Visualization of β‐amyloid plaques in a transgenic mouse model of Alzheimer's disease using MR microscopy without contrast reagents

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Magnetic Resonance in Medicine

• Publication date

  2004-09-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1002/mrm.20196PMID 15334572PMCID PMC3962264
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The metallobiology of Alzheimer's disease.

  2003cited by this paper
• Detection of Alzheimer's amyloid in transgenic mice using magnetic resonance microimaging

  2003cited by this paper
• Senile plaque composition and posttranslational modification of amyloid-beta peptide and associated proteins.

  2002cited by this paper
• Localization of neurofibrillary tangles and beta-amyloid plaques in the brains of living patients with Alzheimer disease.

  2002cited by this paper
• Radioiodinated styrylbenzene derivatives as potential SPECT imaging agents for amyloid plaque detection in alzheimer’s disease

  2002cited by this paper
• A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain.

  2002cited by this paper
• Molecular targeting of Alzheimer's amyloid plaques for contrast-enhanced magnetic resonance imaging.

  2002cited by this paper
• MR microscopy and high resolution small animal MRI: applications in neuroscience research.

  2002cited by this paper
• Imaging Aβ Plaques in Living Transgenic Mice with Multiphoton Microscopy and Methoxy‐X04, a Systemically Administered Congo Red Derivative

  2002cited by this paper
• Senile plaques do not induce susceptibility effects in T 2*‐weighted MR microscopic images

  2002cited by this paper
• Inflammatory responses to amyloidosis in a transgenic mouse model of Alzheimer's disease.

  2001cited by this paper
• Imaging of amyloid-β deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy

  2001cited by this paper
• IBOX(2-(4'-dimethylaminophenyl)-6-iodobenzoxazole): a ligand for imaging amyloid plaques in the brain.

  2001cited by this paper
• In vivo evaluation of brain iron in Alzheimer disease using magnetic resonance imaging.

  2000cited by this paper
• Effect of formalin tissue fixation and processing on immunohistochemistry.

  2000cited by this paper
• Age-related amyloid beta deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid beta precursor protein Swedish mutant is not associated with global neuronal loss.

  2000cited by this paper
• Detection of neuritic plaques in Alzheimer's disease by magnetic resonance microscopy.

  1999cited by this paper
• Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse

  1999cited by this paper
• Amyloid‐β Deposition in Alzheimer Transgenic Mice Is Associated with Oxidative Stress

  1998influential reference
• Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

  1998cited by this paper
• Iron deposits in multiple sclerosis and Alzheimer's disease brains.

  1997cited by this paper
• Iron accumulation in Alzheimer disease is a source of redox-generated free radicals.

  1997cited by this paper
• Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

  1996cited by this paper
• Imaging of brain iron by magnetic resonance: T2 relaxation at different field strengths.

  1995cited by this paper
• Comparison of t2 relaxation in blood, brain, and ferritin

  1995cited by this paper
• Automatic, localized in Vivo adjustment of all first‐and second‐order shim coils

  1993cited by this paper
• A histochemical study of iron, transferrin, and ferritin in Alzheimer's diseased brains

  1992cited by this paper
• MRI of brain iron.

  1986cited by this paper
• Magnetic Resonance in Medicine 51:794–798 (2004) MRI Assessment of Neuropathology in a Transgenic Mouse Model of Alzheimer’s Disease

  year unknowncited by this paper

• Detecting Beta-amyloid Plaque via Low Rank Based Orthogonal Projection and Spatial-spectrum Detector Using High-resolution Quantitative Susceptibility Mapping for Preclinical Studies.

  2025cites this paper
• The diamagnetic component map from quantitative susceptibility mapping (QSM) source separation reveals pathological alteration in Alzheimer's disease-driven neurodegeneration

  2023cites this paper
• Molecular Design of Magnetic Resonance Imaging Agents Binding to Amyloid Deposits

  2023cites this paper
• White Button Mushroom (Agaricus bisporus) Supplementation Ameliorates Spatial Memory Deficits and Plaque Formation in an Amyloid Precursor Protein Mouse Model of Alzheimer’s Disease

  2022cites this paper
• A literature review of MRI techniques used to detect amyloid-beta plaques in Alzheimer's disease patients.

