High mobility group A1 is a molecular target for MYCN in human neuroblastoma.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Cancer Research

• Publication date

  2005-09-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1158/0008-5472.CAN-05-0607PMID 16166307
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Possible involvement of the expression and phosphorylation of N-Myc in the induction of HMGA1a by hypoxia in the human neuroblastoma cell line.

  2005cited by this paper
• The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma.

  2005cited by this paper
• HMGA proteins: isolation, biochemical modifications, and nucleosome interactions.

  2004cited by this paper
• MYCN-mediated regulation of the MRP1 promoter in human neuroblastoma

  2004cited by this paper
• MYCN in neuronal tumours.

  2004cited by this paper
• Neuroblastoma: biological insights into a clinical enigma

  2003cited by this paper
• Effects of MYCN antisense oligonucleotide administration on tumorigenesis in a murine model of neuroblastoma.

  2003cited by this paper
• Genome-wide analysis of gene expression associated with MYCN in human neuroblastoma.

  2003cited by this paper
• Minichromosome maintenance protein MCM7 is a direct target of the MYCN transcription factor in neuroblastoma.

  2002cited by this paper
• retSDR1, a short-chain retinol dehydrogenase/reductase, is retinoic acid-inducible and frequently deleted in human neuroblastoma cell lines.

  2002cited by this paper
• The Expression of the Developmentally Regulated Proto-oncogenePax-3 Is Modulated by N-Myc*

  2002cited by this paper
• Architectural Transcription Factor HMGI(Y) Promotes Tumor Progression and Mesenchymal Transition of Human Epithelial Cells

  2001cited by this paper
• Critical Role of the HMGI(Y) Proteins in Adipocytic Cell Growth and Differentiation

  2001cited by this paper
• EGF regulates a complex pattern of gene expression and represses smooth muscle differentiation during the neurotypic conversion of the neural-crest-derived TC-1S cell line.

  2001cited by this paper
• N‐myc enhances the expression of a large set of genes functioning in ribosome biogenesis and protein synthesis

  2001cited by this paper
• Sequence and analysis of the murine Hmgiy (Hmga1) gene locus.

  2001cited by this paper
• Function of the c-Myc oncoprotein in chromatin remodeling and transcription.

  2001cited by this paper
• Molecular biology of HMGA proteins: hubs of nuclear function.

  2001cited by this paper
• A DNA microarray screen for genes involved in c-MYC and N-MYC oncogenesis in human tumors

  2001cited by this paper
• Function and regulation of the transcription factors of the Myc/Max/Mad network.

  2001cited by this paper
• Coordination of a transcriptional switch by HMGI(Y) acetylation.

  2001cited by this paper
• Transgenic Mice Expressing a Truncated Form of the High Mobility Group I-C Protein Develop Adiposity and an Abnormally High Prevalence of Lipomas*

  2000cited by this paper
• HMG-I/Y, a New c-Myc Target Gene and Potential Oncogene

  2000influential reference
• Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins

  2000cited by this paper
• The oncogenic properties of the HMG-I gene family.

  2000cited by this paper
• Adenovirus-mediated suppression of HMGI(Y) protein synthesis as potential therapy of human malignant neoplasias.

  2000influential reference
• Expression of the HMGI(Y) gene products in human neuroblastic tumours correlates with differentiation status

  2000cited by this paper
• HMGI(Y) and HMGI-C dysregulation: a common occurrence in human tumors.

  1999cited by this paper
• Determination of high mobility group I(Y) expression level in colorectal neoplasias: a potential diagnostic marker.

  1999cited by this paper
• Regulation of HMGIC expression: an architectural transcription factor involved in growth control and development

  1999cited by this paper
• The expression of a truncated HMGI-C gene induces gigantism associated with lipomatosis.

  1999cited by this paper
• HMGI(Y) and HMGI-C genes are expressed in neuroblastoma cell lines and tumors and affect retinoic acid responsiveness.

