Topical application of a bioadhesive black raspberry gel modulates gene expression and reduces cyclooxygenase 2 protein in human premalignant oral lesions.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Cancer Research

• Publication date

  2008-06-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1158/0008-5472.CAN-08-0568PMID 18559542PMCID PMC2892791
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Human papillomavirus and head and neck cancer.

  2010cited by this paper
• Effects of a Topically Applied Bioadhesive Berry Gel on Loss of Heterozygosity Indices in Premalignant Oral Lesions

  2008influential reference
• Recent advances in Oral Oncology.

  2007cited by this paper
• The economics of squamous cell carcinoma of the head and neck

  2007cited by this paper
• Asia and Africa.

  2007cited by this paper
• Formulation and In-Vitro and In-Vivo Evaluation of a Mucoadhesive Gel Containing Freeze Dried Black Raspberries: Implications for Oral Cancer Chemoprevention

  2007influential reference
• Understanding the biology of angiogenesis: review of the most important molecular mechanisms.

  2007cited by this paper
• Chronic inflammation and oxidative stress in human carcinogenesis

  2007cited by this paper
• Cancer Statistics, 2007

  2007cited by this paper
• Oxidative and nitrative DNA damage in animals and patients with inflammatory diseases in relation to inflammation-related carcinogenesis

  2006influential reference
• Black raspberry extracts inhibit benzo(a)pyrene diol-epoxide-induced activator protein 1 activation and VEGF transcription by targeting the phosphotidylinositol 3-kinase/Akt pathway.

  2006cited by this paper
• Urinary excretion of black raspberry (Rubus occidentalis) anthocyanins and their metabolites.

  2006cited by this paper
• Transitioning From Preclinical to Clinical Chemopreventive Assessments of Lyophilized Black Raspberries: Interim Results Show Berries Modulate Markers of Oxidative Stress in Barrett's Esophagus Patients

  2006cited by this paper
• Gene expression differences in normal esophageal mucosa associated with regression and progression of mild and moderate squamous dysplasia in a high-risk Chinese population.

  2006cited by this paper
• Chemopreventive properties of black raspberries in N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis: down-regulation of cyclooxygenase-2, inducible nitric oxide synthase, and c-Jun.

  2006cited by this paper
• Fenretinide Activity in Retinoid-Resistant Oral Leukoplakia

  2006cited by this paper
• Human papillomavirus and head and neck cancer: a systematic review and meta‐analysis

  2006cited by this paper
• The role of cellular flice inhibitory protein (c-FLIP) in the pathogenesis and treatment of cancer

  2006cited by this paper
• Black raspberries inhibit N-nitrosomethylbenzylamine (NMBA)-induced angiogenesis in rat esophagus parallel to the suppression of COX-2 and iNOS.

  2006cited by this paper
• Suppression of the Tumorigenic Phenotype in Human Oral Squamous Cell Carcinoma Cells by an Ethanol Extract Derived From Freeze-Dried Black Raspberries

  2006cited by this paper
• The roles of heterogeneous nuclear ribonucleoproteins in tumour development and progression.

  2006cited by this paper
• Molecular targets of dietary agents for prevention and therapy of cancer.

  2006influential reference
• Pharmacokinetics of Anthocyanins and Ellagic Acid in Healthy Volunteers Fed Freeze‐Dried Black Raspberries Daily for 7 Days

  2005cited by this paper
• Mechanisms of Disease: inflammatory mediators and cancer prevention

  2005influential reference
• Increased nitric oxide levels and iNOS over-expression in oral squamous cell carcinoma.

  2005cited by this paper
• The economic cost of squamous cell cancer of the head and neck: findings from linked SEER-Medicare data.

  2004cited by this paper
• Human galectin-8 isoforms and cancer

  2004cited by this paper
• An attenuated adenovirus, ONYX-015, as mouthwash therapy for premalignant oral dysplasia.

  2003cited by this paper
• A transcriptional progression model for head and neck cancer.

  2003cited by this paper
• Oral Cancer and Precancerous Lesions

  2002cited by this paper
• Differential expression profiling of head and neck squamous carcinoma: significance in their phenotypic and biological classification

  2002cited by this paper
• Chemoprevention of oral cancer by black raspberries.

  2002cited by this paper
• Prognostic significance of cyclooxygenase-2 pathway and angiogenesis in head and neck squamous cell carcinoma.

  2002cited by this paper
• Inhibition of benzo(a)pyrene diol-epoxide-induced transactivation of activated protein 1 and nuclear factor kappaB by black raspberry extracts.

  2002cited by this paper
• Transcriptional expression profiles of oral squamous cell carcinomas

  2002cited by this paper
• Inhibition of cellular transformation by berry extracts.

  2001cited by this paper
• Chemoprevention of esophageal tumorigenesis by dietary administration of lyophilized black raspberries.