  2021cites this paper
• Amyloid β oligomer selective antibodies for Alzheimer’s therapeutics and diagnostics

  2021cites this paper
• A New Tool for the Analysis of the Effect of Intracerebrally Injected Anti-Amyloid-β Compounds

  2021cites this paper
• Decompose quantitative susceptibility mapping (QSM) to sub-voxel diamagnetic and paramagnetic components based on gradient-echo MRI data

  2021cites this paper
• Copper Dyshomeostasis in Neurodegenerative Diseases—Therapeutic Implications

  2020cites this paper
• Linking gradient echo plural contrast imaging metrics of tissue microstructure with Alzheimer disease

  2020cites this paper
• A Snapshot on the Current Status of Alzheimer's Disease, Treatment Perspectives, In-Vitro and In-Vivo Research Studies and Future Opportunities.

  2019cites this paper
• In Vivo MRI of Amyloid Plaques in a Cholesterol-Fed Rabbit Model of Alzheimer’s Disease

  2018cites this paper
• Modulation of the ATP-Binding Cassette B1 Transporter by Neuro-Inflammatory Cytokines: Role in the Pathogenesis of Alzheimer's Disease

  2018cites this paper
• Magnetic Nanoparticles Applications for Amyloidosis Study and Detection: A Review

  2018cites this paper
• Metal complexes for multimodal imaging of misfolded protein-related diseases.

  2017cites this paper
• Tissue magnetic susceptibility mapping as a 1 marker of tau pathology in Alzheimer ’ s Disease 2 3

  2017cites this paper
• Iron, Copper, and Zinc Concentration in Aβ Plaques in the APP/PS1 Mouse Model of Alzheimer's Disease Correlates with Metal Levels in the Surrounding Neuropil.

  2017cites this paper
• POLYCARBOXYLATED PORPHYRINS AND USE THEREOF IN TREATMENT OF METAL TOXCITIES BACKGROUND OF THE INVENTION

  2017cites this paper
• Tissue magnetic susceptibility mapping as a marker of tau pathology in Alzheimer's disease

  2017cites this paper
• [Detection algorithm of amyloid β-protein deposition in magnetic resonance image based on pixel feature learning method].

  2017cites this paper
• In vivo detection of microstructural correlates of brain pathology in preclinical and early Alzheimer Disease with magnetic resonance imaging

  2017cites this paper
• Tissue Damage Quantification in Alzheimer's Disease Brain via Magnetic Resonance Gradient Echo Plural Contrast Imaging (GEPCI)

  2017cites this paper
• Postmortem imaging and neuropathologic correlations.

  2016cites this paper
• Chronic fetal hypoxia affects axonal maturation in guinea pigs during development: A longitudinal diffusion tensor imaging and T2 mapping study

  2015cites this paper
• Development of magnetic resonance imaging techniques for mouse models of Alzheimer's Disease

  2015cites this paper
• Seven-Tesla MRI and neuroimaging biomarkers for Alzheimer's disease.

  2015cites this paper
• Review - Part of the Special Issue: Alzheimer's Disease - Amyloid, Tau and Beyond Perspective on future role of biological markers in clinical therapy trials of Alzheimer's disease: A long-range point of view beyond 2020

  2014cites this paper
• A review of β-amyloid neuroimaging in Alzheimer's disease

  2014influential citation
• MR Microscopy of human Aβ deposits characterization of parenchymal amyloid, diffuse plaques and vascular amyloid Chapter

  2014cites this paper
• Cortical phase changes in Alzheimer's disease at 7T MRI: A novel imaging marker

  2014cites this paper
• The Road Ahead to Cure Alzheimer's Disease: Development of Biological Markers and Neuroimaging Methods for Prevention Trials Across all Stages and Target Populations.

  2014cites this paper
• MR Microscopy of Human Amyloid-β Deposits: Characterization of Parenchymal Amyloid, Diffuse Plaques, and Vascular Amyloid

  2013cites this paper
• Molecular Probes for Magnetic Resonance Imaging of Amyloid β Peptides

  2013cites this paper
• Micro-MRI Study of Cerebral Aging: Ex Vivo Detection of Hippocampal Subfield Reorganization, Microhemorrhages and Amyloid Plaques in Mouse Lemur Primates

  2013cites this paper
• Alzheimer's disease biomarkers in animal models: closing the translational gap.

