Effects of Human Oral Mucosal Tissue, Saliva, and Oral Microflora on Intraoral Metabolism and Bioactivation of Black Raspberry Anthocyanins

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Cancer Prevention Research

• Publication date

  2011-05-10

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1158/1940-6207.CAPR-11-0040PMID 21558412PMCID PMC3151333
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Anthocyanin-derived phenolic acids form glucuronides following simulated gastrointestinal digestion and microsomal glucuronidation.

  2011cited by this paper
• Effects of Cigarette Smoke on the Human Oral Mucosal Transcriptome

  2010cited by this paper
• A rapid and sensitive LC-MS/MS method for quantification of four anthocyanins and its application in a clinical pharmacology study of a bioadhesive black raspberry gel.

  2009cited by this paper
• Enzymatic hemisynthesis of metabolites and conjugates of anthocyanins.

  2009cited by this paper
• Disposition of Flavonoids via Enteric Recycling: UDP-Glucuronosyltransferase (UGT) 1As Deficiency in Gunn Rats Is Compensated by Increases in UGT2Bs Activities

  2009cited by this paper
• Anthocyanins in Black Raspberries Prevent Esophageal Tumors in Rats

  2009cited by this paper
• Distribution of Anthocyanins Delivered from a Bioadhesive Black Raspberry Gel Following Topical Intraoral Application in Normal Healthy Volunteers

  2009influential reference
• Stability of black raspberry anthocyanins in the digestive tract lumen and transport efficiency into gastric and small intestinal tissues in the rat.

  2009influential reference
• Topical application of a bioadhesive black raspberry gel modulates gene expression and reduces cyclooxygenase 2 protein in human premalignant oral lesions.

  2008influential reference
• Effects of a Topically Applied Bioadhesive Berry Gel on Loss of Heterozygosity Indices in Premalignant Oral Lesions

  2008influential reference
• Anthocyanins and their role in cancer prevention.

  2008cited by this paper
• Natural polyphenol disposition via coupled metabolic pathways

  2007cited by this paper
• Cancer prevention with freeze-dried berries and berry components.

  2007cited by this paper
• Anthocyanins: Structural characteristics that result in unique metabolic patterns and biological activities

  2006cited by this paper
• Stability and biotransformation of various dietary anthocyanins in vitro

  2006cited by this paper
• Flavonoid glucosides are hydrolyzed and thus activated in the oral cavity in humans.

  2005cited by this paper
• Identification of cyanidin glycosides as constituents of freeze-dried black raspberries which inhibit anti-benzo[a]pyrene-7,8-diol-9,10-epoxide induced NFkappaB and AP-1 activity.

  2005cited by this paper
• HIGH ABSORPTION BUT VERY LOW BIOAVAILABILITY OF ORAL RESVERATROL IN HUMANS

  2004cited by this paper
• Vertebrate UDP-glucuronosyltransferases: functional and evolutionary aspects.

  2003cited by this paper
• Deglycosylation by small intestinal epithelial cell β-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans

  2003cited by this paper
• Absorption and metabolism of flavonoids in the caco-2 cell culture model and a perused rat intestinal model.

  2002cited by this paper
• Carrier-mediated transport systems for glucose in mucosal cells of the human oral cavity.

  1999cited by this paper
• Localization of beta-glucosidase activity within keratinizing epithelia.

  1993cited by this paper
• Localization of β-glucosidase activity within keratinizing epithelia

  1993cited by this paper
• Interactions of chlorhexidine with salivary films adsorbed at solid/liquid and air/liquid interfaces.

  1993cited by this paper
• Some Aspects of Drug Dynamics as Related to Oral Soft Tissue

  1975cited by this paper
• Enzymes of Human Saliva

  1954cited by this paper
• “Field cancerization” in oral stratified squamous epithelium. Clinical implications of multicentric origin

  1953influential reference

• Anthocyanin-Rich Fraction from Kum Akha Black Rice Attenuates NLRP3 Inflammasome-Driven Lung Inflammation In Vitro and In Vivo

  2025cites this paper
• Cyanidin and Cyanidin-3-Glucoside Alleviate Peptic Ulcer Disease: Insights from in vitro, and in vivo Studies

  2025cites this paper
• Mechanism-driven stabilization of anthocyanins: comparative copigmentation and encapsulation for food applications.

