Strategies for blocking angiogenesis in diabetic retinopathy: from basic science to clinical practice

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Expert Opinion on Investigational Drugs

• Publication date

  2007-08-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1517/13543784.16.8.1209PMID 17685870
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• INTRAVITREAL BEVACIZUMAB (AVASTIN) TREATMENT OF MACULAR EDEMA IN CENTRAL RETINAL VEIN OCCLUSION: A Short-Term Study

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• Inhibition of PKC beta by oral administration of ruboxistaurin is well tolerated and ameliorates diabetes-induced retinal hemodynamic abnormalities in patients.

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• Angiogenic and antiangiogenic factors in proliferative diabetic retinopathy.

  2006influential reference
• A pilot study of multiple intravitreal injections of ranibizumab in patients with center-involving clinically significant diabetic macular edema.

  2006cited by this paper
• Changes in retinal neovascularization after pegaptanib (Macugen) therapy in diabetic individuals.

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• Retinal pigment epithelium damage enhances expression of chemoattractants and migration of bone marrow-derived stem cells.

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• EIAV vector-mediated delivery of endostatin or angiostatin inhibits angiogenesis and vascular hyperpermeability in experimental CNV

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• Vascular endothelial growth factor is a critical stimulus for diabetic macular edema.

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• Pigment epithelium‐derived factor (PEDF) is an endogenous antiinflammatory factor

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• Effect of ruboxistaurin on visual loss in patients with diabetic retinopathy.

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• Intravitreally administered bevacizumab (Avastin) in minimally classic and occult choroidal neovascularization secondary to age-related macular degeneration

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• Induced expression of hematopoietic- and neurologic-expressed sequence 1 in retinal pigment epithelial cells during newt retina regeneration.

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• Intravitreal bevacizumab (Avastin) in the treatment of proliferative diabetic retinopathy.

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• Somatostatin molecular variants in the vitreous fluid: a comparative study between diabetic patients with proliferative diabetic retinopathy and nondiabetic control subjects.

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• The effect of ruboxistaurin on visual loss in patients with moderately severe to very severe nonproliferative diabetic retinopathy. Initial results of the Protein Kinase C beta Inhibitor Diabetic Retinopathy Study (PKC-DRS) Multicenter Randomized Clinical Trial

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• Vascular endothelial growth factor expression and secretion by retinal pigment epithelial cells in high glucose and hypoxia is protein kinase C-dependent.

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• Long-term evaluation of AAV-mediated sFlt-1 gene therapy for ocular neovascularization in mice and monkeys.

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• Optical coherence tomography findings after an intravitreal injection of bevacizumab (avastin) for macular edema from central retinal vein occlusion.

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• SDF-1 is both necessary and sufficient to promote proliferative retinopathy.

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• Diffuse diabetic macular oedema treated by intravitreal triamcinolone acetonide: a comparative, non-randomised study

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• The in vivo effects of the Pro12Ala PPARγ2 polymorphism on adipose tissue NEFA metabolism: the first use of the Oxford Biobank

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• Novel approaches in the treatment of angiogenic eye disease.

  2005influential reference
• Inhibitors of ocular neovascularization: promises and potential problems.

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• Minocycline reduces proinflammatory cytokine expression, microglial activation, and caspase-3 activation in a rodent model of diabetic retinopathy.

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• Optical coherence tomography findings after an intravitreal injection of bevacizumab (avastin) for neovascular age-related macular degeneration.

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• Isolation of retinal progenitor cells from post‐mortem human tissue and comparison with autologous brain progenitors

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• Intravitreal triamcinolone acetonide for diabetic diffuse macular edema: preliminary results of a prospective controlled trial.

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• Somatostatin inhibits IGF-1 mediated induction of VEGF in human retinal pigment epithelial cells.

  2004cited by this paper
• Drug delivery systems for vitreoretinal diseases.

  2004cited by this paper
• Pegaptanib for neovascular age-related macular degeneration.