  2013cites this paper
• Quantitative evaluation of MRI and histological characteristics of the 5xFAD Alzheimer mouse brain

  2013cites this paper
• Alzheimer's disease biomarkers: correspondence between human studies and animal models.

  2013cites this paper
• Current neuroimaging techniques in Alzheimer's disease and applications in animal models.

  2012cites this paper
• In vivo magnetic resonance imaging of amyloid-β plaques in mice.

  2012cites this paper
• Expansion of Corticomedullary Junction High‐Susceptibility Region (CMJ‐HSR) with Aging: A Clue in the Pathogenesis of Alzheimer's Disease?

  2012cites this paper
• Fluid-Attenuated Inversion Recovery Hypointensity of the Pulvinar Nucleus of Patients with Alzheimer Disease: Its Possible Association with Iron Accumulation as Evidenced by the T2* Map

  2012cites this paper
• Automatic segmentation of amyloid plaques in MR images using unsupervised support vector machines

  2012cites this paper
• Generation and Characterization of Transgenic Mice for Noninvasive Cell Tracking with PET and for FRET-based cGMP Imaging

  2012cites this paper
• Ultra-High Field 7T MRI: A New Tool for Studying Alzheimer's Disease

  2011cites this paper
• Regional differences in MRI detection of amyloid plaques in AD transgenic mouse brain

  2011influential citation
• Magnetic resonance imaging of amyloid plaques in transgenic mouse models of Alzheimer's disease.

  2011cites this paper
• Detecting amyloid-β plaques in Alzheimer's disease.

  2011cites this paper
• Amyloid oligomer formation probed by water proton magnetic resonance spectroscopy.

  2011cites this paper
• Detection of amyloid plaques targeted by USPIO-Aβ1-42 in Alzheimer's disease transgenic mice using magnetic resonance microimaging

  2011cites this paper
• APP Transgenic Mice: Their Use and Limitations

  2011cites this paper
• In Vivo Imaging Biomarkers in Mouse Models of Alzheimer's Disease: Are We Lost in Translation or Breaking Through?

  2010cites this paper
• Potential amyloid plaque-specific peptides for the diagnosis of Alzheimer's disease.

  2010cites this paper
• Mouse models in neurological disorders: applications of non-invasive imaging.

  2010cites this paper
• Magnetic Resonance Imaging Detection and Time Course of Cerebral Microhemorrhages during Passive Immunotherapy in Living Amyloid Precursor Protein Transgenic Mice

  2010cites this paper
• Remote sites of structural atrophy predict later amyloid formation in a mouse model of Alzheimer's disease

  2010cites this paper
• In Vivo Monitoring of Liposomal Encapsulated siRNA Delivery

  2010cites this paper
• Neuroimaging Studies in Alzheimer's Disease

  2009cites this paper
• Prospects for early detection of Alzheimer's disease from serial MR images in transgenic mice.

  2009cites this paper
• Prospects for Early Detection of Alzheimers Disease from Serial MR Images in Transgenic Mouse Models

  2009cites this paper
• Comparison of amyloid plaque contrast generated by T2‐weighted, T  2* ‐weighted, and susceptibility‐weighted imaging methods in transgenic mouse models of Alzheimer's disease

  2009cites this paper
• Characterization of in vivo MRI detectable thalamic amyloid plaques from APP/PS1 mice.

  2009cites this paper
• Recent Advances in Visualizing Alzheimer's Plaques by Magnetic Reso- nance Imaging

  2009cites this paper
• Cerebral amyloidosis: postmortem detection with human 7.0-T MR imaging system.

