Engineering triterpene metabolism in tobacco

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Planta

• Publication date

  2012-06-24

• Fields of study

  Biology, Medicine, Engineering, Environmental Science

• Identifiers
  DOI 10.1007/s00425-012-1680-4PMID 22729821PMCID PMC3810399
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Uncovering the Protein Lysine and Arginine Methylation Network in Arabidopsis Chloroplasts

  2014influential reference
• AaORA, a trichome-specific AP2/ERF transcription factor of Artemisia annua, is a positive regulator in the artemisinin biosynthetic pathway and in disease resistance to Botrytis cinerea.

  2013cited by this paper
• Transcriptional regulation of secondary metabolite biosynthesis in plants.

  2013cited by this paper
• Control limits for accumulation of plant metabolites: brute force is no substitute for understanding.

  2013cited by this paper
• Terpenoid biosynthesis in trichomes--current status and future opportunities.

  2013influential reference
• Metabolic engineering of plant monoterpenes, sesquiterpenes and diterpenes--current status and future opportunities.

  2013cited by this paper
• Methionine salvage and S-adenosylmethionine: essential links between sulfur, ethylene and polyamine biosynthesis.

  2013influential reference
• The challenges of cellular compartmentalization in plant metabolic engineering.

  2013cited by this paper
• Transorganellar complementation redefines the biochemical continuity of endoplasmic reticulum and chloroplasts

  2013cited by this paper
• Virus-induced gene silencing identifies Catharanthus roseus 7-deoxyloganic acid-7-hydroxylase, a step in iridoid and monoterpene indole alkaloid biosynthesis.

  2013cited by this paper
• Terpene Down-Regulation Triggers Defense Responses in Transgenic Orange Leading to Resistance against Fungal Pathogens1[W]

  2013cited by this paper
• Architectures, mechanisms and molecular evolution of natural product methyltransferases.

  2012cited by this paper
• Functional Identification of Triterpene Methyltransferases from Botryococcus braunii Race B*

  2012cited by this paper
• Tobacco NtLTP1, a glandular-specific lipid transfer protein, is required for lipid secretion from glandular trichomes.

  2012cited by this paper
• Trichome Specific Expression: Promoters and Their Applications

  2012cited by this paper
• A Regulatory Network for Coordinated Flower Maturation

  2012cited by this paper
• DNA methylation and genome rearrangement characteristics of phase change in cultured shoots of Sequoia sempervirens.

  2012cited by this paper
• Synthesis of enantioenriched tertiary boronic esters from secondary allylic carbamates. Application to the synthesis of C30 botryococcene.

  2012cited by this paper
• Engineering triterpene metabolism in tobacco

  2012cited by this paper
• Arabidopsis MYC2 Interacts with DELLA Proteins in Regulating Sesquiterpene Synthase Gene Expression[W][OA]

  2012cited by this paper
• Remodeling the isoprenoid pathway in tobacco by expressing the cytoplasmic mevalonate pathway in chloroplasts.

  2012influential reference
• Strigolactones: a new musician in the orchestra of plant hormones

  2011cited by this paper
• Generation of the potent anti-malarial drug artemisinin in tobacco

  2011influential reference
• Nutritious crops producing multiple carotenoids--a metabolic balancing act.

  2011cited by this paper
• Triterpenoid Biosynthesis and Engineering in Plants

  2011influential reference
• Natural product in drug discovery: back to future.

  2011cited by this paper
• Brassinosteroid Signal Transduction: From Receptor Kinase Activation to Transcriptional Networks Regulating Plant Development

  2011cited by this paper
• Terpene Down-Regulation in Orange Reveals the Role of Fruit Aromas in Mediating Interactions with Insect Herbivores and Pathogens1[C][W]

  2011cited by this paper
• A golden era—pro-vitamin A enhancement in diverse crops

  2011cited by this paper
• Synergies between synthetic biology and metabolic engineering

  2011cited by this paper
• Investigation of the potential for triterpene synthesis in rice through genome mining and metabolic engineering.