  2004influential reference
• Intravitreal triamcinolone acetonide for diabetic diffuse macular edema: preliminary results of a prospective controlled trial.

  2004influential reference
• Molecular targeting of antiangiogenic factor 16K hPRL inhibits oxygen-induced retinopathy in mice.

  2004cited by this paper
• Preventive Versus Treatment Effect of Ag3340, a Potent Matrix Metalloproteinase Inhibitor in a Rat Model of Choroidal Neovascularization

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• Neural progenitor cells from postmortem adult human retina

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• Identification of the antivasopermeability effect of pigment epithelium-derived factor and its active site.

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• A central role for inflammation in the pathogenesis of diabetic retinopathy

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• THE EFFECT OF PRINOMASTAT (AG3340), A POTENT INHIBITOR OF MATRIX METALLOPROTEINASE, ON A NEW ANIMAL MODEL OF EPIRETINAL MEMBRANE

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• Facile isolation and the characterization of human retinal stem cells.

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• Optic nerve grey crescent

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• Reduction of diabetic macular edema by oral administration of the kinase inhibitor PKC412.

  2004cited by this paper
• VEGF164(165) as the pathological isoform: differential leukocyte and endothelial responses through VEGFR1 and VEGFR2.

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• The effect of angiostatin on vascular leakage and VEGF expression in rat retina

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• Recent developments in ocular gene therapy.

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• Lentivirus-mediated expression of angiostatin efficiently inhibits neovascularization in a murine proliferative retinopathy model

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• Gene therapy for ocular angiogenesis.

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• Inhibition of retinal neovascularization by intravitreal injection of human rPAI-1 in a rat model of retinopathy of prematurity.

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• RhuFab V2 in Wet AMD – 6 Month Continued Improvement Following Multiple Intravitreal Injections

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• Gene therapy for ocular neovascularization: a cure in sight.

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• Intraocular expression of endostatin reduces VEGF‐induced retinal vascular permeability, neovascularization, and retinal detachment

  2003cited by this paper
• Human retinal molecular weight exclusion limit and estimate of species variation.

  2003cited by this paper
• Adeno-associated viral vectors for retinal gene transfer.

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• A deviant immune response to viral proteins and transgene product is generated on subretinal administration of adenovirus and adeno-associated virus.

  2002cited by this paper
• Retinal vascular endothelial growth factor induces intercellular adhesion molecule-1 and endothelial nitric oxide synthase expression and initiates early diabetic retinal leukocyte adhesion in vivo.

  2002cited by this paper
• Pigment epithelium-derived factor suppresses ischemia-induced retinal neovascularization and VEGF-induced migration and growth.

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• Early complement activation and decreased levels of glycosylphosphatidylinositol-anchored complement inhibitors in human and experimental diabetic retinopathy.

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• Acute intensive insulin therapy exacerbates diabetic blood-retinal barrier breakdown via hypoxia-inducible factor-1alpha and VEGF.

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• Bone marrow–derived stem cells target retinal astrocytes and can promote or inhibit retinal angiogenesis

  2002cited by this paper
• Regression of ocular neovascularization in response to increased expression of pigment epithelium-derived factor.

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• Deficit of somatostatin-like immunoreactivity in the vitreous fluid of diabetic patients: possible role in the development of proliferative diabetic retinopathy.

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• An in vivo gene therapy approach for experimental proliferative vitreoretinopathy using the truncated platelet-derived growth factor alpha receptor.

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• Adeno-associated virus type-2 expression of pigmented epithelium-derived factor or Kringles 1–3 of angiostatin reduce retinal neovascularization

  2002influential reference

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  2019cites this paper
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  2019cites this paper
• Regulation of inflammation and angiogenesis in the cornea

  2018cites this paper
• Mechanistic Insights into Pathological Changes in the Diabetic Retina: Implications for Targeting Diabetic Retinopathy.

  2017cites this paper
• Retinal pigment epithelium-secretome: A diabetic retinopathy perspective.