  2009cites this paper
• Bound Water as a Tool to Detect Soluble Amyloid Oligomers and Amyloid Protofibrils , the Early Stage of Development of the Alzheimer ’ s Disease

  2008cites this paper
• Three-Dimensional Tomographic Imaging and Characterization of Iron Compounds within Alzheimer's Plaque Core Material

  2008cites this paper
• Hydration Profiles of Amyloidogenic Molecular Structures

  2008cites this paper
• Investigating Pharmacology In Vivo Using Magnetic Resonance and Optical Imaging

  2008cites this paper
• Preclinical MRI and NMR Biomarkers of Alzheimer’s Disease: Concepts and Applications

  2008cites this paper
• Le diagnostic de la maladie d’Alzheimer : l’apport de la recherche préclinique

  2008cites this paper
• In Vivo Visualization of Senile‐Plaque‐Like Pathology in Alzheimer's Disease Patients by MR Microscopy on a 7T System

  2008cites this paper
• Animal Models in Functional Magnetic Resonance Imaging

  2008cites this paper
• [Diagnosis of Alzheimer's disease: the contribution of preclinical research].

  2008cites this paper
• A non-toxic ligand for voxel-based MRI analysis of plaques in AD transgenic mice.

  2008cites this paper
• In vivo magnetic resonance imaging and spectroscopy of Alzheimer’s disease in transgenic mice

  2008cites this paper
• Quantitative MRI reveals aging‐associated T2 changes in mouse models of Alzheimer's disease

  2007cites this paper
• In Vivo mouse imaging and spectroscopy in drug discovery

  2007cites this paper
• Pathological ageing of the brain: a neuroimaging perspective

  2007cites this paper
• MAGNETIC RESONANCE IMAGING AND BEHAVIOURAL TEST COMPARISONS IN A MOUSE MODEL OF ALZHEIMER'S DISEASE

  2007cites this paper
• Gradient‐echo and CRAZED imaging for minute detection of Alzheimer plaques in an APPV717I × ADAM10‐dn mouse model

  2007cites this paper
• Magnetic Resonance Imaging of Alzheimer's Pathology in the Brains of Living Transgenic Mice: A New Tool in Alzheimer's Disease Research

  2007cites this paper
• MRI of mouse models of neurological disorders

  2007cites this paper
• 8C-6 Anisotropic Viscoelastic Properties of the Corpus Callosum - Application of High-Resolution 3D MR-Elastography to an Alzheimer Mouse Model

  2007cites this paper
• Chapter 15 Advances in Neuroimaging

  2007cites this paper
• Neuroprotective effect of Coenzyme Q10 on ischemic hemisphere in aged mice with mutations in the amyloid precursor protein.

  2007cites this paper
• Review Article MRI of mouse models of neurological disorders y

  2007cites this paper
• In vivo axonal transport rates decrease in a mouse model of Alzheimer's disease

  2007cites this paper
• In vivo measurement of plaque burden in a mouse model of Alzheimer's disease

  2006cites this paper
• Metabolism of amyloid beta peptide and pathogenesis of Alzheimer's disease. Towards presymptomatic diagnosis, prevention and therapy.

  2006cites this paper
• Fully automated shim mapping method for spectroscopic imaging of the mouse brain at 9.4 T

  2006influential citation
• Longitudinal assessment of Alzheimer's β‐amyloid plaque development in transgenic mice monitored by in vivo magnetic resonance microimaging

  2006cites this paper
• Ex situ atomic force microscopy analysis of beta-amyloid self-assembly and deposition on a synthetic template.

  2006cites this paper
• Imaging Alzheimer’s Disease with MRI

  2006cites this paper
• Passive staining: A novel ex vivo MRI protocol to detect amyloid deposits in mouse models of Alzheimer's disease

  2006cites this paper
• Magnetic Resonance Imaging and Spectroscopy in Transgenic Mice Modeling Alzheimer’s Disease

  2006cites this paper
• Age-related evolution of amyloid burden, iron load, and MR relaxation times in a transgenic mouse model of Alzheimer's disease.

  2006cites this paper
• High-Resolution and Microscopic Imaging at High Field

  2006cites this paper
• Research by phage display of peptides with specific affinity for the amyloid peptide A-beta 1-42 for the MRI detection of amyloid plaques in Alzheimer disease

  2006cites this paper
• Metabolism of amyloid β peptide and pathogenesis of Alzheimer's disease Towards presymptomatic diagnosis, prevention and therapy

  2006cites this paper
• Evaluation of white matter integrity in ex vivo brains of amyloid plaque-bearing APPsw transgenic mice using magnetic resonance diffusion tensor imaging.

  2006cites this paper
• High-field Magnetic Resonance Imaging of Brain Iron in Alzheimer Disease

  2006cites this paper