Antiplatelet therapy in secondary stroke prevention – state of the art

•  Introduction •  Prevention of recurrent stroke using antiplatelets in patients with acute ischaemic stroke ‐  Aspirin ‐  Aspirin plus dipyridamole ‐  Aspirin plus clopidogrel ‐  Abciximab ‐  Aspirin versus anticoagulation •  Long‐term secondary stroke prevention in non‐cardioembolic stroke ‐  Aspirin ‐  Aspirin versus anticoagulation ‐  Clopidogrel ‐  Ticlopidine ‐  Triflusal ‐  Lotrafiban ‐  Aspirin plus clopidogrel ‐  Aspirin plus dipyridamole ‐  Aspirin plus dipyridamole versus clopidogrel •  The role of antiplatelets in cardioembolic stroke prevention •  Antiplatelets in patients with symptomatic intracranial stenosis •  Antiplatelets in stroke patients with patent foramen ovale •  Disclosures

• Publication year

  2010

• Venue

  Journal of Cellular and Molecular Medicine

• Publication date

  2010-01-29

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1582-4934.2010.01163.xPMID 20738444PMCID 4373475
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Prediction of Recurrent Stroke and Vascular Death in Patients With Transient Ischemic Attack or Nondisabling Stroke: A Prospective Comparison of Validated Prognostic Scores

  2010cited by this paper
• Antithrombotic drugs for patients with ischaemic stroke and transient ischaemic attack to prevent recurrent major vascular events.

  2010cited by this paper
• Early treatment with aspirin plus extended-release dipyridamole for transient ischaemic attack or ischaemic stroke within 24 h of symptom onset (EARLY trial): a randomised, open-label, blinded-endpoint trial.

  2010cited by this paper
• Effect of Combined Aspirin and Extended-Release Dipyridamole Versus Clopidogrel on Functional Outcome and Recurrence in Acute, Mild Ischemic Stroke: PRoFESS Subgroup Analysis

  2010cited by this paper
• The Essen Stroke Risk Score Predicts Recurrent Cardiovascular Events: A Validation Within the REduction of Atherothrombosis for Continued Health (REACH) Registry

  2009cited by this paper
• Effect of clopidogrel added to aspirin in patients with atrial fibrillation.

  2009cited by this paper
• Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials

  2009cited by this paper
• Emergency Administration of Abciximab for Treatment of Patients With Acute Ischemic Stroke: Results of an International Phase III Trial: Abciximab in Emergency Treatment of Stroke Trial (AbESTT-II)

  2008cited by this paper
• Guidelines for management of ischaemic stroke and transient ischaemic attack 2008.

  2008cited by this paper
• Aspirin and extended-release dipyridamole versus clopidogrel for recurrent stroke.

  2008cited by this paper
• Titrated initiation of acetylsalicylic acid-dipyridamole therapy reduces adverse effects and improves tolerance in patients with stroke.

  2008cited by this paper
• Dipyridamole plus aspirin versus aspirin alone in secondary prevention after TIA or stroke: a meta-analysis by risk

  2008cited by this paper
• Predictive value of the Essen Stroke Risk Score and Ankle Brachial Index in acute ischaemic stroke patients from 85 German stroke units

  2008cited by this paper
• Patients with prior myocardial infarction, stroke, or symptomatic peripheral arterial disease in the CHARISMA trial.

  2007cited by this paper
• Low-molecular-weight heparin compared with aspirin for the treatment of acute ischaemic stroke in Asian patients with large artery occlusive disease: a randomised study

  2007cited by this paper
• Aspirin dose for the prevention of cardiovascular disease: a systematic review.

  2007cited by this paper
• Secondary Stroke Prevention With Ximelagatran Versus Warfarin in Patients With Atrial Fibrillation: Pooled Analysis of SPORTIF III and V Clinical Trials

  2007cited by this paper
• Fast assessment of stroke and transient ischaemic attack to prevent early recurrence (FASTER): a randomised controlled pilot trial.

  2007cited by this paper
• Effect of Age and Glycaemic Control on the Association between Fibrinogen and Risk of Acute Coronary Events after Transient Ischaemic Attack or Stroke

  2007cited by this paper
• Overview of the 2007 Food and Drug Administration Circulatory System Devices Panel Meeting on Patent Foramen Ovale Closure Devices

  2007cited by this paper
• Medium intensity oral anticoagulants versus aspirin after cerebral ischaemia of arterial origin (ESPRIT): a randomised controlled trial.

  2007cited by this paper
• Risk of stroke early after transient ischaemic attack: a systematic review and meta-analysis.

