Rodents

  2023cites this paper
• Aging Changes the Efficacy of Central Urocortin 2 to Induce Weight Loss in Rats

  2023cites this paper
• Pharmacological Evaluation of a Pegylated Urocortin-1 Peptide in Experimental Autoimmune Disease Models

  2022cites this paper
• The Feeding Pattern of C57BL/6J Mice

  2022influential citation
• The effects of CRF and the urocortins on the hippocampal acetylcholine release in rats.

  2021cites this paper
• CRF2 Receptor Agonists and Nicotine Withdrawal

  2019cites this paper
• The CRF Family of Neuropeptides and their Receptors - Mediators of the Central Stress Response

  2018cites this paper
• Epigenetic Programming of Synthesis, Release, and/or Receptor Expression of Common Mediators Participating in the Risk/Resilience for Comorbid Stress-Related Disorders and Coronary Artery Disease

  2018cites this paper
• Treatment with the ghrelin-O-acyltransferase (GOAT) inhibitor GO-CoA-Tat reduces food intake by reducing meal frequency in rats.

  2015cites this paper
• Chronic and acute effects of stress on energy balance: are there appropriate animal models?

  2015cites this paper
• Corticotropin releasing factor: a key role in the neurobiology of addiction.

  2014cites this paper
• CRF and urocortin peptides as modulators of energy balance and feeding behavior during stress

  2014influential citation
• New insights into the evolution of vertebrate CRH (corticotropin-releasing hormone) and invertebrate DH44 (diuretic hormone 44) receptors in metazoans.

  2014cites this paper
• Alcohol-preferring rats show decreased corticotropin-releasing hormone-2 receptor expression and differences in HPA activation compared to alcohol-nonpreferring rats.

  2014cites this paper
• Hypothalamic neurohormones and immune responses

  2013cites this paper
• Gene Network Analysis in Amygdala following Taste Aversion Learning in Rats

  2013cites this paper
• Centrally administered urocortin 2 decreases gorging on high-fat diet in in both diet induced obesity-prone and -resistant rats

  2013cites this paper
• Is It Really a Matter of Simple Dualism? Corticotropin-Releasing Factor Receptors in Body and Mental Health

  2013cites this paper
• CRF1 receptor signaling regulates food and fluid intake in the drinking-in-the-dark model of binge alcohol consumption.

  2013cites this paper
• Obesity Pharmacotherapy: Current Perspectives and Future Directions

  2013cites this paper
• Functional organization of neuronal and humoral signals regulating feeding behavior.

  2013cites this paper
• Rikkunshito and ghrelin secretion.

  2012cites this paper
• Restraint stress and repeated CRF receptor activation in the amygdala both increase amyloid β precursor protein (APP) and amyloid- β (A β ) peptide but have divergent effects on BDNF and pre-synaptic proteins in the prefrontal cortex of rats

  2012cites this paper
• The role of CRF family peptides in the regulation of food intake and anxiety-like behavior

  2011cites this paper
• Chronic Loss of Melanin-Concentrating Hormone Affects Motivational Aspects of Feeding in the Rat

  2011cites this paper
• Restraint stress and repeated corticotrophin-releasing factor receptor activation in the amygdala both increase amyloid-β precursor protein and amyloid-β peptide but have divergent effects on brain-derived neurotrophic factor and pre-synaptic proteins in the prefrontal cortex of rats.

  2011cites this paper
• Peripheral activation of corticotropin-releasing factor receptor 2 inhibits food intake and alters meal structures in mice.