  1999cited by this paper
• Detection of high mobility group I HMGI(Y) protein in the diagnosis of thyroid tumors: HMGI(Y) expression represents a potential diagnostic indicator of carcinoma.

  1998cited by this paper
• Targeted expression of MYCN causes neuroblastoma in transgenic mice

  1997influential reference
• High level expression of the HMGI (Y) gene during embryonic development.

  1996cited by this paper
• A retrospective study of high mobility group protein I(Y) as progression marker for prostate cancer determined by in situ hybridization.

  1996cited by this paper
• Conditional expression of N-myc in human neuroblastoma cells increases expression of alpha-prothymosin and ornithine decarboxylase and accelerates progression into S-phase early after mitogenic stimulation of quiescent cells.

  1996cited by this paper
• Over-expression of transfected N-myc oncogene in human SKNSH neuroblastoma cells down-regulates expression of beta 1 integrin subunit.

  1995cited by this paper
• Differential Regulation of a Multipromoter Gene.

  1995cited by this paper
• Virus induction of human IFN beta gene expression requires the assembly of an enhanceosome.

  1995cited by this paper
• Mutation responsible for the mouse pygmy phenotype in the developmentally regulated factor HMGI-C

  1995cited by this paper
• HMG domain proteins: architectural elements in the assembly of nucleoprotein structures.

  1994cited by this paper
• The biological effects of antisense N-myc expression in human neuroblastoma.

  1994cited by this paper
• Mad: a heterodimeric partner for Max that antagonizes Myc transcriptional activity.

  1993cited by this paper
• Differential patterns of DNA binding by myc and max proteins.

  1993cited by this paper
• Growth factor-induced delayed early response genes

  1992cited by this paper
• Decrease of proliferation rate and induction of differentiation by a MYCN antisense DNA oligomer in a human neuroblastoma cell line.

  1991cited by this paper
• Association of near-diploid DNA content and N-myc amplification in neuroblastomas

  1989cited by this paper
• A mammalian high mobility group protein recognizes any stretch of six A.T base pairs in duplex DNA.

  1986cited by this paper
• Association of multiple copies of the N-myc oncogene with rapid progression of neuroblastomas.

  1985cited by this paper
• Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour

  1983cited by this paper

• Distal-less homeobox 5 transactivated by MYCN contributes to progression of neuroblastoma through AKT signaling pathway.

  2025cites this paper
• A Novel Therapeutic Mechanism of Imipridones ONC201/ONC206 in MYCN-Amplified Neuroblastoma Cells via Differential Expression of Tumorigenic Proteins

  2021cites this paper
• MYCN Drives a Tumor Immunosuppressive Environment Which Impacts Survival in Neuroblastoma

  2021cites this paper
• HMGA1, Moonlighting Protein Function, and Cellular Real Estate: Location, Location, Location!

  2021cites this paper
• Analysis of Asymmetric Cell Division Using Human Neuroblastoma Cell Lines as a Model System

  2021cites this paper
• Genetics of Pediatric Tumors

  2021cites this paper
• The Role of MYCN in Symmetric vs. Asymmetric Cell Division of Human Neuroblastoma Cells

  2020cites this paper
• MYC-regulated pseudogene HMGA1P6 promotes ovarian cancer malignancy via augmenting the oncogenic HMGA1/2

  2020cites this paper
• High Mobility Group A (HMGA): Chromatin Nodes Controlled by a Knotty miRNA Network

  2020cites this paper
• HMGA1 in cancer: Cancer classification by location

  2019cites this paper
• Role of Genetic and Epigenetic Alterations in Pathogenesis of Neuroblastoma

  2019cites this paper
• Comparative Analysis of Putative Prognostic and Predictive Markers in Neuroblastomas: High Expression of PBX1 Is Associated With a Poor Response to Induction Therapy

  2019cites this paper
• MRE11 inhibition highlights a replication stress-dependent vulnerability of MYCN-driven tumors

  2018cites this paper
• Lessons from the Crypt: HMGA1-Amping up Wnt for Stem Cells and Tumor Progression.