  2007influential reference
• Dipyridamole and headache

  2007cited by this paper
• Dipyridamole May Induce Migraine in Patients With Migraine Without Aura

  2006cited by this paper
• Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events.

  2006cited by this paper
• Dose Titration to Reduce Dipyridamole-Related Headache

  2006cited by this paper
• Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): a randomised controlled trial.

  2006cited by this paper
• Aspirin plus dipyridamole versus aspirin alone after cerebral ischaemia of arterial origin (ESPRIT): randomised controlled trial.

  2006cited by this paper
• Risks and benefits of combining aspirin with anticoagulant therapy in patients with atrial fibrillation: an exploratory analysis of stroke prevention using an oral thrombin inhibitor in atrial fibrillation (SPORTIF) trials.

  2006cited by this paper
• Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data.

  2006cited by this paper
• Low-dose aspirin for the prevention of atherothrombosis.

  2005cited by this paper
• CAST: randomised placebo-controlled trial of early aspirin use in 20 000 patients with acute ischaemic stroke

  2005cited by this paper
• Dipyridamole for Preventing Recurrent Ischemic Stroke and Other Vascular Events: A Meta-Analysis of Individual Patient Data From Randomized Controlled Trials

  2005cited by this paper
• The International Stroke Trial (IST): a randomised trial of aspirin, subcutaneous heparin, both, or neither among 19 435 patients with acute ischaemic stroke

  2005cited by this paper
• Cilostazol Prevents the Progression of the Symptomatic Intracranial Arterial Stenosis: The Multicenter Double-Blind Placebo-Controlled Trial of Cilostazol in Symptomatic Intracranial Arterial Stenosis

  2005cited by this paper
• Comparison of warfarin and aspirin for symptomatic intracranial arterial stenosis.

  2005cited by this paper
• Triflusal for Preventing Serious Vascular Events in People at High Risk

  2005cited by this paper
• Emergency Administration of Abciximab for Treatment of Patients With Acute Ischemic Stroke: Results of a Randomized Phase 2 Trial

  2005cited by this paper
• Dipyridamole and headache--a pilot study of initial dose titration.

  2004cited by this paper
• Platelet-active drugs: the relationships among dose, effectiveness, and side effects: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy.

  2004cited by this paper
• Platelet-active drugs : the relationships among dose, effectiveness, and side effects.

  2004cited by this paper
• Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trial.

  2004cited by this paper
• Platelet-active drugs: the relationships among dose, effectiveness, and side effects.

  2004cited by this paper
• Early risk of recurrence by subtype of ischemic stroke in population-based incidence studies

  2004influential reference
• Randomized, Double-Blind, Placebo-Controlled, International Trial of the Oral IIb/IIIa Antagonist Lotrafiban in Coronary and Cerebrovascular Disease

  2003cited by this paper
• Aspirin and ticlopidine for prevention of recurrent stroke in black patients: a randomized trial.

  2003cited by this paper
• Effects of Aspirin Dose When Used Alone or in Combination With Clopidogrel in Patients With Acute Coronary Syndromes: Observations From the Clopidogrel in Unstable angina to prevent Recurrent Events (CURE) Study

  2003cited by this paper
• Lessons from the Stroke Prevention in Atrial Fibrillation Trials

  2003influential reference
• Effect of Medical Treatment in Stroke Patients With Patent Foramen Ovale: Patent Foramen Ovale in Cryptogenic Stroke Study

  2002cited by this paper
• Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients

  2002cited by this paper
• Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients

  2002cited by this paper
• Primäre Prävention kardiovaskulärer Ereignisse durch ASS und Vitamin E PPP das “Primary Prevention Project”

  2001cited by this paper
• A comparison of warfarin and aspirin for the prevention of recurrent ischemic stroke.

  2001cited by this paper
• Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation.

  2001cited by this paper
• Low-dose aspirin and vitamin E in people at cardiovascular risk: a randomised trial in general practice. Collaborative Group of the Primary Prevention Project.

  2001cited by this paper
• CARDIAC SAFETY IN THE EUROPEAN STROKE PREVENTION STUDY 2 (ESPS2)

  2001cited by this paper
• EFFECTS OF CLOPIDOGREL IN ADDITION TO ASPIRIN IN PATIENTS WITH ACUTE CORONARY SYNDROMES WITHOUT ST-SEGMENT ELEVATION

  2001cited by this paper
• Recurrent cerebrovascular events associated with patent foramen ovale, atrial septal aneurysm, or both.

  2001cited by this paper
• Dipyridamole Dilates Large Cerebral Arteries Concomitant to Headache Induction in Healthy Subjects

  2000cited by this paper
• Abciximab in acute ischemic stroke. A randomized, double-blind, placebo-controlled, dose-escalation study.