  2011cited by this paper
• Improving peppermint essential oil yield and composition by metabolic engineering

  2011cited by this paper
• Novel Acidic Sesquiterpenoids Constitute a Dominant Class of Pathogen-Induced Phytoalexins in Maize1[W][OA]

  2011influential reference
• Artemisinin biosynthesis enhancement in transgenic Artemisia annua plants by downregulation of the β-caryophyllene synthase gene.

  2011cited by this paper
• Identification of unique mechanisms for triterpene biosynthesis in Botryococcus braunii

  2011cited by this paper
• Identification and microbial production of a terpene-based advanced biofuel

  2011influential reference
• Tobacco as a production platform for biofuel: overexpression of Arabidopsis DGAT and LEC2 genes increases accumulation and shifts the composition of lipids in green biomass.

  2010cited by this paper
• Induced biogenic volatile organic compounds from plants Biogenic volatile organic compounds and plant competition

  2010cited by this paper
• Trichome specific expression of the tobacco (Nicotiana sylvestris) cembratrien-ol synthase genes is controlled by both activating and repressing cis-regions

  2010influential reference
• Golden Rice and 'Golden' crops for human nutrition.

  2010cited by this paper
• Advanced biofuel production in microbes

  2010cited by this paper
• The Genetic Map of Artemisia annua L. Identifies Loci Affecting Yield of the Antimalarial Drug Artemisinin

  2010cited by this paper
• Monoterpene engineering in a woody plant Eucalyptus camaldulensis using a limonene synthase cDNA.

  2010cited by this paper
• Medicinal natural products

  2010cited by this paper
• The Arabidopsis thaliana FPP synthase isozymes have overlapping and specific functions in isoprenoid biosynthesis, and complete loss of FPP synthase activity causes early developmental arrest.

  2010cited by this paper
• Homolog of tocopherol C methyltransferases catalyzes N methylation in anticancer alkaloid biosynthesis

  2010cited by this paper
• Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli

  2010cited by this paper
• Terpene Bioconversion – How does its Future Look?

  2010cited by this paper
• Development of transgenic Artemisia annua (Chinese wormwood) plants with an enhanced content of artemisinin, an effective anti‐malarial drug, by hairpin‐RNA‐mediated gene silencing

  2009cited by this paper
• Production of taxa-4(5),11(12)-diene by transgenic Physcomitrella patens

  2009cited by this paper
• Insensitivity of chloroplast gene expression to DNA methylation

  2009influential reference
• A Novel Pathway for Sesquiterpene Biosynthesis from Z,Z-Farnesyl Pyrophosphate in the Wild Tomato Solanum habrochaites[W]

  2009cited by this paper
• Genetic engineering of carotenoid formation in tomato fruit and the potential application of systems and synthetic biology approaches.

  2009cited by this paper
• Aspartate-Derived Amino Acid Biosynthesis in Arabidopsis thaliana

  2009cited by this paper
• New microbial fuels: a biotech perspective.

  2009cited by this paper
• Pathway engineering of plants toward astaxanthin production

  2009cited by this paper
• High-Density Renewable Fuels Based on the Selective Dimerization of Pinenes

  2009cited by this paper
• Increased Accumulation of Artemisinin and Anthocyanins in Artemisia annua Expressing the Arabidopsis Blue Light Receptor CRY1

  2009cited by this paper
• PHA bioplastic: A value‐added coproduct for biomass biorefineries

  2009cited by this paper
• Isolation and characterization of AaWRKY1, an Artemisia annua transcription factor that regulates the amorpha-4,11-diene synthase gene, a key gene of artemisinin biosynthesis.

  2009cited by this paper
• Overexpression of the lemon basil alpha-zingiberene synthase gene increases both mono- and sesquiterpene contents in tomato fruit.