  2001cited by this paper
• Cyclooxygenase-2 and carcinogenesis.

  2000cited by this paper
• Placental Levels of Human Decidua- Associated Protein 200 in Normal Pregnancy and Missed Abortion

  2000cited by this paper
• Biochemoprevention for dysplastic lesions of the upper aerodigestive tract.

  1999cited by this paper
• Cyclooxygenase-2 expression is up-regulated in squamous cell carcinoma of the head and neck.

  1999cited by this paper
• A novel function of VEGF receptor-2 (KDR): rapid release of nitric oxide in response to VEGF-A stimulation in endothelial cells.

  1999cited by this paper
• Nitric oxide promotes proliferation and plasminogen activator production by coronary venular endothelium through endogenous bFGF.

  1997cited by this paper
• Regulation of cyclooxygenase enzymes by nitric oxide

  1997cited by this paper
• Oral epithelial dysplasia and the development of invasive squamous cell carcinoma.

  1995cited by this paper
• Oral leukoplakia.

  1995cited by this paper
• Comparison of low-dose isotretinoin with beta carotene to prevent oral carcinogenesis.

  1993cited by this paper
• Treatment of oral leukoplakia with beta-carotene.

  1992cited by this paper
• Cancer statistics

  1989cited by this paper
• [Oral leukoplakia].

  1981cited by this paper

• Dietary plants for oral cancer prevention and therapy: A review of preclinical and clinical studies

  2024cites this paper
• Oral Health and Nutraceutical Agents

  2024influential citation
• Berries vs. Disease: Revenge of the Phytochemicals

  2024cites this paper
• Chemoprevention of oral cancer: A review and future perspectives

  2023cites this paper
• Inducible TgfbR1 and Pten deletion in a model of tongue carcinogenesis and chemoprevention

  2023cites this paper
• Rubus Occidentalis and its bioactive compounds against cancer: From molecular mechanisms to translational advances.

  2023cites this paper
• Novel Strategies for the Bioavailability Augmentation and Efficacy Improvement of Natural Products in Oral Cancer

  2022cites this paper
• Anti-inflammatory and cytotoxic effect of lycopene and raspberry in-situ gel

  2022cites this paper
• Consensus guidelines on management of oral potentially malignant disorders

  2022cites this paper
• Plant Phenolics: Extraction, Analysis and Their Antioxidant and Plant Phenolics: Extraction, Analysis and Their Antioxidant and Anticancer Properties Anticancer Properties

  2022cites this paper
• Black raspberry anthocyanins increased the antiproliferative effects of 5-Fluorouracil and Celecoxib in colorectal cancer cells and mouse model

  2021cites this paper
• Review of Functional and Pharmacological Activities of Berries

  2021cites this paper
• Towards the Development of Delivery Systems of Bioactive Compounds With Eyes Set on Pharmacokinetics

  2021cites this paper
• Predicting the clinical outcome of oral potentially malignant disorders using transcriptomic-based molecular pathology

  2021cites this paper
• Chemopreventive and Anti-tumor Potential of Natural Products in Oral Cancer

  2021cites this paper
• Discovery, Development, and Design of Anthocyanins-Inspired Anticancer Agents-A Comprehensive Review.

  2021cites this paper
• Chemopreventive Effect of Dietary Anthocyanins against Gastrointestinal Cancers: A Review of Recent Advances and Perspectives

  2020cites this paper
• Black Raspberries and Protocatechuic Acid Mitigate DNFB-Induced Contact Hypersensitivity by Down-Regulating Dendritic Cell Activation and Inhibiting Mediators of Effector Responses

  2020cites this paper
• Gene Expression Clustering and Selected Head and Neck Cancer Gene Signatures Highlight Risk Probability Differences in Oral Premalignant Lesions

  2020cites this paper
• Berry chemoprevention: Do berries decrease the window of opportunity for tumorigenesis

  2020cites this paper
• Anthocyanins: Promising Natural Compounds for Prevention and Treatment of Oral Squamous Cell Carcinoma

  2020cites this paper
• Food‐based approach to cancer prevention

  2020cites this paper
• Effect of graphene on the growth and development of Raspberry tissue culture seedlings

  2020cites this paper
• Dose-dependent Increases in Ellagitannin Metabolites as Biomarkers of Intake in Humans Consuming Standardized Black Raspberry Food Products Designed for Clinical Trials.

  2020cites this paper
• Molecular mechanisms linking environmental toxicants to cancer development: Significance for protective interventions with polyphenols.

  2020cites this paper
• An Integrated Approach for Preventing Oral Cavity and Oropharyngeal Cancers: Two Etiologies with Distinct and Shared Mechanisms of Carcinogenesis

  2020cites this paper
• Wine Consumption and Oral Cavity Cancer: Friend or Foe, Two Faces of Janus

  2020cites this paper
• Advances in phytochemical delivery systems for improved anticancer activity.

