Three-Dimensional Tomographic Imaging and Characterization of Iron Compounds within Alzheimer's Plaque Core Material

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Journal of Alzheimer's Disease

• Publication date

  2008-06-04

• Fields of study

  Medicine, Materials Science, Chemistry

• Identifiers
  DOI 10.3233/JAD-2008-14211PMID 18560134
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Aluminium

  2009cited by this paper
• Pierre

  2009cited by this paper
• Direct imaging of single-walled carbon nanotubes in cells.

  2007cited by this paper
• Iron: The Redox-active Center of Oxidative Stress in Alzheimer Disease

  2007cited by this paper
• About the Presence of Hemosiderin in the Hippocampus of Alzheimer Patients

  2007cited by this paper
• Gradient‐echo and CRAZED imaging for minute detection of Alzheimer plaques in an APPV717I × ADAM10‐dn mouse model

  2007cited by this paper
• Mechanisms of amyloid plaque pathogenesis

  2007cited by this paper
• Preliminary observation of elevated levels of nanocrystalline iron oxide in the basal ganglia of neuroferritinopathy patients.

  2007cited by this paper
• Correlation of proton transverse relaxation rates (R2) with iron concentrations in postmortem brain tissue from alzheimer's disease patients

  2007cited by this paper
• Brain ferritin iron may influence age- and gender-related risks of neurodegeneration.

  2007cited by this paper
• Nanoscale Iron Compounds Related to Neurodegenerative Disorders

  2007cited by this paper
• Study of the localization of iron, ferritin, and hemosiderin in Alzheimer's disease hippocampus by analytical microscopy at the subcellular level.

  2006cited by this paper
• Microbleeds in Alzheimer Disease Are More Related to Cerebral Amyloid Angiopathy than Cerebrovascular Disease

  2006cited by this paper
• Magnetic iron compounds in the human brain: a comparison of tumour and hippocampal tissue

  2006cited by this paper
• Mapping and characterization of iron compounds in Alzheimer's tissue

  2006cited by this paper
• Redox cycling of iron by Aβ42

  2006cited by this paper
• Neuropathology of Alzheimer disease: pathognomonic but not pathogenic

  2006cited by this paper
• Redox cycling of iron by Abeta42.

  2006cited by this paper
• Four-dimensional spectral tomography of carbonaceous nanocomposites.

  2006cited by this paper
• Therapeutic opportunities in Alzheimer disease: one for all or all for one?

  2005cited by this paper
• In situ characterization and mapping of iron compounds in Alzheimer's disease tissue

  2005influential reference
• In Vivo Magnetic Resonance Microimaging of Individual Amyloid Plaques in Alzheimer's Transgenic Mice

  2005cited by this paper
• Ultrastructure of the cells forming amyloid fibers in Alzheimer disease and scrapie.

  2005cited by this paper
• Visualization of β‐amyloid plaques in a transgenic mouse model of Alzheimer's disease using MR microscopy without contrast reagents

  2004cited by this paper
• Electron nanodiffraction and high-resolution electron microscopy studies of the structure and composition of physiological and pathological ferritin.

  2004cited by this paper
• Iron, brain ageing and neurodegenerative disorders

  2004influential reference
• Aluminium, iron, zinc and copper influence the in vitro formation of amyloid fibrils of Aβ42 in a manner which may have consequences for metal chelation therapy in Alzheimer's disease

  2004cited by this paper
• The complex of microglial cells and amyloid star in three-dimensional reconstruction

  2004cited by this paper
• Multiple pathways for mineral core formation in mammalian apoferritin. The role of hydrogen peroxide.

  2003cited by this paper
• Iron misregulation in the brain: a primary cause of neurodegenerative disorders.

  2003cited by this paper
• Preliminary evaluation of nanoscale biogenic magnetite in Alzheimer's disease brain tissue

  2003cited by this paper
• Detection limits for ferrimagnetic particle concentrations using magnetic resonance imaging based proton transverse relaxation rate measurements.

  2003cited by this paper
• Metal binding and oxidation of amyloid-beta within isolated senile plaque cores: Raman microscopic evidence.

