Emergency Administration of Abciximab for Treatment of Patients With Acute Ischemic Stroke: Results of a Randomized Phase 2 Trial

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Stroke

• Publication date

  2005-04-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1161/01.STR.0000157668.39374.56PMID 15731473
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• FUNCTIONAL EVALUATION: THE BARTHEL INDEX.

  2018cited by this paper
• Abciximab Emergent Stroke Treatment Trial (AbESTT) Investigators. Emergency administration of abciximab for treatment of patients with acute ischemic stroke: results of a randomized phase 2 trial

  2005cited by this paper
• CAST: randomised placebo-controlled trial of early aspirin use in 20 000 patients with acute ischaemic stroke

  2005cited by this paper
• The International Stroke Trial (IST): a randomised trial of aspirin, subcutaneous heparin, both, or neither among 19 435 patients with acute ischaemic stroke

  2005cited by this paper
• Treatment of Acute Supratentorial Ischemic Stroke with Abciximab Is Safe and May Resultin Early Neurological Improvement

  2004cited by this paper
• An initial experience: using helical CT imaging to detect obscure gastrointestinal bleeding.

  2004cited by this paper
• Measuring Outcomes as a Function of Baseline Severity of Ischemic Stroke

  2004cited by this paper
• Guidelines for the Early Management of Patients With Ischemic Stroke: A Scientific Statement From the Stroke Council of the American Stroke Association

  2003cited by this paper
• Immediate reocclusion following a successful thrombolysis in acute stroke: A pilot study

  2003cited by this paper
• Abciximab Reduces Monocyte Tissue Factor in Carotid Angioplasty and Stenting

  2003cited by this paper
• Evaluation of glycoprotein IIb/IIIa inhibitors in carotid angioplasty and stenting.

  2003cited by this paper
• Adjuvant Treatment With a Glycoprotein IIb/IIIa Receptor Inhibitor Increases the Therapeutic Window for Low-Dose Tissue Plasminogen Activator Administration in a Rat Model of Embolic Stroke

  2003cited by this paper
• Treatment of acute stroke with recombinant tissue plasminogen activator and abciximab.

  2003cited by this paper
• Carotid Artery Stenting in a Community Setting: Experience Outside of a Clinical Trial

  2003cited by this paper
• Carotid Angioplasty and Stent Placement: A Prospective Analysis of Perioperative Complications and Impact of Intravenously Administered Abciximab

  2002cited by this paper
• Acute Basilar Artery Occlusion Treated With Combined Intravenous Abciximab and Intra-arterial Tissue Plasminogen Activator: Report of 3 Cases

  2002cited by this paper
• The GP IIb/IIIa inhibitor abciximab (c7E3) inhibits the binding of various ligands to the leukocyte integrin Mac-1 (CD11b/CD18, αMβ2)

  2002cited by this paper
• Abciximab Bolus Injection Does Not Reduce Cerebral Ischemic Complications of Elective Carotid Artery Stenting: A Randomized Study

  2002cited by this paper
• The Stroke Patient Who Woke Up: Clinical and Radiological Features, Including Diffusion and Perfusion MRI

  2002cited by this paper
• The GP IIb/IIIa inhibitor abciximab (c7E3) inhibits the binding of various ligands to the leukocyte integrin Mac-1 (CD11b/CD18, alphaMbeta2).

  2002cited by this paper
• Comparison of angioplasty with stenting, with or without abciximab, in acute myocardial infarction.

  2002cited by this paper
• Local intraarterial urokinase thrombolysis of acute ischemic stroke with or without intravenous abciximab: a pilot study.

  2002cited by this paper
• Arterial reocclusion in stroke patients treated with intravenous tissue plasminogen activator

  2002cited by this paper
• Testicular Function of Young Men Treated in Childhood for Cryptorchidism

  2001cited by this paper
• Intracarotid Abciximab Injection to Abort Impending Ischemic Stroke during Carotid Angioplasty

  2001cited by this paper
• Platelet glycoprotein IIb/IIIa antagonists for acute ischemic stroke

  2001cited by this paper
• Dynamic platelet accumulation at the site of the occluded middle cerebral artery and in downstream microvessels is associated with loss of microvascular integrity after embolic middle cerebral artery occlusion.

