The role of insulin receptor signaling in the brain.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Trends in endocrinology and metabolism

• Publication date

  2005-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.TEM.2005.01.008PMID 15734146
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Role of brain insulin receptor in control of body weight and reproduction.

  2006cited by this paper
• Rapid Rewiring of Arcuate Nucleus Feeding Circuits by Leptin

  2004cited by this paper
• Hypothalamic control of energy balance: different peptides, different functions.

  2004cited by this paper
• Insulin and leptin as adiposity signals.

  2004cited by this paper
• Insulin and leptin as adiposity signals.

  2004cited by this paper
• Anabolic neuropeptides.

  2004cited by this paper
• Trophic Action of Leptin on Hypothalamic Neurons That Regulate Feeding

  2004cited by this paper
• The source of cerebral insulin.

  2004cited by this paper
• Diet‐induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease

  2004cited by this paper
• Role for neuronal insulin resistance in neurodegenerative diseases.

  2004cited by this paper
• Modulation of memory by insulin and glucose: neuropsychological observations in Alzheimer's disease.

  2004cited by this paper
• Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo.

  2003cited by this paper
• Minireview: nutrient sensing and the regulation of insulin action and energy balance.

  2003cited by this paper
• Selective impairment of insulin signalling in the hypothalamus of obese Zucker rats

  2003cited by this paper
• Adiposity signals and food reward: expanding the CNS roles of insulin and leptin.

  2003cited by this paper
• Insulin Signaling in Health and Disease

  2003cited by this paper
• Gonadotropin-releasing hormone secretion from hypothalamic neurons: stimulation by insulin and potentiation by leptin.

  2003cited by this paper
• Insulin Receptor Substrate-2 Deficiency Impairs Brain Growth and Promotes Tau Phosphorylation

  2003cited by this paper
• Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia.

  2003cited by this paper
• Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo

  2003cited by this paper
• Brain Insulin: Regulation, Mechanisms of Action and Functions

  2003cited by this paper
• Insulin and leptin revisited: adiposity signals with overlapping physiological and intracellular signaling capabilities.

  2003cited by this paper
• Insulin and the blood-brain barrier.

  2003cited by this paper
• Single-trial latency variability of auditory evoked potentials may indicate immediate memory in the albino rat.

  2003cited by this paper
• Effect of Centrally Administered Insulin on Gonadotropin-Releasing Hormone Neuron Activity and Luteinizing Hormone Surge in the Diabetic Female Rat

  2002cited by this paper
• Serum insulin-like growth factor I regulates brain amyloid-β levels

  2002cited by this paper
• The Catabolic Action of Insulin in the Brain Is Mediated by Melanocortins

  2002cited by this paper
• Serum insulin-like growth factor I regulates brain amyloid-beta levels.

  2002cited by this paper
• Sniffing neuropeptides: a transnasal approach to the human brain

  2002cited by this paper
• Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats

  2002cited by this paper
• Lack of Neurodegeneration in Transgenic Mice Overexpressing Mutant Amyloid Precursor Protein Is Associated with Increased Levels of Transthyretin and the Activation of Cell Survival Pathways

  2002cited by this paper
• Hypothalamic insulin signaling is required for inhibition of glucose production

  2002cited by this paper
• Small molecule insulin mimetics reduce food intake and body weight and prevent development of obesity

  2002cited by this paper
• Central melanocortin receptors regulate insulin action.

  2001cited by this paper
• Improving Influence of Insulin on Cognitive Functions in Humans

  2001cited by this paper
• Insulin activates ATP-sensitive K(+) channels in pancreatic beta-cells through a phosphatidylinositol 3-kinase-dependent pathway.

  2001cited by this paper
• Clearing the brain's amyloid cobwebs.

  2001cited by this paper
• Neurodegenerative tauopathies.

  2001cited by this paper
• Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice.

  2001cited by this paper
• Intracellular signalling: Key enzyme in leptin-induced anorexia

  2001cited by this paper
• Decreased nuclear β‐catenin, tau hyperphosphorylation and neurodegeneration in GSK‐3β conditional transgenic mice

  2001cited by this paper
• Insulin and raclopride combine to decrease short-term intake of sucrose solutions.

  2000cited by this paper
• IRS-2 pathways integrate female reproduction and energy homeostasis

  2000cited by this paper
• Why is learning and memory dysfunction in Type 2 diabetes limited to older adults?