  2003influential reference
• The state versus amyloid-β: the trial of the most wanted criminal in Alzheimer disease

  2002cited by this paper
• Redox-active iron mediates amyloid-β toxicity

  2001cited by this paper
• Z-Contrast tomography: a technique inthree-dimensional nanostructural analysis based on Rutherfordscattering

  2001cited by this paper
• Redox-active iron mediates amyloid-beta toxicity.

  2001cited by this paper
• Iron, neuromelanin and ferritin content in the substantia nigra of normal subjects at different ages: consequences for iron storage and neurodegenerative processes

  2001cited by this paper
• Structure of synthetic 2-line ferrihydrite by electron nanodiffraction

  2000cited by this paper
• Sequestration of iron by Lewy bodies in Parkinson’s disease

  2000cited by this paper
• Initial studies with high resolution TEM and electron energy loss spectroscopy studies of ferritin cores extracted from brains of patients with progressive supranuclear palsy and Alzheimer disease.

  2000cited by this paper
• The structure of ferritin cores determined by electron nanodiffraction.

  2000cited by this paper
• Transmission Electron Microscopy of Synthetic 2- and 6-Line Ferrihydrite

  2000cited by this paper
• Mineralization in ferritin: an efficient means of iron storage.

  1999cited by this paper
• Copper, iron and zinc in Alzheimer's disease senile plaques.

  1998cited by this paper
• Confocal observation of senile plaques in Alzheimer's disease: Senile plaque morphology and relationship between senile plaques and astrocytes

  1998cited by this paper
• A method based on ICP-MS for the analysis of Alzheimer's amyloid plaques.

  1998cited by this paper
• Effects of weak magnetic fields on free radical recombination reactions

  1998cited by this paper
• Astrocytes regulate microglial phagocytosis of senile plaque cores of Alzheimer's disease.

  1998cited by this paper
• Electron Energy‐Loss Spectroscopy in the Electron Microscope

  1997influential reference
• Iron accumulation in Alzheimer disease is a source of redox-generated free radicals.

  1997cited by this paper
• Three‐dimensional reconstruction of senile plaques in Alzheimer's disease

  1997cited by this paper
• Dramatic Effect of Magnetite Particles on the Dynamics of Photogenerated Free Radicals

  1997cited by this paper
• Electron Energy-Loss Spectroscopy in the Electron Microscope

  1995cited by this paper
• The role of iron in beta amyloid toxicity.

  1995cited by this paper
• Iron in CNS Disease

  1995cited by this paper
• A Quantitative Analysis of Isoferritins in Select Regions of Aged, Parkinsonian, and Alzheimer's Diseased Brains

  1995cited by this paper
• Re-evaluation of classic senile plaques by three-dimensional analysis

  1994cited by this paper
• Re‐Evaluation of the Structural Organization of Neuritic Plaques in Alzheimer's Disease

  1993cited by this paper
• Magnetite biomineralization in the human brain.

  1992cited by this paper
• Serial reconstruction of beta-protein amyloid plaques: relationship to microvessels and size distribution.

  1992cited by this paper
• THE NON‐HAEMIN IRON IN THE CEREBRAL CORTEX IN ALZHEIMER'S DISEASE

  1960cited by this paper
• THE EFFECT OF AGE ON THE NON‐HAEMIN IRON IN THE HUMAN BRAIN

  1958cited by this paper
• Alzheimer's disease; a clinico-pathologic analysis of twenty-three cases with a theory on pathogenesis.

  1953cited by this paper

• Magnetic dipole imaging of magnetite nanoparticles in brain tissue

  2026cites this paper
• Digging Deep into Alzheimer Disease: How Electron Microscopy Helps Elucidating Its Pathogenesis.