  2018cites this paper
• Tumorigenic proteins upregulated in the MYCN-amplified IMR-32 human neuroblastoma cells promote proliferation and migration

  2018cites this paper
• Fra-1 Regulates the Expression of HMGA1, Which is Associated with a Poor Prognosis in Human Esophageal Squamous Cell Carcinoma

  2017cites this paper
• MiRNA-124-3p Reduces Cell Viability in Cisplatin Resistant Neuroblastoma Cell Models.

  2017influential citation
• The High Mobility Group A1 (HMGA1) Transcriptome in Cancer and Development.

  2016cites this paper
• Cell Proliferation in Neuroblastoma

  2016cites this paper
• RNA-Mediated Regulation of HMGA1 Function.

  2015cites this paper
• RNA-Mediated Regulation of HMGA1 Function

  2015cites this paper
• The MRN complex is transcriptionally regulated by MYCN during neural cell proliferation to control replication stress

  2015cites this paper
• A dynamic model of the MYCN regulated DNA damage response in Neuroblastoma

  2014cites this paper
• Galectin-3 is a marker of favorable prognosis and a biologically relevant molecule in neuroblastic tumors

  2014cites this paper
• The high mobility group A1 molecular switch: turning on cancer – can we turn it off?

  2014cites this paper
• The HMGA1 protoncogene frequently deregulated in cancer is a transcriptional target of E2F1

  2013cites this paper
• The role of genetic and epigenetic alterations in neuroblastoma disease pathogenesis

  2013cites this paper
• Clusterin (CLU) and its interacting proteins in cell signalling and neuroblastoma

  2012cites this paper
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  2012cites this paper
• Galectin-3 Impairment of MYCN-Dependent Apoptosis-Sensitive Phenotype Is Antagonized by Nutlin-3 in Neuroblastoma Cells

  2012cites this paper
• Genetically engineered murine models--contribution to our understanding of the genetics, molecular pathology and therapeutic targeting of neuroblastoma.

  2011cites this paper
• Interaction of adriamycin with a promoter region of hmga1 and its inhibitory effect on HMGA1 expression in A431 human squamous carcinoma cell line.

  2011cites this paper
• MYCN, neuroblastoma and focal adhesion kinase (FAK).

  2011cites this paper
• Silencing of HMGA1 expression by RNA interference suppresses growth of osteogenic sarcoma

  2011cites this paper
• MYCN and MYC regulate tumor proliferation and tumorigenesis directly through BMI1 in human neuroblastomas

  2011cites this paper
• HMGA and cancer.

  2010cites this paper
• MYCN oncoprotein targets and their therapeutic potential.

  2010cites this paper
• NF-kappaB, and not MYCN, regulates MHC class I and endoplasmic reticulum aminopeptidases in human neuroblastoma cells.

  2010cites this paper
• High-Mobility Group A1 (HMGA1) Protein Expression Correlates With Cisplatin-Induced Cell Death in Squamous Cell Carcinoma of Skin

  2010cites this paper
• HMGA1 is induced by Wnt/beta-catenin pathway and maintains cell proliferation in gastric cancer.

  2009cites this paper
• The HMGA proteins: a myriad of functions (Review).

  2008cites this paper
• Human papilloma virus-dependent HMGA1 expression is a relevant step in cervical carcinogenesis.

  2008cites this paper
• Identification of candidate cancer genes involved in human retinoblastoma by data mining

  2008cites this paper
• N-MYC Regulates Focal Adhesion Kinase Expression in Human Neuroblastoma*

  2007cites this paper
• Transcriptional control of the human high mobility group A1 gene: basal and oncogenic Ras-regulated expression.

  2007cites this paper
• Hedgehog checkpoints in medulloblastoma: the chromosome 17p deletion paradigm.

  2005cites this paper
• Dna Damage and Cellular Stress Responses Mycn Sensitizes Human Neuroblastoma to Apoptosis by Hipk2 Activation through a Dna Damage Response

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