  2025cites this paper
• Mechanistic signaling pathways of flavonoid-induced oral squamous cell carcinoma therapy: Clinical evidence and therapeutic application.

  2025cites this paper
• Encapsulation of anthocyanins: A key for improvement of the gut-metabolism health axis?

  2025cites this paper
• Review: Enhancing the Bioavailability and Stability of Anthocyanins for the Prevention and Treatment of Central Nervous System-Related Diseases

  2025cites this paper
• Bioavailability and purification of anthocyanins extracted from blackberry fruit using deep eutectic solvent

  2025cites this paper
• Dietary anthocyanins as natural phytochemicals for regulating hyperuricemia: Proposed intestinal flora, key enzyme activity, and anti-inflammatory pathways

  2024cites this paper
• Bioavailability of Anthocyanins: Whole Foods versus Extracts

  2024cites this paper
• The Cancer-Protective Potential of Protocatechuic Acid: A Narrative Review

  2024cites this paper
• Rattus norvegicus Glutathione Transferase Omega 1 Localization in Oral Tissues and Interactions with Food Phytochemicals.

  2024cites this paper
• Health-Promoting Properties of Anthocyanins from Cornelian Cherry (Cornus mas L.) Fruits

  2024cites this paper
• Can anthocyanins replace antibiotics in food and animal feed? A review

  2024cites this paper
• Green Cancer Prevention and Beyond

  2024cites this paper
• Relevance of Anthocyanin Metabolites Generated During Digestion on Bioactivity Attributed to Intact Anthocyanins

  2024cites this paper
• Functional chewing gum: Transition from a conventional chew to a novel matrix delivering encapsulated bioactives with health-promoting properties

  2024cites this paper
• Emerging Perspectives: The Interplay of Taste Perception and Oral Microbiota Composition in Dietary Preferences and Obesity.

  2024cites this paper
• Bioengineered Anthocyanin-Enriched Tomatoes: A Novel Approach to Colorectal Cancer Prevention

  2024cites this paper
• Exploring the potential benefits of anthocyanins for individuals with cerebral small vessel disease

  2024cites this paper
• Recent advances on cyanidin-3-O-glucoside in preventing obesity-related metabolic disorders: A comprehensive review.

  2024cites this paper
• Cherry fruit anthocyanins cyanidin-3-O-glucoside and cyanidin-3-O-rutinoside protect against blue light-induced cytotoxicity in HaCaT cells

  2023cites this paper
• Exploring strategies to enhance anthocyanin bioavailability and bioaccessibility in food: A literature review

  2023cites this paper
• Single anthocyanins effectiveness modulating inflammation markers in obesity: dosage and matrix composition analysis

  2023cites this paper
• Advances in the Preparation, Stability, Metabolism, and Physiological Roles of Anthocyanins: A Review

  2023cites this paper
• Rubus Occidentalis and its bioactive compounds against cancer: From molecular mechanisms to translational advances.

  2023cites this paper
• Role of Insect and Mammal Glutathione Transferases in Chemoperception

  2023cites this paper
• Nano-encapsulated anthocyanins: A new technological approach to increase physical-chemical stability and bioaccessibility

  2023cites this paper
• Anti-Inflammatory Activity of an In Vitro Digested Anthocyanin-Rich Extract on Intestinal Epithelial Cells Exposed to TNF-α

  2022cites this paper
• The Potential Roles of Dietary Anthocyanins in Inhibiting Vascular Endothelial Cell Senescence and Preventing Cardiovascular Diseases

  2022cites this paper
• Anthocyanins as Key Phytochemicals Acting for the Prevention of Metabolic Diseases: An Overview

  2022cites this paper
• Current knowledge of anthocyanin metabolism in the digestive tract: absorption, distribution, degradation, and interconversion

  2022cites this paper
• Research Progress on Absorption, Metabolism, and Biological Activities of Anthocyanins in Berries: A Review