  2026cites this paper
• On the origin of metal species in the human brain: a perspective on key physicochemical properties

  2025influential citation
• Magnetite particle size and spatial distribution may modulate neural oscillation in the human brain

  2025cites this paper
• Down syndrome with Alzheimer’s disease brains have increased iron and associated lipid peroxidation consistent with ferroptosis

  2025cites this paper
• Down syndrome with Alzheimer's disease brains have increased iron and associated lipid peroxidation consistent with ferroptosis

  2025cites this paper
• Mineralogy of the human brain: a review

  2025cites this paper
• Iron accumulation/overload and Alzheimer's disease risk factors in the precuneus region: A comprehensive narrative review

  2024cites this paper
• Exploring Biomineralization Processes Using In Situ Liquid Transmission Electron Microscopy: A Review

  2024cites this paper
• Specific iron binding to natural sphingomyelin membrane induced by non-specific co-solutes.

  2024cites this paper
• The Irony of Iron: The Element with Diverse Influence on Neurodegenerative Diseases

  2024cites this paper
• Label-Free In Situ Chemical Characterization of Amyloid Plaques in Human Brain Tissues

  2024cites this paper
• The Role of Labile Iron on Brain Proteostasis; Could it be an Early Event of Neurodegenerative Disease?

  2023cites this paper
• Ferritin microheterogeneity, subunit composition, functional, and physiological implications

  2023cites this paper
• Iron‐associated lipid peroxidation in Alzheimer's disease is increased in lipid rafts with decreased ferroptosis suppressors, tested by chelation in mice

  2023cites this paper
• Alzheimer’s Disease associations of ferritin and glutathione with oxidative damage and neuronal loss

  2023cites this paper
• The Role of Iron Metabolism, Lipid Metabolism, and Redox Homeostasis in Alzheimer’s Disease: from the Perspective of Ferroptosis

  2023cites this paper
• Chain‐Like Structures of Biogenic and Nonbiogenic Magnetic Nanoparticles in Vascular Tissues

  2022cites this paper
• A modeling study of the effect of an alternating magnetic field on magnetite nanoparticles in proximity of the neuronal microtubules: A proposed mechanism for detachment of tau proteins

  2022cites this paper
• The metal ion hypothesis of Alzheimer's disease and the anti-neuroinflammatory effect of metal chelators.

  2022cites this paper
• The influence of artificial and biogenic magnetic nanoparticles on the metabolism of fungi

  2021cites this paper
• Exploring valence states of abnormal mineral deposits in biological tissues using correlative microscopy and spectroscopy techniques: A case study on ferritin and iron deposits from Alzheimer's disease patients.

  2021cites this paper
• Biogenic metallic elements in the human brain?

  2021cites this paper
• Proton Stimulation Targeting Plaque Magnetite Reduces Amyloid-β Plaque and Iron Redox Toxicity and Improves Memory in an Alzheimer’s Disease Mouse Model

  2021cites this paper
• Nanoscale chemical speciation of β-amyloid/iron aggregates using soft X-ray spectromicroscopy

  2021cites this paper
• Iron and Ferroptosis as Therapeutic Targets in Alzheimer’s Disease

  2020cites this paper
• Correlative Microscopy to Localize and Characterize Iron Deposition in Alzheimer’s Disease

  2020cites this paper
• Identification of a dysfunctional microglial population in human Alzheimer’s disease cortex using novel single-cell histology image analysis

  2020cites this paper
• Associations of quantitative susceptibility mapping with Alzheimer’s disease clinical and imaging markers

  2020cites this paper
• Potentially Pathogenic Calcium Oxalate Dihydrate and Titanium Dioxide Crystals in the Alzheimer’s Disease Entorhinal Cortex

  2020cites this paper
• Iron stored in ferritin is chemically reduced in the presence of aggregating Aβ(1-42)

  2020cites this paper
• Role of Spirulina on gamma-irradiated rats using Fourier transform infrared attenuated total reflectance and Electron spin resonance for brain

  2020cites this paper
• Iron–oxide minerals in the human tissues

  2020cites this paper
• Metal Ion Binding to the Amyloid β Monomer Studied by Native Top-Down FTICR Mass Spectrometry

  2019cites this paper
• Emerging Approaches to Investigate the Influence of Transition Metals in the Proteinopathies

  2019cites this paper
• Brain oxidative stress in rat with chronic iron or copper overload.