  2001cited by this paper
• From bench to bedside: GP IIb–IIIa inhibitors

  2001cited by this paper
• Rescue treatment with abciximab in acute ischemic stroke

  2001cited by this paper
• Risk of stroke associated with abciximab among patients undergoing percutaneous coronary intervention.

  2001cited by this paper
• Extension of the Therapeutic Window for Recombinant Tissue Plasminogen Activator With Argatroban in a Rat Model of Embolic Stroke

  2001cited by this paper
• Intra-arterial Prourokinase for Acute Ischemic Stroke

  2000cited by this paper
• Stent-assisted angioplasty of intracranial vertebrobasilar atherosclerosis: an initial experience.

  2000cited by this paper
• Abciximab as an adjunct to high-risk carotid or vertebrobasilar angioplasty: preliminary experience.

  2000cited by this paper
• Coronary stenting plus platelet glycoprotein IIb/IIIa blockade compared with tissue plasminogen activator in acute myocardial infarction. Stent versus Thrombolysis for Occluded Coronary Arteries in Patients with Acute Myocardial Infarction Study Investigators.

  2000cited by this paper
• Thrombocytopenia complicating treatment with intravenous glycoprotein IIb/IIIa receptor inhibitors: a pooled analysis.

  2000cited by this paper
• Abciximab in acute ischemic stroke. A randomized, double-blind, placebo-controlled, dose-escalation study.

  2000cited by this paper
• Occurrence and clinical significance of pseudothrombocytopenia during abciximab therapy.

  2000cited by this paper
• Glycoprotein IIb/IIIa inhibitors: current indications and future prospects.

  2000cited by this paper
• Cerebral Microvascular Obstruction by Fibrin is Associated with Upregulation of PAI-1 Acutely after Onset of Focal Embolic Ischemia in Rats

  1999cited by this paper
• Intra-arterial Prourokinase for Acute Ischemic Stroke: The PROACT II Study: A Randomized Controlled Trial

  1999cited by this paper
• Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: a randomized controlled trial. Prolyse in Acute Cerebral Thromboembolism.

  1999cited by this paper
• The clot thickens--thrombolysis and combination therapies.

  1999cited by this paper
• Low molecular weight heparinoid, ORG 10172 (danaparoid), and outcome after acute ischemic stroke: a randomized controlled trial. The Publications Committee for the Trial of ORG 10172 in Acute Stroke Treatment (TOAST) Investigators.

  1998cited by this paper
• Evaluation of a GPIIb/IIIa antagonist YM337 in a primate model of middle cerebral artery thrombosis.

  1998cited by this paper
• Reduced microvascular thrombosis and improved outcome in acute murine stroke by inhibiting GP IIb/IIIa receptor-mediated platelet aggregation.

  1998cited by this paper
• The International Stroke Trial (IST): a randomised trial of aspirin, subcutaneous heparin, both, or neither among 19435 patients with acute ischaemic stroke. International Stroke Trial Collaborative Group.

  1997cited by this paper
• Intracerebral hemorrhage after intravenous t-PA therapy for ischemic stroke. The NINDS t-PA Stroke Study Group.

  1997cited by this paper
• CAST: randomised placebo-controlled trial of early aspirin use in 20,000 patients with acute ischaemic stroke. CAST (Chinese Acute Stroke Trial) Collaborative Group.

  1997cited by this paper
• Tissue plasminogen activator for acute ischemic stroke.

  1996cited by this paper
• Tissue plasminogen activator for acute ischemic stroke.

  1995cited by this paper
• Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group.

  1995cited by this paper
• Classification of Subtype of Acute Ischemic Stroke: Definitions for Use in a Multicenter Clinical Trial

  1993cited by this paper
• Thrombolysis in myocardial Infarction (TIMI) trial–phase I

  1990cited by this paper
• A randomized trial comparing ticlopidine hydrochloride with aspirin for the prevention of stroke in high-risk patients. Ticlopidine Aspirin Stroke Study Group.

  1989cited by this paper
• Measurements of acute cerebral infarction: a clinical examination scale.

  1989cited by this paper
• Interobserver agreement for the assessment of handicap in stroke patients.

  1989cited by this paper
• Thrombolysis in Myocardial Infarction (TIMI) Trial--phase I: hemorrhagic manifestations and changes in plasma fibrinogen and the fibrinolytic system in patients treated with recombinant tissue plasminogen activator and streptokinase.