  2022cites this paper
• The role of perireceptor events in flavor perception

  2022cites this paper
• Neuroinflammation: The Role of Anthocyanins as Neuroprotectants

  2022cites this paper
• Anti-aging effects and mechanisms of anthocyanins and their intestinal microflora metabolites

  2022cites this paper
• Impact of Oral Microbiota on Flavor Perception: From Food Processing to In-Mouth Metabolization

  2021cites this paper
• Research progress on intervention effect and mechanism of protocatechuic acid on nonalcoholic fatty liver disease

  2021cites this paper
• Chemopreventive and Anti-tumor Potential of Natural Products in Oral Cancer

  2021cites this paper
• Novel approaches in anthocyanin research - Plant fortification and bioavailability issues

  2021cites this paper
• Role of anthocyanins in oxidative stress and the prevention of cancer in the digestive system

  2021cites this paper
• Systematic Review of Phenolic Compounds in Apple Fruits: Compositions, Distribution, Absorption, Metabolism, and Processing Stability.

  2021cites this paper
• Bioaccessibility of Antioxidants in Blackcurrant Juice after Treatment Using Supercritical Carbon Dioxide

  2021cites this paper
• Polyphenols and Novel Insights Into Post-kidney Transplant Complications and Cardiovascular Disease: A Narrative Review

  2021cites this paper
• Plant-Derived Substances with Antibacterial, Antioxidant, and Flavoring Potential to Formulate Oral Health Care Products

  2021cites this paper
• Anthocyanins in Colorectal Cancer Prevention Review

  2021cites this paper
• Oral enzymatic detoxification system: Insights obtained from proteome analysis to understand its potential impact on aroma metabolization.

  2021cites this paper
• Acylated anthocyanins: A review on their bioavailability and effects on postprandial carbohydrate metabolism and inflammation.

  2021cites this paper
• Molecular Carcinogenesis

  2020cites this paper
• Factors contributing to interindividual variation in retronasal odor perception from aroma glycosides: the role of odorant sensory detection threshold, oral microbiota and hydrolysis in saliva.

  2020cites this paper
• Anthocyanins from Purple Tomatoes as Novel Antioxidants to Promote Human Health

  2020cites this paper
• Basic Properties of Anthocyanin for Pain Management

  2020cites this paper
• Blackberries

  2020cites this paper
• Dietary Flavonoids for Immunoregulation and Cancer: Food Design for Targeting Disease

  2019cites this paper
• A Review of Factors Affecting Anthocyanin Bioavailability: Possible Implications for the Inter-Individual Variability

  2019cites this paper
• Anthocyanins: Nutrition and Health

  2019cites this paper
• Handbook of Nutraceuticals and Functional Foods

  2019cites this paper
• A Novel Delivering Agent for Bioactive Compounds: Chewing Gum

  2019cites this paper
• Wine-Derived Phenolic Metabolites in the Digestive and Brain Function

  2019cites this paper
• Digestion and absorption of red grape and wine anthocyanins through the gastrointestinal tract

  2019cites this paper
• Metabolism of anthocyanins and consequent effects on the gut microbiota

  2018cites this paper
• Inhibition of Oral Pathogens Adhesion to Human Gingival Fibroblasts by Wine Polyphenols Alone and in Combination with an Oral Probiotic.

  2018cites this paper
• The potential health bene fi ts of haskap ( Lonicera caerulea L . ) : Role of cyanidin-3O-glucoside

  2018cites this paper
• The fruit of black raspberry ( Rubus occidentalis L.) in the prevention and therapy of some cancers – current state of research

  2018cites this paper
• Protective effects of anthocyanins and degradation products on oxidative stress in human colon carcinoma cells

  2018cites this paper
• The potential health benefits of haskap (Lonicera caerulea L.): Role of cyanidin-3-O-glucoside

  2018cites this paper
• Polymeric drug delivery systems for intraoral site-specific chemoprevention of oral cancer.