  2008cited by this paper
• Biosynthesis of plant-derived flavor compounds.

  2008cited by this paper
• Natural Genetic Variation in Lycopene Epsilon Cyclase Tapped for Maize Biofortification

  2008cited by this paper
• Fuel compositions comprising farnesane and farnesane derivatives and method of making and using same

  2007cited by this paper
• Metabolic engineering of sesquiterpene metabolism in yeast

  2007cited by this paper
• Chloroplastic photorespiratory bypass increases photosynthesis and biomass production in Arabidopsis thaliana

  2007cited by this paper
• Up-regulation of an N-terminal truncated 3-hydroxy-3-methylglutaryl CoA reductase enhances production of essential oils and sterols in transgenic Lavandula latifolia.

  2007cited by this paper
• Transcription factor Agamous-like 12 from Arabidopsis promotes tissue-like organization and alkaloid biosynthesis in Catharanthus roseus suspension cells.

  2007cited by this paper
• Metabolic Engineering of Potato Carotenoid Content through Tuber-Specific Overexpression of a Bacterial Mini-Pathway

  2007influential reference
• Production of biopharmaceuticals and vaccines in plants via the chloroplast genome

  2006cited by this paper
• The diverse sesquiterpene profile of patchouli, Pogostemon cablin, is correlated with a limited number of sesquiterpene synthases.

  2006cited by this paper
• Metabolic engineering of potato tuber carotenoids through tuber-specific silencing of lycopene epsilon cyclase

  2006influential reference
• Genes, enzymes and chemicals of terpenoid diversity in the constitutive and induced defence of conifers against insects and pathogens.

  2006influential reference
• Redirection of cytosolic or plastidic isoprenoid precursors elevates terpene production in plants

  2006cited by this paper
• Production of the antimalarial drug precursor artemisinic acid in engineered yeast

  2006cited by this paper
• Arabidopsis SAMT1 Defines a Plastid Transporter Regulating Plastid Biogenesis and Plant Development[W]

  2006influential reference
• Conversion of nicotine to nornicotine in Nicotiana tabacum is mediated by CYP82E4, a cytochrome P450 monooxygenase.

  2005cited by this paper
• Functional Characterization of Sequence Motifs in the Transit Peptide of Arabidopsis Small Subunit of Rubisco1[W]

  2005influential reference
• Breakthrough in chloroplast genetic engineering of agronomically important crops.

  2005cited by this paper
• A decade of progress in understanding vitamin E synthesis in plants.

  2005influential reference
• Overexpression of squalene synthase in Eleutherococcus senticosus increases phytosterol and triterpene accumulation.

  2005cited by this paper
• Biogenesis, molecular regulation and function of plant isoprenoids.

  2005influential reference
• Two sesquiterpene synthases are responsible for the complex mixture of sesquiterpenes emitted from Arabidopsis flowers.

  2005cited by this paper
• Genetic Engineering of Terpenoid Metabolism Attracts Bodyguards to Arabidopsis

  2005influential reference
• New approaches for studying and exploiting an old protuberance, the plant trichome.

  2004cited by this paper
• Relationship between the Heat Tolerance of Photosynthesis and the Thermal Stability of Rubisco Activase in Plants from Contrasting Thermal Environments1

  2004cited by this paper
• Inhibition of photosynthesis by heat stress: the activation state of Rubisco as a limiting factor in photosynthesis.

  2004cited by this paper
• Metabolic engineering of monoterpene biosynthesis: two-step production of (+)-trans-isopiperitenol by tobacco.

  2004cited by this paper
• The metabolic imbalance underlying lesion formation in Arabidopsis thaliana overexpressing farnesyl diphosphate synthase (isoform 1S) leads to oxidative stress and is triggered by the developmental decline of endogenous HMGR activity

  2004cited by this paper
• Transgenic Nicotiana TabacumL. with enhanced trichome exudate cembratrieneols has reduced aphid infestation in the field

  2004cited by this paper
• S-adenosylmethionine: nothing goes to waste.