  1988cited by this paper
• Estimators of the Mantel-Haenszel variance consistent in both sparse data and large-strata limiting models.

  1986cited by this paper
• Sequential treatment assignment with balancing for prognostic factors in the controlled clinical trial.

  1975cited by this paper
• FUNCTIONAL EVALUATION: THE BARTHEL INDEX.

  1965cited by this paper
• Functional evaluation : Barthel index

  1965cited by this paper
• In the Netherlands

  1961cited by this paper
• Statistical aspects of the analysis of data from retrospective studies of disease.

  1959cited by this paper
• Nonparametric Estimation from Incomplete Observations

  1958cited by this paper

• Comparing Early National Institutes of Health Stroke Scale Versus 90‐Day Modified Rankin Scale Outcomes in Acute Ischemic Stroke Trials: A Systematic Review and Analysis

  2025cites this paper
• Les antiplaquettaires dans l’ischémie cérébrale aiguë : limites et perspectives

  2024cites this paper
• Platelet glycoprotein IIb/IIIa antagonists in ischemic stroke patients without endovascular therapy: A meta‐analysis

  2024cites this paper
• Motor sequela of adult and pediatric stroke: Imminent losses and ultimate gains.

  2023cites this paper
• Endovascular therapy for acute ischemic stroke: The importance of blood pressure control, sedation modality and anti-thrombotic management to improve functional outcomes.

  2022cites this paper
• The relationship between age shock index, and severity of stroke and in-hospital mortality in patients with acute ischemic stroke.

  2022cites this paper
• The relationship between serum bilirubin levels and early neurological improvement in patients with acute ischemic stroke treated with intravenous tissue plasminogen activator

  2021cites this paper
• The “distal-to-proximal” strategy for the treatment of posterior circulation tandem occlusions: a single-centre experience

  2020cites this paper
• Pre-clinical to Clinical Translational Failures and Current Status of Clinical Trials in Stroke Therapy: A Brief Review

  2020cites this paper
• Decrease in Pulse Wave Velocity is Associated with Clinical Improvement in Patients with Ischemic Stroke.

  2020cites this paper
• Safety of Glycoprotein IIb-IIIa Inhibitors Used in Stroke-Related Treatment: A Systematic Review and Meta-Analysis

  2020cites this paper
• Antiplatelet Drugs in the Management of Cerebral Ischemia

  2019cites this paper
• Specific treatment of acute ischemic stroke

  2019cites this paper
• Trombólise no Acidente Vascular Cerebral Isquêmico

  2019cites this paper
• Antithrombotic Management After Intracranial Hemorrhage

  2019cites this paper
• Acute Treatment of Stroke (Except Thrombectomy)

  2018cites this paper
• The Efficacy of Ozagrel Sodium as a Rescue or Prophylaxis in the Perioperative Management of Thromboembolism during Coil Embolization of Ruptured and Unruptured Cerebral Aneurysms

  2018cites this paper
• In situ administration of abciximab for thrombus resolution during intracranial bypass surgery: case report.

  2018cites this paper
• uidelines for the treatment of acute ischaemic stroke

  2017cites this paper
• A leap forward in the endovascular management of acute basilar artery occlusion since the appearance of stent retrievers: a single-center comparative study.

  2017cites this paper
• Anterior Circulation Acute Ischemic Stroke Associated with Atherosclerotic Lesions of the Cervical ICA: A Nosologic Entity Apart

  2017cites this paper
• 52 – Antithrombotic Therapy for Treatment of Acute Ischemic Stroke

  2016cites this paper
• Intravenous Thrombolysis and Anti-thrombotics

  2016cites this paper
• Left ventricular ejection fraction and aortic stiffness are independent predictors of neurological outcome in acute ischemic stroke

  2016cites this paper
• DETECTION OF THE PLATELETS RECEPTOR GPIIB POLYMORPHISM IN SUDANESE PATIENT WITH POLYCYTHAEMIA VERA

  2016cites this paper
• The future of endovascular treatment: Insights from the ESCAPE investigators

  2016cites this paper
• Acute Carotid Stent Thrombosis

  2016cites this paper
• Inadvertent Stent Retriever Detachment: A Multicenter Case Series and Review of Device Experience FDA Reports

  2015cites this paper
• Ischemic Involvement of the Primary Motor Cortex is a Prognostic Factor in Acute Stroke

  2015cites this paper
• Safety of Abciximab injection during endovascular treatment of ruptured aneurysms

  2015cites this paper
• Improving early clinical trial phase identification of promising therapeutics

  2015cites this paper
• Do Glycoprotein IIb/IIIa Inhibitors Improve Outcomes in Acute Ischemic Stroke?