  2011cites this paper
• Systemic urocortin 2, but not urocortin 1 or stressin1‐A, suppresses feeding via CRF2 receptors without malaise and stress

  2011influential citation
• Centrally administered urocortin 3 inhibits food intake and gastric emptying in mice

  2011cites this paper
• Localized expression of urocortin genes in the developing zebrafish brain

  2010cites this paper
• Leptin Responsiveness of Mice Deficient in Corticotrophin-Releasing Hormone Receptor Type 2

  2010cites this paper
• New Derivatives from Phencyclidine Increase Food and Water Intake in Wistar Rats

  2010cites this paper
• Perifornical Urocortin-3 mediates the link between stress-induced anxiety and energy homeostasis

  2010cites this paper
• Neonatal immune challenge affects the regulation of estrus cyclicity and feeding behavior in female rats

  2009influential citation
• Central urocortin 3 administration decreases limited-access ethanol intake in nondependent mice

  2009cites this paper
• Inverse association of high‐fat diet preference and anxiety‐like behavior: a putative role for urocortin 2

  2009cites this paper
• Urocortins: emerging metabolic and energy homeostasis perspectives.

  2008cites this paper
• Antagonism of specific corticotropin-releasing factor receptor subtypes selectively modifies weight loss in restrained rats.

  2008cites this paper
• CRF-2 Corticotropin-Releasing Factor Receptor

  2008cites this paper
• ICV leptin effects on spontaneous physical activity and feeding behavior in rats.

  2008cites this paper
• Rhodiola rosea L. extract reduces stress- and CRF-induced anorexia in rats

  2007cites this paper
• Role of the corticotropin‐releasing factor receptor type 2 in the control of food intake in mice: a meal pattern analysis

  2007influential citation
• Extended Access to Nicotine Self-Administration Leads to Dependence: Circadian Measures, Withdrawal Measures, and Extinction Behavior in Rats

  2007cites this paper
• Urocortins and cholecystokinin-8 act synergistically to increase satiation in lean but not obese mice: involvement of corticotropin-releasing factor receptor-2 pathway.

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  2007influential citation
• Physiology, pharmacology, and therapeutic relevance of urocortins in mammals: ancient CRF paralogs.

  2007cites this paper
• Feeding microstructure in diet‐induced obesity susceptible versus resistant rats: central effects of urocortin 2

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• Discovery of pyrazine carboxamide CB1 antagonists: the introduction of a hydroxyl group improves the pharmaceutical properties and in vivo efficacy of the series.

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  2007cites this paper
• Corticotrophin-Releasing Hormone (CRH) and Ingestive Behavior

  2006cites this paper
• The corticotropin-releasing factor system as a mediator of the appetite-suppressing effects of stress in fish.

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  2006cites this paper
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  2006cites this paper
• Chronic disruption of body weight but not of stress peptides or receptors in rats exposed to repeated restraint stress.

  2006cites this paper
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  2006cites this paper
• Activation of the nociceptin/orphanin FQ system is unable to reverse CRF2 receptor mediated anorexia in the rat.

  2006cites this paper
• Sensitivity to stress: dysregulation of CRF pathways and disease development.

  2005cites this paper
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  2005cites this paper
• Regulation of energy balance by peptides: a review.

  2005cites this paper
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  2005cites this paper
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  2005cites this paper
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  2005cites this paper
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  2005cites this paper
• Homeostasis within the corticotropin‐releasing factor system via CRF2 receptor activation: a novel approach for the treatment of anxiety

  2005cites this paper
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  2005cites this paper
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  2005cites this paper
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  2004cites this paper
• Urocortins and the regulation of gastrointestinal motor function and visceral pain.

  2004cites this paper
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  2004cites this paper
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  2004cites this paper
• Both corticotropin-releasing factor receptor type 1 and type 2 are involved in stress-induced inhibition of food intake in rats

  2004cites this paper
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  2004cites this paper
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  2004cites this paper
• [Physiological and neurobiological elements of food intake].

  2004cites this paper
• The corticotropin-releasing factor system as a potential target for antiobesity drugs.

  2004cites this paper
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  2004cites this paper
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  2004cites this paper
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  2004cites this paper
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  2004cites this paper
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  2004cites this paper
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  2004cites this paper
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  2004cites this paper
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  2004cites this paper
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  2004cites this paper
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  2004cites this paper
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  2003cites this paper
• Eléments de physiologie et de neurobiologie de la prise alimentaire

  2003cites this paper
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  2003cites this paper
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  2003cites this paper
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