  2004cited by this paper
• Metabolic engineering of isoprenoid biosynthesis in Arabidopsis for the production of taxadiene, the first committed precursor of Taxol

  2004cited by this paper
• Enhanced triterpene and phytosterol biosynthesis in Panax ginseng overexpressing squalene synthase gene.

  2004cited by this paper
• Terpenoid Metabolism in Wild-Type and Transgenic Arabidopsis Plants Online version contains Web-only data. Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.016253.

  2003influential reference
• Faculty Opinions recommendation of Structural basis for substrate recognition in the salicylic acid carboxyl methyltransferase family.

  2003cited by this paper
• Role of nicotianamine in the intracellular delivery of metals and plant reproductive development.

  2003influential reference
• Limonene production in tobacco with Perilla limonene synthase cDNA.

  2003influential reference
• Molecular farming of recombinant antibodies in plants

  2003cited by this paper
• Many paths to methyltransfer: a chronicle of convergence.

  2003cited by this paper
• Engineering a mevalonate pathway in Escherichia coli for production of terpenoids

  2003influential reference

• Harnessing semiochemicals for parasitoid-based biological control: from laboratory identification to field applications

  2025cites this paper
• Metabolic Engineering of Terpenoid Biosynthesis in Medicinal Plants: From Genomic Insights to Biotechnological Applications

  2025cites this paper
• Engineered poplar for bioproduction of the triterpene squalene

  2024cites this paper
• Yarrowia lipolytica: A promising microbial platform for sustainable squalene production

  2024cites this paper
• Engineering Sclareol Production on the Leaf Surface of Nicotiana tabacum.

  2024cites this paper
• Heterologous Biosynthesis of Betanin Triggers Metabolic Reprogramming in Tobacco.

  2024cites this paper
• Proteomic analysis identified proteins that are differentially expressed in the flavonoid and carotenoid biosynthetic pathways of Camellia Nitidissima flowers

  2024cites this paper
• HY5 and PIF antagonistically regulate HMGR expression and sterol biosynthesis in Arabidopsis thaliana.

  2024cites this paper
• Application of valencene and prospects for its production in engineered microorganisms

  2024cites this paper
• Plant Engineering to Enable Platforms for Sustainable Bioproduction of Terpenoids.

  2024cites this paper
• Construction of plant cell factory for biosynthesis of ginsenoside Rh2 in tobacco

  2023cites this paper
• Engineering custom morpho- and chemotypes of Populus for sustainable production of biofuels, bioproducts, and biomaterials

  2023cites this paper
• Subcellular compartmentalization in the biosynthesis and engineering of plant natural produces.

  2023cites this paper
• Recent advances in triterpenoid pathway elucidation and engineering.

  2023cites this paper
• Unravelling triterpenoid biosynthesis in plants for applications in bioengineering and large-scale sustainable production

  2023cites this paper
• Engineering of tomato type VI glandular trichomes for trans-chrysanthemic acid biosynthesis, the acid moiety of natural pyrethrin insecticides.

  2022cites this paper
• The chemotype core collection of genus Nicotiana

  2022cites this paper
• Transcriptional deregulation of stress-growth balance in Nicotiana benthamiana biofactories producing insect sex pheromones

  2022cites this paper
• Heterologous production of multiple triterpenes, including taraxasterol, in transgenic tobacco overexpressing Taraxacum coreanum oxidosqualene cyclase (TcOSC1)

  2022cites this paper
• Terpene Metabolic Engineering Via Nuclear or Chloroplast Terpene Metabolic Engineering Via Nuclear or Chloroplast Genomes Profoundly and Globally Impacts Off ‐ Target Pathways Genomes Profoundly and Globally Impacts Off Target Pathways Through Metabolite Signalling Through Metabolite Signalling