  2015cites this paper
• An Outcome Model for Intravenous rt-PA in Acute Ischemic Stroke

  2015cites this paper
• Ischämie des vorderen Kreislaufs

  2015cites this paper
• Acute antithrombotic treatment of ischemic stroke.

  2014cites this paper
• Characteristic Adverse Events and Their Incidence Among Patients Participating in Acute Ischemic Stroke Trials

  2014cites this paper
• Intravenous thrombolysis in acute ischemic stroke: standard and potential future applications

  2014cites this paper
• Glycoprotein IIb-IIIa inhibitors for acute ischaemic stroke.

  2014cites this paper
• Guidelines for the treatment of acute ischaemic stroke

  2014cites this paper
• Guidelines for the treatment of acute ischaemic stroke.

  2014cites this paper
• Update in the management of acute ischemic stroke.

  2014cites this paper
• Defining Clinically Relevant Cerebral Hemorrhage After Thrombolytic Therapy for Stroke: Analysis of the National Institute of Neurological Disorders and Stroke Tissue-Type Plasminogen Activator Trials

  2014cites this paper
• Oral antiplatelet therapy for acute ischaemic stroke.

  2014cites this paper
• Central Nervous System Ischemia

  2013cites this paper
• Fibrinogen-Conjugated Gold-coated Magnetite Nanoparticles for Antiplatelet Therapy

  2013cites this paper
• Sonothrombolysis in Ischemic Stroke

  2013cites this paper
• Quantification of Errors in Ordinal Outcome Scales Using Shannon Entropy: Effect on Sample Size Calculations

  2013cites this paper
• Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association

  2013cites this paper
• Management of Acute Ischemic Stroke

  2013cites this paper
• Validation of FLAIR Hyperintense Lesions as Imaging Biomarkers to Predict the Outcome of Acute Stroke after Intra-Arterial Thrombolysis following Intravenous Tissue Plasminogen Activator

  2013cites this paper
• Reperfusion of cerebral artery thrombosis by the GPIb-VWF blockade with the Nanobody ALX-0081 reduces brain infarct size in guinea pigs.

  2013cites this paper
• The effect of covariate adjustment for baseline severity in acute stroke clinical trials with responder analysis outcomes

  2013cites this paper
• The GPVI-Fc Fusion Protein Revacept Improves Cerebral Infarct Volume and Functional Outcome in Stroke

  2013cites this paper
• High-dose albumin treatment for acute ischaemic stroke (ALIAS) Part 2: a randomised, double-blind, phase 3, placebo-controlled trial.

  2013cites this paper
• The Quest for Arterial Recanalization in Acute Ischemic Stroke-The Past, Present and the Future

  2013cites this paper
• Chapter 31 – Prevention and Treatment of Stroke

  2013cites this paper
• Novel antiplatelet drugs in clinical development

  2013cites this paper
• Evidence-Based Clinical Practice Guidelines American College of Chest Physicians and Prevention of Thrombosis, 9th ed: Antiplatelet Drugs : Antithrombotic Therapy

  2012cites this paper
• Combined Treatment with Intravenous Abciximab and Intraarterial tPA Yields High Recanalization Rate in Patients with Acute Basilar Artery Occlusion

  2012cites this paper
• Platelet glycoprotein IIb/IIIa polymorphism HPA-3 b/b is associated with increased risk of ischemic stroke in patients under 60 years of age

  2012cites this paper
• Low patient enrollment sites in multicenter randomized clinical trials of cerebrovascular diseases: associated factors and impact on trial outcomes.

  2012cites this paper
• Antiplatelet drugs: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.

  2012cites this paper
• Pulse wave velocity is associated with early clinical outcome after ischemic stroke.