  2019cites this paper
• Transmission electron microscopy of the iron oxide core in ferritin proteins: current status and future directions

  2019cites this paper
• Possible magneto-mechanical and magneto-thermal mechanisms of ion channel activation in magnetogenetics

  2019cites this paper
• Probing Trace Elements in Human Tissues with Synchrotron Radiation

  2019cites this paper
• The correlation between accumulation of amyloid beta with enhanced neuroinflammation and cognitive impairment after intraventricular hemorrhage.

  2019cites this paper
• Biogenic magnetic nanoparticles in plants

  2019cites this paper
• Generation of maghemite nanocrystals from iron-sulfur centres.

  2019cites this paper
• Interaction between Human Brain and the Heart during Alzheimer’s Disease. Do These Organs Have a Similar Information Storage Mechanism?

  2019cites this paper
• Correlative Spectromicroscopy and Tomography for Biomedical Applications Involving Electron, Ion, and Soft X-ray Microscopies

  2019cites this paper
• 1.04 Magnetic Nanoparticles

  2019cites this paper
• Development of a Multimodal MRI Study to Characterize Morpho-Functional Features in Rodent Models of Alzheimer's Disease

  2019cites this paper
• Ferrimagnetic organelles in multicellular organisms

  2018cites this paper
• Iron metabolism in diabetes-induced Alzheimer’s disease: a focus on insulin resistance in the brain

  2018cites this paper
• Iron and Alzheimer’s Disease: An Update on Emerging Mechanisms

  2018cites this paper
• Sub-cellular In-situ Characterization of Ferritin(iron) in a Rodent Model of Spinal Cord Injury

  2018cites this paper
• Dietary lipophilic iron alters amyloidogenesis and microglial morphology in Alzheimer's disease knock-in APP mice.

  2018cites this paper
• Nanoscale synchrotron X-ray speciation of iron and calcium compounds in amyloid plaque cores from Alzheimer's disease subjects

  2018cites this paper
• Biogenic magnetic nanoparticles in human organs and tissues.

  2018cites this paper
• Initial bonding of ferric ion (Fe 3+ ) and amyloid beta (A ß ) peptide as the precondition for oxidative stress in Alzheimer's disease

  2018cites this paper
• Quantitative comparison of different iron forms in the temporal cortex of Alzheimer patients and control subjects

  2018cites this paper
• Investigating the effect of ascorbate on the Fe(II)-catalyzed transformation of the poorly crystalline iron mineral ferrihydrite.

  2018cites this paper
• Light on the Biomineralization of Ferritin

  2018cites this paper
• Detection of biogenic magnetic nanoparticles in ethmoid bones of migratory and non-migratory fishes

  2018cites this paper
• Investigation of the redox state of magnetite upon Aβ-fibril formation or proton irradiation; implication of iron redox inactivation and β-amyloidolysis

  2018cites this paper
• Determination of Potential Producers of Biogenic Magnetic Nanoparticles Among the Fungi Representatives of Ascomycota and Basidiomycota Divisions

  2018cites this paper
• Using the magnetoencephalogram to noninvasively measure magnetite in the living human brain

  2018cites this paper
• Aerosolized Coal Fly Ash: Risk Factor for Neurodegenerative Disease

  2018cites this paper
• Metals and Mitochondria in Neurodegeneration

  2017cites this paper
• The benefit of thresholding carbon layers in electron tomographic tilt series by intensity downshifting

  2017cites this paper
• Magnetic mapping of iron in rodent spleen.

  2017cites this paper
• Physiological origin of biogenic magnetic nanoparticles in health and disease: from bacteria to humans

  2017cites this paper
• Alzheimer's Disease: What is the Connection between Amyloid Plaques, Magnetite and Memory?