  2022influential citation
• Pathway elucidation of pharmaceutical cucurbitacin IIa in Hemsleya chinensis 1 and high-level production of precursor cucurbitadienol in engineered 2 Saccharomyces cerevisiae and

  2022cites this paper
• Pathway Engineering, Re-targeting, and Synthetic Scaffolding Improve the Production of Squalene in Plants

  2022cites this paper
• Pathway elucidation of pharmaceutical cucurbitacin IIa in Hemsleya chinensis and high-level production of precursor cucurbitadienol in engineered Saccharomyces cerevisiae and Nicotiana benthamiana

  2022cites this paper
• Engineering Nicotiana tabacum trichomes for triterpenic acid production.

  2022cites this paper
• Compartmentalization and transporter engineering strategies for terpenoid synthesis

  2022cites this paper
• Silent constraints: the hidden challenges faced in plant metabolic engineering.

  2021cites this paper
• Terpene Metabolic Engineering Terpene Metabolic Engineering via Nuclear or Chloroplast Nuclear or Chloroplast Genomes Profoundly and Globally Impacts Off-Target Pathways Genomes Profoundly and Globally Impacts Off-Target Pathways Through Metabolite Signalling Through Metabolite Signalling

  2021influential citation
• High-Level Patchoulol Biosynthesis in Artemisia annua L.

  2021cites this paper
• Biosynthesis and Biological Activities of Newly Discovered Amaryllidaceae Alkaloids

  2020cites this paper
• Secondary Metabolism

  2020cites this paper
• Transcriptome analysis and functional characterization of oxidosqualene cyclases of the arjuna triterpene saponin pathway.

  2020cites this paper
• Manipulating Biosynthesis of Plant Natural Products

  2020cites this paper
• Essential Oils: An Update on Their Biosynthesis and Genetic Strategies to Overcome the Production Challenges

  2020cites this paper
• Production of multiple terpenes of different chain length by subcellular targeting of multi-substrate terpene synthase in plants.

  2020cites this paper
• Bioengineering of Secondary Metabolites

  2019cites this paper
• Identification of key genes involved in the biosynthesis of triterpenic acids in the mint family

  2019cites this paper
• Mouse lipogenic proteins promote the co-accumulation of triacylglycerols and sesquiterpenes in plant cells

  2019cites this paper
• Bioenergy: Plants and Products

  2019cites this paper
• Engineering terpenoid production through transient expression in Nicotiana benthamiana

  2018cites this paper
• Co-Compartmentation of Terpene Biosynthesis and Storage via Synthetic Droplet.

  2018cites this paper
• Engineering storage capacity for volatile sesquiterpenes in Nicotiana benthamiana leaves

  2018cites this paper
• Non-photosynthetic plastids as hosts for metabolic engineering.

  2018cites this paper
• RNA Sequencing Provides Insights into the Regulation of Solanesol Biosynthesis in Nicotiana tabacum Induced by Moderately High Temperature

  2018cites this paper
• Co-expression of squalene epoxidases with triterpene cyclases boosts production of triterpenoids in plants and yeast.

  2018cites this paper
• Engineering triterpene metabolism in the oilseed of Arabidopsis thaliana

  2018cites this paper
• Engineering linear, branched‐chain triterpene metabolism in monocots

  2018cites this paper
• Agronomic and chemical performance of field‐grown tobacco engineered for triterpene and methylated triterpene metabolism

  2018cites this paper
• Harnessing Plant Trichome Biochemistry for the Production of Useful Compounds

  2018cites this paper
• Strategies for Enhanced Crop Resistance to Insect Pests.

  2018cites this paper
• Identification of a drimenol synthase and drimenol oxidase from Persicaria hydropiper, involved in the biosynthesis of insect deterrent drimanes

  2017cites this paper
• Plant Glandular Trichomes: Natural Cell Factories of High Biotechnological Interest1[OPEN]

  2017cites this paper
• A WRKY transcription factor from Withania somnifera regulates triterpenoid withanolide accumulation and biotic stress tolerance through modulation of phytosterol and defense pathways.