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• Clinical characteristics and risk factors for retinal diabetic neurodegeneration in type 2 diabetes

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• A Clinico-Pathological Study of the Structural and Functional Changes in the Retina and Optic Nerve Following Diabetic Retinopathy Treatments

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• Neurodegeneration as an early event in the pathogenesis of diabetic retinopathy: therapeutic implications /

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  2016cites this paper
• Metabolomics and Type 2 Diabetes: Translating Basic Research into Clinical Application

  2015cites this paper
• Novel approaches for treating diabetic retinopathy based on recent pathogenic evidence.

  2015cites this paper
• Kallistatin as a marker of microvascular complications in children and adolescents with type 1 diabetes mellitus: Relation to carotid intima media thickness

  2015cites this paper
• Vitreous humor in the pathologic scope: Insights from proteomic approaches

  2015cites this paper
• Retinal neurons curb inflammation and enhance revascularization in ischemic retinopathies via proteinase-activated receptor-2.

  2015cites this paper
• S100A4 gene silencing in oxygen-induced ischemic retinopathy inhibits retinal neovascularization via down-regulation of CREB expression

  2015cites this paper
• Neurodegeneration as a Primary Change and Role of Neuroprotection in Diabetic Retinopathy

  2014cites this paper
• Inhibition of Oxygen-Induced Ischemic Retinal Neovascularization with Adenoviral 15-Lipoxygenase-1 Gene Transfer via Up-Regulation of PPAR-γ and Down-Regulation of VEGFR-2 Expression

  2014cites this paper
• Somatostatin and diabetic retinopathy: current concepts and new therapeutic perspectives

  2014cites this paper
• Somatostatin replacement: a new strategy for treating diabetic retinopathy.

  2013cites this paper
• Neurodegeneration, Neuropeptides, and Diabetic Retinopathy

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• Usefulness of the Vitreous Fluid Analysis in the Translational Research of Diabetic Retinopathy

  2012cites this paper
• Neurodegeneration is an early event in diabetic retinopathy: therapeutic implications

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• Adenoviral 15-lipoxygenase-1 gene transfer inhibits hypoxia-induced proliferation of retinal microvascular endothelial cells in vitro.

  2012cites this paper
• Neuroprotection in Diabetic Retinopathy

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  2012cites this paper
• Retinal and renal vascular permeability changes caused by stem cell stimulation in alloxan-induced diabetic rats, measured by extravasation of fluorescein.

  2012cites this paper
• Neurodegeneration as an early event in diabetic retinopathy.

  2011cites this paper
• Pazopanib, a multitargeted tyrosine kinase inhibitor, reduces diabetic retinal vascular leukostasis and leakage.

  2011cites this paper
• Prevention and treatment of diabetic retinopathy: evidence from clinical trials and perspectives.

  2011cites this paper
• Growth Factors in the Diabetic Eye

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• Predominant cone photoreceptor dysfunction in a hyperglycaemic model of non-proliferative diabetic retinopathy

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• Neurodegeneration: An early event of diabetic retinopathy.

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• Increased serum kallistatin levels in type 1 diabetes patients with vascular complications

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• Selective Inhibition of Retinal Angiogenesis by Targeting PI3 Kinase

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• Angiogenesis in the kidney: a new therapeutic target?

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• The angiogenic process and cancer

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• Suppression of retinal neovascularization by the iNOS inhibitor aminoguanidine in mice of oxygen-induced retinopathy

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• Fenofibrato en el tratamiento de la retinopatía diabética

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• Lowered cortistatin expression is an early event in the human diabetic retina and is associated with apoptosis and glial activation

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• Recent progress in the discovery of selective, non-peptide ligands of somatostatin receptors.

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• Intravitreous anti-VEGF for diabetic retinopathy: hopes and fears for a new therapeutic strategy

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• Vascular endothelial growth factor and diabetic complications.

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• NEW INSIGHTS INTO THE PATHOGENESIS OF DIABETIC RETINOPATHY

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• [Fenofibrate in the treatment of diabetic retinopathy].

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