  2000cited by this paper
• Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats

  2000cited by this paper
• Essential Role of Phosphoinositide 3-Kinase in Leptin-inducedK ATP Channel Activation in the Rat CRI-G1 Insulinoma Cell Line*

  2000cited by this paper
• Region‐specific mRNA expression of phosphatidylinositol 3‐kinase regulatory isoforms in the central nervous system of C57BL/6J mice

  1999cited by this paper
• Neurotransmitter Transporters: Target for Endocrine Regulation

  1999cited by this paper
• Brain glucose sensing and body energy homeostasis: role in obesity and diabetes.

  1999cited by this paper
• Enhancement of memory in Alzheimer disease with insulin and somatostatin, but not glucose.

  1999cited by this paper
• Insulin action in the normal and polycystic ovary.

  1999cited by this paper
• Physiology of glucose counterregulation to hypoglycemia.

  1999cited by this paper
• Central nervous system effects of intranasally administered insulin during euglycemia in men.

  1999cited by this paper
• Brain glucose sensing and body energy homeostasis: role in obesity and diabetes.

  1999cited by this paper
• Effects of age on working memory: an event-related potential study.

  1999cited by this paper
• A Disturbance in the Neuronal Insulin Receptor Signal Transduction in Sporadic Alzheimer's Disease

  1999cited by this paper
• Phenotype and genotype in polycystic ovary syndrome.

  1998cited by this paper
• Brain insulin and insulin receptors in aging and sporadic Alzheimer's disease

  1998cited by this paper
• Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease

  1998cited by this paper
• Short Term Effects of Leptin on Hepatic Gluconeogenesis and in Vivo Insulin Action*

  1997cited by this paper
• Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt

  1997cited by this paper
• Insulin and Insulin-like Growth Factor-1 Regulate Tau Phosphorylation in Cultured Human Neurons*

  1997cited by this paper
• NIDDM and Blood Pressure as Risk Factors for Poor Cognitive Performance: The Framingham Study

  1997cited by this paper
• Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels

  1997cited by this paper
• Local ventromedial hypothalamus glucose perfusion blocks counterregulation during systemic hypoglycemia in awake rats.

  1997cited by this paper
• Identification of targets of leptin action in rat hypothalamus.

  1996cited by this paper
• Effect of Intracerebroventricular Insulin Infusion on Diabetic Hyperphagia and Hypothalamic Neuropeptide Gene Expression

  1995cited by this paper
• Mechanism of neurofibrillary degeneration in Alzheimer's disease

  1994cited by this paper
• Ventromedial hypothalamic lesions in rats suppress counterregulatory responses to hypoglycemia.

  1994cited by this paper
• Differential effects of melanocortin peptides on neural melanocortin receptors.

  1994cited by this paper
• Chronic intrahypothalamic insulin infusion in the rat: behavioral specificity.

  1993cited by this paper
• Inhibition of hypothalamic neuropeptide Y gene expression by insulin.

  1992cited by this paper
• Relationship Between Hyperglycemia and Cognitive Function in Older NIDDM Patients

  1990cited by this paper
• Effects of chronic intrahypothalamic infusion of insulin on food intake and diurnal meal patterning in the rat.

  1990cited by this paper
• Brain dopamine and reward.

  1989cited by this paper
• Twenty-four-hour profiles and pulsatile patterns of insulin secretion in normal and obese subjects.

  1988cited by this paper
• Quantitative study of insulin secretion and clearance in normal and obese subjects.

  1988cited by this paper
• Receptor-mediated transport of insulin across endothelial cells.

  1985cited by this paper
• Immunocytochemical detection of insulin in rat hypothalamus and its possible uptake from cerebrospinal fluid.

  1983cited by this paper
• Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons

  1979cited by this paper
• Insulin-binding sites in the rat brain: in vivo localization to the circumventricular organs by quantitative radioautography.

  1979cited by this paper
• Insulin receptors are widely distributed in the central nervous system of the rat

  1978cited by this paper
• Relationship between plasma and cerebrospinal fluid insulin levels of dogs.

  1977cited by this paper
• Increased feeding in response to bilateral injection of insulin antibodies in the VMH.

  1977cited by this paper
• Glucose and Osmosensitive Neurones of the Rat Hypothalamus

  1969cited by this paper
• The significance of basal insulin levels in the evaluation of the insulin response to glucose in diabetic and nondiabetic subjects.

  1967cited by this paper
• Insulin in the Cerebrospinal Fluid

  1967cited by this paper

• Intracellular mechanisms underlying modulation of inhibitory synaptic transmission by appetite-related peptides in the insular cortex.