  2019cites this paper
• Metabolic Regulation of Glycolysis and AMP Activated Protein Kinase Pathways during Black Raspberry-Mediated Oral Cancer Chemoprevention

  2019cites this paper
• The Epigenetic Targets of Berry Anthocyanins in Cancer Prevention

  2019cites this paper
• Alginate-based Films for Investigative Delivery of Flavonoids

  2019cites this paper
• Squamous Cell Carcinoma of the Oropharynx and the Effect of Botanicals

  2019influential citation
• Review of the health effects of berries and their phytochemicals on the digestive and immune systems

  2018cites this paper
• Polymeric drug delivery systems for intraoral site-specific chemoprevention of oral cancer.

  2018cites this paper
• The fruit of black raspberry ( Rubus occidentalis L.) in the prevention and therapy of some cancers – current state of research

  2018cites this paper
• Preparing black raspberry components for their use as cancer therapeutics

  2018cites this paper
• Critical Evaluation of Gene Expression Changes in Human Tissues in Response to Supplementation with Dietary Bioactive Compounds: Moving Towards Better-Quality Studies

  2018cites this paper
• Effects of Black Raspberry on Dibenzo[a,l]Pyrene Diol Epoxide Induced DNA Adducts, Mutagenesis, and Tumorigenesis in the Mouse Oral Cavity

  2017cites this paper
• Topical agents for oral cancer chemoprevention: A systematic review of the literature.

  2017cites this paper
• Health Risks and Benefits of Chickpea (Cicer arietinum) Consumption.

  2017cites this paper
• Plant-derived anticancer agents: A green anticancer approach

  2017cites this paper
• Chemoprevention of oral cancer in leukoplakia patients: A systematic review and meta-analysis.

  2017cites this paper
• Application of a low polyphenol or low ellagitannin dietary intervention and its impact on ellagitannin metabolism in men

  2017cites this paper
• Carcinogenesis of the Oral Cavity: Environmental Causes and Potential Prevention by Black Raspberry.

  2017cites this paper
• OROTRANSMUCOSAL DRUG DELIVERY SYSTEM : A FORGOTTEN HERO

  2017cites this paper
• Cloudberry (Rubus chamaemorus) and its components as chemopreventive constituents in ApcMin mice and human colon adenocarcinoma cells

  2017cites this paper
• Black raspberries in cancer clinical trials: Past, present and future

  2016influential citation
• Rubus occidentalis: The black raspberry—its potential in the prevention of cancer

  2016cites this paper
• Potential Benefits of Edible Berries in the Management of Aerodigestive and Gastrointestinal Tract Cancers: Preclinical and Clinical Evidence

  2016cites this paper
• Flavonoids, Flavonoid Subclasses, and Esophageal Cancer Risk: A Meta-Analysis of Epidemiologic Studies

  2016cites this paper
• Mucosal Therapy for Potentially Malignant Diseases and OSCC

  2016influential citation
• Suppression of pro-inflammatory and pro-survival biomarkers in oral cancer patients consuming a black raspberry phytochemical-rich troche. Authors and Affiliations:

  2015cites this paper
• Development and characterization of different black raspberry confection matrices designed for delivery of phytochemicals.

  2015cites this paper
• Suppression of Proinflammatory and Prosurvival Biomarkers in Oral Cancer Patients Consuming a Black Raspberry Phytochemical-Rich Troche

  2015cites this paper
• Anti inflammatory and anti angiogenic effect of black raspberry extract on human esophageal and intestinal microvascular endothelial cells.

  2015cites this paper
• Comparison of the storage stability of starch and pectin black raspberry confections

  2015cites this paper
• A phase I pilot study evaluating the beneficial effects of black raspberries in patients with Barrett’s esophagus

  2014cites this paper
• Has Anyone so far Bridged the Gap between microRNA, Botanicals and Oropharyngeal Squamous Cell Carcinoma?

  2014cites this paper
• Bioactive compounds or metabolites from black raspberries modulate T lymphocyte proliferation, myeloid cell differentiation and Jak/STAT signaling

  2014cites this paper
• Anthocyanin structure determines susceptibility to microbial degradation and bioavailability to the buccal mucosa.

  2014cites this paper
• Characterization of black raspberry functional food products for cancer prevention human clinical trials.

  2014cites this paper
• Feasibility of a long-term food-based prevention trial with black raspberries in a post-surgical oral cancer population: Adherence and modulation of biomarkers of DNA damage

  2014influential citation
• Chemoprevention of Oral Squamous Cell Carcinoma: Optimizing Efficacy with Personalized Local Drug Delivery Strategies

  2014influential citation
• APhaseIbStudyoftheEffectsofBlackRaspberriesonRectal Polyps in Patients with Familial Adenomatous Polyposis

  2014cites this paper
• An approach to the evaluation of berries for cancer prevention with emphasis on esophageal cancer

  2014cites this paper
• A Phase Ib Study of the Effects of Black Raspberries on Rectal Polyps in Patients with Familial Adenomatous Polyposis

  2014cites this paper
• Comprehensive evaluation of caspase-14 in vulvar neoplasia: an opportunity for treatment with black raspberry extract.

