Opioid Limbic Circuit for Reward: Interaction between Hedonic Hotspots of Nucleus Accumbens and Ventral Pallidum

μ-Opioid stimulation of cubic millimeter hedonic hotspots in either the nucleus accumbens shell (NAc) or the ventral pallidum (VP) amplifies hedonic “liking” reactions to sweetness and appetitive “wanting” for food reward. How do these two NAc–VP hotspots interact? To probe their interaction and limbic circuit properties, we assessed whether opioid activation of one hotspot recruited the other hotspot (neurobiologically) and whether opioid hedonic and incentive motivational amplification by either opioid hotspot required permissive opioid coactivation in the other (behaviorally). We found that NAc and VP hotspots reciprocally modulated Fos expression in each other and that the two hotspots were needed together to enhance sucrose “liking” reactions, essentially cooperating within a single hedonic NAc–VP circuit. In contrast, the NAc hotspot dominated for opioid stimulation of eating and food intake (“wanting”), independent of VP activation. This pattern reveals differences between limbic opioid circuits that control reward “liking” and “wanting” functions.

• Publication year

  2007

• Venue

  Journal of Neuroscience

• Publication date

  2007-02-14

• Fields of study

  Biology, Medicine, Psychology

• Identifiers
  DOI 10.1523/JNEUROSCI.4205-06.2007PMID 17301168PMCID PMC6673729
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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