  2000cited by this paper
• Prevalence of potential risk factors for stroke assessed by transesophageal echocardiography and carotid ultrasonography: the SPARC study. Stroke Prevention: Assessment of Risk in a Community.

  1999cited by this paper
• Antithrombotic Therapy To Prevent Stroke in Patients with Atrial Fibrillation

  1999influential reference
• Cumulative meta-analysis of aspirin efficacy after cerebral ischaemia of arterial origin

  1999cited by this paper
• Incidence and Clinical Course of Thrombotic Thrombocytopenic Purpura Due to Ticlopidine Following Coronary Stenting

  1999cited by this paper
• Incidence and clinical course of thrombotic thrombocytopenic purpura due to ticlopidine following coronary stenting. EPISTENT Investigators. Evaluation of Platelet IIb/IIIa Inhibitor for Stenting.

  1999cited by this paper
• Face-arm-trunk-leg sensory loss limited to the contralateral side in lateral medullary infarction: a new variant

  1998cited by this paper
• A randomized trial of anticoagulants versus aspirin after cerebral ischemia of presumed arterial origin

  1997cited by this paper
• CAST: randomised placebo-controlled trial of early aspirin use in 20,000 patients with acute ischaemic stroke. CAST (Chinese Acute Stroke Trial) Collaborative Group.

  1997cited by this paper
• The International Stroke Trial (IST): A randomised trial of aspirin, subcutaneous heparin, both, or neither among 19 435 patients with acute ischaemic stroke

  1997cited by this paper
• The International Stroke Trial (IST): a randomised trial of aspirin, subcutaneous heparin, both, or neither among 19435 patients with acute ischaemic stroke. International Stroke Trial Collaborative Group.

  1997cited by this paper
• A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). CAPRIE Steering Committee

  1996cited by this paper
• A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). CAPRIE Steering Committee.

  1996cited by this paper
• A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE)

  1996influential reference
• European Stroke Prevention Study. 2. Dipyridamole and acetylsalicylic acid in the secondary prevention of stroke.

  1996cited by this paper
• Secondary prevention in non-rheumatic atrial fibrillation after transient ischaemic attack or minor stroke

  1993cited by this paper
• Secondary prevention in non-rheumatic atrial fibrillation after transient ischaemic attack or minor stroke. EAFT (European Atrial Fibrillation Trial) Study Group.

  1993cited by this paper
• The United Kingdom transient ischaemic attack (UK-TIA) aspirin trial: final results.

  1991cited by this paper
• A comparison of two doses of aspirin (30 mg vs. 283 mg a day) in patients after a transient ischemic attack or minor ischemic stroke.

  1991cited by this paper
• The Canadian American Ticlopidine Study (CATS) in thromboembolic stroke.

  1989cited by this paper
• A randomized trial comparing ticlopidine hydrochloride with aspirin for the prevention of stroke in high-risk patients. Ticlopidine Aspirin Stroke Study Group.

  1989cited by this paper
• Incidence and size of patent foramen ovale during the first 10 decades of life: an autopsy study of 965 normal hearts.

  1984cited by this paper

• Navigating Fabry Disease in a Military Aviator.

  2025cites this paper
• Efficacy and Safety of Ticagrelor versus Aspirin and Clopidogrel for Stroke Prevention in Patients with Vascular Disease: A Systematic Review and Meta-Analysis

  2023cites this paper
• Cost-effectiveness of CYP2C19 genotyping to guide antiplatelet therapy for acute minor stroke and high-risk transient ischemic attack

  2021cites this paper
• Predicting atrial fibrillation after cryptogenic stroke via a clinical risk score—a prospective observational study

  2021cites this paper
• Neuroprotective effect of heparin Trisulfated disaccharide on ischemic stroke

  2021cites this paper
• Anti-platelet aggregation of Panax notoginseng triol saponins by regulating GP1BA for ischemic stroke therapy

  2020cites this paper
• Sex Differences in Care and Long-Term Mortality After Stroke: Australian Stroke Clinical Registry

  2019cites this paper
• Ischemic Stroke Incidence in Patients With Microvascular Ocular Motor Palsy Versus Patients With Lacunar Ischemic Stroke

  2019cites this paper
• Odontogene pyogene Infektionen im Mund-, Kiefer- und Gesichtsbereich. Eine retrospektive Studie von 2004 bis 2014 in der Klinik für Mund-, Kiefer- und Gesichtschirurgie - Plastische Operationen - am HELIOS Klinikum Erfurt GmbH

  2018cites this paper
• New aspects on efficient anticoagulation and antiplatelet strategies in sheep

  2013cites this paper