  2018cites this paper
• Berries as a potential anti-influenza factor – A review

  2017cites this paper
• Application of a low polyphenol or low ellagitannin dietary intervention and its impact on ellagitannin metabolism in men

  2017cites this paper
• The role of wine and food polyphenols in oral health

  2017cites this paper
• A theoretical physiologically based pharmacokinetic approach for modeling the fate of anthocyanins in vivo

  2017influential citation
• Saliva from healthy men and women after exposure to three amorphous black raspberry confections: an analysis of salivary kinetics and polyphenol profile in oral cancer prevention

  2017cites this paper
• The contribution of wine-derived monoterpene glycosides to retronasal odour during tasting.

  2017influential citation
• Wine Flavonoids in Health and Disease Prevention

  2017cites this paper
• Review of Various Herbal Supplements as Complementary Treatments for Oral Cancer

  2016cites this paper
• Potential Role of Polyphenols in the Prevention of Cardiovascular Diseases: Molecular Bases.

  2016cites this paper
• Unraveling Anthocyanin Bioavailability for Human Health.

  2016cites this paper
• Flavonoids as promoters of the (pseudo-)halogenating activity of lactoperoxidase and myeloperoxidase.

  2016cites this paper
• DEVELOPMENT OF AN ORAL DELIVERY SYSTEM TO MODULATE THE RELEASE OF ANTHOCYANINS EXTRACTED FROM HASKAP BERRIES (LONICERA CAERULEA L.)

  2016cites this paper
• Potential Benefits of Edible Berries in the Management of Aerodigestive and Gastrointestinal Tract Cancers: Preclinical and Clinical Evidence

  2016cites this paper
• Rubus occidentalis: The black raspberry—its potential in the prevention of cancer

  2016cites this paper
• Cyanidin-3-O-glucoside: Physical-Chemistry, Foodomics and Health Effects

  2016influential citation
• Assessing the Changing Oral and Pharyngeal Cancer Demographic in the United States

  2016cites this paper
• Acute Effects of Black Currant Consumption on Salivary Flow Rate and Secretion Rate of Salivary Immunoglobulin A in Healthy Smokers

  2015cites this paper
• Multiple-approach studies to assess anthocyanin bioavailability

  2015cites this paper
• Bioavailability of Citrus Flavanones and Their Effect on Cardiovascular Health Biomarkers

  2015cites this paper
• Lyophilized strawberries prevent 7,12-dimethylbenz[α]anthracene (DMBA)-induced oral squamous cell carcinogenesis in hamsters

  2015cites this paper
• Sequential light programs shape kale (Brassica napus) sprout appearance and alter metabolic and nutrient content

  2014cites this paper
• Diet and esophageal disease

  2014cites this paper
• Topical Application of a Mucoadhesive Freeze-Dried Black Raspberry Gel Induces Clinical and Histologic Regression and Reduces Loss of Heterozygosity Events in Premalignant Oral Intraepithelial Lesions: Results from a Multicentered, Placebo-Controlled Clinical Trial

  2014cites this paper
• Bioavailability of anthocyanins and derivatives

  2014cites this paper
• Anthocyanin structure determines susceptibility to microbial degradation and bioavailability to the buccal mucosa.

  2014cites this paper
• Bioavailability of anthocyanins

  2014cites this paper
• Anthocyanins and human health: How gastric absorption may influence acute human physiology

  2014cites this paper
• A pilot sweet cherry feeding study in overweight men: Tolerance, safety, and anthocyanin exposure

  2014cites this paper
• Some anthocyanins could be efficiently absorbed across the gastrointestinal mucosa: extensive presystemic metabolism reduces apparent bioavailability.

  2014cites this paper
• Biodisponibilidade de antocianinas do vinho de mesa

  2014cites this paper
• Chemopreventive Potential of Flavonoids in Oral Squamous Cell Carcinoma in Human Studies

  2013cites this paper
• Basic and Translational Research on Dietary Phytochemicals and Cancer Prevention

  2013cites this paper
• Mitochondria as Targets for Phytochemicals in Cancer Prevention and Therapy

  2013cites this paper
• Bioavailability of anthocyanins

  2013cites this paper