  2026cites this paper
• Cytosolic phospholipase A2 links tau pathology to insulin signaling impairment in Alzheimer’s disease

  2025cites this paper
• Metabolic breakdown: Linking insulin resistance and mitochondrial dysfunction to neurodegeneration in Alzheimer's disease.

  2025cites this paper
• Potential benefits of kefir and its compounds on Alzheimer's disease: A systematic review

  2025cites this paper
• Short-Term: Cellular Metabolism and Gene Expression During the Onset of Diabetic Kidney Disease: A Diabetes Mellitus Experimental Model

  2025cites this paper
• Drugs repurposing in the experimental models of Alzheimer’s disease

  2025cites this paper
• Abnormal cardiovascular control during exercise: Role of insulin resistance in the brain.

  2025cites this paper
• Metformin Improves Spatial Memory and Reduces Seizure Severity in a Rat Model of Epilepsy and Alzheimer’s Disease comorbidity via PI3K/Akt Signaling Pathway

  2025cites this paper
• Computational Modeling of PI3K/AKT Pathway in Bipolar Disorder and Type 2 Diabetes: Implications for Lithium Treatment and Curcumin as a Potential Alternative

  2025cites this paper
• Insulin signaling disruption exacerbates memory impairment and seizure susceptibility in an epilepsy model with Alzheimer’s disease-like pathology

  2025cites this paper
• Early Oral Administration of D-Chiro-Inositol Reverses Hippocampal Insulin and Glutamate Signaling Deficits in the 3×Tg Humanized Mouse Model of Alzheimer’s Disease

  2025cites this paper
• Blockade of insulin receptor signaling in the medullary cardiovascular centers impairs open‐loop arterial baroreflex function via attenuated neural arc in healthy male rats

  2025cites this paper
• Maternal Diet and Vulnerability to Cognitive Impairment in Adulthood: Possible Link with Alzheimer’s Disease?

  2025cites this paper
• Insulin Receptor Regulates Neurotrophin and Neurotrophin Receptor Expression in the Differentiation of Neural Stem Cells: In Vitro Study

  2025cites this paper
• The Conceivable Role of Metabolic Syndrome in the Pathogenesis of Alzheimer’s Disease: Cellular and Subcellular Alterations in Underpinning a Tale of Two

  2025cites this paper
• Diabetes Mellitus-related Pathogeny: A Precipitating Factor for Alzheimer’s Disease—An Insight on Repurposing Diabetes Pharmacological Treatments in Alzheimer’s Disease

  2025cites this paper
• Brain Insulin Resistance as an early target to attenuate neuroinflammation, oxidative stress and proteinopathies in Alzheimer’s Disease: A systematic review of five Natural Products

  2025cites this paper
• Development of a novel anti-erythropoietin-producing hepatocellular receptor B6 monoclonal antibody Eb6Mab-3 for flow cytometry

  2025cites this paper
• T-regulatory cells and extracellular vesicles in Alzheimer's disease: New therapeutic concepts and hypotheses.

  2024cites this paper
• Olfactory Dysfunction as a Biomarker for Early Diagnosis of Cognitive Impairment in Patients With Type 2 Diabetes: A Systematic Review

  2024cites this paper
• Targeting Glucose Metabolism: A Novel Therapeutic Approach for Parkinson’s Disease

  2024cites this paper
• Mechanistic Insights and Potential Therapeutic Implications of NRF2 in Diabetic Encephalopathy

  2024cites this paper
• The Interplay of Stress, Inflammation, and Metabolic Factors in the Course of Parkinson’s Disease

  2024cites this paper
• Insulin enhances acid-sensing ion channel currents in rat primary sensory neurons

  2024cites this paper
• Can we target insulin signalling for cognition therapeutics?

  2024cites this paper
• Impaired olfactory system in metabolic imbalance-related neuropathology.

  2024cites this paper
• Cognitive Disorders in Type 1 Diabetes: Role of Brain Glucose Variation, Insulin Activity, and Glucocorticoid Exposure

  2024cites this paper
• Assessing the Clinical Correlation between Alzheimer's disease and Type-2 Diabetes Mellitus: Current Strategies and Emerging Perspectives

  2024cites this paper
• SUMOylation of Warts kinase promotes neural stem cell reactivation

  2024cites this paper
• Olfactory Dysfunction in Obesity and Type 2 Diabetes

  2024cites this paper
• Glucose Metabolism and Sex Hormones in Male Patients with Medication-naïve First-episode Schizophrenia: A Large-scale Cross-sectional Study

  2024cites this paper
• Intranasal Insulin Eases Autism in Rats via GDF-15 and Anti-Inflammatory Pathways

  2024cites this paper
• Evidence of Disturbed Insulin Signaling in Animal Models of Alzheimer's Disease.