  2014cites this paper
• Anti-Inflammatory and Immunomodulatory Properties of Dietary Flavonoids

  2014cites this paper
• Topical Application of a Mucoadhesive Freeze-Dried Black Raspberry Gel Induces Clinical and Histologic Regression and Reduces Loss of Heterozygosity Events in Premalignant Oral Intraepithelial Lesions: Results from a Multicentered, Placebo-Controlled Clinical Trial

  2014cites this paper
• APhase IbStudyof theEffectsofBlackRaspberriesonRectal Polyps in Patients with Familial Adenomatous Polyposis

  2014cites this paper
• The Indian Blackberry (Jamun), Antioxidant Capacity, and Cancer Protection

  2014cites this paper
• Odontoiatria e nutraceutica: applicazioni cliniche

  2014cites this paper
• Cancer chemopreventive and therapeutic properties of fruits and vegetables against head and neck malignancies

  2014cites this paper
• Chemoprevention of head and neck squamous cell carcinoma through inhibition of NF-κB signaling.

  2014cites this paper
• Upper esophageal and pharyngeal cancers

  2014cites this paper
• Traditional Phytomedicinal Systems, Scientific Validations and Current Popularity as Nutraceuticals

  2013cites this paper
• Natural Products as Anti-inflammatory Agents

  2013cites this paper
• Chemopreventive Potential of Flavonoids in Oral Squamous Cell Carcinoma in Human Studies

  2013cites this paper
• Potential Health Benefits of Blackcurrants

  2013cites this paper
• Metabolism and Anti-inflammatory Activity of Anthocyanins in Human Oral Cavity

  2012cites this paper
• Strawberry Fields Forever?

  2012cites this paper
• Tissue Expression of inducible Nitric Oxide Synthase (iNOS) and p53 in Oral Squameous Cell Carcinoma Patients

  2012cites this paper
• Cancer prevention by targeting angiogenesis

  2012cites this paper
• Evaluation of a mucoadhesive fenretinide patch for local intraoral delivery: a strategy to reintroduce fenretinide for oral cancer chemoprevention.

  2012cites this paper
• Mucoadhesive fenretinide patches for site-specific chemoprevention of oral cancer: enhancement of oral mucosal permeation of fenretinide by coincorporation of propylene glycol and menthol.

  2012cites this paper
• PROAPOPTOTIC, ANTI-CELL PROLIFERATIVE, ANTI-INFLAMMATORY AND ANTIANGIOGENIC POTENTIAL OF CARNOSIC ACID DURING 7,12 HAMSTER BUCCAL POUCH CARCINOGENESIS.

  2012cites this paper
• Developing Fruit Cultivars with Enhanced Health Properties

  2012cites this paper
• Plasma Cytokines as Potential Response Indicators to Dietary Freeze-Dried Black Raspberries in Colorectal Cancer Patients

  2012cites this paper
• Oral local drug delivery and new perspectives in oral drug formulation.

  2012cites this paper
• Bioactive polyphenol antioxidants protect oral fibroblasts from ROS-inducing agents

  2012cites this paper
• Topical Polyethylene Glycol as a Novel Chemopreventive Agent for Oral Cancer via Targeting of Epidermal Growth Factor Response

  2012cites this paper
• Ellagic Acid – Chemopreventive Role in Oral Cancer

  2012cites this paper
• Proapoptotic, anti-cell proliferative, anti-inflammatory and anti-angiogenic potential of carnosic acid during 7,12 dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis.

  2012cites this paper
• Susceptibility of anthocyanins to ex vivo degradation in human saliva.

  2012cites this paper
• Effects of Black Raspberries on UV-Induced Cutaneous Inflammation and Tumor Development

  2011cites this paper
• Optimizing therapeutic efficacy of chemopreventive agents: A critical review of delivery strategies in oral cancer chemoprevention clinical trials

  2011cites this paper
• Effects of Human Oral Mucosal Tissue, Saliva, and Oral Microflora on Intraoral Metabolism and Bioactivation of Black Raspberry Anthocyanins

  2011influential citation
• Use of antioxidants in oral healthcare.

  2011cites this paper
• Development and In Vitro-In Vivo Evaluation of Fenretinide-Loaded Oral Mucoadhesive Patches for Site-Specific Chemoprevention of Oral Cancer

  2011cites this paper
• Local drug delivery for oral mucosal diseases: challenges and opportunities.

  2011cites this paper