  2017cites this paper
• Detection of Iron in Biological Samples Using Magnetic Force Microscopy

  2017cites this paper
• NOVEL MODEL FOR LOADING BRAIN IRON IN MICE: IMPLICATIONS FOR STUDYING AGING AND AMYLOID PATHOLOGY

  2017cites this paper
• Multielement concentration analysis of Swiss mice brains on experimental model of Alzheimer's disease induced by β‐amyloid oligomers

  2017cites this paper
• Alzheimer’s disease: How metal ions define β-amyloid function

  2017cites this paper
• Revealing the Iron Oxides Mineral Core in Ferritin due to the Variations in the H and L Subunits

  2017cites this paper
• Iron Biochemistry is Correlated with Amyloid Plaque Morphology in an Established Mouse Model of Alzheimer's Disease.

  2017influential citation
• Rat Brain Damage due to Iron and Copper Toxicity

  2017cites this paper
• High-resolution analytical imaging and electron holography of magnetite particles in amyloid cores of Alzheimer’s disease

  2016cites this paper
• Nucleic acid oxidative damage in Alzheimer's disease-explained by the hepcidin-ferroportin neuronal iron overload hypothesis?

  2016cites this paper
• A Bacterial Component to Alzheimer’s-Type Dementia Seen via a Systems Biology Approach that Links Iron Dysregulation and Inflammagen Shedding to Disease

  2016cites this paper
• A ferromagnetic model for the action of electric and magnetic fields 5 in cryopreservation q , qq

  2016cites this paper
• Sodium selenate regulates the brain ionome in a transgenic mouse model of Alzheimer’s disease

  2016cites this paper
• Iron Oxides in the Human Brain

  2016cites this paper
• Amyloid Aβ42, a promoter of magnetite nanoparticle formation in Alzheimer’s disease

  2016cites this paper
• Understanding Aspects of Aluminum Exposure in Alzheimer's Disease Development

  2016influential citation
• Tempol and perindopril protect against lipopolysaccharide-induced cognition impairment and amyloidogenesis by modulating brain-derived neurotropic factor, neuroinflammation and oxido-nitrosative stress

  2016cites this paper
• The Influence of Extremely Low-Frequency Magnetic Field and Magnetic Nanoparticle on $\text{A}{\boldsymbol \beta }_{\boldsymbol {40}}$ Aggregation In Vitro

  2015cites this paper
• Quantitative T2, T2*, and T2′ MR imaging in patients with ischemic leukoaraiosis might detect microstructural changes and cortical hypoxia

  2015cites this paper
• Activated iron-containing microglia in the human hippocampus identified by magnetic resonance imaging in Alzheimer disease.

  2015cites this paper
• The relationship between iron dyshomeostasis and amyloidogenesis in Alzheimer's disease: Two sides of the same coin.

  2015cites this paper
• The effect of iron in MRI and transverse relaxation of amyloid‐beta plaques in Alzheimer's disease

  2015cites this paper
• Impact of Iron Incorporation on 2–4 nm Size Silicon Nanoparticles Properties

  2015cites this paper
• Biomedical and agricultural applications of energy dispersive X-ray spectroscopy in electron microscopy

  2015cites this paper
• Brain iron deposits and lifespan cognitive ability

  2015cites this paper
• The influence of extremely low frequency magnetic field and magnetic nanoparticle on Aβ1-40 aggregation in vitro

  2015cites this paper
• Perspective Is there a Connection between Alzheimer’s Disease, Magnetite and Prions?

  2015cites this paper
• Iron oxides in human spleen

  2015cites this paper
• Cortical iron regulation and inflammatory response in Alzheimer's disease and APPSWE/PS1ΔE9 mice: a histological perspective

  2015influential citation
• MR Microscopy of human Aβ deposits characterization of parenchymal amyloid, diffuse plaques and vascular amyloid Chapter

  2014cites this paper
• Evidence of redox-active iron formation following aggregation of ferrihydrite and the Alzheimer's disease peptide β-amyloid.

  2014cites this paper
• A ferromagnetic model for the action of electric and magnetic fields in cryopreservation.

  2014cites this paper
• iron and the Alzheimer's disease peptide Ferrous iron formation following the co-aggregation of ferric

  2014cites this paper
• Genetic and biochemical markers in patients with Alzheimer's disease support a concerted systemic iron homeostasis dysregulation.

  2014cites this paper