Critical Role of the HMGI(Y) Proteins in Adipocytic Cell Growth and Differentiation

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Molecular and Cellular Biology

• Publication date

  2001-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/MCB.21.7.2485-2495.2001PMID 11259597PMCID PMC86881
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1989cited by this paper
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  1980influential reference
• A new technique for the assay of infectivity of human adenovirus 5 DNA.

  1973influential reference
• Printed in U.S.A. Copyright © 1998 by The Endocrine Society Regulation of Leptin Promoter Function by Sp1, C/EBP, and a Novel Factor*

  year unknowncited by this paper

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