  2012cites this paper
• Future trials of endovascular mechanical recanalisation therapy in acute ischemic stroke patients - A position paper endorsed by ESMINT and ESNR

  2012cites this paper
• Delayed catastrophic intracerebral hemorrhage preceded by progressive recovery after carotid stenting for acute ischemic stroke.

  2012cites this paper
• Multimodal endovascular reperfusion therapies

  2012cites this paper
• Glycoprotein IIb/IIIa Antagonists in Acute Ischaemic Stroke

  2012cites this paper
• Stroke: Thrombolysis and Antithrombotic Therapy

  2012cites this paper
• Re-establishing Blood Flow After Intravascular Thrombosis

  2012cites this paper
• ANTITHROMBOTIC THERAPY AND PREVENTION OF THROMBOSIS, 9TH ED: ACCP GUIDELINES

  2012cites this paper
• A Critical Review of Stroke Trial Analytical Methodology: Outcome Measures, Study Design, and Correction for Imbalances

  2012cites this paper
• [Treatment of arterial and venous brain ischemia. Experts' recommendations: stroke management in the intensive care unit].

  2012cites this paper
• Management of Acute Ischemic Stroke

  2011cites this paper
• Measuring and Analysis of Outcome in Stroke Trials

  2011cites this paper
• 21 – Clinical Scales to Assess Patients with Stroke

  2011cites this paper
• Safety and feasibility of intraarterial eptifibatide as a revascularization tool in acute ischemic stroke.

  2011cites this paper
• Fibrinolysis and Beyond: Bridging the Gap between Local and Systemic Clot Removal

  2011cites this paper
• 50 – Antithrombotic Therapy for Treatment of Acute Ischemic Stroke

  2011cites this paper
• Intra-arterial versus intra-venous thrombolysis within and after the first 3 hours of stroke onset

  2010cites this paper
• Ischaemic Stroke and Transient Ischaemic Attack

  2010cites this paper
• Making the right choice: optimizing rt-PA and eptifibatide lysis, an in vitro study.

  2010cites this paper
• Combined thrombolysis with abciximab and rtPA in patients with middle cerebral artery occlusion

  2010cites this paper
• Frühe Sekundärprävention bei TIA und ischämischem Insult mit Thrombozytenfunktionshemmern

  2010cites this paper
• Feasibility and Safety of Magnetic Resonance Imaging-Based Thrombolysis in Patients with Stroke on Awakening: Initial Single-Centre Experience

  2010cites this paper
• Antiplatelet therapy in secondary stroke prevention – state of the art

  2010cites this paper
• Acute stroke therapies: Title: Emergency administration of abciximab for treatment of patients with acute ischemic stroke: Results of an international phase III trial. Abciximab (a chimeric mouse/human monoclonal antibody with a high affinity for platelet glycopro

  2010cites this paper
• A Pilot Trial of Low-Dose Intravenous Abciximab and Unfractionated Heparin for Acute Ischemic Stroke: Translating GP IIb/IIIa Receptor Inhibition to Clinical Practice

  2010cites this paper
• A method to determine stroke trial success using multidimensional pooled control functions.

  2009cites this paper
• Antiplatelet Drugs for Ischemic Stroke Prevention

  2009cites this paper
• Should Stroke Trials Adjust Functional Outcome for Baseline Prognostic Factors?

  2009cites this paper
• Systematic Reviews as a Tool for Planning and Interpreting Trials

  2009cites this paper
• Recanalization Therapies in Acute Ischemic Stroke: Pharmacological Agents, Devices, and Combinations

  2009cites this paper
• Assessment of a patient with stroke neurological examination and clinical rating scales.

  2009cites this paper
• Severity of leukoaraiosis correlates with clinical outcome after ischemic stroke

  2009cites this paper
• Antiplatelet agents in stroke prevention

  2009cites this paper
• Antiplatelet treatment in ischemic stroke treatment.

  2009cites this paper
• Predicting Final Extent of Ischemic Infarction Using Artificial Neural Network Analysis of Multi-Parametric MRI in Patients with Stroke

  2009cites this paper
• Critical role of eukaryotic translation initiation factor 4g degradation in mediating ischemia-induced neuronal death

  2009cites this paper
• Treatment of stroke after carotid endarterectomy using intravenous abciximab.

  2009cites this paper
• Antithrombotic and Neuroprotective Therapy in Acute Ischemic Stroke

  2009cites this paper