  2023cites this paper
• Comparative Therapeutic Effect of Single/Combined Administration of Saxagliptin, Metformin and Intranasal Insulin on Dexamethasone Induced Insulin Resistance in Wistar Rat Model

  2023cites this paper
• Effect of Dietary Calcium Propionate Inclusion Level and Duration in High-Risk Newly Received Stocker Calves: Growth Performance, Body Fat Reserves, and Health

  2023cites this paper
• Insulin signaling promotes neurogenesis in the brain of adult zebrafish

  2023cites this paper
• PKCα Isoform Inhibits Insulin Signaling and Aggravates Neuronal Insulin Resistance

  2023cites this paper
• Hypometabolism, Alzheimer’s Disease, and Possible Therapeutic Targets: An Overview

  2023cites this paper
• Postmortem Brains from Subjects with Diabetes Mellitus Display Reduced GLUT4 Expression and Soma Area in Hippocampal Neurons: Potential Involvement of Inflammation

  2023cites this paper
• Rosa canina L. improves learning and memory-associated cognitive impairment by regulating glucose levels and reducing hippocampal insulin resistance in high-fat diet/streptozotocin-induced diabetic rats.

  2023cites this paper
• Insulin potentiates inhibitory synaptic currents between fast-spiking and pyramidal neurons in the rat insular cortex.

  2023cites this paper
• Patients with type 1 diabetes and albuminuria have a reduced brain glycolytic capability that is correlated with brain atrophy

  2023cites this paper
• The pivotal role of JAK/STAT and IRS/PI3K signaling pathways in neurodegenerative diseases: Mechanistic approaches to polyphenols and alkaloids.

  2023cites this paper
• Insulin facilitates synaptic transmission via gap junctions between fast-spiking interneurons in the rat insular cortex.

  2023cites this paper
• Amygdala activity and amygdala-hippocampus connectivity: Metabolic diseases, dementia, and neuropsychiatric issues.

  2023cites this paper
• Metabolic Syndrome as a Risk Factor for Alzheimer’s Disease: A Focus on Insulin Resistance

  2023cites this paper
• Type 2 Diabetes (T2DM) and Parkinson’s Disease (PD): a Mechanistic Approach

  2023cites this paper
• Pathophysiological mechanism and natural preventive and therapeutic strategies of Alzheimer's disease

  2022cites this paper
• Brain insulin resistance and cognitive function: influence of exercise.

  2022cites this paper
• Hypothalamic insulin expression remains unaltered after short-term fasting in female rats

  2022cites this paper
• Impaired spatial navigation and age‐dependent hippocampal synaptic dysfunction are associated with chronic inflammatory response in db/db mice

  2022cites this paper
• Clinical Study of Neurodegenerative Treatment on Glaucoma by Insulin Intravitreal Injection

  2022cites this paper
• Can Alzheimer's Disease Be Secondary to Type-2 Diabetes Mellitus?

  2022cites this paper
• Cross talk mechanisms of aerobic exercise training on obesity, type 2 diabetes, and Alzheimer's disease: the role of insulin resistance

  2022cites this paper
• Type 2 diabetes mellitus augments Parkinson's disease risk or the other way around: facts, challenges and future possibilities.

  2022cites this paper
• Insulin signaling as a therapeutic mechanism of lithium in bipolar disorder

  2022cites this paper
• Insulin and insulin-like growth factor-I receptors in astrocytes exert different effects on behavior and Alzheimer´s-like pathology

  2022cites this paper
• Association of hyperglycemia and molecular subclass on survival in IDH-wildtype glioblastoma

  2022cites this paper
• Insulin replacement prevents the acquisition but not the expression of morphine-induced conditioned place preference in streptozotocin-induced diabetic rats

  2022cites this paper
• Inside the diabetic brain: Insulin resistance and molecular mechanism associated with cognitive impairment and its possible therapeutic strategies.

  2022cites this paper
• The Effectiveness of Antidiabetic Drugs in Treating Dementia: A Peek into Pharmacological and Pharmacokinetic Properties

  2022cites this paper
• Alterations in hippocampal neurogenesis and hippocampal insulin signaling pathway in rat with metabolic syndrome

  2022cites this paper
• Molecular basis of fluoride toxicities: Beyond benefits and implications in human disorders

  2022cites this paper
• Chronic exposure of bisphenol-A impairs cognitive function and disrupts hippocampal insulin signaling pathway in male mice.