  2017cites this paper
• TRANSCRIPTOMIC ANALYSES OF CATHATRANTHUS ROSEUS HAIRY ROOTS OVEREXPRESSING CRMYC2 AND ORCA3 AND ROLES OF CROSS-FAMILY TRANSCRIPTION FACTOR INTERACTION IN TERPENOID INDOLE ALKALOID BIOSYNTHESIS

  2017cites this paper
• Improved fruit α‐tocopherol, carotenoid, squalene and phytosterol contents through manipulation of Brassica juncea 3‐HYDROXY‐3‐METHYLGLUTARYL‐COA SYNTHASE1 in transgenic tomato

  2017cites this paper
• Engineering of Tomato Glandular Trichomes for the Production of Specialized Metabolites.

  2016influential citation
• Transient expression for engineering triterpenoid diversity in plants

  2016cites this paper
• Research progress in glandular trichomes of medicinal plants

  2016influential citation
• Metabolic Engineering of PhenylPropanoids in Plants

  2016cites this paper
• Insights into Triterpene Metabolism in Model Monocotyledonous and Oilseed Plants Genetically Engineered with Genes from Botryococcus Braunii

  2016influential citation
• Terpene metabolic engineering via nuclear or chloroplast genomes profoundly and globally impacts off‐target pathways through metabolite signalling

  2016influential citation
• An Intronless β-amyrin Synthase Gene is More Efficient in Oleanolic Acid Accumulation than its Paralog in Gentiana straminea

  2016cites this paper
• Biosynthesis and biological functions of terpenoids in plants.

  2015cites this paper
• Study of drimane sesquiterpenoids from the Persicaria genus and zigiberene from Callitropsis noorkatensis and their effect on the feeding behaviour of Myzus persicae and Bemisia tabaci

  2015cites this paper
• Production of Biofuel-Related Isoprenoids Derived from Botryococcus braunii Algae

  2015cites this paper
• (+)‐Valencene production in Nicotiana benthamiana is increased by down‐regulation of competing pathways

  2015cites this paper
• Cytochromes P450 for terpene functionalisation and metabolic engineering.

  2015cites this paper
• Photosynthetic terpene hydrocarbon production for fuels and chemicals.

  2015cites this paper
• Engineering Triterpene and Methylated Triterpene Production in Plants Provides Biochemical and Physiological Insights into Terpene Metabolism1[OPEN]

  2015cites this paper
• Triterpene hydrocarbon production engineered into a metabolically versatile host—Rhodobacter capsulatus

  2015cites this paper
• Engineering of Secondary Metabolism.

  2015cites this paper
• Metabolic engineering of higher plants and algae for isoprenoid production.

  2015influential citation
• Gene clustering in plant specialized metabolism.

  2014cites this paper
• Enhanced accumulation of individual ganoderic acids in a submerged culture of Ganoderma lucidum by the overexpression of squalene synthase gene

  2014cites this paper
• Introduction to metabolic genetic engineering for the production of valuable secondary metabolites in in vivo and in vitro plant systems.

  2014cites this paper
• Engineering novel terpene production platforms in the yeast Saccharomyces cerevisiae

  2013influential citation
• The challenges of cellular compartmentalization in plant metabolic engineering.

  2013cites this paper
• Investigation of glycosyltransferases from oat

  2013cites this paper
• Bioengineering of plant (tri)terpenoids: from metabolic engineering of plants to synthetic biology in vivo and in vitro.

  2013cites this paper
• Strigolactones: a new musician in the orchestra of plant hormones

  2011cites this paper
• Lipogenic Proteins in Plants: Functional Homologues and Applications

  year unknowncites this paper
• Defence from the wild Specialised metabolism in tomato glandular trichomes

  year unknowncites this paper