The cargo-selective retromer complex is a recruiting hub for protein complexes that regulate endosomal tubule dynamics

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Journal of Cell Science

• Publication date

  2010-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/jcs.071472PMID 20923837PMCID PMC2964111
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2004influential reference
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  2004influential reference
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