  2022cites this paper
• Dysmetabolism and Neurodegeneration: Trick or Treat?

  2022influential citation
• Response of some indicators of the respiratory system to dosed hypoxia in elderly people with impaired glucose tolerance

  2022cites this paper
• The Therapeutic Role of Ketogenic Diet in Neurological Disorders

  2022influential citation
• Pathological Human Tau Induces Alterations in the Brain Insulin Signaling Cascade

  2022cites this paper
• A Bioinformatics Approach Toward Unravelling the Synaptic Molecular Crosstalk Between Alzheimer’s Disease and Diabetes

  2022cites this paper
• Type 2 Diabetes Mellitus-associated Cognitive Dysfunction: Advances in Potential Mechanisms and Therapies.

  2022cites this paper
• The interactions between adipose tissue secretions and Parkinson's disease: The role of leptin

  2022cites this paper
• The Correlation between Diabetes Mellitus and Neurodegenerative Diseases

  2022cites this paper
• Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance

  2022cites this paper
• Association of Non-Dipping Blood Pressure Patterns with Diabetic Peripheral Neuropathy: A Cross-Sectional Study among a Population with Diabetes in Greece

  2022cites this paper
• Ser/Thr phosphatases: One of the key regulators of insulin signaling

  2022cites this paper
• Secreted decoy of insulin receptor is required for blood-brain and blood-retina barrier integrity in Drosophila

  2022cites this paper
• Diabetes Mellitus Management in the Context of Cranial Tumors.

  2022cites this paper
• Dementia in Diabetes mellitus and Atherosclerosis; Two Interrelated Systemic Diseases.

  2022cites this paper
• Type 2 Diabetes Mellitus as a Risk Factor for Alzheimer’s Disease: Review and Meta-Analysis

  2022cites this paper
• The Feeding Pattern of C57BL/6J Mice

  2022cites this paper
• The Impact of Insulin Resistance on Cardiovascular Control during Exercise in Diabetes.

  2021cites this paper
• Insulin Resistance as a Common Link Between Current Alzheimer’s Disease Hypotheses

  2021cites this paper
• Eat, sleep, repeat – endocrine regulation of behavioural circadian rhythms

  2021cites this paper
• Physiological and Pathological Factors Affecting Drug Delivery to the Brain by Nanoparticles

  2021cites this paper
• Insulin Signaling as a Therapeutic Target in Glaucomatous Neurodegeneration

  2021cites this paper
• Insulin Resistance and Cardiometabolic Syndrome

  2021cites this paper
• Insulin Resistance Exacerbates Alzheimer Disease via Multiple Mechanisms

  2021cites this paper
• The melanocortin pathway and energy homeostasis: From discovery to obesity therapy

  2021cites this paper
• Olfactory dysfunction predicts the development of dementia in older patients with type 2 diabetes.

  2021cites this paper
• Evolving new-age strategies to transport therapeutics across the blood-brain-barrier.

  2021cites this paper
• Insulin-Dependent Maturation of Newly Generated Olfactory Sensory Neurons after Injury

  2021cites this paper
• Food for Memory: A Review of the Effects of Diet on Alzheimer's Disease Progression

  2021cites this paper
• Insulin-dependent maturation of newly generated olfactory 1 sensory neurons after injury 2 3 Abbreviated title : Role of insulin in olfactory neuron maturation 4 5

  2021cites this paper
• Insulin on the brain: The role of central insulin signalling in energy and glucose homeostasis

  2021cites this paper
• Untangling the effect of insulin action on brain mitochondria and metabolism

  2021cites this paper
• Insulin differentially modulates GABA signalling in hippocampal neurons and, in an age‐dependent manner, normalizes GABA‐activated currents in the tg‐APPSwe mouse model of Alzheimer’s disease

  2021cites this paper
• Repurposing of Omarigliptin as a Neuroprotective Agent Based on Docking with A2A Adenosine and AChE Receptors, Brain GLP-1 Response and Its Brain/Plasma Concentration Ratio after 28 Days Multiple Doses in Rats Using LC-MS/MS

  2021cites this paper
• Hippocampal subfields atrophy contribute more to cognitive impairment in middle-aged patients with type 2 diabetes rather than microvascular lesions

  2021cites this paper
• Taurine in the Cerebellum

  2021cites this paper
• Selective CNS Targeting and Distribution with a Refined Region-Specific Intranasal Delivery Technique via the Olfactory Mucosa

  2021cites this paper